KEGG   PATHWAY: lcat04714
Entry
lcat04714                   Pathway                                
Name
Thermogenesis - Lemur catta (Ring-tailed lemur)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
lcat04714  Thermogenesis
lcat04714

Other DBs
GO: 1990845
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620231  [KO:K02258]
123620401  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
123620596  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
123620754  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
123620876  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651]
123620978  [KO:K18175]
123621470  [KO:K02138]
123621504  [KO:K02991]
123621509  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
123621542  ZNF516; LOW QUALITY PROTEIN: zinc finger protein 516 [KO:K22411]
123621590  [KO:K03948]
123621881  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
123621919  [KO:K02271]
123622308  [KO:K04632]
123622310  [KO:K04632]
123622325  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
123622743  ATP5ME; ATP synthase subunit e, mitochondrial [KO:K02129]
123622824  NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162] [EC:2.1.1.-]
123622847  [KO:K02263]
123623298  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008]
123623300  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
123623309  [KO:K00414]
123623327  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
123623799  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
123623808  CPT1C; LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
123623856  FGF21; fibroblast growth factor 21 [KO:K22429]
123624035  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
123624236  [KO:K02128]
123624263  [KO:K02271]
123624276  [KO:K00411] [EC:7.1.1.8]
123624388  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
123624433  [KO:K02270]
123624463  [KO:K02264]
123624466  [KO:K02267]
123624540  [KO:K17797]
123624681  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
123624699  [KO:K02267]
123625340  [KO:K02263]
123625466  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
123625728  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
123625824  [KO:K00419]
123625931  [KO:K02266]
123625945  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
123626172  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
123626307  [KO:K03940] [EC:7.1.1.2]
123626670  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123626686  ADRB3; beta-3 adrenergic receptor [KO:K04143]
123626873  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
123627044  [KO:K00415]
123627373  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
123627432  [KO:K18179]
123627554  [KO:K18184]
123627562  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
123627957  [KO:K02268]
123627979  [KO:K02130]
123628649  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
123628707  ACSL4; long-chain-fatty-acid--CoA ligase 4 isoform X1 [KO:K01897] [EC:6.2.1.3]
123628789  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
123630171  [KO:K02127]
123630276  [KO:K18184]
123630285  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
123630288  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
123630472  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
123630502  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
123630509  [KO:K02260]
123630658  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
123630707  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
123630777  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
123631474  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
123631484  TSC2; tuberin isoform X1 [KO:K07207]
123631490  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
123631525  ACTB; actin, cytoplasmic 1 [KO:K05692]
123631545  [KO:K03938]
123631576  ATP5MF; ATP synthase subunit f, mitochondrial [KO:K02130]
123631638  ACTL6B; actin-like protein 6B [KO:K11652]
123631742  [KO:K03947]
123632061  [KO:K02140]
123632194  CNR1; cannabinoid receptor 1 isoform X1 [KO:K04277]
123632319  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
123632466  [KO:K00415]
123632485  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
123632544  [KO:K18183]
123632685  [KO:K02266]
123632797  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
123632845  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
123632869  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123632871  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123632873  [KO:K00420]
123632900  [KO:K11265] [EC:4.6.1.1]
123633005  [KO:K02270]
123633089  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
123633303  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123633404  ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653]
123633420  [KO:K03960]
123633454  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
123633859  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
123633885  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
123633897  SIRT6; NAD-dependent protein deacetylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
123633999  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
123634008  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
123634125  [KO:K03963]
123634180  [KO:K00416]
123634354  ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653]
123634356  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
123634438  KDM1A; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
123634463  SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647] [EC:5.6.2.-]
123634467  NPPB; natriuretic peptides B [KO:K12335]
123634468  NPPA; natriuretic peptides A [KO:K12334]
123634479  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
123634947  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
123635033  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127]
123635081  NRAS; GTPase NRas [KO:K07828]
123635220  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
123635226  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
123635476  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123635558  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
123635597  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
123635635  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
123635644  [KO:K18180]
123635659  [KO:K03948]
123635710  [KO:K16622]
123635716  BMP8A; bone morphogenetic protein 8A [KO:K16622]
123635724  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
123635928  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
123635985  PRDM16; histone-lysine N-methyltransferase PRDM16 [KO:K22410] [EC:2.1.1.367]
123636458  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
123636670  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
123636803  NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial [KO:K18164]
123636823  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123636840  [KO:K02270]
123636952  [KO:K02140]
123636997  [KO:K03963]
123637143  KDM3A; lysine-specific demethylase 3A [KO:K15601] [EC:1.14.11.65]
123637222  [KO:K02265]
123637229  [KO:K18178]
123637336  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
123637372  KLB; beta-klotho [KO:K22404]
123637699  [KO:K02991]
123637743  ACSL6; long-chain-fatty-acid--CoA ligase 6 [KO:K01897] [EC:6.2.1.3]
123637748  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123637759  [KO:K00418]
123637819  KDM3B; lysine-specific demethylase 3B isoform X1 [KO:K15601] [EC:1.14.11.65]
123637866  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
123637869  [KO:K03963]
123638078  [KO:K00416]
123638104  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
123638210  [KO:K03948]
123638412  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
123638547  UCP1; mitochondrial brown fat uncoupling protein 1 [KO:K08769]
123638560  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
123638641  ACSL1; long-chain-fatty-acid--CoA ligase 1 isoform X1 [KO:K01897] [EC:6.2.1.3]
123639435  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
123639528  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
123639613  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
123639636  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
123639645  [KO:K03957]
123639659  SMARCC2; SWI/SNF complex subunit SMARCC2 isoform X1 [KO:K11649]
123639755  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
123639921  KRAS; GTPase KRas [KO:K07827]
123640141  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
123640204  [KO:K02268]
123640284  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
123640386  [KO:K18181]
123640387  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650]
123640431  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
123640442  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
123640642  [KO:K02268]
123640744  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
123640770  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123640771  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123641054  [KO:K18177]
123641447  [KO:K02273]
123641516  ATP5MG; ATP synthase subunit g, mitochondrial [KO:K02140]
123641584  [KO:K02268]
123641691  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
123642293  [KO:K03968]
123642645  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
123642684  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
123642737  [KO:K03945]
123642811  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
123642823  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
123642832  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
123642847  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123642954  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
123643408  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123643482  GCG; pro-glucagon [KO:K05259]
123643524  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
123643576  [KO:K00417]
123643900  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
123643998  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
123644027  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
123644073  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
123644088  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
123644153  ACSL3; fatty acid CoA ligase Acsl3 [KO:K01897] [EC:6.2.1.3]
123644332  [KO:K02268]
123644339  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
123644357  [KO:K03959]
123644439  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
123644528  [KO:K00417]
123644535  SLC25A29; mitochondrial basic amino acids transporter [KO:K15109]
123644576  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163]
123644587  [KO:K00417]
123644675  [KO:K02268]
123644875  [KO:K00413]
123645117  [KO:K02273]
123645140  PLIN1; perilipin-1 [KO:K08768]
123645245  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957]
123645738  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
123645978  RPS6; 40S ribosomal protein S6 [KO:K02991]
123646158  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
123646230  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
123646445  [KO:K03945]
123646450  SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647] [EC:5.6.2.-]
123646562  TSC1; hamartin [KO:K07206]
123647227  DPF3; zinc finger protein DPF3 [KO:K22198]
123647232  [KO:K18173]
123647253  [KO:K02272]
123647256  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
123647367  [KO:K18182]
123647452  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
123647499  RHEB; GTP-binding protein Rheb [KO:K07208]
123647504  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
123647634  [KO:K09047]
123647646  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
123647675  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
123647682  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
123647735  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
123648035  NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160]
123648063  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
123648206  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
123648345  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
123648605  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
123648630  [KO:K02272]
123648644  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
123648935  [KO:K11651]
123649468  SOS2; son of sevenless homolog 2 [KO:K03099]
123649868  ACSL5; long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
123649962  [KO:K02135]
123650126  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
123650146  [KO:K02259] [EC:1.17.99.9]
123650455  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
123650554  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
123650598  [KO:K02257] [EC:2.5.1.141]
123650672  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
123650680  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
123650684  NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 isoform X1 [KO:K24726]
123650686  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123650775  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
123650792  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
68929161  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
68929162  COX3; cytochrome c oxidase subunit III [KO:K02262]
68929165  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
68929167  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
68929174  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
68929177  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
68929182  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
68929184  COX2; cytochrome c oxidase subunit II [KO:K02261]
68929185  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
68929186  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
68929187  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
68929190  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
68929191  CYTB; cytochrome b [KO:K00412]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
  Authors
Inagaki T, Sakai J, Kajimura S
  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
  Journal
Nat Rev Mol Cell Biol 17:480-95 (2016)
DOI:10.1038/nrm.2016.62
Reference
  Authors
Harms M, Seale P
  Title
Brown and beige fat: development, function and therapeutic potential.
  Journal
Nat Med 19:1252-63 (2013)
DOI:10.1038/nm.3361
Reference
  Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
  Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
  Journal
FASEB J 28:5361-75 (2014)
DOI:10.1096/fj.13-247643
Reference
  Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
  Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
  Journal
Mol Nutr Food Res 60:18-42 (2016)
DOI:10.1002/mnfr.201500251
Reference
  Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
  Title
Regulation of brown fat by AMP-activated protein kinase.
  Journal
Trends Mol Med 21:571-9 (2015)
DOI:10.1016/j.molmed.2015.07.003
Reference
  Authors
Kooijman S, van den Heuvel JK, Rensen PC
  Title
Neuronal Control of Brown Fat Activity.
  Journal
Trends Endocrinol Metab 26:657-68 (2015)
DOI:10.1016/j.tem.2015.09.008
Reference
  Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
  Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
  Journal
Redox Biol 12:854-863 (2017)
DOI:10.1016/j.redox.2017.04.019
Reference
  Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
  Title
Regulation of adipocyte lipolysis.
  Journal
Nutr Res Rev 27:63-93 (2014)
DOI:10.1017/S095442241400002X
Reference
  Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
  Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
  Journal
IUBMB Life 56:379-85 (2004)
DOI:10.1080/15216540400009968
Reference
  Authors
Collins S, Yehuda-Shnaidman E, Wang H
  Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
  Journal
Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
DOI:10.1038/ijo.2010.180
Reference
  Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
  Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
  Journal
Mol Cell Biol 25:5466-79 (2005)
DOI:10.1128/MCB.25.13.5466-5479.2005
Reference
  Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
  Title
ASK1 signalling regulates brown and beige adipocyte function.
  Journal
Nat Commun 7:11158 (2016)
DOI:10.1038/ncomms11158
Reference
  Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
  Journal
Nat Commun 6:7052 (2015)
DOI:10.1038/ncomms8052
Reference
  Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
  Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
  Journal
Mol Cell 57:235-46 (2015)
DOI:10.1016/j.molcel.2014.12.005
Reference
  Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
  Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
  Journal
Cell Rep 15:2536-49 (2016)
DOI:10.1016/j.celrep.2016.05.019
Reference
  Authors
Villarroya F, Peyrou M, Giralt M
  Title
Transcriptional regulation of the uncoupling protein-1 gene.
  Journal
Biochimie 134:86-92 (2017)
DOI:10.1016/j.biochi.2016.09.017
Reference
  Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
  Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
  Journal
Mol Cell Biol 24:3057-67 (2004)
DOI:10.1128/MCB.24.7.3057-3067.2004
Reference
  Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
  Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
  Journal
J Biol Chem 286:12983-90 (2011)
DOI:10.1074/jbc.M110.215889
Reference
  Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
  Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
  Journal
Cell Rep 20:641-654 (2017)
DOI:10.1016/j.celrep.2017.06.069
Reference
  Authors
Klingenberg M
  Title
UCP1 - A sophisticated energy valve.
  Journal
Biochimie 134:19-27 (2017)
DOI:10.1016/j.biochi.2016.10.012
Reference
  Authors
Bertholet AM, Kirichok Y
  Title
UCP1: A transporter for H(+) and fatty acid anions.
  Journal
Biochimie 134:28-34 (2017)
DOI:10.1016/j.biochi.2016.10.013
Reference
  Authors
Betz MJ, Enerback S
  Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
  Journal
Nat Rev Endocrinol 14:77-87 (2018)
DOI:10.1038/nrendo.2017.132
Reference
  Authors
Tseng YH, Cypess AM, Kahn CR
  Title
Cellular bioenergetics as a target for obesity therapy.
  Journal
Nat Rev Drug Discov 9:465-82 (2010)
DOI:10.1038/nrd3138
Reference
  Authors
Fenzl A, Kiefer FW
  Title
Brown adipose tissue and thermogenesis.
  Journal
Horm Mol Biol Clin Investig 19:25-37 (2014)
DOI:10.1515/hmbci-2014-0022
Reference
  Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
  Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
  Journal
Cell Rep 17:29-36 (2016)
DOI:10.1016/j.celrep.2016.08.086
Reference
  Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
  Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
  Journal
Genes Dev 26:271-81 (2012)
DOI:10.1101/gad.177857.111
Reference
  Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
  Title
Natriuretic peptides in cardiometabolic regulation and disease.
  Journal
Nat Rev Cardiol 11:403-12 (2014)
DOI:10.1038/nrcardio.2014.64
Reference
  Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
  Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
  Journal
Mol Aspects Med 32:223-33 (2011)
DOI:10.1016/j.mam.2011.10.008
Reference
  Authors
McCoin CS, Knotts TA, Adams SH
  Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
  Journal
Nat Rev Endocrinol 11:617-25 (2015)
DOI:10.1038/nrendo.2015.129
Reference
  Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
  Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
  Journal
Biochem Biophys Rep 10:32-38 (2017)
DOI:10.1016/j.bbrep.2017.02.002
Related
pathway
lcat00020  Citrate cycle (TCA cycle)
lcat00190  Oxidative phosphorylation
lcat04010  MAPK signaling pathway
lcat04022  cGMP-PKG signaling pathway
lcat04024  cAMP signaling pathway
lcat04150  mTOR signaling pathway
lcat04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   

DBGET integrated database retrieval system