Entry
Name
Thermogenesis - Lemur catta (Ring-tailed lemur)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
BRITE hierarchy
Pathway map
Other DBs
Organism
Lemur catta (Ring-tailed lemur) [GN:
lcat ]
Gene
123620596 SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650 ]
123620754 ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128 ]
123620876 SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 [KO:K11651 ]
123622824 NDUFAF5; arginine-hydroxylase NDUFAF5, mitochondrial isoform X1 [KO:K18162 ] [EC:2.1.1.-]
123623298 NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [KO:K09008 ]
123623300 SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109 ]
123624681 NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947 ]
123625945 PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199 ]
123626172 SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648 ]
123626873 ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136 ]
123627562 NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159 ]
123628649 NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351 ]
123628789 NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945 ]
123630288 NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961 ]
123630502 NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960 ]
123630658 ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131 ]
123630777 NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944 ]
123631474 NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966 ]
123631490 MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266 ]
123632797 NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940 ] [EC:7.1.1.2 ]
123633089 NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161 ]
123633404 ARID1B; AT-rich interactive domain-containing protein 1B isoform X1 [KO:K11653 ]
123633859 PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199 ]
123633885 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048 ]
123634008 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048 ]
123634354 ARID1A; AT-rich interactive domain-containing protein 1A isoform X1 [KO:K11653 ]
123634463 SMARCA4; transcription activator BRG1 isoform X1 [KO:K11647 ] [EC:5.6.2.-]
123635033 ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial isoform X1 [KO:K02127 ]
123635220 NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935 ] [EC:7.1.1.2 ]
123635226 SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236 ]
123635558 NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951 ]
123635724 NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938 ]
123635928 SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235 ] [EC:1.3.5.1 ]
123636458 NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956 ]
123636803 NDUFAF7; protein arginine methyltransferase NDUFAF7, mitochondrial [KO:K18164 ]
123637336 PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202 ]
123637866 NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946 ]
123638104 PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530 ]
123638412 NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353 ]
123638560 NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967 ]
123639435 NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352 ]
123639613 NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948 ]
123639755 ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128 ]
123640141 NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953 ]
123640284 NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950 ]
123640387 SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [KO:K11650 ]
123640431 PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200 ]
123641691 SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237 ]
123642645 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048 ]
123642684 NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936 ] [EC:7.1.1.2 ]
123642823 NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941 ] [EC:7.1.1.2 ]
123643408 ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450 ]
123643524 NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954 ]
123643900 NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959 ]
123643998 PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200 ]
123644027 ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128 ]
123644073 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
123644439 NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965 ]
123644535 SLC25A29; mitochondrial basic amino acids transporter [KO:K15109 ]
123644576 NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 isoform X1 [KO:K18163 ]
123645245 NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 isoform X1 [KO:K03957 ]
123645738 NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952 ]
123646158 CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048 ]
123646230 NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962 ]
123646450 SMARCA2; probable global transcription activator SNF2L2 isoform X1 [KO:K11647 ] [EC:5.6.2.-]
123647452 NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949 ]
123647504 SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650 ]
123647646 NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958 ]
123647675 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048 ]
123647682 PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200 ]
123648035 NDUFAF2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2 [KO:K18160 ]
123648206 NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939 ]
123648345 SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234 ] [EC:1.3.5.1 ]
123648644 NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937 ]
123650126 NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964 ]
123650672 RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204 ]
123650684 NDUFAF8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 isoform X1 [KO:K24726 ]
Compound
Reference
Authors
Inagaki T, Sakai J, Kajimura S
Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
Journal
Reference
Authors
Harms M, Seale P
Title
Brown and beige fat: development, function and therapeutic potential.
Journal
Reference
Authors
Boon MR, Kooijman S, van Dam AD, Pelgrom LR, Berbee JF, Visseren CA, van Aggele RC, van den Hoek AM, Sips HC, Lombes M, Havekes LM, Tamsma JT, Guigas B, Meijer OC, Jukema JW, Rensen PC
Title
Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
Journal
Reference
Authors
Merlin J, Evans BA, Dehvari N, Sato M, Bengtsson T, Hutchinson DS
Title
Could burning fat start with a brite spark? Pharmacological and nutritional ways to promote thermogenesis.
Journal
Reference
Authors
van Dam AD, Kooijman S, Schilperoort M, Rensen PC, Boon MR
Title
Regulation of brown fat by AMP-activated protein kinase.
Journal
Reference
Authors
Kooijman S, van den Heuvel JK, Rensen PC
Title
Neuronal Control of Brown Fat Activity.
Journal
Reference
Authors
Contreras C, Nogueiras R, Dieguez C, Rahmouni K, Lopez M
Title
Traveling from the hypothalamus to the adipose tissue: The thermogenic pathway.
Journal
Reference
Authors
Fruhbeck G, Mendez-Gimenez L, Fernandez-Formoso JA, Fernandez S, Rodriguez A
Title
Regulation of adipocyte lipolysis.
Journal
Reference
Authors
Tansey JT, Sztalryd C, Hlavin EM, Kimmel AR, Londos C
Title
The central role of perilipin a in lipid metabolism and adipocyte lipolysis.
Journal
Reference
Authors
Collins S, Yehuda-Shnaidman E, Wang H
Title
Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
Journal
Reference
Authors
Robidoux J, Cao W, Quan H, Daniel KW, Moukdar F, Bai X, Floering LM, Collins S
Title
Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
Journal
Reference
Authors
Hattori K, Naguro I, Okabe K, Funatsu T, Furutani S, Takeda K, Ichijo H
Title
ASK1 signalling regulates brown and beige adipocyte function.
Journal
Reference
Authors
Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
Journal
Reference
Authors
Dempersmier J, Sambeat A, Gulyaeva O, Paul SM, Hudak CS, Raposo HF, Kwan HY, Kang C, Wong RH, Sul HS
Title
Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.
Journal
Reference
Authors
Sambeat A, Gulyaeva O, Dempersmier J, Tharp KM, Stahl A, Paul SM, Sul HS
Title
LSD1 Interacts with Zfp516 to Promote UCP1 Transcription and Brown Fat Program.
Journal
Reference
Authors
Villarroya F, Peyrou M, Giralt M
Title
Transcriptional regulation of the uncoupling protein-1 gene.
Journal
Reference
Authors
Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S
Title
p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene.
Journal
Reference
Authors
Hondares E, Iglesias R, Giralt A, Gonzalez FJ, Giralt M, Mampel T, Villarroya F
Title
Thermogenic activation induces FGF21 expression and release in brown adipose tissue.
Journal
Reference
Authors
Yao L, Cui X, Chen Q, Yang X, Fang F, Zhang J, Liu G, Jin W, Chang Y
Title
Cold-Inducible SIRT6 Regulates Thermogenesis of Brown and Beige Fat.
Journal
Reference
Authors
Klingenberg M
Title
UCP1 - A sophisticated energy valve.
Journal
Reference
Authors
Bertholet AM, Kirichok Y
Title
UCP1: A transporter for H(+) and fatty acid anions.
Journal
Reference
Authors
Betz MJ, Enerback S
Title
Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.
Journal
Reference
Authors
Tseng YH, Cypess AM, Kahn CR
Title
Cellular bioenergetics as a target for obesity therapy.
Journal
Reference
Authors
Fenzl A, Kiefer FW
Title
Brown adipose tissue and thermogenesis.
Journal
Reference
Authors
Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stockli J, James DE
Title
mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.
Journal
Reference
Authors
Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM
Title
FGF21 regulates PGC-1alpha and browning of white adipose tissues in adaptive thermogenesis.
Journal
Reference
Authors
Zois NE, Bartels ED, Hunter I, Kousholt BS, Olsen LH, Goetze JP
Title
Natriuretic peptides in cardiometabolic regulation and disease.
Journal
Reference
Authors
Indiveri C, Iacobazzi V, Tonazzi A, Giangregorio N, Infantino V, Convertini P, Console L, Palmieri F
Title
The mitochondrial carnitine/acylcarnitine carrier: function, structure and physiopathology.
Journal
Reference
Authors
McCoin CS, Knotts TA, Adams SH
Title
Acylcarnitines--old actors auditioning for new roles in metabolic physiology.
Journal
Reference
Authors
Ohtomo T, Ino K, Miyashita R, Chigira M, Nakamura M, Someya K, Inaba N, Fujita M, Takagi M, Yamada J
Title
Chronic high-fat feeding impairs adaptive induction of mitochondrial fatty acid combustion-associated proteins in brown adipose tissue of mice.
Journal
Related pathway
lcat04923 Regulation of lipolysis in adipocytes
KO pathway