KEGG   PATHWAY: otc04010
Entry
otc04010                    Pathway                                
Name
MAPK signaling pathway - Onychostruthus taczanowskii (white-rumped snowfinch)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
otc04010  MAPK signaling pathway
otc04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Onychostruthus taczanowskii (white-rumped snowfinch) [GN:otc]
Gene
121331356  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121331390  PGF; placenta growth factor isoform X1 [KO:K16859]
121331417  EGF; pro-epidermal growth factor [KO:K04357]
121331461  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
121331524  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
121331593  ANGPT4; angiopoietin-4 [KO:K05467]
121331672  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
121331694  PPM1A; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
121331724  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
121331755  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
121331999  [KO:K05866] [EC:3.1.3.48]
121332035  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
121332133  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
121332134  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
121332149  [KO:K05462]
121332151  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
121332208  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121332220  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
121332253  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
121332255  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
121332269  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
121332343  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
121332379  DUSP1; dual specificity protein phosphatase 1 isoform X1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
121332559  RASA1; ras GTPase-activating protein 1 [KO:K04352]
121332585  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
121332630  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
121332631  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121332644  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
121332670  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121332674  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
121332735  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
121332742  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121332765  KRAS; GTPase KRas [KO:K07827]
121332806  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
121332824  IGF1; insulin-like growth factor I [KO:K05459]
121332891  [KO:K16342] [EC:3.1.1.4]
121332892  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121332918  FGF23; fibroblast growth factor 23 [KO:K22428]
121332935  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121332950  FGF6; fibroblast growth factor 6 [KO:K04358]
121332978  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
121333037  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
121333079  CDC42; cell division control protein 42 homolog [KO:K04393]
121333089  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
121333162  FOS; proto-oncogene c-Fos [KO:K04379]
121333210  [KO:K16342] [EC:3.1.1.4]
121333237  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
121333319  [KO:K16342] [EC:3.1.1.4]
121333326  [KO:K16342] [EC:3.1.1.4]
121333423  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
121333745  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
121333951  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
121334122  TGFA; protransforming growth factor alpha [KO:K08774]
121334137  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
121334200  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
121334254  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
121334298  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
121334313  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
121334327  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
121334382  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
121334509  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
121334533  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121334535  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
121334557  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121334558  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
121334601  RASGRP1; RAS guanyl-releasing protein 1 [KO:K04350]
121334606  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
121334956  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121334972  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
121334977  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
121335142  FGF20; fibroblast growth factor 20 [KO:K04358]
121335186  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
121335230  [KO:K16342] [EC:3.1.1.4]
121335248  [KO:K16342] [EC:3.1.1.4]
121335296  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
121335529  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
121335582  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
121335736  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
121335752  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121335758  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
121335759  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
121335763  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
121335781  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121335821  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
121335869  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
121336057  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121336116  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
121336198  CHUK; LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
121336290  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
121336301  HGF; hepatocyte growth factor [KO:K05460]
121336326  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
121336380  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
121336547  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
121336666  [KO:K04723]
121336794  MAX; protein max [KO:K04453]
121336904  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
121336980  [KO:K04849]
121337177  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
121337229  IKBKG; NF-kappa-B essential modulator [KO:K07210]
121337475  MYC; myc proto-oncogene protein [KO:K04377]
121337638  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
121337807  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
121337889  SRF; serum response factor [KO:K04378]
121337974  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
121338045  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
121338070  [KO:K04421] [EC:2.7.11.25]
121338131  MRAS; ras-related protein M-Ras [KO:K07831]
121338173  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
121338227  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
121338241  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
121338247  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121338347  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
121338419  [KO:K04388] [EC:2.7.11.30]
121338479  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121338485  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
121338488  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
121338489  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
121338620  KITLG; kit ligand isoform X1 [KO:K05461]
121338652  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
121338675  SOS2; son of sevenless homolog 2 [KO:K03099]
121338963  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
121339021  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121339061  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
121339162  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
121339170  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
121339307  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
121339432  RAP1B; ras-related protein Rap-1b [KO:K07836]
121339461  FGF19; fibroblast growth factor 19 [KO:K22603]
121339466  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
121339665  [KO:K04435]
121339684  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
121339721  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
121339852  FGF2; fibroblast growth factor 2 [KO:K18497]
121339869  FGF3; fibroblast growth factor 3 [KO:K04358]
121339886  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121339895  FGF4; fibroblast growth factor 4 [KO:K04358]
121339953  [KO:K04872]
121339974  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121340076  [KO:K03156]
121340207  ANGPT1; angiopoietin-1 [KO:K05465]
121340270  STK3; serine/threonine-protein kinase 3 [KO:K04412]
121340600  RELA; transcription factor p65 [KO:K04735]
121340642  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
121340733  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
121340919  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
121341034  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121341149  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
121341271  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
121341361  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
121341486  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121341518  RRAS2; ras-related protein R-Ras2 [KO:K07830]
121341525  PTPN5; tyrosine-protein phosphatase non-receptor type 5 [KO:K18018] [EC:3.1.3.48]
121341561  INS; insulin [KO:K04526]
121341566  IGF2; insulin-like growth factor II [KO:K13769]
121341643  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121341673  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
121341713  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
121341716  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
121341856  FGF8; fibroblast growth factor 8 [KO:K04358]
121341866  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121341955  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121341965  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
121341980  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
121342010  FGF9; fibroblast growth factor 9 [KO:K04358]
121342026  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
121342095  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
121342107  MAP3K13; mitogen-activated protein kinase kinase kinase 13 isoform X1 [KO:K04422] [EC:2.7.11.25]
121342246  EFNA2; ephrin-A2 [KO:K05462]
121342258  VEGFD; vascular endothelial growth factor D [KO:K05449]
121342294  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
121342323  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
121342336  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
121342411  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
121342441  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
121342470  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
121342519  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121342547  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
121342793  STMN1; stathmin [KO:K04381]
121342944  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
121343111  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
121343112  FGF18; fibroblast growth factor 18 [KO:K04358]
121343206  [KO:K04386]
121343296  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121343378  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
121343470  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
121343508  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121343563  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121343789  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
121343894  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
121344219  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
121344224  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
121344355  PSPN; persephin [KO:K25416]
121344397  CRKL; crk-like protein [KO:K04438]
121344505  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
121344537  [KO:K02308]
121344543  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
121344622  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
121344791  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
121344817  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
121344866  HRAS; GTPase HRas [KO:K02833]
121344869  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121344926  ARTN; artemin isoform X1 [KO:K25415]
121344945  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121345002  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
121345151  JUN; transcription factor AP-1 [KO:K04448]
121345458  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
121345503  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
121345510  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
121345524  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
121345545  PTPN7; tyrosine-protein phosphatase non-receptor type 7 [KO:K18019] [EC:3.1.3.48]
121345569  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
121345642  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
121345667  NGF; beta-nerve growth factor [KO:K02582]
121345673  NRAS; GTPase NRas [KO:K07828]
121345696  CRK; adapter molecule crk isoform X1 [KO:K04438]
121345824  HSPB1; heat shock protein beta-1 [KO:K04455]
121345880  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
121346041  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
121346192  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
121346527  [KO:K05096] [EC:2.7.10.1]
121346532  FGF16; fibroblast growth factor 16 [KO:K04358]
121346564  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
121346582  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
121346585  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
121346652  FGF10; fibroblast growth factor 10 [KO:K04358]
121346741  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121346743  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
121346759  IL1B; interleukin-1 beta [KO:K04519]
121346775  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121346776  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
121346818  NRTN; neurturin isoform X1 [KO:K25414]
121346981  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121347054  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
121347093  NF1; neurofibromin isoform X1 [KO:K08052]
121347178  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
121347256  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
121347288  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
121347294  JUND; transcription factor jun-D [KO:K04449]
121347336  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
121347385  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
121347543  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 [KO:K04862]
121347567  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
121347628  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
121347659  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
121347686  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
121347732  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
121347760  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
121347800  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
121347876  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
121348027  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
121348029  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
121348043  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
121348077  EREG; proepiregulin [KO:K09784]
121348148  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
121348168  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
121348171  AREG; amphiregulin [KO:K09782]
121348208  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
121348224  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
121348231  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121348413  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
121348428  PDGFC; platelet-derived growth factor C [KO:K05450]
121348435  VEGFC; vascular endothelial growth factor C [KO:K05449]
121348441  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
otc04070  Phosphatidylinositol signaling system
otc04110  Cell cycle
otc04115  p53 signaling pathway
otc04210  Apoptosis
otc04310  Wnt signaling pathway
KO pathway
ko04010   

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