KEGG   PATHWAY: mcoc04148
Entry
mcoc04148                   Pathway                                
Name
Efferocytosis - Mastomys coucha (southern multimammate mouse)
Class
Cellular Processes; Transport and catabolism
Pathway map
mcoc04148  Efferocytosis
mcoc04148

Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116067878  Pla2g15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
116068338  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
116068368  Atp2a2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
116068397  Vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116068922  Atp11a; probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934]
116068938  Gas6; growth arrest-specific protein 6 [KO:K05464]
116069039  Adam9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
116069144  Dusp4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116069240  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
116069264  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116069729  Calr; calreticulin [KO:K08057]
116069910  Cx3cl1; fractalkine [KO:K05508]
116070090  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116070135  Il10; interleukin-10 [KO:K05443]
116070207  Bcar1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
116070506  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
116070961  Epo; erythropoietin isoform X1 [KO:K05437]
116071123  Atp8a1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
116072518  Panx1; pannexin-1 [KO:K03443]
116072579  [KO:K01370] [EC:3.4.22.36]
116072784  Vps11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
116073027  Epor; erythropoietin receptor isoform X1 [KO:K05079]
116073078  Dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116073346  Tmem30a; cell cycle control protein 50A [KO:K26935]
116073390  Cx3cr1; CX3C chemokine receptor 1 [KO:K04192]
116073569  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116073764  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
116073805  Adgrb1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
116073842  Adam10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
116073874  Megf11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
116074315  Ppard; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
116074344  Rab5a; ras-related protein Rab-5A [KO:K07887]
116075030  Cd24; signal transducer CD24 [KO:K06469]
116075101  Mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
116075265  Sirt1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
116075328  Ager; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
116075516  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
116075748  Ano4; anoctamin-4 isoform X1 [KO:K19499]
116075844  Pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
116076013  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
116076052  Rab5b; ras-related protein Rab-5B [KO:K07888]
116076253  Bsg; basigin [KO:K06535]
116076385  Stab2; stabilin-2 [KO:K19013]
116076429  Lrp1; prolow-density lipoprotein receptor-related protein 1 isoform X1 [KO:K04550]
116076871  Scarf1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
116076904  Pecam1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
116076922  Itgb3; integrin beta-3 [KO:K06493]
116077331  [KO:K20413]
116077667  Atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
116077765  Mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
116077791  Mapk12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
116078025  Cpt1b; carnitine O-palmitoyltransferase 1, muscle isoform [KO:K19523] [EC:2.3.1.21]
116078295  [KO:K26936]
116078345  Sphk1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
116078490  Ano6; anoctamin-6 isoform X1 [KO:K19500]
116078506  Havcr2; hepatitis A virus cellular receptor 2 isoform X1 [KO:K20414]
116078641  [KO:K20413]
116078642  [KO:K20413]
116078733  Rab5c; ras-related protein Rab-5C [KO:K07889]
116078814  Crk; adapter molecule crk isoform X1 [KO:K04438]
116079580  Arg2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
116080255  Odc1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
116080345  Tmem30b; cell cycle control protein 50B [KO:K26935]
116080355  Gpr132; probable G-protein coupled receptor 132 [KO:K08426]
116080637  Dnmt3a; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
116080989  Adam17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
116081194  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
116082198  [KO:K00411] [EC:7.1.1.8]
116082714  Vps41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
116082718  Elmo1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
116083366  Ptger4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
116084352  Stab1; stabilin-1 [KO:K19020]
116084618  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
116084777  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116084884  Xkr6; XK-related protein 6 [KO:K26811]
116084940  Ptger2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
116085144  Atp8a2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
116085600  Atp11c; phospholipid-transporting ATPase IG isoform X1 [KO:K26934]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116085656  Crkl; crk-like protein [KO:K04438]
116085738  Vps8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
116085844  Itgb5; integrin beta-5 isoform X1 [KO:K06588]
116085968  [KO:K06266]
116085971  [KO:K06266]
116086009  [KO:K26935]
116086042  Pros1; vitamin K-dependent protein S isoform X1 [KO:K03908]
116087186  Megf10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
116087223  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116087416  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
116088125  Xkr4; XK-related protein 4 [KO:K26811]
116088366  Tgfbrap1; transforming growth factor-beta receptor-associated protein 1 isoform X1 [KO:K20177]
116088380  Gulp1; PTB domain-containing engulfment adapter protein 1 [KO:K23285]
116088513  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
116088799  Ano7; anoctamin-7 isoform X1 [KO:K19501]
116089063  Xkr9; XK-related protein 9 [KO:K26814]
116089297  Rab17; ras-related protein Rab-17 [KO:K07909]
116089888  Rxra; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
116090058  Rab14; ras-related protein Rab-14 isoform X1 [KO:K07881]
116090387  Itgav; integrin alpha-V isoform X1 [KO:K06487]
116090464  Nr1h3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
116090631  Ano3; anoctamin-3 isoform X1 [KO:K19498]
116090684  Thbs1; thrombospondin-1 isoform X1 [KO:K16857]
116090719  Vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
116090736  Tyro3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
116090757  Vps39; vam6/Vps39-like protein isoform X1 [KO:K20183]
116090901  Mertk; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
116090918  [KO:K06551]
116090929  Vps16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
116091187  Xkr7; XK-related protein 7 [KO:K26811]
116091432  Cebpb; CCAAT/enhancer-binding protein beta [KO:K10048]
116091445  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
116092345  Dusp2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116092922  P2ry12; P2Y purinoceptor 12 [KO:K04298]
116093411  Arnt; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
116093552  Slc16a1; monocarboxylate transporter 1 [KO:K08179]
116093668  S1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
116093748  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
116094965  [KO:K06551]
116095090  Atp11b; probable phospholipid-transporting ATPase IF isoform X1 [KO:K26934]
116095580  [KO:K01581] [EC:4.1.1.17]
116095616  [KO:K03986]
116096020  Abca1; phospholipid-transporting ATPase ABCA1 [KO:K05641]
116096395  [KO:K08057]
116096528  Slc2a1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
116096770  Xkr8; XK-related protein 8 [KO:K26813]
116096923  Slc66a1; lysosomal amino acid transporter 1 homolog isoform X1 [KO:K23678]
116097492  Cd36; platelet glycoprotein 4 [KO:K06259]
116097712  Arg1; arginase-1 [KO:K01476] [EC:3.5.3.1]
116097831  Sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
116098772  Mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
116098920  Rab7b; ras-related protein Rab-7b [KO:K07898]
116099215  Rab7a; ras-related protein Rab-7a [KO:K07897] [EC:3.6.5.2]
116099428  Pparg; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
116099451  Alox5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
116099571  Ptpn6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
116099697  Dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116100966  Ano9; anoctamin-9 isoform X1 [KO:K19503]
116101152  Ch25h; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
116101208  [KO:K06749]
116101857  Tgfb1; transforming growth factor beta-1 proprotein [KO:K13375]
116101859  Axl; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
116102056  [KO:K07889]
116102137  Nr1h2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
116102159  Cpt1c; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
116102280  Ano5; anoctamin-5 isoform X1 [KO:K19480]
116102431  Mfge8; lactadherin isoform X1 [KO:K17253]
116102657  P2ry6; P2Y purinoceptor 6 [KO:K04272]
116102659  P2ry2; P2Y purinoceptor 2 isoform X1 [KO:K04269]
116102951  Atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116103106  Pbx1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
116103130  Dock1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
116103239  Dusp8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116103290  Cpt1a; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
116103711  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
116103762  Lipa; lysosomal acid lipase/cholesteryl ester hydrolase isoform X1 [KO:K01052] [EC:3.1.1.13]
116104000  Dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
116104023  Casp7; caspase-7 [KO:K04397] [EC:3.4.22.60]
116104574  [KO:K04397] [EC:3.4.22.60]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
mcoc00010  Glycolysis / Gluconeogenesis
mcoc04140  Autophagy - animal
mcoc04145  Phagocytosis
KO pathway
ko04148   

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