KEGG   PATHWAY: ccad04151
Entry
ccad04151                   Pathway                                
Name
PI3K-Akt signaling pathway - Cervus canadensis (wapiti)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
ccad04151  PI3K-Akt signaling pathway
ccad04151

Other DBs
GO: 0043491
Organism
Cervus canadensis (wapiti) [GN:ccad]
Gene
122419720  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
122420110  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
122420237  RBL2; retinoblastoma-like protein 2 [KO:K16332]
122420500  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122420551  YWHAH; 14-3-3 protein eta [KO:K16198]
122420615  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
122420797  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
122420963  NTF4; neurotrophin-4 [KO:K12457]
122421029  OSM; oncostatin-M isoform X1 [KO:K05418]
122421031  GYS1; glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
122421214  [KO:K16197]
122421313  [KO:K04079]
122421346  [KO:K02991]
122421575  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
122421659  FGF21; fibroblast growth factor 21 [KO:K22429]
122421672  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
122422050  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
122422171  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
122422237  [KO:K06253]
122422253  SPP1; osteopontin [KO:K06250]
122422342  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
122422566  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
122422681  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
122422901  FOXO3; forkhead box protein O3 isoform X1 [KO:K09408]
122423084  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
122423142  [KO:K02991]
122423250  VWF; von Willebrand factor [KO:K03900]
122423293  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
122423312  HSP90B1; endoplasmin [KO:K09487]
122423665  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
122423666  [KO:K05069]
122423697  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
122423815  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
122423876  KRAS; GTPase KRas isoform X1 [KO:K07827]
122423919  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
122423970  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
122424006  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
122424008  FGF23; fibroblast growth factor 23 [KO:K22428]
122424015  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
122424018  FGF6; fibroblast growth factor 6 [KO:K04358]
122424243  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
122424302  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
122424328  ITGA9; integrin alpha-9 [KO:K06585]
122424462  [KO:K06243]
122424593  [KO:K06243]
122424748  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
122425059  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
122425446  [KO:K02991]
122425560  [KO:K02991]
122425623  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
122425744  [KO:K02991]
122425783  LAMA1; laminin subunit alpha-1 [KO:K05637]
122425797  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 isoform X1 [KO:K16340] [EC:3.1.3.16]
122425862  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
122426125  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
122426266  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
122426316  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
122426397  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
122426410  FN1; fibronectin isoform X1 [KO:K05717]
122426466  ERBB4; receptor tyrosine-protein kinase ErbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
122426833  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
122426865  IRS1; insulin receptor substrate 1 [KO:K16172]
122427060  ERBB3; receptor tyrosine-protein kinase ErbB-3 [KO:K05084] [EC:2.7.10.1]
122427080  [KO:K06643] [EC:2.3.2.27]
122427124  ITGA5; integrin alpha-5 [KO:K06484]
122427126  KITLG; kit ligand isoform X1 [KO:K05461]
122427135  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
122427141  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
122427209  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
122427215  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
122427252  ITGB7; integrin beta-7 [KO:K06590]
122427513  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
122427662  [KO:K04079]
122427802  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
122427991  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
122428017  EREG; proepiregulin [KO:K09784]
122428025  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
122428068  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
122428200  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
122428214  AREG; amphiregulin [KO:K09782]
122428216  FGF5; fibroblast growth factor 5 [KO:K04358]
122428377  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
122428739  IFNAR1; interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
122428743  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
122429142  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
122429164  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
122429197  [KO:K05439]
122429220  [KO:K05439]
122429221  [KO:K05439]
122429249  [KO:K04354]
122429307  TNXB; tenascin-X isoform X1 [KO:K06252]
122429308  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
122429373  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
122429439  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
122429565  [KO:K05439]
122429567  [KO:K05439]
122429568  [KO:K05439]
122429569  [KO:K05439]
122429627  [KO:K05439]
122429646  [KO:K05439]
122429670  [KO:K05439]
122429675  [KO:K05439]
122429699  [KO:K05439]
122429740  [KO:K05439]
122429741  [KO:K05439]
122429742  [KO:K05439]
122429747  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
122429748  [KO:K05439]
122429749  [KO:K05439]
122429770  [KO:K05439]
122429797  [KO:K05439]
122429800  [KO:K05439]
122429823  [KO:K05439]
122429838  [KO:K05439]
122430591  HRAS; GTPase HRas isoform X1 [KO:K02833]
122430600  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
122430633  RELA; transcription factor p65 isoform X1 [KO:K04735]
122430652  BAD; bcl2-associated agonist of cell death [KO:K02158]
122430666  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
122430796  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
122430962  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
122430978  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
122430981  INS; insulin [KO:K04526]
122431123  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
122431192  FGF3; fibroblast growth factor 3 [KO:K04358]
122431275  FGF19; fibroblast growth factor 19 [KO:K22603]
122431344  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
122431410  FGF4; fibroblast growth factor 4 [KO:K04358]
122431666  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
122431738  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 isoform X1 [KO:K04545]
122431749  TNC; tenascin isoform X1 [KO:K06252]
122431765  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
122431778  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
122431869  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
122431924  TLR4; toll-like receptor 4 [KO:K10160]
122431987  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
122432004  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
122432225  VEGFC; vascular endothelial growth factor C [KO:K05449]
122432228  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
122432467  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
122432473  FGF20; fibroblast growth factor 20 [KO:K04358]
122432485  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
122432503  ANGPT2; angiopoietin-2 [KO:K05466]
122432589  THBS3; thrombospondin-3 [KO:K04659]
122432633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
122432667  EFNA1; ephrin-A1 [KO:K05462]
122432713  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
122432722  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
122432732  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
122432790  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X1 [KO:K04547]
122432797  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
122432849  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
122432986  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
122433033  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122433037  [KO:K02991]
122433054  YWHAG; 14-3-3 protein gamma [KO:K16198]
122433132  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
122433155  CD19; B-lymphocyte antigen CD19 [KO:K06465]
122433215  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
122433265  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
122433316  TSC2; tuberin isoform X1 [KO:K07207]
122433317  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
122433321  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
122433436  EPO; erythropoietin [KO:K05437]
122433693  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
122433890  THBS2; thrombospondin-2 [KO:K04659]
122434014  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
122434060  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
122434129  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
122434130  [KO:K02991]
122434328  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
122434356  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
122434442  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
122434540  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
122434652  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
122434723  [KO:K11583]
122434746  VEGFD; vascular endothelial growth factor D [KO:K05449]
122434847  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
122435152  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
122435210  MTCP1; protein p13 MTCP-1 [KO:K16837]
122435267  [KO:K09487]
122435397  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
122435407  [KO:K16197]
122435408  [KO:K16197]
122435827  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
122435907  FGF16; fibroblast growth factor 16 [KO:K04358]
122435910  [KO:K03456]
122435924  NRAS; GTPase NRas [KO:K07828]
122436569  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
122436698  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
122436723  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
122436761  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
122436768  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
122436836  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
122436869  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
122436917  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
122437038  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
122437089  ARTN; artemin isoform X1 [KO:K25415]
122437161  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
122437214  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
122437292  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
122438094  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
122438100  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
122438102  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
122438189  ITGB8; integrin beta-8 [KO:K06591]
122438196  IL6; interleukin-6 [KO:K05405]
122438212  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
122438250  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
122438258  MAGI2; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
122438288  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
122438308  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
122438320  LAMB1; laminin subunit beta-1 [KO:K05636]
122438321  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
122438342  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
122438446  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
122438688  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
122438693  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
122438889  RHEB; GTP-binding protein Rheb [KO:K07208]
122439269  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
122439278  [KO:K04736]
122439281  IL4; interleukin-4 [KO:K05430]
122439299  EPOR; erythropoietin receptor [KO:K05079]
122439478  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
122439570  [KO:K02991]
122439586  [KO:K02991]
122439621  [KO:K05438]
122439706  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
122439712  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
122439750  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
122439770  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
122439917  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
122439964  EFNA2; ephrin-A2 [KO:K05462]
122439965  ITGB3; integrin beta-3 [KO:K06493]
122440004  [KO:K02991]
122440044  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
122440215  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
122440231  [KO:K04369] [EC:2.7.12.2]
122440234  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
122440279  NRTN; neurturin [KO:K25414]
122440295  PSPN; persephin [KO:K25416]
122440366  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
122440424  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
122440505  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
122440557  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
122440569  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
122440727  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
122440738  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
122440740  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
122440769  [KO:K04659]
122440799  LPAR2; lysophosphatidic acid receptor 2 isoform X1 [KO:K04291]
122440910  [KO:K04369] [EC:2.7.12.2]
122441015  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
122441335  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
122441336  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
122441342  [KO:K04570]
122441530  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
122441591  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
122442084  YWHAQ; 14-3-3 protein theta [KO:K16197]
122442228  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
122442281  LAMC3; laminin subunit gamma-3 isoform X1 [KO:K06247]
122442295  [KO:K05094] [EC:2.7.10.1]
122442300  TSC1; hamartin isoform X1 [KO:K07206]
122442371  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
122442989  F2R; proteinase-activated receptor 1 [KO:K03914]
122443019  THBS4; thrombospondin-4 [KO:K04659]
122443021  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
122443062  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
122443065  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
122443085  ITGA11; integrin alpha-11 [KO:K06587]
122443161  ITGA3; integrin alpha-3 [KO:K06482]
122443177  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
122443199  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
122443359  CHAD; chondroadherin [KO:K06248]
122443364  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
122443464  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
122443483  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
122443592  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
122443630  FGF7; fibroblast growth factor 7 [KO:K04358]
122443734  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
122443865  PGF; placenta growth factor isoform X1 [KO:K16859]
122444653  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
122444818  [KO:K02991]
122444829  [KO:K04374]
122444905  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
122444906  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
122445154  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
122445227  [KO:K16197]
122445271  [KO:K00922] [EC:2.7.1.153]
122445310  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
122445331  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
122445441  COL6A1; collagen alpha-1(VI) chain isoform X1 [KO:K06238]
122445442  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
122445494  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
122445496  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
122445589  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
122445826  TP53; cellular tumor antigen P53 [KO:K04451]
122445860  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
122446045  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
122446047  [KO:K07827]
122446062  [KO:K04369] [EC:2.7.12.2]
122446080  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
122446136  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
122446193  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
122446421  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
122446614  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
122446823  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
122447130  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
122447131  [KO:K02991]
122447261  [KO:K04371] [EC:2.7.11.24]
122447460  FGF9; fibroblast growth factor 9 isoform X1 [KO:K04358]
122447566  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
122447604  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
122447620  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
122447621  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
122447805  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
122447849  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
122447938  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
122447948  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
122448122  LAMA5; laminin subunit alpha-5 [KO:K06240]
122448159  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
122448181  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
122448519  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
122448537  VTN; vitronectin [KO:K06251]
122448557  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
122448567  [KO:K04392]
122448662  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
122448845  BCL2L1; bcl-2-like protein 1 [KO:K04570]
122449331  [KO:K04570]
122449620  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
122449654  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
122450141  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
122450320  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
122450381  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
122450884  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
122450896  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
122450994  [KO:K13304] [EC:2.7.11.1]
122451056  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
122451126  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
122451212  MYC; myc proto-oncogene protein [KO:K04377]
122451349  IL7; interleukin-7 isoform X1 [KO:K05431]
122451361  TLR2; toll-like receptor 2 [KO:K10159]
122451650  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
122451688  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
122452110  LAMC2; laminin subunit gamma-2 [KO:K06246]
122452241  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
122452383  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
122452408  [KO:K04542]
122452409  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
122452448  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122452451  TNR; tenascin-R [KO:K06252]
122452499  TNN; tenascin-N isoform X1 [KO:K06252]
122452508  LAMC1; laminin subunit gamma-1 [KO:K05635]
122452515  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform X1 [KO:K11584]
122452540  LAMB3; laminin subunit beta-3 [KO:K06244]
122452823  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
122452832  RPS6; 40S ribosomal protein S6 [KO:K02991]
122452858  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
122452906  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
122452950  [KO:K05414]
122452998  [KO:K05414]
122452999  [KO:K05414]
122453000  [KO:K05414]
122453001  [KO:K05414]
122453072  [KO:K16197]
122453073  [KO:K16197]
122453084  [KO:K16197]
122453085  [KO:K16197]
122453090  [KO:K05126] [EC:2.7.10.1]
122453141  [KO:K05414]
122453183  FGF2; fibroblast growth factor 2 [KO:K18497]
122453193  [KO:K02991]
122453281  IL2; interleukin-2 [KO:K05429]
122453310  [KO:K05414]
122453350  [KO:K05414]
122453372  [KO:K16197]
122453373  [KO:K16197]
122453394  [KO:K05415]
122453395  [KO:K05415]
122453396  [KO:K05415]
122453397  [KO:K05415]
122453398  [KO:K05415]
122453400  [KO:K05415]
122453527  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
122453548  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
122453606  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
122453611  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
122453709  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
122453895  [KO:K04542]
122453909  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
122453949  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
122454166  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
122454175  [KO:K11583]
122454231  ITGA2; integrin alpha-2 [KO:K06481]
122454276  PRLR; prolactin receptor isoform X1 [KO:K05081]
122454405  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
122454456  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
122454463  [KO:K02991]
122454465  GHR; growth hormone receptor isoform X1 [KO:K05080]
122454504  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
122454541  [KO:K03258]
122454543  FGF10; fibroblast growth factor 10 [KO:K04358]
122454583  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
122454587  FGF18; fibroblast growth factor 18 [KO:K04358]
122454626  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
122454737  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
122454848  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
122455107  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122455113  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
122455223  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
122455282  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
122455309  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
ccad00010  Glycolysis / Gluconeogenesis
ccad04010  MAPK signaling pathway
ccad04012  ErbB signaling pathway
ccad04062  Chemokine signaling pathway
ccad04064  NF-kappa B signaling pathway
ccad04068  FoxO signaling pathway
ccad04110  Cell cycle
ccad04115  p53 signaling pathway
ccad04150  mTOR signaling pathway
ccad04210  Apoptosis
ccad04370  VEGF signaling pathway
ccad04510  Focal adhesion
ccad04620  Toll-like receptor signaling pathway
ccad04630  JAK-STAT signaling pathway
ccad04662  B cell receptor signaling pathway
ccad04910  Insulin signaling pathway
KO pathway
ko04151   

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