KEGG   PATHWAY: cgib04141
Entry
cgib04141                   Pathway                                
Name
Protein processing in endoplasmic reticulum - Carassius gibelio (silver crucian carp)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
cgib04141  Protein processing in endoplasmic reticulum
cgib04141

Other DBs
GO: 0030433 0034976
Organism
Carassius gibelio (silver crucian carp) [GN:cgib]
Gene
127959478  protein transport protein Sec61 subunit alpha-like 2 [KO:K10956]
127959575  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
128015757  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
128015826  protein transport protein Sec61 subunit alpha-like 1 [KO:K10956]
127975127  protein transport protein Sec61 subunit beta [KO:K09481]
128030663  protein transport protein Sec61 subunit beta-like [KO:K09481]
127945888  protein transport protein Sec61 subunit gamma [KO:K07342]
128013147  protein transport protein Sec61 subunit gamma [KO:K07342]
127951626  translocation protein SEC62-like isoform X1 [KO:K12275]
128031607  translocation protein SEC62-like [KO:K12275]
127983902  translocation protein SEC63 homolog [KO:K09540]
127938643  translocation protein SEC63 homolog isoform X1 [KO:K09540]
127968226  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [KO:K12666]
128022584  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1-like [KO:K12666]
127967984  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like isoform X1 [KO:K12667]
128022634  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2-like isoform X1 [KO:K12667]
127937357  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
127950950  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1-like [KO:K12668]
128011772  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 [KO:K12668]
127944903  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
128012130  dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [KO:K12670]
127966264  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [KO:K07151] [EC:2.4.99.18]
127975128  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
127935738  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
128020950  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A-like [KO:K07151] [EC:2.4.99.18]
128030463  dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B-like [KO:K07151] [EC:2.4.99.18]
127970992  magnesium transporter protein 1-like [KO:K19478]
128026888  magnesium transporter protein 1 [KO:K19478]
127948508  tumor suppressor candidate 3 [KO:K19478]
127969259  tumor suppressor candidate 3 [KO:K19478]
127947484  transmembrane protein 258 [KO:K26502]
128014183  transmembrane protein 258 [KO:K26502]
127949248  mannosyl-oligosaccharide glucosidase-like isoform X1 [KO:K01228] [EC:3.2.1.106]
128019106  mannosyl-oligosaccharide glucosidase-like [KO:K01228] [EC:3.2.1.106]
127956163  cytoskeleton-associated protein 4 [KO:K13999]
127942788  ribosome-binding protein 1-like isoform X1 [KO:K14000]
127970010  ribosome-binding protein 1a isoform X1 [KO:K14000]
128026052  ribosome-binding protein 1-like isoform X1 [KO:K14000]
127988400  ribosome-binding protein 1-like [KO:K14000]
127971565  nucleotide exchange factor SIL1-like isoform X1 [KO:K14001]
128027455  nucleotide exchange factor SIL1-like [KO:K14001]
127966559  hypoxia up-regulated protein 1 [KO:K09486]
128021121  hypoxia up-regulated protein 1-like [KO:K09486]
127957214  endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
128014920  endoplasmic reticulum chaperone BiP-like [KO:K09490] [EC:3.6.4.10]
128014921  endoplasmic reticulum chaperone BiP-like [KO:K09490] [EC:3.6.4.10]
127965473  dnaJ homolog subfamily B member 11 [KO:K09517]
128019928  dnaJ homolog subfamily B member 11-like [KO:K09517]
127950405  dnaJ homolog subfamily C member 1-like [KO:K09521]
128028031  dnaJ homolog subfamily C member 1-like [KO:K09521]
127962464  dnaJ homolog subfamily C member 3-like [KO:K09523]
127964575  dnaJ homolog subfamily C member 3-like [KO:K09523]
128017200  dnaJ homolog subfamily C member 3-like isoform X1 [KO:K09523]
128019859  dnaJ homolog subfamily C member 3-like [KO:K09523]
127964357  dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
128020121  dnaJ homolog subfamily C member 10 [KO:K09530] [EC:1.8.4.-]
127956404  endoplasmin [KO:K09487]
127976717  endoplasmin [KO:K09487]
127970950  neutral alpha-glucosidase AB-like isoform X1 [KO:K05546] [EC:3.2.1.207]
127957918  neutral alpha-glucosidase AB isoform X1 [KO:K05546] [EC:3.2.1.207]
128027518  neutral alpha-glucosidase AB-like [KO:K05546] [EC:3.2.1.207]
127952788  glucosidase 2 subunit beta-like [KO:K08288]
127953310  glucosidase 2 subunit beta-like [KO:K08288]
127971595  calnexin-like isoform X1 [KO:K08054]
128026883  si:ch211-274f20.2; calnexin [KO:K08054]
128026931  calnexin-like isoform X1 [KO:K08054]
127979542  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
127946978  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
127975423  protein disulfide isomerase family A, member 7 [KO:K08056] [EC:5.3.4.1]
127935516  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
128014101  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
128030605  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
127942801  calreticulin-like [KO:K08057]
127963928  calreticulin [KO:K08057]
127938184  calreticulin-like [KO:K08057]
127950947  calreticulin-like [KO:K08057]
127987294  calreticulin-like [KO:K08057]
128018834  calreticulin-like [KO:K08057]
127983482  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
127964879  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB-like [KO:K01230] [EC:3.2.1.113]
127975424  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA isoform X1 [KO:K01230] [EC:3.2.1.113]
127938301  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like [KO:K01230] [EC:3.2.1.113]
128019693  mannosyl-oligosaccharide 1,2-alpha-mannosidase IB-like [KO:K01230] [EC:3.2.1.113]
128030323  mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like isoform X1 [KO:K01230] [EC:3.2.1.113]
127942375  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like isoform X1 [KO:K23741] [EC:3.2.1.209]
127957672  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
127986268  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
128009014  endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase-like [KO:K23741] [EC:3.2.1.209]
127971335  vesicular integral-membrane protein VIP36-like isoform X1 [KO:K10082]
128027325  vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
127941456  protein ERGIC-53-like [KO:K10080]
127986477  protein ERGIC-53-like [KO:K10080]
127975365  prolactin regulatory element-binding protein-like isoform X1 [KO:K14003]
128031120  prolactin regulatory element-binding protein [KO:K14003]
127970529  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
127968770  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
127941437  GTP-binding protein SAR1b [KO:K07953] [EC:3.6.5.-]
127985996  GTP-binding protein SAR1b-like [KO:K07953] [EC:3.6.5.-]
128026137  GTP-binding protein SAR1b-like isoform X1 [KO:K07953] [EC:3.6.5.-]
127942618  protein SEC13 homolog [KO:K14004]
127988433  protein SEC13 homolog [KO:K14004]
127966306  protein transport protein Sec31A-like isoform X1 [KO:K14005]
127968883  protein transport protein Sec31A isoform X1 [KO:K14005]
128021445  protein transport protein Sec31A-like isoform X1 [KO:K14005]
127933399  protein transport protein Sec23A-like isoform X1 [KO:K14006]
127976265  protein transport protein Sec23A [KO:K14006]
127959841  protein transport protein Sec23B [KO:K14006]
128015337  protein transport protein Sec23A [KO:K14006]
127962191  protein transport protein Sec24D [KO:K14007]
127971535  protein transport protein Sec24B isoform X1 [KO:K14007]
127957092  protein transport protein Sec24C-like [KO:K14007]
127968920  protein transport protein Sec24C isoform X1 [KO:K14007]
127941417  protein transport protein Sec24A [KO:K14007]
128016462  protein transport protein Sec24D-like isoform X1 [KO:K14007]
128025450  protein transport protein Sec24C-like [KO:K14007]
128027713  protein transport protein Sec24B-like isoform X1 [KO:K14007]
127951061  UDP-glucose:glycoprotein glucosyltransferase 1-like isoform X1 [KO:K11718] [EC:2.4.1.-]
127964571  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1 [KO:K11718] [EC:2.4.1.-]
127934017  UDP-glucose:glycoprotein glucosyltransferase 1-like isoform X1 [KO:K11718] [EC:2.4.1.-]
127959722  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
128015833  ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
127944465  ER degradation-enhancing alpha-mannosidase-like protein 2 isoform X1 [KO:K10085]
128012052  ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
127941963  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
127963887  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
127985478  ER degradation-enhancing alpha-mannosidase-like protein 3 [KO:K10086]
128018777  ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X1 [KO:K10086]
127959334  protein disulfide-isomerase isoform X1 [KO:K09580] [EC:5.3.4.1]
127946553  protein disulfide-isomerase A4-like [KO:K09582] [EC:5.3.4.1]
128013358  protein disulfide-isomerase A4 [KO:K09582] [EC:5.3.4.1]
127983445  protein disulfide-isomerase A6 [KO:K09584] [EC:5.3.4.1]
127938469  protein disulfide-isomerase A6-like [KO:K09584] [EC:5.3.4.1]
127946071  thioredoxin domain-containing protein 5-like isoform X1 [KO:K13984] [EC:5.3.4.1]
128013497  thioredoxin domain-containing protein 5-like [KO:K13984] [EC:5.3.4.1]
127976028  ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
128031739  ERO1-like protein alpha [KO:K10950] [EC:1.8.4.-]
127968464  ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
127960109  protein OS-9-like isoform X1 [KO:K10088]
128015728  protein OS-9-like isoform X1 [KO:K10088]
127970544  endoplasmic reticulum lectin 1 isoform X1 [KO:K14008]
127946004  translocon-associated protein subunit alpha-like isoform X1 [KO:K13249]
128012986  translocon-associated protein subunit alpha-like isoform X1 [KO:K13249]
127978901  translocon-associated protein subunit beta isoform X1 [KO:K13250]
127935524  translocon-associated protein subunit beta-like [KO:K13250]
127934161  translocon-associated protein subunit gamma [KO:K13251]
127976945  translocon-associated protein subunit gamma [KO:K13251]
127944468  translocon-associated protein subunit delta-like [KO:K04571]
128011594  translocon-associated protein subunit delta-like [KO:K04571]
127963644  B-cell receptor-associated protein 31-like [KO:K14009]
128018945  B-cell receptor-associated protein 31-like [KO:K14009]
127944705  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
127946489  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
128013432  translocating chain-associated membrane protein 1-like 1 [KO:K14010]
128011178  zgc:113278; translocating chain-associated membrane protein 1-like 1-like [KO:K14010]
127975387  derlin-1 [KO:K11519]
128030673  derlin-1-like [KO:K11519]
127962895  derlin-2-like [KO:K13989]
127958642  derlin-2 [KO:K13989]
127995381  derlin-2-like [KO:K13989]
128018524  derlin-2-like isoform X1 [KO:K13989]
127970952  UBX domain-containing protein 1-like [KO:K24348]
127964916  UBX domain-containing protein 4-like [KO:K24348]
128027516  UBX domain-containing protein 1 isoform X1 [KO:K24348]
128020048  UBX domain-containing protein 4-like [KO:K24348]
127983581  UBX domain-containing protein 2A isoform X1 [KO:K24349]
127938079  UBX domain-containing protein 2A-like isoform X1 [KO:K24349]
127942436  UBX domain-containing protein 6 [KO:K14011]
127987447  UBX domain-containing protein 6-like [KO:K14011]
127988215  UBX domain-containing protein 6-like [KO:K14011]
127965963  UBX domain-containing protein 8 [KO:K24351]
127944537  NSFL1 cofactor p47-like [KO:K14012]
128011588  NSFL1 cofactor p47 [KO:K14012]
127947202  small VCP/p97-interacting protein-like [KO:K14014]
128014427  small VCP/p97-interacting protein-like [KO:K14014]
127958110  transitional endoplasmic reticulum ATPase [KO:K13525]
128001851  transitional endoplasmic reticulum ATPase-like [KO:K13525]
128017828  zgc:136908; transitional endoplasmic reticulum ATPase [KO:K13525]
127968925  nuclear protein localization protein 4 homolog [KO:K14015]
128019001  ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
127952357  heat shock 70 kDa protein-like [KO:K03283]
127952381  heat shock 70 kDa protein-like [KO:K03283]
127952382  heat shock 70 kDa protein-like [KO:K03283]
127963744  LOW QUALITY PROTEIN: heat shock 70 kDa protein-like [KO:K03283]
127972703  heat shock cognate 71 kDa protein [KO:K03283]
127966680  heat shock cognate 71 kDa protein [KO:K03283]
127947330  heat shock 70 kDa protein-like [KO:K03283]
127948379  heat shock 70 kDa protein-like [KO:K03283]
127948387  heat shock 70 kDa protein [KO:K03283]
128021116  heat shock cognate 71 kDa protein-like [KO:K03283]
128018651  heat shock 70 kDa protein 1-like [KO:K03283]
127949359  dnaJ homolog subfamily A member 1-like [KO:K09502]
128019076  dnaJ homolog subfamily A member 1-like [KO:K09502]
127933878  dnaJ homolog subfamily A member 2-like [KO:K09503]
127977250  dnaJ homolog subfamily A member 2-like [KO:K09503]
127961515  dnaJ homolog subfamily A member 2-like [KO:K09503]
128016738  dnaJ homolog subfamily A member 2 [KO:K09503]
127952866  dnaJ homolog subfamily B member 1-like [KO:K09507]
127953697  dnaJ homolog subfamily B member 1-like [KO:K09507]
127949513  dnaJ homolog subfamily B member 1-like [KO:K09507]
128017813  dnaJ homolog subfamily B member 1-like [KO:K09507]
127965175  dnaJ homolog subfamily B member 2 isoform X1 [KO:K09508]
128021604  dnaJ homolog subfamily B member 6-like isoform X1 [KO:K09508]
128019627  dnaJ homolog subfamily B member 6-like isoform X1 [KO:K09508]
127970757  dnaJ homolog subfamily B member 12a [KO:K09518]
127969244  dnaJ homolog subfamily B member 12-like [KO:K09518]
128025566  dnaJ homolog subfamily B member 12-like [KO:K09518]
128026139  dnaJ homolog subfamily B member 12-like [KO:K09518]
127963528  dnaJ (Hsp40) homolog, subfamily C, member 5aa [KO:K09525]
127984105  dnaJ (Hsp40) homolog, subfamily C, member 5 gamma a isoform X1 [KO:K09525]
127944422  dnaJ homolog subfamily C member 5-like [KO:K09525]
127946481  dnaJ homolog subfamily C member 5-like [KO:K09525]
127976449  dnaJ homolog subfamily C member 5-like [KO:K09525]
127938156  dnaJ homolog subfamily C member 5-like isoform X1 [KO:K09525]
128013423  dnaJ homolog subfamily C member 5-like [KO:K09525]
128031807  dnaJ (Hsp40) homolog, subfamily C, member 5 gamma b isoform X1 [KO:K09525]
128018697  dnaJ homolog subfamily C member 5-like [KO:K09525]
128011329  dnaJ homolog subfamily C member 5-like [KO:K09525]
127984001  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
127984070  heat shock protein HSP 90-beta [KO:K04079]
127938112  heat shock protein HSP 90-alpha [KO:K04079]
127938113  heat shock protein HSP 90-alpha 1 [KO:K04079]
127938157  heat shock protein HSP 90-beta-like [KO:K04079]
127975783  heat shock 70 kDa protein 4L-like isoform X1 [KO:K09485]
128031686  heat shock 70 kDa protein 4L-like isoform X1 [KO:K09485]
128028928  heat shock protein 105 kDa isoform X1 [KO:K09485]
127951519  BAG family molecular chaperone regulator 1-like [KO:K09555]
128030069  BAG family molecular chaperone regulator 1-like isoform X1 [KO:K09555]
127969700  BAG family molecular chaperone regulator 2 [KO:K09556]
127954312  hsp70-binding protein 1 [KO:K09562]
127949665  alpha-crystallin A chain [KO:K09541]
128015399  alpha-crystallin A chain-like [KO:K09541]
127973125  crystallin, alpha B, a [KO:K09542]
127958603  crystallin, alpha B, b [KO:K09542]
127994887  alpha-crystallin B chain-like [KO:K09542]
128029500  alpha-crystallin B chain-like [KO:K09542]
127968641  ubiquitin thioesterase OTU1-like isoform X1 [KO:K13719] [EC:3.1.2.-]
128022103  ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
127961768  phospholipase A-2-activating protein [KO:K14018]
128016629  phospholipase A-2-activating protein-like [KO:K14018]
127942077  UV excision repair protein RAD23 homolog B-like [KO:K10839]
127942802  UV excision repair protein RAD23 homolog B-like [KO:K10839]
127949040  RAD23 homolog A, nucleotide excision repair protein a [KO:K10839]
127986305  UV excision repair protein RAD23 homolog B-like [KO:K10839]
127987295  UV excision repair protein RAD23 homolog B-like [KO:K10839]
128020703  UV excision repair protein RAD23 homolog A-like [KO:K10839]
127974801  ubiquilin-4-like [KO:K04523]
128030360  ubiquilin-4-like [KO:K04523]
127935160  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase isoform X1 [KO:K01456] [EC:3.5.1.52]
127978573  peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase-like isoform X1 [KO:K01456] [EC:3.5.1.52]
127933220  ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
127975817  ataxin-3-like [KO:K11863] [EC:3.4.22.-]
127944622  ubiquitin conjugation factor E4 B-like isoform X1 [KO:K10597] [EC:2.3.2.27]
128011558  ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
127970650  eukaryotic translation initiation factor 2-alpha kinase 3-like [KO:K08860] [EC:2.7.11.1]
128026357  eukaryotic translation initiation factor 2-alpha kinase 3-like isoform X1 [KO:K08860] [EC:2.7.11.1]
127984073  eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
127933619  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
127938044  eukaryotic translation initiation factor 2 subunit 1-like [KO:K03237]
127976622  eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
127964717  nuclear factor erythroid 2-related factor 2-like [KO:K05638]
128019576  nuclear factor erythroid 2-related factor 2-like isoform X1 [KO:K05638]
127953568  activating transcription factor 4b [KO:K04374]
127946235  cyclic AMP-dependent transcription factor ATF-4-like [KO:K04374]
127959420  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
128015302  cyclic AMP-dependent transcription factor ATF-4-like isoform X1 [KO:K04374]
127959764  DNA damage-inducible transcript 3 protein-like [KO:K04452]
128016068  DNA damage-inducible transcript 3 protein-like [KO:K04452]
127946353  apoptosis regulator Bcl-2-like [KO:K02161]
127950859  apoptosis regulator Bcl-2-like isoform X1 [KO:K02161]
128025189  apoptosis regulator Bcl-2 [KO:K02161]
128013154  apoptosis regulator Bcl-2-like [KO:K02161]
127984135  cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
127938488  cyclic AMP-dependent transcription factor ATF-6 alpha-like [KO:K09054]
127979193  cyclic AMP-dependent transcription factor ATF-6 beta-like isoform X1 [KO:K09049]
127934886  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
127971019  wolframin [KO:K14020]
127948682  wolframin [KO:K14020]
127934276  membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
127977671  membrane-bound transcription factor site-1 protease-like [KO:K08653] [EC:3.4.21.112]
127946591  membrane-bound transcription factor site-2 protease-like [KO:K07765] [EC:3.4.24.85]
128013506  membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
128013555  LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
127944307  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
127953343  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
127948907  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
127984931  serine/threonine-protein kinase/endoribonuclease IRE1-like [KO:K08852] [EC:2.7.11.1 3.1.26.-]
127957102  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
127957622  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
127957860  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
127958691  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
127958692  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
128014856  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
127989236  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
128009188  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
127974831  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
127938309  mitogen-activated protein kinase kinase kinase 5-like isoform X1 [KO:K04426] [EC:2.7.11.25]
127984350  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
128030501  mitogen-activated protein kinase kinase kinase 5-like [KO:K04426] [EC:2.7.11.25]
127949730  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
128018826  dual specificity mitogen-activated protein kinase kinase 7-like isoform X1 [KO:K04431] [EC:2.7.12.2]
127941650  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127941964  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
127969169  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127970144  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
127985904  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
127986165  mitogen-activated protein kinase 10-like isoform X1 [KO:K04440] [EC:2.7.11.24]
128025723  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
128026122  mitogen-activated protein kinase 8B isoform X1 [KO:K04440] [EC:2.7.11.24]
127951570  apoptosis regulator BAX-like [KO:K02159]
127962465  apoptosis regulator BAX-like [KO:K02159]
127952265  apoptosis regulator BAX-like isoform X1 [KO:K02159]
128016539  apoptosis regulator BAX-like [KO:K02159]
127942705  calpain-1 catalytic subunit b [KO:K01367] [EC:3.4.22.52]
127976007  si:ch211-202f3.3; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
127961292  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
127969903  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
128031603  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
127986600  si:dkeyp-50d11.2; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
128025939  calpain-1 catalytic subunit-like [KO:K01367] [EC:3.4.22.52]
127988335  uncharacterized protein LOC127988335 [KO:K01367] [EC:3.4.22.52]
128017418  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
127970457  calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
127942702  calpain 2, (m/II) large subunit b [KO:K03853] [EC:3.4.22.53]
127943373  calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
127943374  calpain-8 [KO:K03853] [EC:3.4.22.53]
127956591  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
128025938  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
127988414  calpain-2 catalytic subunit-like isoform X1 [KO:K03853] [EC:3.4.22.53]
127988415  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
127988417  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
127950745  E3 ubiquitin-protein ligase MARCHF6 isoform X1 [KO:K10661] [EC:2.3.2.27]
128029934  E3 ubiquitin-protein ligase MARCHF6-like [KO:K10661] [EC:2.3.2.27]
127938321  ubiquitin-conjugating enzyme E2 J1-like isoform X1 [KO:K10578] [EC:2.3.2.23]
127984370  ubiquitin-conjugating enzyme E2 J1-like isoform X1 [KO:K10578] [EC:2.3.2.23]
127944985  ubiquitin-conjugating enzyme E2 J2 isoform X1 [KO:K04554] [EC:2.3.2.23]
128012002  ubiquitin-conjugating enzyme E2 J2-like [KO:K04554] [EC:2.3.2.23]
127941773  ubiquitin-conjugating enzyme E2 G1-like [KO:K10575] [EC:2.3.2.23]
127958507  ubiquitin-conjugating enzyme E2 G1a isoform X1 [KO:K10575] [EC:2.3.2.23]
127986156  ubiquitin-conjugating enzyme E2G 1b [KO:K10575] [EC:2.3.2.23]
128007853  ubiquitin-conjugating enzyme E2 G1-like isoform X1 [KO:K10575] [EC:2.3.2.23]
127959968  ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
128016142  ubiquitin-conjugating enzyme E2 G2-like [KO:K04555] [EC:2.3.2.23]
127971334  E3 ubiquitin-protein ligase synoviolin-like [KO:K10601] [EC:2.3.2.27]
128027322  E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
127979043  E3 ubiquitin-protein ligase RNF5-like [KO:K10666] [EC:2.3.2.27]
127935291  E3 ubiquitin-protein ligase RNF5-like [KO:K10666] [EC:2.3.2.27]
127958652  E3 ubiquitin-protein ligase RNF185 isoform X1 [KO:K10666] [EC:2.3.2.27]
127962013  selenoprotein S-like isoform X1 [KO:K14025]
128017394  selenoprotein S-like isoform X1 [KO:K14025]
127984206  protein sel-1 homolog 1-like [KO:K14026]
127938650  protein sel-1 homolog 1-like isoform X1 [KO:K14026]
127934579  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
127977615  homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein [KO:K14027]
127947128  E3 ubiquitin-protein ligase AMFR-like [KO:K10636] [EC:2.3.2.36]
128014355  autocrine motility factor receptor a isoform X1 [KO:K10636] [EC:2.3.2.36]
127945851  E3 ubiquitin-protein ligase CHIP-like [KO:K09561] [EC:2.3.2.27]
128013552  E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
127970908  ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast), like isoform X1 [KO:K06689] [EC:2.3.2.23]
127963856  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
127976513  ubiquitin-conjugating enzyme E2 D1a isoform X1 [KO:K06689] [EC:2.3.2.23]
127969002  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
127969743  ubiquitin-conjugating enzyme E2 D3 isoform X1 [KO:K06689] [EC:2.3.2.23]
128031674  ubiquitin-conjugating enzyme E2 D4-like [KO:K06689] [EC:2.3.2.23]
128025015  ubiquitin-conjugating enzyme E2 D1b [KO:K06689] [EC:2.3.2.23]
128026327  ubiquitin-conjugating enzyme E2 D2-like isoform X1 [KO:K06689] [EC:2.3.2.23]
128018303  ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
128027658  ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
127969883  E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
127953577  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
127945830  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
127951171  cullin-1-like [KO:K03347]
127946209  cullin-1-like [KO:K03347]
127936157  cullin-1 [KO:K03347]
128013172  cullin-1b [KO:K03347]
127941481  S-phase kinase-associated protein 1 [KO:K03094]
127985703  S-phase kinase-associated protein 1 [KO:K03094]
127967859  F-box only protein 2-like isoform X1 [KO:K10099]
128022077  F-box only protein 2 [KO:K10099]
127944574  F-box only protein 44-like [KO:K10100]
Compound
C00076  Calcium cation
G00009   
G00010   
G00011   
G00012   
G10694   
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
cgib00510  N-Glycan biosynthesis
cgib03050  Proteasome
cgib03060  Protein export
cgib04210  Apoptosis
KO pathway
ko04141   
LinkDB

DBGET integrated database retrieval system