KEGG   PATHWAY: panu04510
Entry
panu04510                   Pathway                                
Name
Focal adhesion - Papio anubis (olive baboon)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
panu04510  Focal adhesion
panu04510

Other DBs
GO: 0005925
Organism
Papio anubis (olive baboon) [GN:panu]
Gene
100126666  CAV1; caveolin-1 [KO:K06278]
100126667  CAV2; caveolin-2 [KO:K12958]
100126669  MET; hepatocyte growth factor receptor precursor [KO:K05099] [EC:2.7.10.1]
100126735  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
100137215  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
100137263  FLNA; filamin-A [KO:K04437]
100137333  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100137415  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
100381179  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100510872  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
100510873  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X4 [KO:K02649]
100997019  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100997299  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
100997319  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100997603  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
100997634  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100997671  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.39]
100997868  PARVA; alpha-parvin [KO:K06275]
100998149  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
100998457  [KO:K04725] [EC:2.3.2.27]
100998521  PDGFA; platelet-derived growth factor subunit A isoform X2 [KO:K04359]
100998800  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100998840  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
100999166  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X2 [KO:K06277]
100999739  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100999959  PARVB; beta-parvin isoform X4 [KO:K06275]
101000307  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101000402  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101000409  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
101000665  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
101000787  LAMB2; laminin subunit beta-2 [KO:K06243]
101000993  PARVG; gamma-parvin isoform X3 [KO:K06275]
101001939  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
101002054  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
101002096  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
101002278  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101002360  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
101002457  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
101002500  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
101002675  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
101002971  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101002992  HRAS; GTPase HRas isoform X2 [KO:K02833]
101003085  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
101003099  ROCK2; rho-associated protein kinase 2 isoform X5 [KO:K17388] [EC:2.7.11.39]
101003160  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
101003191  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
101003196  PXN; paxillin isoform X6 [KO:K05760]
101003243  [KO:K06482]
101003380  EMP2; epithelial membrane protein 2 [KO:K26256]
101003510  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
101003588  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
101003717  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
101003749  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101003924  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
101003935  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101004025  FN1; fibronectin isoform X9 [KO:K05717]
101004371  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101004530  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101004771  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
101004833  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101004976  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101005010  MAPK10; mitogen-activated protein kinase 10 isoform X3 [KO:K04440] [EC:2.7.11.24]
101005052  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
101005084  LAMB3; laminin subunit beta-3 isoform X1 [KO:K06244]
101005361  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
101005587  THBS2; thrombospondin-2 [KO:K04659]
101005612  THBS1; thrombospondin-1 [KO:K16857]
101005809  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101006054  [KO:K17447]
101006375  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
101006376  LAMC3; laminin subunit gamma-3 [KO:K06247]
101006436  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
101006463  ITGA4; integrin alpha-4 [KO:K06483]
101006510  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
101006637  DIAPH1; protein diaphanous homolog 1 isoform X3 [KO:K05740]
101006669  ITGA8; integrin alpha-8 [KO:K06584]
101006756  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101007122  CRKL; crk-like protein [KO:K04438]
101007177  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
101007269  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101007274  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101007278  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
101007358  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
101007972  LAMC2; laminin subunit gamma-2 [KO:K06246]
101008056  EMP1; epithelial membrane protein 1 [KO:K26255]
101008264  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
101008394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101008443  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X6 [KO:K12329]
101008699  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101008710  CHAD; chondroadherin [KO:K06248]
101008748  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
101008905  LAMC1; laminin subunit gamma-1 isoform X1 [KO:K05635]
101009029  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101009063  LAMA3; laminin subunit alpha-3 isoform X5 [KO:K06240]
101009064  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101009206  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X2 [KO:K04349]
101009280  ZYX; zyxin isoform X1 [KO:K06273]
101009359  THBS3; thrombospondin-3 isoform X3 [KO:K04659]
101009395  ITGA2B; integrin alpha-IIb [KO:K06476]
101009516  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101009639  VEGFC; vascular endothelial growth factor C [KO:K05449]
101009767  [KO:K06271]
101009865  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101009939  CAV3; caveolin-3 [KO:K12959]
101009981  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101010276  IGF1; insulin-like growth factor I isoform X2 [KO:K05459]
101010563  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
101010894  JUN; transcription factor AP-1 [KO:K04448]
101010999  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
101011160  CRK; adapter molecule crk isoform X1 [KO:K04438]
101011383  MYL7; myosin regulatory light chain 2, atrial isoform isoform X2 [KO:K12754]
101011528  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
101011576  VWF; von Willebrand factor isoform X1 [KO:K03900]
101011877  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101011983  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X2 [KO:K07861]
101012041  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101012095  ITGB3; integrin beta-3 [KO:K06493]
101012328  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
101012551  BAD; bcl2-associated agonist of cell death [KO:K02158]
101012673  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
101012779  TNN; tenascin-N isoform X1 [KO:K06252]
101012839  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
101012923  TNC; tenascin isoform X1 [KO:K06252]
101013495  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101013590  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X4 [KO:K05726]
101013799  ITGA1; integrin alpha-1 [KO:K06480]
101013880  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101014051  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
101014095  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
101014159  ITGA2; integrin alpha-2 [KO:K06481]
101014297  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
101014342  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101014475  FLNB; filamin-B isoform X1 [KO:K27392]
101014480  ITGA9; integrin alpha-9 [KO:K06585]
101014591  [KO:K06238]
101014651  [KO:K17449]
101014707  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
101014712  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
101015074  VAV2; guanine nucleotide exchange factor VAV2 isoform X7 [KO:K05730]
101015341  [KO:K12757]
101015348  IBSP; bone sialoprotein 2 [KO:K06253]
101015643  TNR; tenascin-R isoform X3 [KO:K06252]
101015689  SPP1; osteopontin isoform X1 [KO:K06250]
101016118  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [KO:K06269] [EC:3.1.3.16]
101016465  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
101016532  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
101016585  VCL; vinculin isoform X4 [KO:K05700]
101016586  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
101016648  [KO:K12757]
101016956  ITGA7; integrin alpha-7 isoform X7 [KO:K06583]
101016979  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
101017655  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
101017806  ITGB8; integrin beta-8 [KO:K06591]
101018133  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101018226  PGF; placenta growth factor isoform X1 [KO:K16859]
101018541  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
101018714  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
101018767  TLN1; talin-1 isoform X2 [KO:K06271]
101019435  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101019884  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101019923  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101020203  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
101020518  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
101020640  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
101021265  ITGA11; integrin alpha-11 [KO:K06587]
101021299  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X3 [KO:K06270]
101021364  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
101021974  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
101022024  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101022030  CAPN2; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
101022081  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
101022199  COMP; cartilage oligomeric matrix protein [KO:K04659]
101022320  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
101022780  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101022825  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
101022936  PTK2; focal adhesion kinase 1 isoform X25 [KO:K05725] [EC:2.7.10.2]
101022961  VAV3; guanine nucleotide exchange factor VAV3 isoform X6 [KO:K05730]
101023125  VTN; vitronectin [KO:K06251]
101023586  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101024253  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
101024290  MYL10; myosin regulatory light chain 10 isoform X3 [KO:K12756]
101024356  LAMA5; laminin subunit alpha-5 [KO:K06240]
101024393  SHC3; SHC-transforming protein 3 [KO:K17448]
101024648  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
101024690  COL4A6; collagen alpha-6(IV) chain isoform X2 [KO:K06237]
101024696  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
101024910  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
101025143  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
101025494  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
101025530  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
101025668  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101025814  LAMB1; LOW QUALITY PROTEIN: laminin subunit beta-1 [KO:K05636]
101026183  BCL2; apoptosis regulator Bcl-2 isoform X3 [KO:K02161]
101026303  [KO:K00889] [EC:2.7.1.68]
101026503  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060]
101026514  LAMB4; laminin subunit beta-4 [KO:K06245]
101026665  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
101026688  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
101026869  ACTB; actin, cytoplasmic 1 [KO:K05692]
103877691  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
110741987  [KO:K05692]
116268521  [KO:K06271]
116269767  [KO:K04659]
116271056  [KO:K06482]
116271057  [KO:K06482]
116272720  [KO:K17449]
116272724  [KO:K17449]
116272729  [KO:K17449]
116272733  [KO:K17449]
116272742  [KO:K05637]
116272789  [KO:K17449]
116274155  [KO:K12756]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
panu04010  MAPK signaling pathway
panu04060  Cytokine-cytokine receptor interaction
panu04070  Phosphatidylinositol signaling system
panu04110  Cell cycle
panu04151  PI3K-Akt signaling pathway
panu04310  Wnt signaling pathway
panu04512  ECM-receptor interaction
panu04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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