KEGG   PATHWAY: otc04810
Entry
otc04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Onychostruthus taczanowskii (white-rumped snowfinch)
Class
Cellular Processes; Cell motility
Pathway map
otc04810  Regulation of actin cytoskeleton
otc04810

Other DBs
GO: 0030036
Organism
Onychostruthus taczanowskii (white-rumped snowfinch) [GN:otc]
Gene
121331417  EGF; pro-epidermal growth factor [KO:K04357]
121331529  C9; complement component C9 [KO:K04000]
121331625  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
121331674  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
121331675  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
121331709  [KO:K05733] [EC:2.7.11.1]
121331731  MSN; moesin isoform X1 [KO:K05763]
121331744  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
121332051  ITGB2; integrin beta-2 [KO:K06464]
121332113  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
121332157  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
121332220  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
121332255  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
121332343  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
121332367  [KO:K05764]
121332397  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
121332600  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
121332620  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
121332631  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121332670  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121332682  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
121332742  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121332765  KRAS; GTPase KRas [KO:K07827]
121332827  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
121332918  FGF23; fibroblast growth factor 23 [KO:K22428]
121332950  FGF6; fibroblast growth factor 6 [KO:K04358]
121332991  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
121333019  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
121333057  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
121333079  CDC42; cell division control protein 42 homolog [KO:K04393]
121333104  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
121333117  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
121333136  BDKRB2; B2 bradykinin receptor [KO:K03916]
121333147  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
121333149  BDKRB1; B1 bradykinin receptor isoform X1 [KO:K03915]
121333174  [KO:K12757]
121333176  [KO:K12757]
121333342  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
121333627  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
121333657  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
121333727  NCKAP1L; nck-associated protein 1-like [KO:K05750]
121333829  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
121333870  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
121334110  C7; complement component C7 isoform X1 [KO:K03996]
121334112  C6; complement component C6 [KO:K03995]
121334276  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
121334327  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
121334382  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
121334393  ACTB; actin, cytoplasmic 1 [KO:K05692]
121334470  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
121334471  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
121334533  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121334617  MYH11; myosin-11 isoform X1 [KO:K10352]
121334813  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
121334956  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121334977  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
121335142  FGF20; fibroblast growth factor 20 [KO:K04358]
121335277  ABI2; abl interactor 2 isoform X1 [KO:K05751]
121335292  ITGAV; integrin alpha-V [KO:K06487]
121335313  ITGB6; integrin beta-6 [KO:K06589]
121335353  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
121335411  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
121335521  ITGA4; integrin alpha-4 [KO:K06483]
121335673  ITGA10; integrin alpha-10 [KO:K06586]
121335706  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
121335752  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121335766  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
121335781  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121336023  WASF2; LOW QUALITY PROTEIN: wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
121336089  VCL; vinculin isoform X1 [KO:K05700]
121336262  ITGB5; integrin beta-5 [KO:K06588]
121336334  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
121336528  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121336626  KNG1; kininogen-1 [KO:K03898]
121336674  PFN2; profilin-2 isoform X1 [KO:K05759]
121336778  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
121336871  GSN; gelsolin [KO:K05768]
121336911  C8G; complement component C8 gamma chain [KO:K03999]
121336970  C5; complement C5 [KO:K03994]
121337059  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
121337153  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
121337291  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
121337292  RGCC; regulator of cell cycle RGCC [KO:K26108]
121337405  [KO:K06585]
121337473  CYRIB; CYFIP-related Rac1 interactor B isoform X1 [KO:K27976]
121337563  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K00889] [EC:2.7.1.68]
121337615  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
121337713  [KO:K05733] [EC:2.7.11.1]
121337952  ACTR3; actin-related protein 3 [KO:K18584]
121337958  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
121337981  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
121338082  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
121338129  ACTR3B; actin-related protein 3B [KO:K18584]
121338131  MRAS; ras-related protein M-Ras [KO:K07831]
121338181  ITGA8; integrin alpha-8 [KO:K06584]
121338241  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
121338264  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
121338266  ACTG1; actin, cytoplasmic 2 [KO:K05692]
121338294  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
121338401  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
121338585  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
121338675  SOS2; son of sevenless homolog 2 [KO:K03099]
121338761  ITGA7; integrin alpha-7 [KO:K06583]
121338825  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
121338842  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
121338915  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
121338965  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
121339021  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121339317  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
121339461  FGF19; fibroblast growth factor 19 [KO:K22603]
121339579  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
121339679  FN1; fibronectin isoform X1 [KO:K05717]
121339685  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
121339690  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
121339779  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
121339852  FGF2; fibroblast growth factor 2 [KO:K18497]
121339869  FGF3; fibroblast growth factor 3 [KO:K04358]
121339895  FGF4; fibroblast growth factor 4 [KO:K04358]
121340298  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
121340492  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
121340501  PFN1; profilin-1 [KO:K05759]
121340629  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
121340790  ARHGEF12; rho guanine nucleotide exchange factor 12 [KO:K07532]
121341034  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121341074  RDX; radixin isoform X1 [KO:K05762]
121341222  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121341257  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
121341299  F2R; proteinase-activated receptor 1 isoform X1 [KO:K03914]
121341403  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
121341455  [KO:K05730]
121341518  RRAS2; ras-related protein R-Ras2 [KO:K07830]
121341561  INS; insulin [KO:K04526]
121341636  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
121341713  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
121341792  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
121341824  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121341856  FGF8; fibroblast growth factor 8 [KO:K04358]
121341866  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121342010  FGF9; fibroblast growth factor 9 [KO:K04358]
121342023  SPATA13; spermatogenesis-associated protein 13 [KO:K05769]
121342095  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
121342130  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121342141  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
121342207  [KO:K06484]
121342230  TMSB4X; thymosin beta-4 [KO:K05764]
121342278  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
121342292  MYH9; myosin-9 [KO:K10352]
121342323  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
121342399  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
121342441  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
121342519  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121342681  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
121342704  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
121342779  [KO:K27976]
121343112  FGF18; fibroblast growth factor 18 [KO:K04358]
121343113  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
121343243  SCIN; adseverin [KO:K05768]
121343281  ITGB8; integrin beta-8 [KO:K06591]
121343431  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
121343508  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121343563  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121343627  [KO:K05692]
121343636  ITGA11; integrin alpha-11 [KO:K06587]
121343826  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
121343856  [KO:K04291]
121343951  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121344259  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
121344362  PXN; paxillin isoform X1 [KO:K05760]
121344397  CRKL; crk-like protein [KO:K04438]
121344518  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
121344529  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
121344616  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
121344620  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
121344662  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121344866  HRAS; GTPase HRas [KO:K02833]
121344891  CYRIA; CYFIP-related Rac1 interactor A isoform X1 [KO:K27976]
121344995  [KO:K02649]
121345108  C8B; complement component C8 beta chain [KO:K03998]
121345128  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
121345308  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
121345381  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
121345537  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
121345673  NRAS; GTPase NRas [KO:K07828]
121345696  CRK; adapter molecule crk isoform X1 [KO:K04438]
121345766  MYL10; myosin regulatory light chain 10 [KO:K12756]
121345784  [KO:K05766] [EC:3.1.3.16 3.1.3.48]
121345840  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
121346043  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
121346253  EZR; ezrin isoform X1 [KO:K08007]
121346451  [KO:K26108]
121346522  [KO:K05733] [EC:2.7.11.1]
121346532  FGF16; fibroblast growth factor 16 [KO:K04358]
121346631  ITGA2; integrin alpha-2 [KO:K06481]
121346640  ITGA1; integrin alpha-1 [KO:K06480]
121346652  FGF10; fibroblast growth factor 10 [KO:K04358]
121346743  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
121346775  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121346898  LIMK1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
121346908  ENAH; protein enabled homolog isoform X1 [KO:K05746]
121346981  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121347092  [KO:K04289]
121347136  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
121347139  RHOA; transforming protein RhoA [KO:K04513]
121347231  BRK1; protein BRICK1 [KO:K05752]
121347536  ITGA3; integrin alpha-3 [KO:K06482]
121348103  MYH10; myosin-10 [KO:K10352]
121348168  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
121348231  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121348297  [KO:K04291]
121348322  CFL2; cofilin-2 [KO:K05765]
121348428  PDGFC; platelet-derived growth factor C [KO:K05450]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
otc04010  MAPK signaling pathway
otc04510  Focal adhesion
otc04520  Adherens junction
KO pathway
ko04810   

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