KEGG   PATHWAY: bspl04621
Entry
bspl04621                   Pathway                                
Name
NOD-like receptor signaling pathway - Betta splendens (Siamese fighting fish)
Description
Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis.
Class
Organismal Systems; Immune system
Pathway map
bspl04621  NOD-like receptor signaling pathway
bspl04621

Organism
Betta splendens (Siamese fighting fish) [GN:bspl]
Gene
114843085  nod1; nucleotide-binding oligomerization domain-containing protein 1 isoform X1 [KO:K08727]
114845064  receptor-interacting serine/threonine-protein kinase 2-like [KO:K08846] [EC:2.7.11.1]
114858847  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
114845361  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
114870842  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
114861862  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
114848588  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
114849518  NF-kappa-B inhibitor alpha-like [KO:K04734]
114864181  nfkb1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
114851349  rela; transcription factor p65 isoform X1 [KO:K04735]
114863211  interleukin-1 beta-like [KO:K04519]
114865591  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
114851355  growth-regulated alpha protein-like [KO:K10030]
114844587  cxcl8a; C-X-C motif chemokine 2 [KO:K10030]
114850070  cxcl19; interleukin-8 [KO:K10030]
114852704  nod2; nucleotide-binding oligomerization domain-containing protein 2 isoform X1 [KO:K10165]
114848301  mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
114849393  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
114859929  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
114849544  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
114854441  tab3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 [KO:K12793]
114860359  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
114861888  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
114841906  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114845408  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
114867198  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
114864012  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
114858494  mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
114859152  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
114859326  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
114861856  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
114861857  mapk11; mitogen-activated protein kinase 11 isoform X6 [KO:K04441] [EC:2.7.11.24]
114855788  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
114857567  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
114844877  transcription factor Jun-like [KO:K04448]
114867319  june; junE proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
114854282  jun; transcription factor AP-1 isoform X2 [KO:K04448]
114867566  atg16l1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
114842691  atg5; autophagy protein 5 [KO:K08339]
114842758  atg12; ubiquitin-like protein ATG12 [KO:K08336]
114842980  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
114852513  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
114856892  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
114850771  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
114857959  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
114855541  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
114857061  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
114864411  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
114844812  sugt1; protein SGT1 homolog isoform X1 [KO:K12795]
114845097  ranBP-type and C3HC4-type zinc finger-containing protein 1-like isoform X1 [KO:K20894]
114854200  shrprbck1r; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X1 [KO:K10630] [EC:2.3.2.31]
114855664  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 isoform X2 [KO:K10630] [EC:2.3.2.31]
114853294  E3 ubiquitin-protein ligase RNF31-like isoform X1 [KO:K11974] [EC:2.3.2.31]
114844318  si:dkey-181m9.8; E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
114844705  E3 ubiquitin-protein ligase RNF31 isoform X2 [KO:K11974] [EC:2.3.2.31]
114863939  xiap; E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
114847140  trip6; thyroid receptor-interacting protein 6 isoform X1 [KO:K12792]
114866410  erbin; erbin isoform X1 [KO:K12796]
114869611  birc2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
114845605  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
114866528  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
114866591  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
114860027  traf5; TNF receptor-associated factor 5 [KO:K09849]
114852159  traf6; TNF receptor-associated factor 6 isoform X1 [KO:K03175] [EC:2.3.2.27]
114841963  tnfaip3; tumor necrosis factor alpha-induced protein 3 isoform X1 [KO:K11859] [EC:3.4.19.12]
114848314  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
114848462  traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
114861284  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
114855091  ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
114847754  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
114845285  irf3; interferon regulatory factor 3 [KO:K05411]
114857241  irf7; interferon regulatory factor 7 [KO:K09447]
114846466  interferon a3-like [KO:K05414]
114867505  nlrx1; NLR family member X1 [KO:K12653]
114863159  anthrax toxin receptor 1-like [KO:K20909]
114870633  antxr1d; LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909]
114866791  anthrax toxin receptor 1 [KO:K20909]
114867035  antxr2b; ANTXR cell adhesion molecule 2b [KO:K20909]
114862349  antxr2a; ANTXR cell adhesion molecule 2a isoform X1 [KO:K20909]
114846227  antxr1c; LOW QUALITY PROTEIN: anthrax toxin receptor 1 [KO:K20909]
114843270  pycard; apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
114868518  caspase a-like isoform X1 [KO:K01370] [EC:3.4.22.36]
114844269  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
114853980  apoptosis regulator Bcl-2-like [KO:K02161]
114858201  bcl2l1; bcl-2-like protein 1 isoform X1 [KO:K04570]
114855762  bcl-2-like protein 1 [KO:K04570]
114852126  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
114849798  cathepsin B-like [KO:K01363] [EC:3.4.22.1]
114867817  pannexin-1-like [KO:K03443]
114862427  pannexin-1-like isoform X1 [KO:K03443]
114862888  pannexin-1-like [KO:K03443]
114861592  p2rx7; P2X purinoceptor 7 isoform X1 [KO:K05220]
114847666  trpm2; transient receptor potential cation channel subfamily M member 2 isoform X2 [KO:K04977] [EC:3.6.1.13]
114852630  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
114869412  casr; extracellular calcium-sensing receptor [KO:K04612]
114843736  gprc6a; G-protein coupled receptor family C group 6 member A [KO:K04622]
114848466  G-protein coupled receptor family C group 6 member A-like [KO:K04622]
114846581  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
114848922  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
114849424  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
114849425  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
114870761  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
114855079  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114856386  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
114857939  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
114858253  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
114869122  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
114845680  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
114870699  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
114866989  zgc:56235; voltage-dependent anion-selective channel protein 2-like isoform X1 [KO:K15041]
114861867  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
114870568  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
114869030  dhx33; ATP-dependent RNA helicase DHX33 isoform X1 [KO:K17820] [EC:5.6.2.6]
114844651  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
114844658  mitofusin-1-like [KO:K21356] [EC:3.6.5.-]
114854434  mfn1b; mitofusin-1b [KO:K21356] [EC:3.6.5.-]
114859097  mfn2; mitofusin-2 [KO:K06030] [EC:3.6.5.-]
114845086  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
114857396  receptor-interacting serine/threonine-protein kinase 3-like isoform X1 [KO:K08847] [EC:2.7.11.1]
114847805  ripk3; receptor-interacting serine/threonine-protein kinase 3 isoform X1 [KO:K08847] [EC:2.7.11.1]
114863155  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
114857217  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
114855563  nampt2; nicotinamide phosphoribosyltransferase 2 isoform X1 [KO:K03462] [EC:2.4.2.12]
114862336  nampt1; nicotinamide phosphoribosyltransferase [KO:K03462] [EC:2.4.2.12]
114851168  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
114852765  cytochrome b-245 light chain [KO:K08009]
114843224  thioredoxin-interacting protein-like isoform X1 [KO:K20910]
114865542  txnipa; thioredoxin interacting protein a [KO:K20910]
114860311  txn2; thioredoxin, mitochondrial [KO:K03671]
114867580  txn; thioredoxin isoform X2 [KO:K03671]
114867589  thioredoxin-like [KO:K03671]
114852883  nek7; serine/threonine-protein kinase Nek7 isoform X1 [KO:K20876] [EC:2.7.11.34]
114866723  brcc3; lys-63-specific deubiquitinase BRCC36 [KO:K11864] [EC:3.4.19.-]
114849323  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [KO:K04079]
114849324  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
114849876  hsp90ab1; heat shock protein HSP 90-beta isoform X1 [KO:K04079]
114852484  proline-serine-threonine phosphatase-interacting protein 1-like isoform X2 [KO:K12804]
114856865  pstpip1a; proline-serine-threonine phosphatase-interacting protein 1a [KO:K12804]
114844036  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
114844038  caspase-3-like [KO:K04398] [EC:3.4.22.61]
114847689  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
114852435  fadd; protein FADD [KO:K02373]
114855205  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
114852051  tp53bp1; TP53-binding protein 1 isoform X1 [KO:K20915]
114858233  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
114858620  rho-related GTP-binding protein RhoA-D-like [KO:K04513]
114859320  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
114859359  rhoab; rho-related GTP-binding protein RhoA-B isoform X1 [KO:K04513]
114855843  rho-related GTP-binding protein RhoA-B [KO:K04513]
114856260  rho-related GTP-binding protein RhoA-D [KO:K04513]
114863826  pkn1a; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
114844634  pkn2a; serine/threonine-protein kinase N2 isoform X2 [KO:K23691] [EC:2.7.11.13]
114868370  ywhae1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1 isoform X1 [KO:K06630]
114869273  14-3-3 protein epsilon isoform X1 [KO:K06630]
114847468  interferon alpha/beta receptor 2 [KO:K05131]
114853126  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
114859997  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
114845713  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
114846801  signal transducer and activator of transcription 1-alpha/beta-like isoform X2 [KO:K11220]
114855222  stat2; signal transducer and activator of transcription 2 [KO:K11221]
114853295  irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
114845051  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
114854334  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
114857648  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
114864860  sting1; stimulator of interferon genes protein isoform X2 [KO:K12654]
Compound
C00002  ATP
C00076  Calcium cation
C00155  L-Homocysteine
C00238  Potassium cation
C00533  Nitric oxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:23124073
  Authors
Vandenabeele P, Bertrand MJ
  Title
The role of the IAP E3 ubiquitin ligases in regulating pattern-recognition receptor signalling.
  Journal
Nat Rev Immunol 12:833-44 (2012)
DOI:10.1038/nri3325
Reference
PMID:16493424
  Authors
Strober W, Murray PJ, Kitani A, Watanabe T
  Title
Signalling pathways and molecular interactions of NOD1 and NOD2.
  Journal
Nat Rev Immunol 6:9-20 (2006)
DOI:10.1038/nri1747
Reference
PMID:24718315
  Authors
Estornes Y, Bertrand MJ
  Title
IAPs, regulators of innate immunity and inflammation.
  Journal
Semin Cell Dev Biol 39:106-14 (2015)
DOI:10.1016/j.semcdb.2014.03.035
Reference
PMID:24707857
  Authors
Jakopin Z
  Title
Nucleotide-binding oligomerization domain (NOD) inhibitors: a rational approach toward inhibition of NOD signaling pathway.
  Journal
J Med Chem 57:6897-918 (2014)
DOI:10.1021/jm401841p
Reference
PMID:25526305
  Authors
Caruso R, Warner N, Inohara N, Nunez G
  Title
NOD1 and NOD2: signaling, host defense, and inflammatory disease.
  Journal
Immunity 41:898-908 (2014)
DOI:10.1016/j.immuni.2014.12.010
Reference
PMID:19767725
  Authors
Murray PJ
  Title
Beyond peptidoglycan for Nod2.
  Journal
Nat Immunol 10:1053-4 (2009)
DOI:10.1038/ni1009-1053
Reference
PMID:20643110
  Authors
Lecat A, Piette J, Legrand-Poels S
  Title
The protein Nod2: an innate receptor more complex than previously assumed.
  Journal
Biochem Pharmacol 80:2021-31 (2010)
DOI:10.1016/j.bcp.2010.07.016
Reference
PMID:26655628
  Authors
Man SM, Kanneganti TD
  Title
Converging roles of caspases in inflammasome activation, cell death and innate immunity.
  Journal
Nat Rev Immunol 16:7-21 (2016)
DOI:10.1038/nri.2015.7
Reference
PMID:27291964
  Authors
Broz P, Dixit VM
  Title
Inflammasomes: mechanism of assembly, regulation and signalling.
  Journal
Nat Rev Immunol 16:407-20 (2016)
DOI:10.1038/nri.2016.58
Reference
PMID:25879280
  Authors
Man SM, Kanneganti TD
  Title
Regulation of inflammasome activation.
  Journal
Immunol Rev 265:6-21 (2015)
DOI:10.1111/imr.12296
Reference
PMID:26549800
  Authors
Jo EK, Kim JK, Shin DM, Sasakawa C
  Title
Molecular mechanisms regulating NLRP3 inflammasome activation.
  Journal
Cell Mol Immunol 13:148-59 (2016)
DOI:10.1038/cmi.2015.95
Reference
PMID:23846113
  Authors
Broz P, Monack DM
  Title
Newly described pattern recognition receptors team up against intracellular pathogens.
  Journal
Nat Rev Immunol 13:551-65 (2013)
DOI:10.1038/nri3479
Reference
PMID:22430786
  Authors
Rathinam VA, Vanaja SK, Fitzgerald KA
  Title
Regulation of inflammasome signaling.
  Journal
Nat Immunol 13:333-42 (2012)
DOI:10.1038/ni.2237
Reference
PMID:24840700
  Authors
Sutterwala FS, Haasken S, Cassel SL
  Title
Mechanism of NLRP3 inflammasome activation.
  Journal
Ann N Y Acad Sci 1319:82-95 (2014)
DOI:10.1111/nyas.12458
Reference
PMID:23702978
  Authors
Latz E, Xiao TS, Stutz A
  Title
Activation and regulation of the inflammasomes.
  Journal
Nat Rev Immunol 13:397-411 (2013)
DOI:10.1038/nri3452
Reference
PMID:25145756
  Authors
Blander JM
  Title
A long-awaited merger of the pathways mediating host defence and programmed cell death.
  Journal
Nat Rev Immunol 14:601-18 (2014)
DOI:10.1038/nri3720
Reference
PMID:23215645
  Authors
von Moltke J, Ayres JS, Kofoed EM, Chavarria-Smith J, Vance RE
  Title
Recognition of bacteria by inflammasomes.
  Journal
Annu Rev Immunol 31:73-106 (2013)
DOI:10.1146/annurev-immunol-032712-095944
Reference
PMID:25330206
  Authors
Abais JM, Xia M, Zhang Y, Boini KM, Li PL
  Title
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?
  Journal
Antioxid Redox Signal 22:1111-29 (2015)
DOI:10.1089/ars.2014.5994
Reference
PMID:25879288
  Authors
Storek KM, Monack DM
  Title
Bacterial recognition pathways that lead to inflammasome activation.
  Journal
Immunol Rev 265:112-29 (2015)
DOI:10.1111/imr.12289
Reference
PMID:27012466
  Authors
Hu H, Sun SC
  Title
Ubiquitin signaling in immune responses.
  Journal
Cell Res 26:457-83 (2016)
DOI:10.1038/cr.2016.40
Reference
PMID:26121197
  Authors
Guo H, Callaway JB, Ting JP
  Title
Inflammasomes: mechanism of action, role in disease, and therapeutics.
  Journal
Nat Med 21:677-87 (2015)
DOI:10.1038/nm.3893
Reference
PMID:26482951
  Authors
Man SM, Kanneganti TD
  Title
Gasdermin D: the long-awaited executioner of pyroptosis.
  Journal
Cell Res 25:1183-4 (2015)
DOI:10.1038/cr.2015.124
Reference
PMID:22819539
  Authors
Rathinam VA, Vanaja SK, Waggoner L, Sokolovska A, Becker C, Stuart LM, Leong JM, Fitzgerald KA
  Title
TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria.
  Journal
Cell 150:606-19 (2012)
DOI:10.1016/j.cell.2012.07.007
Reference
PMID:21575908
  Authors
Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B
  Title
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.
  Journal
Cell Host Microbe 9:363-75 (2011)
DOI:10.1016/j.chom.2011.04.008
Reference
PMID:29148036
  Authors
Heilig R, Broz P
  Title
Function and mechanism of the pyrin inflammasome.
  Journal
Eur J Immunol 48:230-238 (2018)
DOI:10.1002/eji.201746947
Reference
PMID:25816776
  Authors
Chakrabarti A, Banerjee S, Franchi L, Loo YM, Gale M Jr, Nunez G, Silverman RH
  Title
RNase L activates the NLRP3 inflammasome during viral infections.
  Journal
Cell Host Microbe 17:466-77 (2015)
DOI:10.1016/j.chom.2015.02.010
Related
pathway
bspl04010  MAPK signaling pathway
bspl04140  Autophagy - animal
bspl04620  Toll-like receptor signaling pathway
KO pathway
ko04621   
LinkDB

DBGET integrated database retrieval system