KEGG   PATHWAY: bbub04613
Entry
bbub04613                   Pathway                                
Name
Neutrophil extracellular trap formation - Bubalus bubalis (water buffalo)
Description
Neutrophils play a central role in innate immune defense. One of the mechanisms of neutrophil action is the formation of neutrophil extracellular traps (NETs), the extracellular structures composed of chromatin coated with histones, proteases and granular and cytosolic proteins that help catch and kill microorganisms. NETs are formed by a process known as "NETosis" that can be triggered by microorganisms and endogenous stimuli, such as damage-associated molecular patterns and immune complexes, and involves activation in most cases of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase, which produces reactive oxygen species (ROS). Recent study has reported that there are two different mechanisms of NETosis, including a lytic NETosis and a vital NETosis. Lytic NETosis begins with nuclear delobulation and the disassembly of the nuclear envelope and continues with loss of cellular polarization, chromatin decondensation and plasma membrane rupture. Vital NETosis can occur independently of cell death and involves the secreted expulsion of nuclear chromatin that is accompanied by the release of granule proteins through degranulation.
Class
Organismal Systems; Immune system
Pathway map
bbub04613  Neutrophil extracellular trap formation
bbub04613

Organism
Bubalus bubalis (water buffalo) [GN:bbub]
Gene
102410092  low affinity immunoglobulin gamma Fc region receptor III isoform X1 [KO:K06463]
102412306  SYK; tyrosine-protein kinase SYK isoform X2 [KO:K05855] [EC:2.7.10.2]
102415113  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X4 [KO:K04427] [EC:2.7.11.25]
102412922  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102396842  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
102401744  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102396206  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
102403296  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102415288  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
102413685  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
102413072  cytochrome b-245 light chain [KO:K08009]
102394950  NCF2; neutrophil cytosol factor 2 isoform X1 [KO:K08010]
102413684  NCF4; neutrophil cytosol factor 4 [KO:K08012]
102392559  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102393591  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
102409386  TLR7; toll-like receptor 7 isoform X1 [KO:K05404]
102408845  TLR8; toll-like receptor 8 isoform X1 [KO:K10170]
102411920  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
102404921  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
102393959  ACTG1; actin, cytoplasmic 2 [KO:K05692]
102413719  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
102409656  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102391970  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102400092  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X2 [KO:K15041]
102405012  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102413768  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102400898  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102415498  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102413761  ADP/ATP translocase 2-like [KO:K05863]
102390799  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
102405988  PADI4; protein-arginine deiminase type-4 isoform X2 [KO:K24669] [EC:3.5.3.15]
112582609  uncharacterized protein LOC112582609 [KO:K06856]
112582664  uncharacterized protein LOC112582664 [KO:K06856]
102410120  FCGR1A; LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
102411087  low affinity immunoglobulin gamma Fc region receptor II isoform X2 [KO:K06472]
102396526  integrin alpha-M [KO:K06461]
102400120  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
102412430  ITGAL; integrin alpha-L isoform X1 [KO:K05718]
102406913  CLEC7A; C-type lectin domain family 7 member A [KO:K10074]
102410133  SRC; proto-oncogene tyrosine-protein kinase Src isoform X2 [KO:K05704] [EC:2.7.10.2]
102412320  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X3 [KO:K05858] [EC:3.1.4.11]
102405830  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X2 [KO:K05858] [EC:3.1.4.11]
102413748  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
102389945  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
102400354  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
102396307  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102415611  PRKCA; protein kinase C alpha type isoform X4 [KO:K02677] [EC:2.7.11.13]
102407189  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
102397646  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102402138  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X5 [KO:K08337]
102404165  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102400519  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102404610  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102415109  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102404517  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
102395384  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102397969  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102398761  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102391021  AKT3; RAC-gamma serine/threonine-protein kinase isoform X4 [KO:K04456] [EC:2.7.11.1]
102407977  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102403930  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X2 [KO:K02580]
102397938  RELA; transcription factor P65 [KO:K04735]
102407588  C3; complement C3 [KO:K03990]
102400518  C5; complement C5 [KO:K03994]
102400801  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
102415236  HMGB1; high mobility group protein B1 [KO:K10802]
102397791  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
102407022  TLR4; toll-like receptor 4 precursor [KO:K10160]
102409665  MAPK12; mitogen-activated protein kinase 12 isoform X3 [KO:K04441] [EC:2.7.11.24]
102397149  MAPK14; mitogen-activated protein kinase 14 isoform X4 [KO:K04441] [EC:2.7.11.24]
102397694  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102401103  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
102391335  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102416238  FGA; fibrinogen alpha chain [KO:K03903]
102415912  FGB; fibrinogen beta chain [KO:K03904]
102416562  FGG; fibrinogen gamma chain isoform X2 [KO:K03905]
102415564  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
102397126  VWF; von Willebrand factor [KO:K03900]
102397837  P-selectin [KO:K06496]
102413078  SELPLG; P-selectin glycoprotein ligand 1 [KO:K06544]
102399460  AGER; advanced glycosylation end product-specific receptor isoform X4 [KO:K19722]
102394992  caspase-13 isoform X2 [KO:K04394] [EC:3.4.22.57 3.4.22.64]
102395839  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
102393748  GSDMD; gasdermin-D isoform X1 [KO:K20917]
102413958  HAT1; histone acetyltransferase type B catalytic subunit [KO:K11303] [EC:2.3.1.48]
102415835  LOW QUALITY PROTEIN: histone acetyltransferase type B catalytic subunit-like [KO:K11303] [EC:2.3.1.48]
102408956  core histone macro-H2A.2 isoform X1 [KO:K11251]
102408136  histone H2A type 1-H [KO:K11251]
102411659  histone H2A type 1-B [KO:K11251]
102404666  histone H2A type 3 [KO:K11251]
102400686  histone H2A.Z [KO:K11251]
102393782  histone H2A type 1-A [KO:K11251]
102416286  histone H2A-Bbd type 2/3-like [KO:K11251]
102414917  LOW QUALITY PROTEIN: histone H2A-Bbd type 2/3 [KO:K11251]
112587905  histone H2A type 1-D [KO:K11251]
112587907  histone H2A type 1 [KO:K11251]
112587908  histone H2A type 1-H [KO:K11251]
102400351  histone H2A type 1 [KO:K11251]
102413735  histone H2A type 2-A [KO:K11251]
102410332  histone H2A type 1 isoform X1 [KO:K11251]
102402131  histone H2A.J [KO:K11251]
102392276  histone H2A-beta, sperm [KO:K11251]
102392737  histone H2A type 1-J [KO:K11251]
102413952  histone H2A type 1 [KO:K11251]
102414630  histone H2A type 1-C [KO:K11251]
102389168  histone H2A type 1-H [KO:K11251]
102391051  histone H2A-Bbd type 2/3 [KO:K11251]
102412097  histone H2A-beta, sperm-like [KO:K11251]
102410517  core histone macro-H2A.1 isoform X5 [KO:K11251]
102392520  histone H2AX [KO:K11251]
102409148  histone H2A.Z [KO:K11251]
102389822  histone H2A type 1-D [KO:K11251]
102411314  histone H2A type 1 [KO:K11251]
102413094  histone H2A type 2-A [KO:K11251]
102414738  histone H2A type 2-C [KO:K11251]
102415072  histone H2A type 2-B [KO:K11251]
102395706  histone H2A.V [KO:K11251]
102412582  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
102405405  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
102392466  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
102402411  histone H2B type 1-C/E/F/G/I [KO:K11252]
102407809  histone H2B type 1-J [KO:K11252]
102410999  histone H2B type 1-C/E/F/G/I [KO:K11252]
102411322  histone H2B type 1-C/E/F/G/I [KO:K11252]
102404341  histone H2B type 3-B [KO:K11252]
102400687  histone H2B type 1-N-like [KO:K11252]
112587290  histone H2B type 1-L-like [KO:K11252]
102409122  histone H2B type 1-M [KO:K11252]
102408478  histone H2B type 1-K [KO:K11252]
102410005  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
112587924  histone H2B type 1-C/E/F/G/I [KO:K11252]
102413428  histone H2B type 2-E [KO:K11252]
102410329  histone H2B type 1-C/E/F/G/I [KO:K11252]
102400450  late histone H2B.L4-like [KO:K11252]
102390439  histone H2B subacrosomal variant [KO:K11252]
102409993  histone H2B type 1-N [KO:K11252]
102394425  histone H2B type 1-A [KO:K11252]
102400872  histone H2B [KO:K11252]
102393518  histone H2B type 2-E-like [KO:K11252]
102392428  histone H2B type 1-C/E/F/G/I [KO:K11252]
102413318  histone H2B type 1-C/E/F/G/I [KO:K11252]
102414965  histone H2B type 1-C/E/F/G/I [KO:K11252]
102389499  histone H2B type 1-B [KO:K11252]
102413516  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
102409454  late histone H2B.L4-like [KO:K11252]
102409792  histone H2B-like [KO:K11252]
102400427  late histone H2B.L4-like [KO:K11252]
102404200  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
102411916  late histone H2B.L4-like [KO:K11252]
102392042  histone H2B type 1-C/E/F/G/I [KO:K11252]
112582033  histone H2B-like [KO:K11252]
112582036  late histone H2B.L4-like [KO:K11252]
112582037  histone H2B type F-M-like [KO:K11252]
112583653  histone H2B type 1-L-like [KO:K11252]
112579914  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
102398832  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
102411450  histone H2B type 2-F isoform X3 [KO:K11252]
102412752  histone H2B type 2-E [KO:K11252]
102414399  histone H2B type 2-E [KO:K11252]
102400663  histone H2B type 1-C/E/F/G/I [KO:K11252]
102399756  histone H2B type 2-E-like [KO:K11252]
102409329  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
123333078  histone H2B type 1-K-like [KO:K11252]
123333630  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
123334369  histone H2B type 1-L-like [KO:K11252]
123335181  histone H2B type 2-F-like [KO:K11252]
123335276  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
123464642  histone H2B type 1-L-like [KO:K11252]
123464726  histone H2B type 2-E-like [KO:K11252]
123464969  histone H2B type 1-C/E/F/G/I-like [KO:K11252]
123464990  histone H2B type 2-E-like [KO:K11252]
123465698  histone H2B type 1-L-like [KO:K11252]
112587037  histone H4-like [KO:K11254]
102414837  histone H4-like [KO:K11254]
102406674  histone H4-like [KO:K11254]
102391078  histone H4 [KO:K11254]
102392571  histone H4 [KO:K11254]
102411988  uncharacterized protein LOC102411988 isoform X3 [KO:K11253]
102395983  histone H3.3C-like [KO:K11253]
102396450  histone H3.3A-like [KO:K11253]
102410667  histone H3.1 [KO:K11253]
102399019  histone H3.3A-like [KO:K11253]
102389804  histone H3.3-like [KO:K11253]
112582190  histone H3.3A-like [KO:K11253]
112587898  histone H3.1 [KO:K11253]
102394835  histone H3.1-like [KO:K11253]
102413645  uncharacterized protein LOC102413645 [KO:K11253]
102416610  histone H3.1 [KO:K11253]
102414136  histone H3.3A [KO:K11253]
102402179  histone H3.3C [KO:K11253]
102414870  histone H3.3A-like [KO:K11253]
102410792  histone H3.3A-like [KO:K11253]
102412183  histone H3.1 [KO:K11253]
102400013  histone H3.1 [KO:K11253]
102395477  uncharacterized protein LOC102395477 [KO:K11253]
123330296  histone H3.3A-like [KO:K11253]
123464546  uncharacterized protein LOC123464546 [KO:K11253]
123464785  histone H3.3A-like [KO:K11253]
102401017  histone H3.3A [KO:K11253]
102406199  histone H3.3A [KO:K11253]
102407100  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
102400806  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
102411856  HDAC3; histone deacetylase 3 [KO:K11404] [EC:3.5.1.98]
102407435  HDAC5; histone deacetylase 5 isoform X3 [KO:K11406] [EC:3.5.1.98]
102409427  HDAC4; histone deacetylase 4 isoform X3 [KO:K11406] [EC:3.5.1.98]
102397989  HDAC6; histone deacetylase 6 isoform X2 [KO:K11407] [EC:3.5.1.98]
102406487  HDAC7; histone deacetylase 7 isoform X5 [KO:K11408] [EC:3.5.1.98]
102394623  HDAC8; histone deacetylase 8 isoform X2 [KO:K11405] [EC:3.5.1.98]
102413835  HDAC9; histone deacetylase 9 isoform X3 [KO:K11409] [EC:3.5.1.98]
102408584  HDAC10; polyamine deacetylase HDAC10 [KO:K18671] [EC:3.5.1.98]
102398045  HDAC11; histone deacetylase 11 isoform X1 [KO:K11418] [EC:3.5.1.98]
102412566  AZU1; azurocidin [KO:K24665]
102397903  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
102398425  cathepsin G [KO:K01319] [EC:3.4.21.20]
102413293  LOW QUALITY PROTEIN: cathelicidin-1 [KO:K13916]
112577733  cathelicidin-4 [KO:K13916]
102402381  cathelicidin-5 isoform X1 [KO:K13916]
112581107  cathelicidin-4 [KO:K13916]
102414941  cathelicidin-6 [KO:K13916]
102413623  cathelicidin-7-like [KO:K13916]
123464561  cathelicidin-4-like [KO:K13916]
123465246  cathelicidin-1-like [KO:K13916]
102414747  CLCN4; H(+)/Cl(-) exchange transporter 4 isoform X1 [KO:K05012]
102389779  CLCN3; H(+)/Cl(-) exchange transporter 3 isoform X1 [KO:K05012]
102390539  CLCN5; H(+)/Cl(-) exchange transporter 5 isoform X1 [KO:K05012]
102408274  AQP9; aquaporin-9 isoform X1 [KO:K09877]
Compound
C00027  Hydrogen peroxide
C00039  DNA
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00464  Mannan
C00518  Hyaluronate
C00551  beta-D-Glucan
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05151  12-O-Tetradecanoylphorbol 13-acetate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11221  Formylmethionyl-leucyl-phenylalanine methyl ester
Reference
PMID:29543328
  Authors
Van Avondt K, Hartl D
  Title
Mechanisms and disease relevance of neutrophil extracellular trap formation.
  Journal
Eur J Clin Invest 48 Suppl 2:e12919 (2018)
DOI:10.1111/eci.12919
Reference
PMID:31518165
  Authors
Sorvillo N, Cherpokova D, Martinod K, Wagner DD
  Title
Extracellular DNA NET-Works With Dire Consequences for Health.
  Journal
Circ Res 125:470-488 (2019)
DOI:10.1161/CIRCRESAHA.119.314581
Reference
PMID:28990587
  Authors
Papayannopoulos V
  Title
Neutrophil extracellular traps in immunity and disease.
  Journal
Nat Rev Immunol 18:134-147 (2018)
DOI:10.1038/nri.2017.105
Reference
PMID:24837201
  Authors
Liu FC, Chuang YH, Tsai YF, Yu HP
  Title
Role of neutrophil extracellular traps following injury.
  Journal
Shock 41:491-8 (2014)
DOI:10.1097/SHK.0000000000000146
Reference
PMID:27570525
  Authors
Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y, Herrmann M
  Title
New Insights into Neutrophil Extracellular Traps: Mechanisms of Formation and Role in Inflammation.
  Journal
Front Immunol 7:302 (2016)
DOI:10.3389/fimmu.2016.00302
Reference
PMID:28983472
  Authors
Zawrotniak M, Bochenska O, Karkowska-Kuleta J, Seweryn-Ozog K, Aoki W, Ueda M, Kozik A, Rapala-Kozik M
  Title
Aspartic Proteases and Major Cell Wall Components in Candida albicans Trigger the Release of Neutrophil Extracellular Traps.
  Journal
Front Cell Infect Microbiol 7:414 (2017)
DOI:10.3389/fcimb.2017.00414
Reference
PMID:29382950
  Authors
Honda M, Kubes P
  Title
Neutrophils and neutrophil extracellular traps in the liver and gastrointestinal system.
  Journal
Nat Rev Gastroenterol Hepatol 15:206-221 (2018)
DOI:10.1038/nrgastro.2017.183
Reference
PMID:31416265
  Authors
Hamam HJ, Palaniyar N
  Title
Post-Translational Modifications in NETosis and NETs-Mediated Diseases.
  Journal
Biomolecules 9:E369 (2019)
DOI:10.3390/biom9080369
Reference
PMID:31767647
  Authors
Burgener SS, Schroder K
  Title
Neutrophil Extracellular Traps in Host Defense.
  Journal
Cold Spring Harb Perspect Biol 12:a037028 (2020)
DOI:10.1101/cshperspect.a037028
Reference
PMID:33202203
  Authors
Vorobjeva NV, Chernyak BV
  Title
NETosis: Molecular Mechanisms, Role in Physiology and Pathology.
  Journal
Biochemistry (Mosc) 85:1178-1190 (2020)
DOI:10.1134/S0006297920100065
Reference
PMID:31416173
  Authors
Ravindran M, Khan MA, Palaniyar N
  Title
Neutrophil Extracellular Trap Formation: Physiology, Pathology, and Pharmacology.
  Journal
Biomolecules 9:E365 (2019)
DOI:10.3390/biom9080365
Reference
PMID:28267716
  Authors
Jorch SK, Kubes P
  Title
An emerging role for neutrophil extracellular traps in noninfectious disease.
  Journal
Nat Med 23:279-287 (2017)
DOI:10.1038/nm.4294
Reference
PMID:31342866
  Authors
Goggs R, Jeffery U, LeVine DN, Li RHL
  Title
Neutrophil-Extracellular Traps, Cell-Free DNA, and Immunothrombosis in Companion Animals: A Review.
  Journal
Vet Pathol 57:6-23 (2020)
DOI:10.1177/0300985819861721
Reference
PMID:27876233
  Authors
Kim SJ, Jenne CN
  Title
Role of platelets in neutrophil extracellular trap (NET) production and tissue injury.
  Journal
Semin Immunol 28:546-554 (2016)
DOI:10.1016/j.smim.2016.10.013
Reference
PMID:29572545
  Authors
de Bont CM, Boelens WC, Pruijn GJM
  Title
NETosis, complement, and coagulation: a triangular relationship.
  Journal
Cell Mol Immunol 16:19-27 (2019)
DOI:10.1038/s41423-018-0024-0
Reference
PMID:31129510
  Authors
Zawrotniak M, Bartnicka D, Rapala-Kozik M
  Title
UVA and UVB radiation induce the formation of neutrophil extracellular traps by human polymorphonuclear cells.
  Journal
J Photochem Photobiol B 196:111511 (2019)
DOI:10.1016/j.jphotobiol.2019.111511
Reference
PMID:21293492
  Authors
Remijsen Q, Kuijpers TW, Wirawan E, Lippens S, Vandenabeele P, Vanden Berghe T
  Title
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality.
  Journal
Cell Death Differ 18:581-8 (2011)
DOI:10.1038/cdd.2011.1
Reference
PMID:23819131
  Authors
Zawrotniak M, Rapala-Kozik M
  Title
Neutrophil extracellular traps (NETs) - formation and implications.
  Journal
Acta Biochim Pol 60:277-84 (2013)
Reference
PMID:28373871
  Authors
Rosales C
  Title
Fcgamma Receptor Heterogeneity in Leukocyte Functional Responses.
  Journal
Front Immunol 8:280 (2017)
DOI:10.3389/fimmu.2017.00280
Reference
PMID:25716722
  Authors
Vorobjeva NV, Pinegin BV
  Title
Neutrophil extracellular traps: mechanisms of formation and role in health and disease.
  Journal
Biochemistry (Mosc) 79:1286-96 (2014)
DOI:10.1134/S0006297914120025
Reference
PMID:28220120
  Authors
Delgado-Rizo V, Martinez-Guzman MA, Iniguez-Gutierrez L, Garcia-Orozco A, Alvarado-Navarro A, Fafutis-Morris M
  Title
Neutrophil Extracellular Traps and Its Implications in Inflammation: An Overview.
  Journal
Front Immunol 8:81 (2017)
DOI:10.3389/fimmu.2017.00081
Reference
PMID:30023352
  Authors
Fonseca Z, Diaz-Godinez C, Mora N, Aleman OR, Uribe-Querol E, Carrero JC, Rosales C
  Title
Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) Formation.
  Journal
Front Cell Infect Microbiol 8:226 (2018)
DOI:10.3389/fcimb.2018.00226
Reference
PMID:27923601
  Authors
Agraz-Cibrian JM, Giraldo DM, Mary FM, Urcuqui-Inchima S
  Title
Understanding the molecular mechanisms of NETs and their role in antiviral innate immunity.
  Journal
Virus Res 228:124-133 (2017)
DOI:10.1016/j.virusres.2016.11.033
Reference
PMID:27698656
  Authors
Schonrich G, Raftery MJ
  Title
Neutrophil Extracellular Traps Go Viral.
  Journal
Front Immunol 7:366 (2016)
DOI:10.3389/fimmu.2016.00366
Reference
PMID:22817992
  Authors
Saitoh T, Komano J, Saitoh Y, Misawa T, Takahama M, Kozaki T, Uehata T, Iwasaki H, Omori H, Yamaoka S, Yamamoto N, Akira S
  Title
Neutrophil extracellular traps mediate a host defense response to human immunodeficiency virus-1.
  Journal
Cell Host Microbe 12:109-16 (2012)
DOI:10.1016/j.chom.2012.05.015
Reference
PMID:29908538
  Authors
Kumar S, Gupta E, Kaushik S, Jyoti A
  Title
Neutrophil Extracellular Traps: Formation and Involvement in Disease Progression.
  Journal
Iran J Allergy Asthma Immunol 17:208-220 (2018)
Related
pathway
bbub04010  MAPK signaling pathway
bbub04020  Calcium signaling pathway
bbub04140  Autophagy - animal
bbub04151  PI3K-Akt signaling pathway
bbub04610  Complement and coagulation cascades
bbub04611  Platelet activation
bbub04620  Toll-like receptor signaling pathway
bbub04621  NOD-like receptor signaling pathway
bbub04666  Fc gamma R-mediated phagocytosis
KO pathway
ko04613   
LinkDB

DBGET integrated database retrieval system