KEGG   PATHWAY: aml05146
Entry
aml05146                    Pathway                                
Name
Amoebiasis - Ailuropoda melanoleuca (giant panda)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
aml05146  Amoebiasis
aml05146

Disease
H00360  Amoebiasis
Organism
Ailuropoda melanoleuca (giant panda) [GN:aml]
Gene
100462659  IFNG; interferon gamma precursor [KO:K04687]
100463539  C9; complement component C9 isoform X1 [KO:K04000]
100463583  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
100463584  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
100463732  [KO:K05505]
100463775  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100463849  [KO:K04636]
100464134  FN1; fibronectin isoform X1 [KO:K05717]
100464257  HSPB1; heat shock protein beta-1 [KO:K04455]
100464496  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
100464853  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100465129  TLR2; toll-like receptor 2 [KO:K10159]
100465232  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
100465597  LAMB3; laminin subunit beta-3 isoform X2 [KO:K06244]
100465830  LAMA1; laminin subunit alpha-1 [KO:K05637]
100466241  [KO:K05505]
100466243  PRDX1; peroxiredoxin-1 isoform X2 [KO:K13279] [EC:1.11.1.24]
100467182  SERPINB10; serpin B10 [KO:K13963]
100467208  CD14; monocyte differentiation antigen CD14 [KO:K04391]
100467263  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
100467906  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100467916  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100468187  [KO:K13963]
100468252  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
100468386  [KO:K06448]
100468736  RAB5B; ras-related protein Rab-5B [KO:K07888]
100469007  RAB5C; ras-related protein Rab-5C [KO:K07889]
100469056  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
100469138  CD1E; T-cell surface glycoprotein CD1e, membrane-associated isoform X1 [KO:K06448]
100469231  [KO:K04632]
100469389  [KO:K06448]
100469441  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
100469628  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100469689  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100469944  GNA15; guanine nucleotide-binding protein subunit alpha-15 isoform X1 [KO:K04637]
100470060  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100470471  IL12A; interleukin-12 subunit alpha isoform X2 [KO:K05406]
100470703  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
100470994  [KO:K06448]
100471155  [KO:K06448]
100471490  [KO:K05505]
100471563  TNF; tumor necrosis factor [KO:K03156]
100472054  CXCL8; interleukin-8 [KO:K10030]
100472341  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
100472350  COL3A1; collagen alpha-1(III) chain [KO:K19720]
100472398  [KO:K06448]
100472419  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
100472572  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
100472777  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100472815  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
100472991  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
100473502  [KO:K05427]
100473680  [KO:K04632]
100474779  PLCB2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
100474885  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100475077  LAMC2; laminin subunit gamma-2 [KO:K06246]
100475113  C8B; complement component C8 beta chain [KO:K03998]
100475271  RAB7B; ras-related protein Rab-7b [KO:K07898]
100475291  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100475340  [KO:K06461]
100475861  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
100475938  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
100476098  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
100476237  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100476326  LAMC1; laminin subunit gamma-1 [KO:K05635]
100476722  VCL; vinculin isoform X1 [KO:K05700]
100477151  IL6; interleukin-6 precursor [KO:K05405]
100477198  LAMC3; laminin subunit gamma-3 [KO:K06247]
100477326  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100477380  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
100477772  IL12B; interleukin-12 subunit beta [KO:K05425]
100477974  LAMB2; laminin subunit beta-2 [KO:K06243]
100478007  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100478660  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100478752  COL4A1; collagen alpha-1(IV) chain isoform X4 [KO:K06237]
100478914  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
100479004  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
100479294  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100479580  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100479688  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
100479782  C8A; complement component C8 alpha chain [KO:K03997]
100479878  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
100480073  RAB7A; ras-related protein Rab-7a [KO:K07897]
100480158  RELA; transcription factor p65 isoform X1 [KO:K04735]
100480195  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
100480603  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100480640  [KO:K06448]
100480874  IL1B; interleukin-1 beta [KO:K04519]
100481281  RAB5A; ras-related protein Rab-5A [KO:K07887]
100481671  IL10; interleukin-10 [KO:K05443]
100481755  PLCB1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100482082  SERPINB13; serpin B13 [KO:K13963]
100482780  LAMA5; laminin subunit alpha-5 [KO:K06240]
100483145  SERPINB6; serpin B6 [KO:K13963]
100483395  SERPINB9; serpin B9 isoform X2 [KO:K13963]
100483828  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100484264  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
100484669  LAMA3; laminin subunit alpha-3 isoform X3 [KO:K06240]
100484712  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100484719  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
105238033  MUC2; LOW QUALITY PROTEIN: mucin-2 [KO:K10955]
109488324  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
109488338  [KO:K06448]
109488341  [KO:K06448]
117797265  [KO:K01319] [EC:3.4.21.20]
117799555  [KO:K13279] [EC:1.11.1.24]
117799874  [KO:K13279] [EC:1.11.1.24]
117803984  [KO:K05405]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
aml00330  Arginine and proline metabolism
aml00590  Arachidonic acid metabolism
aml04144  Endocytosis
aml04210  Apoptosis
aml04510  Focal adhesion
aml04610  Complement and coagulation cascades
aml04612  Antigen processing and presentation
aml04620  Toll-like receptor signaling pathway
aml04672  Intestinal immune network for IgA production
aml04810  Regulation of actin cytoskeleton
KO pathway
ko05146   

DBGET integrated database retrieval system