Entry Name Axon guidance - Callithrix jacchus (white-tufted-ear marmoset)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Callithrix jacchus (white-tufted-ear marmoset) [GN:
cjc ]
Gene 100411136 TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
100387575 TRPC3; short transient receptor potential channel 3 isoform X3 [KO:K04966 ]
100408892 TRPC4; short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
100384971 TRPC5; LOW QUALITY PROTEIN: short transient receptor potential channel 5 [KO:K04968 ]
100387059 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4 [KO:K04348 ] [EC:3.1.3.16 ]
100386452 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X5 [KO:K04348 ] [EC:3.1.3.16 ]
100414856 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
100406801 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333 ]
100385008 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
100404109 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
100895294 LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392 ]
100400756 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
100404291 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
100402498 LOW QUALITY PROTEIN: myosin regulatory light chain 2, smooth muscle major isoform [KO:K12755 ]
100411450 ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532 ]
100400661 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2 [KO:K24609 ]
100404474 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
100405745 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630 ]
100388113 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
100406661 SRGAP3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X4 [KO:K07526 ]
100415197 SRGAP2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526 ]
100398023 SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
100402877 RHOD; rho-related GTP-binding protein RhoD isoform X3 [KO:K07530 ]
100386950 DPYSL5; dihydropyrimidinase-related protein 5 isoform X1 [KO:K07529 ]
100391260 DPYSL2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528 ]
100397956 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9 [KO:K04515 ] [EC:2.7.11.17 ]
100405903 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
100390938 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
100410352 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4 [KO:K04515 ] [EC:2.7.11.17 ]
100403494 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100391655 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
100398849 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100406689 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100392639 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
100414659 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649 ]
100388182 PARD6B; partitioning defective 6 homolog beta isoform X1 [KO:K06093 ]
100391194 PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related cjc04060 Cytokine-cytokine receptor interaction
cjc04810 Regulation of actin cytoskeleton
KO pathway LinkDB All DBs
