Entry
Name
Phagocytosis - Mastomys coucha (southern multimammate mouse)
Description
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
Class
Cellular Processes; Transport and catabolism
BRITE hierarchy
Pathway map
Other DBs
Organism
Mastomys coucha (southern multimammate mouse) [GN:
mcoc ]
Gene
116068083 Dynlrb2; dynein light chain roadblock-type 2 isoform X1 [KO:K10419 ]
116068397 Vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182 ]
116068448 Scarb1; scavenger receptor class B member 1 isoform X1 [KO:K13885 ]
116068931 Lamp1; lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528 ]
116069179 Msr1; macrophage scavenger receptor types I and II isoform X1 [KO:K06558 ]
116069414 Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147 ]
116069491 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
116070010 Dync1li2; cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416 ]
116070121 Sec61g; LOW QUALITY PROTEIN: protein transport protein Sec61 subunit gamma [KO:K07342 ]
116070214 Gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341 ]
116070224 Mon1b; vacuolar fusion protein MON1 homolog B isoform X1 [KO:K20195 ]
116070311 Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435 ]
116072330 Dync1li1; cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416 ]
116072784 Vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179 ]
116073054 Dync2h1; cytoplasmic dynein 2 heavy chain 1 isoform X1 [KO:K10414 ]
116073204 Mon1a; vacuolar fusion protein MON1 homolog A isoform X1 [KO:K20195 ]
116073906 Atg4d; cysteine protease ATG4D isoform X1 [KO:K08342 ] [EC:3.4.22.-]
116073929 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116074224 Vamp7; vesicle-associated membrane protein 7 isoform X1 [KO:K08515 ]
116075508 Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860 ]
116077104 Gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341 ]
116077131 Hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182 ]
116077943 Atp6v0e1; V-type proton ATPase subunit e 1 isoform X1 [KO:K02153 ]
116078194 Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155 ]
116078351 Lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528 ]
116079228 Atp6v0a1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
116080803 Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148 ]
116080822 Dync2li1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417 ]
116082463 Sec61a2; protein transport protein Sec61 subunit alpha [KO:K10956 ]
116082714 Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184 ]
116083721 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
116085951 Atg3; ubiquitin-like-conjugating enzyme ATG3 isoform X1 [KO:K08343 ]
116086270 Rubcn; run domain Beclin-1-interacting and cysteine-rich domain-containing protein [KO:K19330 ]
116086854 Osbpl1a; oxysterol-binding protein-related protein 1 isoform X1 [KO:K20174 ]
116088808 Atg4b; cysteine protease ATG4B isoform X1 [KO:K08342 ] [EC:3.4.22.-]
116089020 Atg4a; cysteine protease ATG4A isoform X1 [KO:K08342 ] [EC:3.4.22.-]
116089999 Lcn2; neutrophil gelatinase-associated lipocalin isoform X1 [KO:K21129 ]
116090043 Gapvd1; GTPase-activating protein and VPS9 domain-containing protein 1 isoform X1 [KO:K27566 ]
116090210 Pla2r1; secretory phospholipase A2 receptor isoform X1 [KO:K06560 ]
116090294 Dync1i2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415 ]
116090719 Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181 ]
116090768 Snap23; synaptosomal-associated protein 23 isoform X1 [KO:K08508 ]
116090929 Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180 ]
116091231 Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435 ]
116091302 Bpi; bactericidal permeability-increasing protein isoform X1 [KO:K25374 ]
116094184 Fcgr1a; high affinity immunoglobulin gamma Fc receptor I isoform X1 [KO:K06498 ]
116095058 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116096279 Atg4c; cysteine protease ATG4C isoform X1 [KO:K08342 ] [EC:3.4.22.-]
116096465 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649 ]
116096509 Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit isoform X1 [KO:K03661 ]
116097037 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
116098352 Clec7a; C-type lectin domain family 7 member A isoform X1 [KO:K10074 ]
116098353 Olr1; oxidized low-density lipoprotein receptor 1 isoform X1 [KO:K08763 ]
116098555 Dync1i1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415 ]
116098742 Atp6v0a4; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
116098857 Atp6v0e2; V-type proton ATPase subunit e 2 isoform X1 [KO:K02153 ]
116099225 Sec61a1; protein transport protein Sec61 subunit alpha [KO:K10956 ]
116099420 Atg7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337 ]
116099677 Gabarapl1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341 ]
116099943 Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147 ]
116102614 Uvrag; UV radiation resistance-associated gene protein isoform X1 [KO:K21249 ]
116103299 Fcgr2a; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472 ]
116103300 Tcirg1; V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154 ]
Compound
C04549 1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
Authors
Stuart LM, Ezekowitz RA
Title
Phagocytosis: elegant complexity.
Journal
Reference
Authors
Tjelle TE, Lovdal T, Berg T
Title
Phagosome dynamics and function.
Journal
Reference
Authors
Dupuy AG, Caron E
Title
Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.
Journal
Reference
Authors
Brumell JH, Grinstein S
Title
Salmonella redirects phagosomal maturation.
Journal
Reference
Authors
Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S
Title
LAMP proteins are required for fusion of lysosomes with phagosomes.
Journal
Reference
Authors
Luzio JP, Pryor PR, Bright NA
Title
Lysosomes: fusion and function.
Journal
Reference
Authors
Sumimoto H
Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
Journal
Reference
Authors
Depierre M, Pompili C, Niedergang F
Title
Phagocytosis at a glance.
Journal
Reference
Authors
Lee HJ, Woo Y, Hahn TW, Jung YM, Jung YJ
Title
Formation and Maturation of the Phagosome: A Key Mechanism in Innate Immunity against Intracellular Bacterial Infection.
Journal
Reference
Authors
Heckmann BL, Green DR
Title
LC3-associated phagocytosis at a glance.
Journal
Reference
Authors
Yuan J, Zhang Q, Chen S, Yan M, Yue L
Title
LC3-Associated Phagocytosis in Bacterial Infection.
Journal
Reference
Authors
Pena-Martinez C, Rickman AD, Heckmann BL
Title
Beyond autophagy: LC3-associated phagocytosis and endocytosis.
Journal
Reference
Authors
Othman A, Sekheri M, Filep JG
Title
Roles of neutrophil granule proteins in orchestrating inflammation and immunity.
Journal
Reference
Authors
Rosales C
Title
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Journal
Reference
Authors
Naish E, Wood AJ, Stewart AP, Routledge M, Morris AC, Chilvers ER, Lodge KM
Title
The formation and function of the neutrophil phagosome.
Journal
Reference
Authors
Skubitz KM
Title
The role of CEACAMs in neutrophil function.
Journal
Reference
Authors
Weiss G, Schaible UE
Title
Macrophage defense mechanisms against intracellular bacteria.
Journal
Reference
Authors
Cruz FM, Chan A, Rock KL
Title
Pathways of MHC I cross-presentation of exogenous antigens.
Journal
Related pathway
mcoc04610 Complement and coagulation cascades
mcoc04612 Antigen processing and presentation
mcoc04613 Neutrophil extracellular trap formation
mcoc04620 Toll-like receptor signaling pathway
mcoc04666 Fc gamma R-mediated phagosome formation
KO pathway