KEGG   PATHWAY: ccad05418
Entry
ccad05418                   Pathway                                
Name
Fluid shear stress and atherosclerosis - Cervus canadensis (wapiti)
Description
Shear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress of atherosclerosis. Sustained laminar flow with high shear stress upregulates expressions of endothelial cell (EC) genes and proteins that are protective against atherosclerosis. The key shear stress-induced transcription factors that govern the expression of these genes are Kruppel-like factor 2 (KLF2) and nuclear factor erythroid 2-like 2 (Nrf2). On the other hand, disturbed flow with associated reciprocating, low shear stress generally upregulates the EC genes and proteins that promote oxidative and inflammatory states in the artery wall, resulting in atherogenesis. Important transcriptional events that reflect this condition of ECs in disturbed flow include the activation of activator protein 1 (AP-1) and nuclear factor kappaB (NF-kappaB).
Class
Human Diseases; Cardiovascular disease
Pathway map
ccad05418  Fluid shear stress and atherosclerosis
ccad05418

Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122429164  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
122421313  heat shock protein HSP 90-alpha-like [KO:K04079]
122455223  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
122427662  heat shock protein HSP 90-alpha-like [KO:K04079]
122423312  HSP90B1; endoplasmin [KO:K09487]
122435267  endoplasmin-like [KO:K09487]
122438344  CAV1; caveolin-1 isoform X1 [KO:K06278]
122438346  CAV2; caveolin-2 isoform X1 [KO:K12958]
122424247  CAV3; caveolin-3 [KO:K12959]
122420755  CALM3; calmodulin-3 [KO:K02183]
122420753  calmodulin-1-like [KO:K02183]
122448900  calmodulin-2/4-like [KO:K02183]
122448285  calmodulin-like [KO:K02183]
122441648  CALM2; calmodulin-2 [KO:K02183]
122453208  calmodulin-1-like [KO:K02183]
122443081  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
122451732  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
122443955  CALM1; calmodulin-1 isoform X1 [KO:K02183]
122445547  calmodulin-1 [KO:K02183]
122437323  GPC1; glypican-1 [KO:K08107]
122442032  SDC1; syndecan-1 [KO:K06257]
122451387  SDC2; syndecan-2 [KO:K16336]
122448411  SDC4; syndecan-4 [KO:K16338]
122422291  TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
122440418  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
122453600  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
122423719  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
122429584  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
122429585  glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
122429518  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
122429517  glutathione S-transferase A1 [KO:K00799] [EC:2.5.1.18]
122429516  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
122438812  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
122423550  MGST1; microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
122452401  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
122419924  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
122419940  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
122420542  glutathione S-transferase theta-4-like isoform X1 [KO:K00799] [EC:2.5.1.18]
122429843  MGST3; microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
122436571  GSTM3; glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
122436577  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
122436575  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
122436574  glutathione S-transferase Mu 1-like [KO:K00799] [EC:2.5.1.18]
122436573  uncharacterized protein LOC122436573 isoform X1 [KO:K00799] [EC:2.5.1.18]
122436576  glutathione S-transferase Mu 1 [KO:K00799] [EC:2.5.1.18]
122446233  GSTO2; glutathione S-transferase omega-2 [KO:K00799] [EC:2.5.1.18]
122446364  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
122446015  glutathione S-transferase omega-1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
122431348  glutathione S-transferase P-like isoform X1 [KO:K23790] [EC:2.5.1.18]
122431193  glutathione S-transferase P [KO:K23790] [EC:2.5.1.18]
122420950  NQO1; NAD(P)H dehydrogenase [quinone] 1 [KO:K00355] [EC:1.6.5.2]
122440582  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
122431926  TXN; thioredoxin [KO:K03671]
122423411  TXN2; thioredoxin, mitochondrial [KO:K03671]
122426721  thioredoxin-like [KO:K03671]
122426763  NPPC; C-type natriuretic peptide [KO:K12336]
122442275  ASS1; argininosuccinate synthase [KO:K01940] [EC:6.3.4.5]
122448458  THBD; thrombomodulin [KO:K03907]
122432505  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
122420539  CDH5; cadherin-5 isoform X1 [KO:K06533]
122428068  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
122425067  CTNNB1; catenin beta-1 [KO:K02105]
122454166  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
122436917  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
122439493  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
122451688  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122445271  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
122444906  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122440740  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122454626  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122437038  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
122420500  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122452448  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122455107  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122443078  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
122444207  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
122419624  MEF2A; myocyte-specific enhancer factor 2A isoform X1 [KO:K09260]
122439544  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
122440672  KLF2; Krueppel-like factor 2 [KO:K17845]
122440505  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
122453909  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
122439965  ITGB3; integrin beta-3 [KO:K06493]
122448145  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
122451056  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122432290  ARHGEF2; rho guanine nucleotide exchange factor 2 isoform X1 [KO:K12791]
122424963  RHOA; transforming protein RhoA [KO:K04513]
122438358  ACTG1; actin, cytoplasmic 2 [KO:K05692]
122432952  ACTB; actin, cytoplasmic 1 [KO:K05692]
122454393  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
122423229  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
122441438  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
122441437  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
122422588  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
122434540  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122446045  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122432633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122422050  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122430633  RELA; transcription factor p65 isoform X1 [KO:K04735]
122433913  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
122445001  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
122428005  dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
122440347  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
122440572  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
122428339  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
122446321  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
122429019  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
122429123  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
122429963  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
122423531  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
122423529  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
122443873  FOS; proto-oncogene C-Fos [KO:K04379]
122436906  JUN; transcription factor AP-1 [KO:K04448]
122420084  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
122448603  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
122431848  CTSL; procathepsin L [KO:K01365] [EC:3.4.22.15]
122431933  CTSV; cathepsin L2 isoform X1 [KO:K01365] [EC:3.4.22.15]
122449214  C-C motif chemokine 2 [KO:K14624]
122436633  vascular cell adhesion protein 1-like isoform X1 [KO:K06527]
122436632  vascular cell adhesion protein 1-like [KO:K06527]
122440432  ICAM1; intercellular adhesion molecule 1 [KO:K06490]
122452289  SELE; E-selectin [KO:K06494]
122430072  TNF; tumor necrosis factor [KO:K03156]
122442617  IL1A; interleukin-1 alpha [KO:K04383]
122441784  IL1B; interleukin-1 beta [KO:K04519]
122427438  IFNG; interferon gamma [KO:K04687]
122433132  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122429914  EDN1; endothelin-1 [KO:K16366]
122429439  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
122443659  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
122426765  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
122453864  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
122424487  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
122453976  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
122446247  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
122422280  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
122435041  NOX1; NADPH oxidase 1 [KO:K08008]
122420817  cytochrome b-245 light chain [KO:K08009]
122432985  NCF1; neutrophil cytosol factor 1 isoform X1 [KO:K08011]
122452111  NCF2; neutrophil cytosol factor 2 [KO:K08010]
122448567  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
122433321  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122423661  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
122438676  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
122452072  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
122440229  PIAS4; E3 SUMO-protein ligase PIAS4 [KO:K16065] [EC:2.3.2.27]
122445826  TP53; cellular tumor antigen P53 [KO:K04451]
122420975  small ubiquitin-related modifier 3-like [KO:K12160]
122421116  small ubiquitin-related modifier 1 [KO:K12160]
122422001  small ubiquitin-related modifier 2-like [KO:K12160]
122449413  small ubiquitin-related modifier 2-like [KO:K12160]
122436623  SUMO2; small ubiquitin-related modifier 2 [KO:K12160]
122441721  small ubiquitin-related modifier 1 [KO:K12160]
122423649  small ubiquitin-related modifier 1-like [KO:K12160]
122451109  small ubiquitin-related modifier 3-like [KO:K12160]
122433959  small ubiquitin-related modifier 1-like [KO:K12160]
122443598  small ubiquitin-related modifier 1 [KO:K12160]
122443912  small ubiquitin-related modifier 1-like [KO:K12160]
122452842  small ubiquitin-related modifier 2-A-like isoform X1 [KO:K12160]
122426023  SUMO1; small ubiquitin-related modifier 1 isoform X1 [KO:K12160]
122436462  small ubiquitin-related modifier 2-like [KO:K12160]
122436463  small ubiquitin-related modifier 2-like [KO:K12160]
122445427  SUMO3; small ubiquitin-related modifier 3 [KO:K12160]
122446748  small ubiquitin-related modifier 1-like isoform X1 [KO:K12160]
122446446  small ubiquitin-related modifier 2-like isoform X1 [KO:K12160]
122425862  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C00076  Calcium cation
C00272  Tetrahydrobiopterin
C00518  Hyaluronate
C00533  Nitric oxide
C00607  Chondroitin sulfate
C00704  Superoxide
C00925  Heparan sulfate
C16845  Peroxynitrite
Reference
PMID:21050140
  Authors
Nigro P, Abe J, Berk BC
  Title
Flow shear stress and atherosclerosis: a matter of site specificity.
  Journal
Antioxid Redox Signal 15:1405-14 (2011)
DOI:10.1089/ars.2010.3679
Reference
PMID:26597822
  Authors
McSweeney SR, Warabi E, Siow RC
  Title
Nrf2 as an Endothelial Mechanosensitive Transcription Factor: Going With the Flow.
  Journal
Hypertension 67:20-9 (2016)
DOI:10.1161/HYPERTENSIONAHA.115.06146
Reference
PMID:22076424
  Authors
Heo KS, Fujiwara K, Abe J
  Title
Disturbed-flow-mediated vascular reactive oxygen species induce endothelial dysfunction.
  Journal
Circ J 75:2722-30 (2011)
DOI:10.1253/circj.CJ-11-1124
Reference
PMID:24573382
  Authors
Wild J, Soehnlein O, Dietel B, Urschel K, Garlichs CD, Cicha I
  Title
Rubbing salt into wounded endothelium: sodium potentiates proatherogenic effects of TNF-alpha under non-uniform shear stress.
  Journal
Thromb Haemost 112:183-95 (2014)
DOI:10.1160/TH13-11-0908
Reference
PMID:21457103
  Authors
Noguchi N, Jo H
  Title
Redox going with vascular shear stress.
  Journal
Antioxid Redox Signal 15:1367-8 (2011)
DOI:10.1089/ars.2011.4011
Reference
PMID:25165867
  Authors
Li X, Yang Q, Wang Z, Wei D
  Title
Shear stress in atherosclerotic plaque determination.
  Journal
DNA Cell Biol 33:830-8 (2014)
DOI:10.1089/dna.2014.2480
Reference
PMID:17599600
  Authors
Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH
  Title
Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior.
  Journal
J Am Coll Cardiol 49:2379-93 (2007)
DOI:10.1016/j.jacc.2007.02.059
Reference
PMID:21733876
  Authors
Lu D, Kassab GS
  Title
Role of shear stress and stretch in vascular mechanobiology.
  Journal
J R Soc Interface 8:1379-85 (2011)
DOI:10.1098/rsif.2011.0177
Reference
PMID:27027326
  Authors
Givens C, Tzima E
  Title
Endothelial Mechanosignaling: Does One Sensor Fit All?
  Journal
Antioxid Redox Signal 25:373-88 (2016)
DOI:10.1089/ars.2015.6493
Reference
PMID:16765337
  Authors
Paravicini TM, Touyz RM
  Title
Redox signaling in hypertension.
  Journal
Cardiovasc Res 71:247-58 (2006)
DOI:10.1016/j.cardiores.2006.05.001
Reference
PMID:19151844
  Authors
Boon RA, Horrevoets AJ
  Title
Key transcriptional regulators of the vasoprotective effects of shear stress.
  Journal
Hamostaseologie 29:39-40, 41-3 (2009)
Reference
PMID:24947523
  Authors
Bryan MT, Duckles H, Feng S, Hsiao ST, Kim HR, Serbanovic-Canic J, Evans PC
  Title
Mechanoresponsive networks controlling vascular inflammation.
  Journal
Arterioscler Thromb Vasc Biol 34:2199-205 (2014)
DOI:10.1161/ATVBAHA.114.303424
Reference
PMID:26822720
  Authors
Brown AJ, Teng Z, Evans PC, Gillard JH, Samady H, Bennett MR
  Title
Role of biomechanical forces in the natural history of coronary atherosclerosis.
  Journal
Nat Rev Cardiol 13:210-20 (2016)
DOI:10.1038/nrcardio.2015.203
Reference
PMID:24876354
  Authors
Zhou J, Li YS, Chien S
  Title
Shear stress-initiated signaling and its regulation of endothelial function.
  Journal
Arterioscler Thromb Vasc Biol 34:2191-8 (2014)
DOI:10.1161/ATVBAHA.114.303422
Reference
PMID:23429585
  Authors
Liu HB, Zhang J, Xin SY, Liu C, Wang CY, Zhao D, Zhang ZR
  Title
Mechanosensitive properties in the endothelium and their roles in the regulation of endothelial function.
  Journal
J Cardiovasc Pharmacol 61:461-70 (2013)
DOI:10.1097/FJC.0b013e31828c0933
Reference
PMID:20032497
  Authors
Boon RA, Leyen TA, Fontijn RD, Fledderus JO, Baggen JM, Volger OL, van Nieuw Amerongen GP, Horrevoets AJ
  Title
KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium.
  Journal
Blood 115:2533-42 (2010)
DOI:10.1182/blood-2009-06-228726
Reference
PMID:20353494
  Authors
Whyte JJ, Laughlin MH
  Title
The effects of acute and chronic exercise on the vasculature.
  Journal
Acta Physiol (Oxf) 199:441-50 (2010)
DOI:10.1111/j.1748-1716.2010.02127.x
Reference
PMID:25638487
  Authors
Quillon A, Fromy B, Debret R
  Title
Endothelium microenvironment sensing leading to nitric oxide mediated vasodilation: a review of nervous and biomechanical signals.
  Journal
Nitric Oxide 45:20-6 (2015)
DOI:10.1016/j.niox.2015.01.006
Reference
PMID:15388638
  Authors
Sorescu GP, Song H, Tressel SL, Hwang J, Dikalov S, Smith DA, Boyd NL, Platt MO, Lassegue B, Griendling KK, Jo H
  Title
Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase.
  Journal
Circ Res 95:773-9 (2004)
DOI:10.1161/01.RES.0000145728.22878.45
Reference
PMID:23899566
  Authors
Hopkins PN
  Title
Molecular biology of atherosclerosis.
  Journal
Physiol Rev 93:1317-542 (2013)
DOI:10.1152/physrev.00004.2012
Reference
PMID:22003002
  Authors
Johnson BD, Mather KJ, Wallace JP
  Title
Mechanotransduction of shear in the endothelium: basic studies and clinical implications.
  Journal
Vasc Med 16:365-77 (2011)
DOI:10.1177/1358863X11422109
Reference
PMID:23555159
  Authors
Hu LS, George J, Wang JH
  Title
Current concepts on the role of nitric oxide in portal hypertension.
  Journal
World J Gastroenterol 19:1707-17 (2013)
DOI:10.3748/wjg.v19.i11.1707
Reference
PMID:23084990
  Authors
Collins C, Guilluy C, Welch C, O'Brien ET, Hahn K, Superfine R, Burridge K, Tzima E
  Title
Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway.
  Journal
Curr Biol 22:2087-94 (2012)
DOI:10.1016/j.cub.2012.08.051
Reference
PMID:24190880
  Authors
Conway DE, Schwartz MA
  Title
Flow-dependent cellular mechanotransduction in atherosclerosis.
  Journal
J Cell Sci 126:5101-9 (2013)
DOI:10.1242/jcs.138313
Reference
PMID:26212910
  Authors
Chen J, Green J, Yurdagul A Jr, Albert P, McInnis MC, Orr AW
  Title
alphavbeta3 Integrins Mediate Flow-Induced NF-kappaB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation.
  Journal
Am J Pathol 185:2575-89 (2015)
DOI:10.1016/j.ajpath.2015.05.013
Reference
PMID:20538799
  Authors
Nigro P, Abe J, Woo CH, Satoh K, McClain C, O'Dell MR, Lee H, Lim JH, Li JD, Heo KS, Fujiwara K, Berk BC
  Title
PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5.
  Journal
Blood 116:1971-9 (2010)
DOI:10.1182/blood-2010-02-269134
Related
pathway
ccad04010  MAPK signaling pathway
ccad04064  NF-kappa B signaling pathway
ccad04151  PI3K-Akt signaling pathway
ccad04210  Apoptosis
ccad04270  Vascular smooth muscle contraction
ccad04510  Focal adhesion
ccad04514  Cell adhesion molecules
ccad04670  Leukocyte transendothelial migration
KO pathway
ko05418   
LinkDB

DBGET integrated database retrieval system