Entry Name JAK-STAT signaling pathway - Equus caballus (horse)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Equus caballus (horse) [GN:
ecb ]
Gene 100033922 CSF3; granulocyte colony-stimulating factor isoform 2 [KO:K05423 ]
100033981 CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427 ]
100034011 STAT3; signal transducer and activator of transcription 3 [KO:K04692 ]
100050053 STAT6; signal transducer and activator of transcription 6 [KO:K11225 ]
100050227 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649 ]
100051623 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100051753 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
100052513 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
100052549 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
100052741 PIAS1; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706 ] [EC:2.3.2.-]
100052904 STAT5A; signal transducer and activator of transcription 5A isoform X1 [KO:K11223 ]
100053757 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X2 [KO:K05064 ]
100054613 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
100054693 STAT4; signal transducer and activator of transcription 4 [KO:K11222 ]
100054765 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
100055086 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
100056943 FHL1; four and a half LIM domains protein 1 isoform X4 [KO:K14365 ]
100057607 IFNLR1; LOW QUALITY PROTEIN: interferon lambda receptor 1 [KO:K05140 ]
100057673 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077 ]
100058141 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100061510 CISH; cytokine-inducible SH2-containing protein isoform X2 [KO:K04701 ]
100062017 IL31RA; LOW QUALITY PROTEIN: interleukin-31 receptor subunit alpha [KO:K22630 ]
100065141 PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064 ] [EC:2.3.2.-]
100066346 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
100066819 OSMR; oncostatin-M-specific receptor subunit beta isoform X4 [KO:K05057 ]
100068325 STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
100068493 GALT; galactose-1-phosphate uridylyltransferase isoform X2 [KO:K05056 ]
100068879 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X3 [KO:K16063 ] [EC:2.3.2.-]
100069253 CSF3R; granulocyte colony-stimulating factor receptor isoform X5 [KO:K05061 ]
100069633 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
100069676 IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
100070283 PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386 ]
100070292 IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068 ]
100070311 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
100071172 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
100073190 IL20RA; LOW QUALITY PROTEIN: interleukin-20 receptor subunit alpha [KO:K05136 ]
100146348 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100146590 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
100146651 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
100146965 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
102148787 IL6R; interleukin-6 receptor subunit alpha isoform X2 [KO:K05055 ]
791252 IL4R; interleukin-4 receptor subunit alpha precursor [KO:K05071 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related ecb04060 Cytokine-cytokine receptor interaction
KO pathway
