KEGG   PATHWAY: cclu00310
Entry
cclu00310                   Pathway                                
Name
Lysine degradation - Coregonus clupeaformis (lake whitefish)
Class
Metabolism; Amino acid metabolism
Pathway map
cclu00310  Lysine degradation
cclu00310

Module
cclu_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:cclu00310]
Other DBs
GO: 0006554
Organism
Coregonus clupeaformis (lake whitefish) [GN:cclu]
Gene
121530909  [KO:K15588] [EC:2.1.1.357]
121530937  [KO:K11428] [EC:2.1.1.361]
121531191  [KO:K14157] [EC:1.5.1.8 1.5.1.9]
121531456  [KO:K20796] [EC:2.1.1.354]
121531607  [KO:K15791] [EC:1.2.4.-]
121531884  [KO:K11429] [EC:2.1.1.362]
121532031  [KO:K00382] [EC:1.8.1.4]
121533480  [KO:K11703] [EC:2.4.1.50]
121533519  [KO:K11427] [EC:2.1.1.360]
121533848  [KO:K00149] [EC:1.2.1.47 1.2.1.3]
121534845  [KO:K00471] [EC:1.14.11.1]
121535290  [KO:K09188] [EC:2.1.1.354]
121535589  aldh9a1b; 4-trimethylaminobutyraldehyde dehydrogenase B [KO:K00149] [EC:1.2.1.47 1.2.1.3]
121537893  [KO:K09187] [EC:2.1.1.354]
121538205  [KO:K11419] [EC:2.1.1.355]
121538233  prdm16; histone-lysine N-methyltransferase PRDM16 isoform X1 [KO:K22410] [EC:2.1.1.367]
121538237  plod1a; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform X1 [KO:K00473] [EC:1.14.11.4]
121538291  prdm2a; PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
121538517  [KO:K11419] [EC:2.1.1.355]
121538892  [KO:K15588] [EC:2.1.1.357]
121539107  [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121539278  dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
121539559  hadhab; hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha b [KO:K07515] [EC:4.2.1.17 1.1.1.211]
121539764  smyd3; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase SMYD3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121540306  [KO:K11703] [EC:2.4.1.50]
121540357  [KO:K11427] [EC:2.1.1.360]
121540551  aass; alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X1 [KO:K14157] [EC:1.5.1.8 1.5.1.9]
121540555  [KO:K00382] [EC:1.8.1.4]
121541595  [KO:K11420] [EC:2.1.1.355]
121541701  [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121541803  [KO:K00474] [EC:1.14.11.8]
121542611  setd2; histone-lysine N-methyltransferase SETD2 isoform X1 [KO:K11423] [EC:2.1.1.359]
121542657  setd7; histone-lysine N-methyltransferase SETD7 isoform X1 [KO:K11431] [EC:2.1.1.364]
121542806  [KO:K11423] [EC:2.1.1.359]
121543045  [KO:K00128] [EC:1.2.1.3]
121543877  [KO:K11421] [EC:2.1.1.366]
121544574  [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121544655  [KO:K07515] [EC:4.2.1.17 1.1.1.211]
121544721  phykpl; 5-phosphohydroxy-L-lysine phospho-lyase isoform X1 [KO:K18202] [EC:4.2.3.134]
121544914  [KO:K00658] [EC:2.3.1.61]
121545072  [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121545532  [KO:K11419] [EC:2.1.1.355]
121545663  [KO:K11419] [EC:2.1.1.355]
121545990  [KO:K22410] [EC:2.1.1.367]
121546498  [KO:K09187] [EC:2.1.1.354]
121547581  [KO:K20796] [EC:2.1.1.354]
121547658  camkmt; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
121547801  setdb2; histone-lysine N-methyltransferase SETDB2 isoform X1 [KO:K18494] [EC:2.1.1.355]
121548575  [KO:K00658] [EC:2.3.1.61]
121548754  [KO:K00626] [EC:2.3.1.9]
121548814  [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121549477  [KO:K09188] [EC:2.1.1.354]
121549776  ezh2; histone-lysine N-methyltransferase EZH2 isoform X1 [KO:K11430] [EC:2.1.1.356]
121550365  aldh16a1; aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
121550404  [KO:K11703] [EC:2.4.1.50]
121550571  [KO:K17451] [EC:2.1.1.356]
121551004  [KO:K00252] [EC:1.3.8.6]
121551679  [KO:K15588] [EC:2.1.1.357]
121552292  [KO:K00626] [EC:2.3.1.9]
121552910  [KO:K00658] [EC:2.3.1.61]
121553216  echs1; enoyl-CoA hydratase, mitochondrial [KO:K07511] [EC:4.2.1.17]
121553854  gcdha; glutaryl-CoA dehydrogenase a [KO:K00252] [EC:1.3.8.6]
121554858  ehhadh; peroxisomal bifunctional enzyme isoform X1 [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
121555611  [KO:K13645] [EC:1.14.11.4]
121555682  [KO:K00128] [EC:1.2.1.3]
121556695  nsd2; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
121556964  [KO:K14959] [EC:2.1.1.354]
121557767  plod3; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
121560684  [KO:K11429] [EC:2.1.1.362]
121560747  [KO:K09186] [EC:2.1.1.354]
121562471  [KO:K11425] [EC:2.1.1.370 2.1.1.371]
121564826  [KO:K04462] [EC:2.1.1.367]
121567356  [KO:K09186] [EC:2.1.1.354]
121567563  [KO:K04462] [EC:2.1.1.367]
121567675  [KO:K00128] [EC:1.2.1.3]
121567754  pipox; peroxisomal sarcosine oxidase isoform X1 [KO:K00306] [EC:1.5.3.1 1.5.3.7]
121568624  [KO:K11422] [EC:2.1.1.354]
121568683  [KO:K09188] [EC:2.1.1.354]
121569320  [KO:K11430] [EC:2.1.1.356]
121569429  [KO:K00252] [EC:1.3.8.6]
121569566  [KO:K17451] [EC:2.1.1.356]
121569741  [KO:K11703] [EC:2.4.1.50]
121569958  [KO:K13645] [EC:1.14.11.4]
121570210  [KO:K11429] [EC:2.1.1.362]
121570258  [KO:K00128] [EC:1.2.1.3]
121571221  [KO:K00825] [EC:2.6.1.7 2.6.1.39]
121571388  [KO:K14959] [EC:2.1.1.354]
121571414  ash1l; histone-lysine N-methyltransferase ASH1L isoform X2 [KO:K06101] [EC:2.1.1.354]
121571467  [KO:K11420] [EC:2.1.1.355]
121573297  [KO:K00471] [EC:1.14.11.1]
121573458  [KO:K11703] [EC:2.4.1.50]
121573795  [KO:K11422] [EC:2.1.1.354]
121574138  [KO:K11428] [EC:2.1.1.361]
121575762  [KO:K11432] [EC:2.1.1.355]
121575866  [KO:K11433] [EC:2.1.1.357]
121576502  hykk.2; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
121576631  [KO:K11429] [EC:2.1.1.362]
121577079  [KO:K15791] [EC:1.2.4.-]
121577816  [KO:K20796] [EC:2.1.1.354]
121578499  prdm2b; PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
121578879  [KO:K15588] [EC:2.1.1.357]
121579219  kmt2e; LOW QUALITY PROTEIN: inactive histone-lysine N-methyltransferase 2E [KO:K09189] [EC:2.1.1.354]
121579752  aldh3a2b; aldehyde dehydrogenase family 3 member A2b [KO:K00128] [EC:1.2.1.3]
121579797  [KO:K00626] [EC:2.3.1.9]
121580329  [KO:K00474] [EC:1.14.11.8]
121580684  hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [KO:K00022] [EC:1.1.1.35]
121580704  [KO:K11703] [EC:2.4.1.50]
121581316  [KO:K09188] [EC:2.1.1.354]
121581880  [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121581995  aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
121582371  [KO:K11422] [EC:2.1.1.354]
121582469  [KO:K11426] [EC:2.1.1.354 2.1.1.357]
121582604  [KO:K11420] [EC:2.1.1.355]
121582766  [KO:K11428] [EC:2.1.1.361]
121582863  [KO:K11703] [EC:2.4.1.50]
121584618  prdm6; putative histone-lysine N-methyltransferase PRDM6 isoform X1 [KO:K20795] [EC:2.1.1.361]
121584696  [KO:K11420] [EC:2.1.1.355]
121584965  nsd3; histone-lysine N-methyltransferase NSD3 isoform X1 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
121585346  [KO:K14959] [EC:2.1.1.354]
121585995  [KO:K00128] [EC:1.2.1.3]
121586284  [KO:K14959] [EC:2.1.1.354]
121586317  [KO:K06101] [EC:2.1.1.354]
121586324  [KO:K11421] [EC:2.1.1.366]
121586361  [KO:K11420] [EC:2.1.1.355]
121586707  [KO:K00128] [EC:1.2.1.3]
123481170  [KO:K00128] [EC:1.2.1.3]
123483328  [KO:K00825] [EC:2.6.1.7 2.6.1.39]
123484099  [KO:K11421] [EC:2.1.1.366]
123491170  [KO:K11422] [EC:2.1.1.354]
123492857  [KO:K00128] [EC:1.2.1.3]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
cclu00020  Citrate cycle (TCA cycle)
cclu00780  Biotin metabolism
KO pathway
ko00310   

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