KEGG   PATHWAY: oas04010
Entry
oas04010                    Pathway                                
Name
MAPK signaling pathway - Ovis aries (sheep)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
oas04010  MAPK signaling pathway
oas04010

Other DBs
GO: 0000165
Organism
Ovis aries (sheep) [GN:oas]
Gene
101120920  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
101122774  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101116562  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X6 [KO:K04850]
101106371  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X9 [KO:K04851]
101102503  voltage-dependent R-type calcium channel subunit alpha-1E isoform X2 [KO:K04852]
101104552  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
101117004  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X2 [KO:K04854]
101119120  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
101123461  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
101108767  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101123550  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
101115165  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X3 [KO:K04859]
101105365  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X3 [KO:K04860]
101116306  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
101122960  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X2 [KO:K04862]
101112498  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X5 [KO:K04863]
101104978  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X3 [KO:K04864]
101117907  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X2 [KO:K04865]
101110606  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
101122427  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
101105970  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
101110347  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
105616470  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
101118891  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
101116675  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
105602094  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
443094  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
101108785  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101110074  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
101118410  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101116423  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
101111070  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
106991180  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101115838  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101108104  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101115429  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X4 [KO:K04348] [EC:3.1.3.16]
101122602  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
101120802  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
114108765  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
101113014  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
101121934  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
101105504  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
101104023  RASGRP2; RAS guanyl-releasing protein 2 isoform X2 [KO:K12361]
101101969  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
101112342  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
101111578  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X2 [KO:K08018]
101117432  NF1; neurofibromin isoform X1 [KO:K08052]
101119216  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
101108362  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
101115080  RAP1A; ras-related protein Rap-1A [KO:K04353]
101106317  RAP1B; ras-related protein Rap-1b [KO:K07836]
114113232  ras-related protein Rap-1b [KO:K07836]
101106508  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
101103724  EREG; proepiregulin isoform X1 [KO:K09784]
443427  AREG; amphiregulin isoform X2 [KO:K09782]
101109353  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
443306  FGF2; fibroblast growth factor 2 precursor [KO:K18497]
101116844  FGF9; fibroblast growth factor 9 [KO:K04358]
101116004  FGF4; fibroblast growth factor 4 [KO:K04358]
443074  FGF10; fibroblast growth factor 10 precursor [KO:K04358]
101113716  FGF8; fibroblast growth factor 8 [KO:K04358]
101104968  FGF16; fibroblast growth factor 16 [KO:K04358]
443095  FGF7; fibroblast growth factor 7 [KO:K04358]
100642180  FGF5; fibroblast growth factor 5 isoform 1 precursor [KO:K04358]
101121489  FGF20; fibroblast growth factor 20 [KO:K04358]
101118502  FGF17; fibroblast growth factor 17 isoform X2 [KO:K04358]
101114608  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
101116719  FGF6; fibroblast growth factor 6 [KO:K04358]
780460  FGF18; fibroblast growth factor 18 [KO:K04358]
101116269  FGF3; fibroblast growth factor 3 isoform X1 [KO:K04358]
101115744  FGF19; fibroblast growth factor 19 [KO:K22603]
101108510  FGF21; fibroblast growth factor 21 [KO:K22429]
101112475  FGF23; fibroblast growth factor 23 [KO:K22428]
101104540  NGF; beta-nerve growth factor [KO:K02582]
101117275  BDNF; brain-derived neurotrophic factor [KO:K04355]
101115018  NTF3; neurotrophin-3 isoform X2 [KO:K04356]
101104334  NTF4; neurotrophin-4 [KO:K12457]
114110121  INS; insulin [KO:K04526]
443318  IGF1; insulin-like growth factor I precursor [KO:K05459]
443325  IGF2; insulin-like growth factor II preproprotein [KO:K13769]
114110564  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
443545  PDGFB; platelet-derived growth factor subunit B precursor [KO:K17386]
101117784  PDGFD; platelet-derived growth factor D isoform X3 [KO:K05450]
101112600  PDGFC; platelet-derived growth factor C isoform X4 [KO:K05450]
101104200  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
443371  KITLG; kit ligand precursor [KO:K05461]
780525  FLT3LG; fms-related tyrosine kinase 3 ligand precursor [KO:K05454]
443103  VEGFA; vascular endothelial growth factor A precursor [KO:K05448]
101115840  VEGFB; vascular endothelial growth factor B isoform X2 [KO:K16858]
443245  PGF; placenta growth factor isoform X2 [KO:K16859]
101105629  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
101102873  VEGFD; vascular endothelial growth factor D [KO:K05449]
443075  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
497271  ANGPT1; angiopoietin-1 [KO:K05465]
497273  ANGPT2; angiopoietin-2 [KO:K05466]
101107460  ANGPT4; angiopoietin-4 [KO:K05467]
101105380  EFNA4; ephrin-A4 isoform X2 [KO:K05462]
101105624  EFNA1; ephrin-A1 isoform X3 [KO:K05462]
101115414  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
101114443  EFNA2; ephrin-A2 [KO:K05462]
101115792  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
114114837  NRTN; neurturin [KO:K25414]
105607299  ARTN; artemin [KO:K25415]
101109705  PSPN; persephin [KO:K25416]
780479  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
780519  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X2 [KO:K05083] [EC:2.7.10.1]
101103889  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
101103044  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
780507  FGFR1; fibroblast growth factor receptor 1 isoform X2 [KO:K04362] [EC:2.7.10.1]
443548  FGFR2; fibroblast growth factor receptor 2 isoform X3 [KO:K05093] [EC:2.7.10.1]
554324  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
101120660  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
101119064  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
101109763  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
101116015  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
443431  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
443515  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
101106012  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101122783  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101109969  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
780504  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
101112331  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
443088  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
101117247  FLT4; vascular endothelial growth factor receptor 3 isoform X2 [KO:K05097] [EC:2.7.10.1]
443087  KDR; vascular endothelial growth factor receptor 2 precursor [KO:K05098] [EC:2.7.10.1]
443076  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
497272  TEK; angiopoietin-1 receptor isoform X4 [KO:K05121] [EC:2.7.10.1]
101110575  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
101119787  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [KO:K05126] [EC:2.7.10.1]
101109893  GRB2; growth factor receptor-bound protein 2 isoform X5 [KO:K04364]
114110058  growth factor receptor-bound protein 2 [KO:K04364]
101118865  SOS1; son of sevenless homolog 1 isoform X2 [KO:K03099]
101102732  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101104357  HRAS; GTPase HRas isoform X1 [KO:K02833]
114114919  GTPase HRas-like [KO:K02833]
101114005  KRAS; GTPase KRas isoform X1 [KO:K07827]
101102438  NRAS; GTPase NRas [KO:K07828]
101107545  RRAS; ras-related protein R-Ras [KO:K07829]
101118556  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101110290  MRAS; ras-related protein M-Ras [KO:K07831]
100305131  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
101107438  BRAF; serine/threonine-protein kinase B-raf isoform X3 [KO:K04365] [EC:2.7.11.1]
101103190  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
101123635  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
101113846  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
101110413  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
101115485  MAPK1; mitogen-activated protein kinase 1 isoform X2 [KO:K04371] [EC:2.7.11.24]
101123008  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101104102  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
101122519  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
101121915  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X8 [KO:K04373] [EC:2.7.11.1]
101114530  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
101110124  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
101111428  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X2 [KO:K04373] [EC:2.7.11.1]
100216465  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
101113988  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101114794  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
443447  MYC; myc proto-oncogene protein [KO:K04377]
101111402  SRF; serum response factor [KO:K04378]
443218  FOS; protein c-Fos [KO:K04379]
101121024  MAPT; microtubule-associated protein tau isoform X3 [KO:K04380]
101113917  STMN1; stathmin [KO:K04381]
101104505  stathmin-like [KO:K04381]
101111472  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
101115372  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
101115878  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X2 [KO:K16342] [EC:3.1.1.4]
101116150  PLA2G4D; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
101116403  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
443540  TNF; tumor necrosis factor [KO:K03156]
443404  IL1A; interleukin-1 alpha precursor [KO:K04383]
443539  IL1B; interleukin-1 beta precursor [KO:K04519]
443417  TGFB1; transforming growth factor beta-1 proprotein precursor [KO:K13375]
554322  TGFB2; transforming growth factor beta-2 proprotein isoform X2 [KO:K13376]
554323  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
100135698  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A precursor [KO:K03158]
101103054  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
101108354  IL1RAP; interleukin-1 receptor accessory protein isoform X3 [KO:K04723]
554326  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
494191  TGFBR2; TGF-beta receptor type-2 isoform X2 [KO:K04388] [EC:2.7.11.30]
100135696  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
100144426  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
443216  CD14; monocyte differentiation antigen CD14 precursor [KO:K04391]
100101233  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101107592  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X2 [KO:K07860]
101112406  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
101102792  CDC42; cell division control protein 42 homolog [KO:K04393]
114108599  cell division control protein 42 homolog [KO:K04393]
101111042  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
443031  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101105235  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
100505403  DAXX; death domain-associated protein 6 [KO:K02308]
678682  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
101121405  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X2 [KO:K04730] [EC:2.7.11.1]
100216438  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
101107132  TRAF6; TNF receptor-associated factor 6 isoform X2 [KO:K03175] [EC:2.3.2.27]
101115240  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100885762  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
101120573  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
101122943  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
101122114  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
101120161  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
101118350  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
101109789  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X4 [KO:K04407] [EC:2.7.11.1]
101111480  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
101111756  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101123517  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
101110437  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
101106085  STK3; serine/threonine-protein kinase 3 isoform X2 [KO:K04412]
101118145  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X4 [KO:K04414] [EC:2.7.11.1]
101117094  MAP3K8; mitogen-activated protein kinase kinase kinase 8 isoform X2 [KO:K04415] [EC:2.7.11.25]
101112260  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
101108969  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
101109858  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
101122537  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X2 [KO:K04421] [EC:2.7.11.25]
101103160  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X2 [KO:K04417] [EC:2.7.11.25]
101118723  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
101115427  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
101102889  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X3 [KO:K04423] [EC:2.7.11.25]
101117036  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
101111776  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X3 [KO:K04424] [EC:2.7.11.25]
101113737  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
101121018  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X2 [KO:K04426] [EC:2.7.11.25]
101108056  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X4 [KO:K04427] [EC:2.7.11.25]
114118284  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
101113246  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X3 [KO:K04428] [EC:2.7.11.25]
101108689  TAOK3; serine/threonine-protein kinase TAO3 isoform X2 [KO:K04429] [EC:2.7.11.1]
101109719  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
101117721  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
114115646  serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
101115045  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X3 [KO:K04430] [EC:2.7.12.2]
100302082  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
101122959  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
101115047  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101116934  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X2 [KO:K04434]
101119037  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
101110293  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
101120390  FLNA; filamin-A isoform X1 [KO:K04437]
101115380  CRK; adapter molecule crk isoform X1 [KO:K04438]
101117537  CRKL; crk-like protein [KO:K04438]
101112493  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
101108418  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101116201  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101120826  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101120665  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
100194428  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100217411  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
101116223  MAPK11; mitogen-activated protein kinase 11 isoform X2 [KO:K04441] [EC:2.7.11.24]
101115956  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
101116258  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X4 [KO:K04442] [EC:2.7.11.1]
101118118  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101118996  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
101115714  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
101117122  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
101120511  CDC25B; M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
114110349  LOW QUALITY PROTEIN: M-phase inducer phosphatase 2-like [KO:K05866] [EC:3.1.3.48]
101108097  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X6 [KO:K04446]
101117607  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X3 [KO:K17333]
443219  JUN; transcription factor Jun [KO:K04448]
443102  JUND; transcription factor JunD [KO:K04449]
101108548  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
443421  TP53; cellular tumor antigen p53 [KO:K04451]
132657128  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
101120670  MAX; protein max isoform X1 [KO:K04453]
100286738  MEF2C; myocyte-specific enhancer factor 2C [KO:K04454]
101115754  HSPB1; heat shock protein beta-1 [KO:K04455]
101118462  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
101119242  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100294652  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101103650  PPM1A; protein phosphatase 1A isoform X3 [KO:K04457] [EC:3.1.3.16]
101121162  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
101121131  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
101114718  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
101107632  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
101118748  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101112604  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101103535  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101122905  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101115699  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101118942  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
101110315  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
101123448  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
101106025  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
101114374  DUSP3; dual specificity protein phosphatase 3 isoform X2 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
101120943  PPP5C; serine/threonine-protein phosphatase 5 isoform X1 [KO:K04460] [EC:3.1.3.16]
101112467  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
100913152  HSPA1A; heat shock 70 kDa protein 1A/1B [KO:K03283]
101112844  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
101117117  HSPA1L; heat shock 70 kDa protein 1-like [KO:K03283]
101107064  HSPA6; heat shock 70 kDa protein 6 [KO:K03283]
101102392  LOW QUALITY PROTEIN: heat shock cognate 71 kDa protein-like [KO:K03283]
114110979  heat shock cognate 71 kDa protein-like [KO:K03283]
121815981  heat shock 70 kDa protein 1B [KO:K03283]
101121055  MECOM; histone-lysine N-methyltransferase MECOM isoform X2 [KO:K04462] [EC:2.1.1.367]
101104069  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X9 [KO:K04463] [EC:2.7.12.2]
101110073  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
101113222  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 isoform X1 [KO:K04465]
101118799  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
101111143  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
780484  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2 [KO:K07209] [EC:2.7.11.10]
101107332  IKBKG; NF-kappa-B essential modulator isoform X3 [KO:K07210]
101103076  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
114118747  LOW QUALITY PROTEIN: serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
101108228  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
443119  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
101102191  RELA; transcription factor p65 [KO:K04735]
101113005  RELB; transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
oas04070  Phosphatidylinositol signaling system
oas04110  Cell cycle
oas04115  p53 signaling pathway
oas04210  Apoptosis
oas04310  Wnt signaling pathway
oas04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

DBGET integrated database retrieval system