KEGG   PATHWAY: asn05168
Entry
asn05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Alligator sinensis (Chinese alligator)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
asn05168  Herpes simplex virus 1 infection
asn05168

Organism
Alligator sinensis (Chinese alligator) [GN:asn]
Gene
102383040  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
102381689  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
102384689  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102370403  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
102377560  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102374729  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
102374662  IKBKG; NF-kappa-B essential modulator [KO:K07210]
102381268  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102369946  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102377458  RELA; transcription factor p65 [KO:K04735]
102368067  inhibitor of apoptosis protein-like [KO:K16060]
102371379  NECTIN1; nectin-1 [KO:K06081]
112548658  NECTIN2; nectin-2 [KO:K06531]
102371778  PTPN11; LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102386995  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
102382434  ITGA5; LOW QUALITY PROTEIN: integrin alpha-5 [KO:K06484]
102372699  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102371874  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102369846  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
102380379  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
102368478  IRF3; interferon regulatory factor 3 isoform X2 [KO:K05411]
102376594  TP53; cellular tumor antigen p53 isoform X2 [KO:K04451]
102382385  C3; complement C3 [KO:K03990]
102382810  venom factor-like [KO:K03990]
102378186  C5; complement C5 [KO:K03994]
102382265  CFP; LOW QUALITY PROTEIN: properdin [KO:K15412]
102368109  TLR2; toll-like receptor 2 [KO:K10159]
102368346  toll-like receptor 2 type-2 [KO:K10159]
102384063  toll-like receptor 2 [KO:K10159]
102383734  toll-like receptor 2 [KO:K10159]
102372553  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102387082  IRF7; interferon regulatory factor 7 [KO:K09447]
102370112  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
102372528  TICAM1; TIR domain-containing adapter molecule 1 isoform X1 [KO:K05842]
102375747  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102374837  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
102368234  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
102386999  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X2 [KO:K04427] [EC:2.7.11.25]
102378385  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
102386987  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
102369595  LOW QUALITY PROTEIN: interleukin-1 beta [KO:K04519]
112547978  interleukin-1 beta-like [KO:K04519]
102370207  C-C motif chemokine 5-like [KO:K12499]
102377828  IL6; interleukin-6 [KO:K05405]
102378738  tumor necrosis factor [KO:K03156]
102368752  IL12A; interleukin-12 subunit alpha [KO:K05406]
102379831  IL12B; interleukin-12 subunit beta [KO:K05425]
102388849  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
102384738  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
106722801  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
102382120  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
102372815  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
102383892  TBK1; serine/threonine-protein kinase TBK1 isoform X2 [KO:K05410] [EC:2.7.11.10]
102376462  interferon alpha-7 [KO:K05414]
102375321  interferon epsilon-like [KO:K05414]
112552120  interferon type B-like [KO:K05414]
102388310  CGAS; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
102379168  LOW QUALITY PROTEIN: cyclic GMP-AMP synthase-like [KO:K17834] [EC:2.7.7.86]
102373608  TMEM173; stimulator of interferon genes protein isoform X2 [KO:K12654]
102375415  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102373171  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
102383008  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
102388628  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
102379754  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
102380802  EIF2AK4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
102374223  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102380950  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
102385807  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
102385395  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
102369878  EIF2B4; LOW QUALITY PROTEIN: translation initiation factor eIF-2B subunit delta [KO:K03680]
102378188  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
102387444  RNASEL; 2-5A-dependent ribonuclease isoform X3 [KO:K01165]
102375077  host cell factor 1 [KO:K14966]
102368359  HCFC2; host cell factor 2 [KO:K27390]
102384930  POU2F3; POU domain, class 2, transcription factor 3 [KO:K09364]
102375917  POU2F2; POU domain, class 2, transcription factor 2 [KO:K09364]
102388500  POU2F1; POU domain, class 2, transcription factor 1 isoform X4 [KO:K09364]
102381089  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
102381921  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
102386715  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
102382170  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102385598  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X3 [KO:K11219] [EC:2.7.10.2]
102374439  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
106721797  STAT2; LOW QUALITY PROTEIN: signal transducer and activator of transcription 2 [KO:K11221]
102386225  IRF9; interferon regulatory factor 9 [KO:K04693]
102386961  zinc finger protein 436-like [KO:K09228]
102374925  zinc finger protein 664-like isoform X1 [KO:K09228]
102381744  zinc finger protein 436-like isoform X2 [KO:K09228]
102385622  zinc finger protein 282-like [KO:K09228]
102373116  zinc finger protein 420-like [KO:K09228]
102381781  zinc finger protein 420-like [KO:K09228]
102371447  zinc finger protein 391-like [KO:K09228]
102383274  zinc finger protein 135-like [KO:K09228]
102385460  zinc finger protein 250-like [KO:K09228]
102380150  zinc finger protein 345-like [KO:K09228]
112549067  zinc finger protein 501-like [KO:K09228]
102369451  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
102377321  zinc finger protein 91-like [KO:K09228]
102371443  zinc finger protein 501-like isoform X1 [KO:K09228]
102371704  zinc finger protein 2-like [KO:K09228]
102378914  zinc finger protein 883-like [KO:K09228]
102374452  LOW QUALITY PROTEIN: zinc finger protein 271-like [KO:K09228]
102383673  zinc finger protein 771-like [KO:K09228]
102380615  zinc finger protein 501-like [KO:K09228]
102380383  zinc finger protein 436-like [KO:K09228]
112548746  zinc finger protein 271-like [KO:K09228]
102371858  zinc finger protein 345-like [KO:K09228]
102371725  zinc finger protein 30 homolog isoform X1 [KO:K09228]
102382797  zinc finger protein 501-like isoform X2 [KO:K09228]
106721986  zinc finger protein 436-like [KO:K09228]
102382042  zinc finger protein 493-like isoform X1 [KO:K09228]
102380602  zinc finger protein 345-like isoform X1 [KO:K09228]
102383179  zinc finger protein 883-like isoform X1 [KO:K09228]
102387496  zinc finger protein 420-like [KO:K09228]
102369530  zinc finger protein 420-like [KO:K09228]
102369793  zinc finger protein 154-like [KO:K09228]
102380306  zinc finger protein 883-like isoform X1 [KO:K09228]
102368338  zinc finger protein 34-like [KO:K09228]
102370857  zinc finger protein 420-like [KO:K09228]
102379653  uncharacterized protein LOC102379653 [KO:K09228]
102384835  zinc finger protein 883 isoform X1 [KO:K09228]
102371274  zinc finger protein 501-like [KO:K09228]
102379897  LOW QUALITY PROTEIN: zinc finger protein 85-like [KO:K09228]
102380076  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
102385009  zinc finger protein 383-like [KO:K09228]
106723416  zinc finger protein 836-like [KO:K09228]
102372868  zinc finger protein 501-like [KO:K09228]
102368767  LOW QUALITY PROTEIN: zinc finger protein 11-like [KO:K09228]
106723366  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
112548888  zinc finger protein 679-like [KO:K09228]
102379094  zinc finger protein 239-like [KO:K09228]
106723438  zinc finger protein 34-like [KO:K09228]
102376018  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
102385011  zinc finger protein 883-like [KO:K09228]
102369081  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
102385314  zinc finger protein 398 isoform X1 [KO:K09228]
102379980  zinc finger protein 883-like [KO:K09228]
102383249  zinc finger protein 383-like [KO:K09228]
106722998  zinc finger protein 135-like isoform X2 [KO:K09228]
106723051  zinc finger protein 135-like isoform X1 [KO:K09228]
102375908  zinc finger protein 420-like isoform X1 [KO:K09228]
102380612  LOW QUALITY PROTEIN: zinc finger protein 841-like [KO:K09228]
102369880  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
102374868  gastrula zinc finger protein XlCGF57.1-like isoform X2 [KO:K09228]
102375105  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102371278  zinc finger protein 664-like [KO:K09228]
102385260  zinc finger protein 420-like isoform X2 [KO:K09228]
106722820  zinc finger protein 398-like [KO:K09228]
102385385  zinc finger protein 777-like isoform X1 [KO:K09228]
106722840  zinc finger protein 501-like isoform X1 [KO:K09228]
102377053  zinc finger protein 135-like isoform X1 [KO:K09228]
106722841  zinc finger protein 271-like [KO:K09228]
106722842  zinc finger protein 135-like isoform X1 [KO:K09228]
102375104  zinc finger protein 883-like isoform X2 [KO:K09228]
102374290  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
106723269  zinc finger protein 501-like [KO:K09228]
106723280  oocyte zinc finger protein XlCOF6-like isoform X4 [KO:K09228]
106721826  zinc finger protein 420-like isoform X3 [KO:K09228]
106723487  zinc finger protein 883-like [KO:K09228]
102379632  LOW QUALITY PROTEIN: zinc finger protein 420 [KO:K09228]
112548007  zinc finger protein 883-like [KO:K09228]
102379172  zinc finger protein 420-like isoform X1 [KO:K09228]
102368260  zinc finger protein 485-like [KO:K09228]
102368011  zinc finger protein 383-like [KO:K09228]
102380464  zinc finger protein OZF-like [KO:K09228]
102372509  zinc finger protein OZF-like isoform X1 [KO:K09228]
102372100  zinc finger protein 664 isoform X1 [KO:K09228]
112548082  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
112547871  zinc finger protein 883-like [KO:K09228]
102377295  LOW QUALITY PROTEIN: zinc finger protein 2 homolog [KO:K09228]
102379560  zinc finger protein 2 homolog [KO:K09228]
102379171  zinc finger protein 436-like isoform X3 [KO:K09228]
102370167  zinc finger protein 2 homolog [KO:K09228]
102374328  zinc finger protein 239-like [KO:K09228]
102372196  zinc finger protein 345-like [KO:K09228]
102386813  zinc finger protein 883-like isoform X1 [KO:K09228]
102387240  zinc finger protein 883-like isoform X1 [KO:K09228]
102369020  zinc finger protein 420-like isoform X1 [KO:K09228]
102377404  zinc finger protein 345 isoform X1 [KO:K09228]
106721985  zinc finger protein 7-like isoform X1 [KO:K09228]
102384269  uncharacterized protein LOC102384269 [KO:K09228]
112549718  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
102376938  LOW QUALITY PROTEIN: zinc finger protein 883-like [KO:K09228]
102372299  zinc finger protein 271-like [KO:K09228]
102384228  uncharacterized protein LOC102384228 [KO:K09228]
102372589  zinc finger protein 883-like isoform X1 [KO:K09228]
102387619  zinc finger protein 883-like isoform X1 [KO:K09228]
102368310  LOW QUALITY PROTEIN: zinc finger protein 777 [KO:K09228]
102368074  zinc finger protein 777-like isoform X1 [KO:K09228]
106721829  zinc finger protein 665-like [KO:K09228]
106722835  zinc finger protein 436-like [KO:K09228]
112552133  zinc finger protein 135-like [KO:K09228]
112551238  zinc finger protein OZF-like [KO:K09228]
106721814  zinc finger protein OZF-like [KO:K09228]
102387024  LOW QUALITY PROTEIN: zinc finger protein 420-like [KO:K09228]
102369228  zinc finger protein 135-like [KO:K09228]
106722586  zinc finger protein 570-like [KO:K09228]
112551422  zinc finger protein 660-like isoform X1 [KO:K09228]
102378041  zinc finger protein 184-like isoform X1 [KO:K09228]
102367929  zinc finger protein 420-like isoform X1 [KO:K09228]
102383531  zinc finger protein 883-like isoform X2 [KO:K09228]
102383029  zinc finger protein 257-like isoform X3 [KO:K09228]
106722162  zinc finger protein 585A-like [KO:K09228]
102369055  zinc finger protein 501-like [KO:K09228]
102369312  zinc finger protein 845-like [KO:K09228]
102380031  zinc finger protein 397-like isoform X1 [KO:K09228]
106723052  zinc finger protein CKR1-like [KO:K09228]
102381686  zinc finger protein 135-like isoform X4 [KO:K09228]
102368501  zinc finger protein 501-like [KO:K09228]
106723292  zinc finger protein 271-like [KO:K09228]
106723411  zinc finger protein 551-like isoform X1 [KO:K09228]
102373299  putative zinc finger protein 56 [KO:K09228]
102387162  gastrula zinc finger protein XlCGF17.1-like [KO:K09228]
102385069  zinc finger protein 271-like [KO:K09228]
102377453  zinc finger protein 271 isoform X1 [KO:K09228]
106723479  zinc finger protein 79-like [KO:K09228]
102379900  zinc finger protein 883-like [KO:K09228]
102384262  zinc finger protein 436-like isoform X1 [KO:K09228]
102372852  zinc finger protein 2-like [KO:K09228]
102381950  zinc finger protein 664-like [KO:K09228]
106721813  zinc finger protein 501-like [KO:K09228]
102386729  LOW QUALITY PROTEIN: uncharacterized protein LOC102386729 [KO:K09228]
102369799  zinc finger protein 3-like isoform X1 [KO:K09228]
112548998  zinc finger protein 2 homolog [KO:K09228]
106723450  zinc finger protein 317-like [KO:K09228]
102372678  zinc finger protein 345-like isoform X1 [KO:K09228]
102379969  zinc finger protein 271-like [KO:K09228]
102369241  zinc finger protein 501-like isoform X3 [KO:K09228]
102378718  zinc finger protein 436-like isoform X1 [KO:K09228]
102377484  zinc finger protein 708-like [KO:K09228]
106722584  zinc finger protein 135-like isoform X1 [KO:K09228]
102379781  zinc finger protein 239-like [KO:K09228]
102386321  zinc finger protein 92 homolog [KO:K09228]
112549087  zinc finger protein 184-like [KO:K09228]
102383803  interferon gamma-like [KO:K04687]
102384045  interferon gamma-like [KO:K04687]
102374995  IFNGR1; interferon gamma receptor 1 [KO:K05132]
102384623  IFNGR2; interferon gamma receptor 2 [KO:K05133]
102370961  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
102371840  DAXX; death domain-associated protein 6 [KO:K02308]
102372629  PML; protein PML [KO:K10054] [EC:2.3.2.-]
102378535  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
102372873  protein PML-like isoform X2 [KO:K10054] [EC:2.3.2.-]
102371332  TAPBP; tapasin [KO:K08058]
102387284  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
102380818  CALR; calreticulin [KO:K08057]
102380341  CALR3; calreticulin-3 [KO:K08057]
102367803  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102378986  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102379493  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
102368919  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102384475  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
102382365  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102385058  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102382206  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102375088  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
102368503  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102378561  class I histocompatibility antigen, F10 alpha chain-like isoform X1 [KO:K06751]
102379232  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
102388210  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102388710  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102380209  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
102386566  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102388506  B2M; beta-2-microglobulin [KO:K08055]
102379029  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
102376901  HLA class II histocompatibility antigen, DR alpha chain isoform X1 [KO:K06752]
102377679  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
102381926  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
102384987  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
102368015  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
102380075  uncharacterized protein LOC102380075 [KO:K06752]
102383340  DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752]
102379074  DLA class II histocompatibility antigen, DR-1 beta chain [KO:K06752]
112552082  HLA class II histocompatibility antigen, DP beta 1 chain-like [KO:K06752]
112552083  HLA class II histocompatibility antigen, DM beta chain-like [KO:K06752]
112552084  class II histocompatibility antigen, M alpha chain [KO:K06752]
102386612  DLA class II histocompatibility antigen, DR-1 beta chain isoform X1 [KO:K06752]
102371382  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
102388304  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102372482  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102387818  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102382060  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102377899  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102380057  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102388514  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
102388207  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102372104  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102383470  TSC1; LOW QUALITY PROTEIN: hamartin [KO:K07206]
102387523  TSC2; tuberin isoform X1 [KO:K07207]
102381385  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
102372197  MTOR; serine/threonine-protein kinase mTOR isoform X2 [KO:K07203] [EC:2.7.11.1]
102375059  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
102386802  SRSF1; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 1 [KO:K12890]
102379605  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
102379116  SRSF5; serine/arginine-rich splicing factor 5 isoform X2 [KO:K12893]
102373471  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
102388763  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
102379682  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
102377813  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
102388837  SRSF9; LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 9 [KO:K21123]
102374093  NXF1; nuclear RNA export factor 1 [KO:K14284]
102383182  ALYREF; THO complex subunit 4 [KO:K12881]
102375471  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
102378637  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102386161  B3GNT9; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 isoform X2 [KO:K03171]
102377608  FADD; FAS-associated death domain protein [KO:K02373]
102384848  caspase-8-like [KO:K04398] [EC:3.4.22.61]
102385102  caspase-8-like [KO:K04398] [EC:3.4.22.61]
102375926  BH3-interacting domain death agonist [KO:K04726]
102384471  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
102374149  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
112548233  BAD; bcl2-associated agonist of cell death [KO:K02158]
102370035  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
102370658  BCL2L1; bcl-2-like protein 1 [KO:K04570]
102383053  cytochrome c [KO:K08738]
102379965  cytochrome c, somatic-like [KO:K08738]
102371819  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
102384999  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102383553  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
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Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
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Cytokine Growth Factor Rev 14:289-96 (2003)
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Reference
PMID:19495760
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Steinberg MW, Shui JW, Ware CF, Kronenberg M
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Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
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PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
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Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
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Proc Natl Acad Sci U S A 109:19792-7 (2012)
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Reference
PMID:25375272
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Gianni T, Campadelli-Fiume G
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The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
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Reference
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The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
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  Authors
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J Mol Biol 426:1133-47 (2014)
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Virol J 13:38 (2016)
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Reference
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  Authors
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
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Viruses 1:737-59 (2009)
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Reference
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  Authors
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The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
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Reference
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Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
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The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
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J Virol 87:859-71 (2013)
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Reference
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Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
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The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Viruses 1:1240-64 (2009)
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Reference
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Reference
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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
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Vink EI, Smiley JR, Mohr I
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J Virol 91:e00295-17 (2017)
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The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
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Reference
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The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Related
pathway
asn03040  Spliceosome
asn03050  Proteasome
asn04115  p53 signaling pathway
asn04210  Apoptosis
asn04620  Toll-like receptor signaling pathway
asn04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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