KEGG   PATHWAY: oas04140
Entry
oas04140                    Pathway                                
Name
Autophagy - animal - Ovis aries (sheep)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
oas04140  Autophagy - animal
oas04140

Other DBs
GO: 0006914
Organism
Ovis aries (sheep) [GN:oas]
Gene
100127210  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
100135450  SQSTM1; sequestosome-1 [KO:K14381]
100135694  RPS27A; ubiquitin-ribosomal protein eS31 fusion protein [KO:K02977]
100145880  RAB7A; ras-related protein Rab-7a [KO:K07897]
100271659  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100294652  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100302063  RAB8A; ras-related protein Rab-8A [KO:K07901]
100302065  RAB1A; ras-related protein Rab-1A [KO:K07874]
100302067  RRAGA; ras-related GTP-binding protein A [KO:K16185]
100302069  RHEB; GTP-binding protein Rheb [KO:K07208]
100302070  RRAGC; ras-related GTP-binding protein C [KO:K16186]
100913169  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
100913170  BECN1; beclin-1 isoform X1 [KO:K08334]
100913171  ATG9A; autophagy-related protein 9A isoform X1 [KO:K17907]
101102204  [KO:K03237]
101102293  IRS1; insulin receptor substrate 1 [KO:K16172]
101102342  MTMR14; myotubularin-related protein 14 isoform X2 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
101102438  NRAS; GTPase NRas [KO:K07828]
101102580  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
101102633  VAMP8; vesicle-associated membrane protein 8 [KO:K08512]
101102746  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
101103190  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
101103267  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
101103425  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
101103635  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X4 [KO:K10586] [EC:2.3.2.23]
101103839  ATG16L2; protein Atg16l2 isoform X8 [KO:K20868]
101103972  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
101104288  [KO:K12650]
101104357  HRAS; GTPase HRas isoform X1 [KO:K02833]
101104410  SUPT20H; transcription factor SPT20 homolog isoform X1 [KO:K21245]
101105306  RAB39B; ras-related protein Rab-39B [KO:K07925]
101105343  MTMR4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
101105602  RAB33B; ras-related protein Rab-33B [KO:K07920]
101105709  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X2 [KO:K00914] [EC:2.7.1.137]
101105885  WDR45; WD repeat domain phosphoinositide-interacting protein 4 isoform X4 [KO:K22991]
101105939  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101106105  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
101106158  [KO:K04570]
101106703  OPTN; optineurin isoform X3 [KO:K19946]
101106914  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
101107132  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
101107357  ATG12; ubiquitin-like protein ATG12 isoform X2 [KO:K08336]
101107358  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
101107371  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101107545  RRAS; ras-related protein R-Ras [KO:K07829]
101107639  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
101107847  RRAGB; ras-related GTP-binding protein B isoform X2 [KO:K16185]
101108002  ATG4C; cysteine protease ATG4C isoform X2 [KO:K08342] [EC:3.4.22.-]
101108056  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X4 [KO:K04427] [EC:2.7.11.25]
101108148  BECN2; beclin-2 [KO:K08334]
101108239  ULK2; serine/threonine-protein kinase ULK2 isoform X3 [KO:K08269] [EC:2.7.11.1]
101108352  [KO:K04382] [EC:3.1.3.16]
101108441  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
101108632  TANK; TRAF family member-associated NF-kappa-B activator isoform X2 [KO:K12650]
101108687  UVRAG; UV radiation resistance-associated gene protein isoform X1 [KO:K21249]
101108785  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101108864  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X4 [KO:K04958]
101109026  NBR1; next to BRCA1 gene 1 protein isoform X3 [KO:K17987]
101109028  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X3 [KO:K17908]
101109114  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
101109194  WDR45B; WD repeat domain phosphoinositide-interacting protein 3 isoform X2 [KO:K22991]
101109238  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
101109302  MTMR3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
101109319  EPG5; ectopic P granules protein 5 homolog isoform X1 [KO:K23883]
101109574  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101109759  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101110015  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101110042  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X2 [KO:K08860] [EC:2.7.11.1]
101110290  MRAS; ras-related protein M-Ras [KO:K07831]
101110438  [KO:K02927]
101110676  WDFY3; WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
101110830  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101111156  PIK3R4; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
101111388  [KO:K10802]
101111546  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X2 [KO:K02649]
101111552  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
101111774  C9orf72; guanine nucleotide exchange factor C9orf72 homolog isoform X2 [KO:K23609]
101112071  HMGB1; high mobility group protein B1 [KO:K10802]
101112226  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
101112274  [KO:K02977]
101112330  [KO:K10802]
101112456  IRS4; insulin receptor substrate 4 isoform X2 [KO:K17446]
101112693  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
101112811  ATG9B; autophagy-related protein 9B [KO:K17907]
101112968  ATG101; autophagy-related protein 101 [KO:K19730]
101113247  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
101113307  LAMP2; lysosome-associated membrane glycoprotein 2 isoform X3 [KO:K06528]
101113390  ATG4A; cysteine protease ATG4A isoform X2 [KO:K08342] [EC:3.4.22.-]
101113414  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
101113426  PRKCQ; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
101113725  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
101113846  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101113985  DAPK1; death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
101114005  KRAS; GTPase KRas isoform X1 [KO:K07827]
101114034  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 [KO:K21348]
101114114  RRAGD; ras-related GTP-binding protein D isoform X1 [KO:K16186]
101114352  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
101114584  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
101114666  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
101114930  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101115063  ATG13; autophagy-related protein 13 isoform X7 [KO:K08331]
101115088  TSC2; tuberin isoform X1 [KO:K07207]
101115230  UBC; LOW QUALITY PROTEIN: polyubiquitin-C [KO:K08770]
101115485  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
101115978  RAB7B; ras-related protein Rab-7b isoform X2 [KO:K07898]
101116201  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101116521  SH3GLB1; endophilin-B1 isoform X3 [KO:K11248]
101116657  VPS39; vam6/Vps39-like protein isoform X2 [KO:K20183]
101116901  YKT6; synaptobrevin homolog YKT6 [KO:K08516]
101117138  GORASP2; Golgi reassembly-stacking protein 2 [KO:K26797]
101117211  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
101117245  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
101117348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
101117406  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 isoform X2 [KO:K08341]
101117540  GORASP1; Golgi reassembly-stacking protein 1 isoform X1 [KO:K26797]
101117701  ULK1; serine/threonine-protein kinase ULK1 isoform X1 [KO:K21357] [EC:2.7.11.1]
101117963  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
101118272  ATG4D; cysteine protease ATG4D isoform X2 [KO:K08342] [EC:3.4.22.-]
101118285  GABARAP; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
101118292  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A isoform X2 [KO:K10435]
101118462  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101118469  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
101118556  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101119061  PLEKHM1; pleckstrin homology domain-containing family M member 1 isoform X2 [KO:K23282]
101119069  TP53INP2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
101119127  TSC1; hamartin isoform X1 [KO:K07206]
101119171  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
101119220  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
101119242  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101119321  RPTOR; regulatory-associated protein of mTOR isoform X4 [KO:K07204]
101119351  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101119403  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
101119602  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
101120002  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101120176  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
101120659  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X2 [KO:K20184]
101120665  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
101120826  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101121043  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
101121455  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X3 [KO:K02649]
101121560  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
101121655  [KO:K17445]
101121712  VPS33A; vacuolar protein sorting-associated protein 33A isoform X2 [KO:K20182]
101121748  IGBP1; immunoglobulin-binding protein 1 isoform X1 [KO:K17606]
101121977  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X3 [KO:K08337]
101122127  [KO:K02977]
101122159  RUBCN; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X3 [KO:K19330]
101122243  ATG4B; cysteine protease ATG4B [KO:K08342] [EC:3.4.22.-]
101122499  STX17; syntaxin-17 [KO:K08491]
101122660  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
101122947  ATG10; ubiquitin-like-conjugating enzyme ATG10 isoform X2 [KO:K17888]
101123008  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101123247  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101123304  DAPK2; death-associated protein kinase 2 isoform X2 [KO:K08803] [EC:2.7.11.1]
101123382  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
101123563  STX7; syntaxin-7 isoform X1 [KO:K08488]
101123635  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
105601865  [KO:K17606]
105603811  [KO:K08512]
105603981  [KO:K03237]
105604794  [KO:K10435]
105610887  [KO:K04570]
105614945  [KO:K02977]
106991367  IRS2; insulin receptor substrate 2 [KO:K07187]
106992034  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
114108855  SNAP29; synaptosomal-associated protein 29 isoform X6 [KO:K08509]
114110121  INS; insulin [KO:K04526]
114110272  PRAP1; proline-rich acidic protein 1 [KO:K21250]
114111549  [KO:K10802]
114114919  [KO:K02833]
114116170  [KO:K08488]
114118284  [KO:K04427] [EC:2.7.11.25]
121820543  VMP1; vacuole membrane protein 1 isoform X1 [KO:K21248]
443009  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
443016  UBB; polyubiquitin-B [KO:K04551]
443060  CTSD; cathepsin D isoform X2 [KO:K01379] [EC:3.4.23.5]
443061  BCL2L1; bcl-2-like protein 1 [KO:K04570]
443094  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
443296  UBA52; ubiquitin-ribosomal protein eL40 fusion protein [KO:K02927]
443297  [KO:K02977]
443515  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
443519  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
780444  BAD; bcl2-associated agonist of cell death [KO:K02158]
780470  CTSB; cathepsin B precursor [KO:K01363] [EC:3.4.22.1]
780510  [KO:K01365] [EC:3.4.22.15]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
oas04010  MAPK signaling pathway
oas04141  Protein processing in endoplasmic reticulum
oas04142  Lysosome
oas04150  mTOR signaling pathway
oas04152  AMPK signaling pathway
oas04910  Insulin signaling pathway
KO pathway
ko04140   

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