KEGG   PATHWAY: bmus04936
Entry
bmus04936                   Pathway                                
Name
Alcoholic liver disease - Balaenoptera musculus (blue whale)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
bmus04936  Alcoholic liver disease
bmus04936

Organism
Balaenoptera musculus (blue whale) [GN:bmus]
Gene
118889661  C1QA; complement C1q subcomponent subunit A [KO:K03986]
118903150  C2; complement C2 [KO:K01332] [EC:3.4.21.43]
118903146  complement C4-like [KO:K03989]
118892101  C3; complement C3 [KO:K03990]
118902290  C3AR1; C3a anaphylatoxin chemotactic receptor isoform X1 [KO:K04009]
118897527  C5; complement C5 [KO:K03994]
118885391  C5AR1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010]
118880935  lipopolysaccharide-binding protein isoform X1 [KO:K05399]
118892438  CD14; monocyte differentiation antigen CD14 [KO:K04391]
118883528  LY96; lymphocyte antigen 96 isoform X1 [KO:K05400]
118897312  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
118899167  toll/interleukin-1 receptor domain-containing adapter protein isoform X1 [KO:K05403]
118904029  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
118902731  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
118888703  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
118899213  TRAF6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
118901691  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
118905110  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
118905068  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
118883002  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118887797  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118889045  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
118891010  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
118899660  RELA; transcription factor p65 isoform X1 [KO:K04735]
118895446  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
118903810  TNF; tumor necrosis factor [KO:K03156]
118906007  IL1B; interleukin-1 beta [KO:K04519]
118900814  IL6; interleukin-6 [KO:K05405]
118894377  IL12A; interleukin-12 subunit alpha [KO:K05406]
118893547  IL12B; interleukin-12 subunit beta [KO:K05425]
118895640  CXCL8; interleukin-8 [KO:K10030]
118892933  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
118890316  TRAF3; LOW QUALITY PROTEIN: TNF receptor-associated factor 3 [KO:K03174]
118893413  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
118902324  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
118884995  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
118896746  interferon alpha-1-like [KO:K05414]
118896908  interferon alpha-1-like [KO:K05414]
118896929  interferon alpha-1-like [KO:K05414]
118896943  interferon alpha-1-like [KO:K05414]
118897134  interferon alpha-1-like [KO:K05414]
118897323  IFNB1; interferon beta [KO:K05415]
118904104  IL17A; interleukin-17A [KO:K05489]
118901685  IL17RA; interleukin-17 receptor A [KO:K05164]
118903575  IL17RC; LOW QUALITY PROTEIN: interleukin-17 receptor C [KO:K05166]
118895157  growth-regulated protein homolog alpha-like [KO:K05505]
118895677  growth-regulated protein homolog alpha-like [KO:K05505]
118895684  growth-regulated protein homolog alpha-like [KO:K05505]
118906923  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
118882330  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118899681  FADD; FAS-associated death domain protein isoform X1 [KO:K02373]
118901803  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
118885950  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118897732  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
118887867  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
118889206  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
118903372  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
118888478  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
118887057  SREBF1; sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
118886381  FASN; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
118886187  ACACA; acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
118882565  SCD; acyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
118895798  SCD5; stearoyl-CoA desaturase 5 [KO:K00507] [EC:1.14.19.1]
118880208  LPIN2; phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
118906091  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
118881400  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
118882663  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
118894100  TRA2B; transformer-2 protein homolog beta isoform X1 [KO:K12897]
118900637  TRA2A; transformer-2 protein homolog alpha [KO:K12897]
118884182  transformer-2 protein homolog beta-like [KO:K12897]
118903457  LOW QUALITY PROTEIN: transformer-2 protein homolog alpha-like [KO:K12897]
118894399  ADIPOQ; adiponectin [KO:K07296]
118892379  ADIPOR1; adiponectin receptor protein 1 isoform X1 [KO:K07297]
118888575  LOW QUALITY PROTEIN: adiponectin receptor protein 1-like [KO:K07297]
118902439  ADIPOR2; adiponectin receptor protein 2 isoform X1 [KO:K07297]
118890467  LOW QUALITY PROTEIN: adiponectin receptor protein 2-like [KO:K07297]
118906968  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
118893106  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118890034  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
118898524  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
118906832  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
118898407  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
118900839  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
118902461  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
118884195  FOXO1; forkhead box protein O1 [KO:K07201]
118905129  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
118895621  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
118901898  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
118898953  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
118886462  ACADVL; LOW QUALITY PROTEIN: very long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K09479] [EC:1.3.8.9]
118879993  ACADM; medium-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K00249] [EC:1.3.8.7]
118886954  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
118896140  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
118906143  FABP1; fatty acid-binding protein, liver [KO:K08750]
118895724  alcohol dehydrogenase S chain [KO:K13951] [EC:1.1.1.1]
118896070  LOW QUALITY PROTEIN: all-trans-retinol dehydrogenase [NAD(+)] ADH7-like [KO:K13951] [EC:1.1.1.1]
118895895  LOW QUALITY PROTEIN: all-trans-retinol dehydrogenase [NAD(+)] ADH4-like [KO:K13980] [EC:1.1.1.1]
118895605  ADH5; alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
118886085  ALDH3A2; aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
118880258  ALDH2; aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
118896338  ALDH1B1; LOW QUALITY PROTEIN: aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
118892669  alpha-aminoadipic semialdehyde dehydrogenase-like [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
118893577  ALDH7A1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
118899147  ALDH9A1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
118882825  cytochrome P450 2E1 isoform X1 [KO:K07415] [EC:1.14.14.-]
118906860  acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
118884525  MLYCD; malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
118902112  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
118884994  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X1 [KO:K19524] [EC:2.3.1.21]
118900227  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
118884787  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118900614  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118890216  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118894954  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118903019  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
118892102  TCF7; transcription factor 7 isoform X1 [KO:K02620]
118905868  TCF7L1; transcription factor 7-like 1 [KO:K04490]
118888134  LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491]
118882500  TCF7L2; LOW QUALITY PROTEIN: transcription factor 7-like 2 [KO:K04491]
118896149  LEF1; lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
118898958  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
118905124  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
118886388  MAP2K4; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
118892192  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
118893249  MAPK9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
118896118  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
118883114  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118886770  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
118886696  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
118904356  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
118904357  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
118901762  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
118901763  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
118887081  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
bmus00061  Fatty acid biosynthesis
bmus00071  Fatty acid degradation
bmus01040  Biosynthesis of unsaturated fatty acids
bmus03040  Spliceosome
bmus04010  MAPK signaling pathway
bmus04064  NF-kappa B signaling pathway
bmus04152  AMPK signaling pathway
bmus04210  Apoptosis
bmus04310  Wnt signaling pathway
bmus04610  Complement and coagulation cascades
bmus04620  Toll-like receptor signaling pathway
bmus04657  IL-17 signaling pathway
bmus04668  TNF signaling pathway
bmus04920  Adipocytokine signaling pathway
bmus05034  Alcoholism
bmus05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

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