KEGG   PATHWAY: csyr05208
Entry
csyr05208                   Pathway                                
Name
Chemical carcinogenesis - reactive oxygen species - Carlito syrichta (Philippine tarsier)
Description
It is well established that cancer is a multi-step process which involves initiation, promotion and progression. Chemical carcinogens can alter any of these processes to induce their carcinogenic effects. In the majority of instances, chemical carcinogens, directly or after xenobiotic metabolism, induce DNA damage and act in a 'genotoxic' manner. There is, however, a group of carcinogens that induce cancer via nongenotoxic mechanisms. The biochemical modes of action for nongenotoxic carcinogens are diverse, one example of which is induction of oxidative stress. Trace metals and organic xenobiotics are typical classes of environmental pollutants with prooxidant effects. Trace metals generate reactive oxygen species (ROS) depending on their ability to lose electrons and catalyze Haber Weiss and Fenton reactions. ROS are also generated due to induction of various cytochrome P450 isoenzymes during detoxification of chemical carcinogens. Increased ROS generation often has been linked to DNA damage that can lead to mutations and may, therefore, play an important role in the initiation and progression of multistage carcinogenesis. Besides causing DNA damage, ROS further induce multiple intracellular signaling pathways, notably NF-kappa B, JNK/SAPK/p38, as well as Erk/MAPK. These signaling routes can lead to transcriptional induction of target genes that could promote proliferation or confer apoptosis resistance to exposed cells.
Class
Human Diseases; Cancer: overview
Pathway map
csyr05208  Chemical carcinogenesis - reactive oxygen species
csyr05208

Organism
Carlito syrichta (Philippine tarsier) [GN:csyr]
Gene
103259883  MGST2; microsomal glutathione S-transferase 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
103260052  glutathione S-transferase A3 isoform X1 [KO:K00799] [EC:2.5.1.18]
103260053  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
103260054  glutathione S-transferase A1-like [KO:K00799] [EC:2.5.1.18]
103260055  glutathione S-transferase A2-like [KO:K00799] [EC:2.5.1.18]
103260057  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
103260058  glutathione S-transferase A4 isoform X1 [KO:K00799] [EC:2.5.1.18]
103260062  glutathione S-transferase A3-like [KO:K00799] [EC:2.5.1.18]
103260063  glutathione S-transferase alpha-4-like [KO:K00799] [EC:2.5.1.18]
103269077  glutathione S-transferase Mu 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
103269078  GSTM3; glutathione S-transferase Mu 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
103260836  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
103271334  glutathione S-transferase theta-2B-like isoform X1 [KO:K00799] [EC:2.5.1.18]
103271335  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
103263407  GSTO2; glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
103263410  GSTO1; glutathione S-transferase omega-1 isoform X2 [KO:K00799] [EC:2.5.1.18]
103263427  glutathione S-transferase Mu 1 isoform X1 [KO:K00799] [EC:2.5.1.18]
103263433  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
103255107  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
103273648  MGST3; microsomal glutathione S-transferase 3 isoform X1 [KO:K00799] [EC:2.5.1.18]
103269085  glutathione S-transferase Mu 2 isoform X1 [KO:K00799] [EC:2.5.1.18]
103269084  glutathione S-transferase Mu 2-like [KO:K00799] [EC:2.5.1.18]
103271348  LOW QUALITY PROTEIN: glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
103277301  glutathione S-transferase theta-4 [KO:K00799] [EC:2.5.1.18]
7944474  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
7944462  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
7944463  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
7944470  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
7944467  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
7944472  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
7944471  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
103251659  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
103258337  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
103272691  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
110596544  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
103276211  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
103265401  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
103277104  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X3 [KO:K03946]
103276463  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
103249583  NDUFA4; cytochrome c oxidase subunit NDUFA4 isoform X1 [KO:K03948]
103256865  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
103250410  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
103262643  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X2 [KO:K03949]
103253105  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
103259404  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
103276353  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
103264348  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
103266338  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
103259129  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
103275551  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
103271430  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
103257860  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
103266003  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
103256260  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
103262897  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
110594486  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
103271180  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
103273362  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
103256427  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
103262863  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
103263506  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
103261895  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
103261731  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
103250117  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
103252786  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
103262943  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
103260252  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
103253931  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
103258126  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
103266780  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
103267568  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
103252583  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
103250207  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
103271841  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial-like [KO:K03941] [EC:7.1.1.2]
103252346  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
103271254  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
103275417  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
103257385  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial isoform X1 [KO:K00235] [EC:1.3.5.1]
103251186  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
103260260  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
103268018  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
103254098  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
103265462  cytochrome b-c1 complex subunit Rieske, mitochondrial isoform X1 [KO:K00411] [EC:7.1.1.8]
7944473  CYTB; cytochrome b [KO:K00412]
103272505  cytochrome c1, heme protein, mitochondrial [KO:K00413]
103270632  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
103260331  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
103249224  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
103258555  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
103267371  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit 7-like [KO:K00417]
103259262  cytochrome b-c1 complex subunit 8 [KO:K00418]
103271686  cytochrome b-c1 complex subunit 9 [KO:K00419]
103251009  cytochrome b-c1 complex subunit 10 [KO:K00420]
7944464  COX3; cytochrome c oxidase subunit III [KO:K02262]
7944468  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
7944469  COX2; cytochrome c oxidase subunit II [KO:K02261]
103252018  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
103266174  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
103270898  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
103266568  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
103251688  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
103251157  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
110595358  cytochrome c oxidase subunit 6B1-like [KO:K02267]
103263084  cytochrome c oxidase subunit 6B1-like [KO:K02267]
103273566  COX6B; cytochrome c oxidase subunit 6B1-like [KO:K02267]
110596473  cytochrome c oxidase subunit 6B1-like [KO:K02267]
110596696  cytochrome c oxidase subunit 6B1-like [KO:K02267]
110594497  cytochrome c oxidase subunit 6B1-like [KO:K02267]
110595091  cytochrome c oxidase subunit 6C-like [KO:K02268]
110596061  cytochrome c oxidase subunit 6C-like [KO:K02268]
110596332  cytochrome c oxidase subunit 6C-like [KO:K02268]
110596375  cytochrome c oxidase subunit 6C-like [KO:K02268]
110596503  cytochrome c oxidase subunit 6C-like [KO:K02268]
110596727  cytochrome c oxidase subunit 6C-like [KO:K02268]
103268110  cytochrome c oxidase subunit 6C-like [KO:K02268]
103273442  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
103276236  COX7AH; cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
103276500  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
103274382  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
103267420  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
110594887  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
103267388  ATP5A1; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
103251114  ATP synthase subunit beta, mitochondrial-like isoform X1 [KO:K02133] [EC:7.1.2.2]
103275145  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
103276345  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
103270009  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
110594963  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
110596205  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
110596280  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
110594496  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
7944466  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
103271456  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
103251673  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
103253408  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
103264736  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
103275931  ATP5H; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
103275990  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
103276196  ATP synthase subunit O, mitochondrial-like [KO:K02137]
103267552  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
7944465  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
103276928  SOD2; superoxide dismutase [Mn], mitochondrial isoform X1 [KO:K04564] [EC:1.15.1.1]
103268316  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X2 [KO:K05862]
103263904  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X2 [KO:K15040]
103257263  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
103252175  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
103268812  ADP/ATP translocase 4 [KO:K05863]
103276203  SLC25A5; LOW QUALITY PROTEIN: ADP/ATP translocase 2 [KO:K05863]
103254788  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
103258177  LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase F, mitochondrial-like [KO:K09565] [EC:5.2.1.8]
103250291  SOD1; superoxide dismutase [Cu-Zn] isoform X2 [KO:K04565] [EC:1.15.1.1]
103258675  CAT; catalase isoform X2 [KO:K03781] [EC:1.11.1.6]
103257332  sulfate anion transporter 1-like [KO:K14700]
103263372  SLC26A2; sulfate transporter [KO:K14701]
103270629  SLC26A6; solute carrier family 26 member 6 [KO:K14704]
103266394  SLC26A9; solute carrier family 26 member 9 [KO:K14706]
103271647  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
103265545  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
103259623  cytochrome P450 2F5 [KO:K07416] [EC:1.14.14.1]
103271646  cytochrome P450 1A1 isoform X1 [KO:K07408] [EC:1.14.14.1]
103271895  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
103269955  EPHX1; epoxide hydrolase 1 [KO:K01253] [EC:3.3.2.9]
103250514  EPHX2; bifunctional epoxide hydrolase 2 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
103260731  EPHX3; epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
103270752  EPHX4; epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
103271363  AKR1A1; alcohol dehydrogenase [NADP(+)] [KO:K00002] [EC:1.1.1.2]
103261880  prostaglandin F synthase 1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103261879  prostaglandin F synthase 1-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103261882  putative aldo-keto reductase family 1 member C8 [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103261883  aldo-keto reductase family 1 member C3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103263300  aldo-keto reductase family 1 member C23-like protein [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103263298  aldo-keto reductase family 1 member C3-like [KO:K04119] [EC:1.1.1.51 1.1.1.188 1.1.1.213 1.1.1.357]
103272538  NQO1; NAD(P)H dehydrogenase [quinone] 1 isoform X1 [KO:K00355] [EC:1.6.5.2]
103260442  carbonyl reductase [NADPH] 1 isoform X1 [KO:K00079] [EC:1.1.1.184 1.1.1.189 1.1.1.197]
103272879  AHR; aryl hydrocarbon receptor [KO:K09093]
103266721  LPO; lactoperoxidase isoform X1 [KO:K12550] [EC:1.11.1.7]
103253446  NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
103277354  cytochrome b-245 light chain [KO:K08009]
103266034  NOX1; NADPH oxidase 1 isoform X1 [KO:K08008]
103270043  NCF1; LOW QUALITY PROTEIN: neutrophil cytosol factor 1 [KO:K08011]
103276970  NCF2; neutrophil cytosol factor 2 [KO:K08010]
103267942  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
103268107  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103249922  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
103268739  MET; hepatocyte growth factor receptor isoform X2 [KO:K05099] [EC:2.7.10.1]
103275922  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103270607  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
103276422  SOS2; son of sevenless homolog 2 isoform X2 [KO:K03099]
103250130  HRAS; GTPase HRas isoform X1 [KO:K02833]
103263630  KRAS; GTPase KRas isoform X2 [KO:K07827]
103259236  NRAS; GTPase NRas [KO:K07828]
103270865  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
103271179  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
103263745  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
103277453  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103251709  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103265435  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
103274188  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103256327  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
103274589  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
103251143  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
103252280  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
103272968  MAPK8; mitogen-activated protein kinase 8 isoform X5 [KO:K04440] [EC:2.7.11.24]
103255312  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
103249454  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103249455  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103263392  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103263391  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
103274529  JUN; transcription factor AP-1 [KO:K04448]
103266527  FOS; proto-oncogene c-Fos [KO:K04379]
103262537  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
103272136  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
103251553  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
103266233  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103276054  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
103264336  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103273938  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
103265584  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
103257728  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103254239  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103263958  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
103265323  FOXO3; forkhead box protein O3 [KO:K09408]
103262955  PTPN1; tyrosine-protein phosphatase non-receptor type 1 isoform X1 [KO:K05696] [EC:3.1.3.48]
103274296  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
103263189  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103256847  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
103255498  IKBKG; NF-kappa-B essential modulator [KO:K07210]
103273993  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103252103  RELA; transcription factor p65 [KO:K04735]
103274648  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103268097  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
103252480  PTPRJ; receptor-type tyrosine-protein phosphatase eta [KO:K05698] [EC:3.1.3.48]
103251228  ACP1; low molecular weight phosphotyrosine protein phosphatase [KO:K14394] [EC:3.1.3.2 3.1.3.48]
103253614  LOW QUALITY PROTEIN: low molecular weight phosphotyrosine protein phosphatase-like [KO:K14394] [EC:3.1.3.2 3.1.3.48]
103253724  LOW QUALITY PROTEIN: low molecular weight phosphotyrosine protein phosphatase-like [KO:K14394] [EC:3.1.3.2 3.1.3.48]
103268179  LOW QUALITY PROTEIN: low molecular weight phosphotyrosine protein phosphatase-like [KO:K14394] [EC:3.1.3.2 3.1.3.48]
103276181  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
103273857  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103258968  ABL1; tyrosine-protein kinase ABL1 [KO:K06619] [EC:2.7.10.2]
103267546  ABL2; Abelson tyrosine-protein kinase 2 isoform X1 [KO:K08887] [EC:2.7.10.2]
103261048  PRKD3; serine/threonine-protein kinase D3 [KO:K06070] [EC:2.7.11.13]
103271434  PRKD2; serine/threonine-protein kinase D2 [KO:K06070] [EC:2.7.11.13]
103267886  PRKD1; serine/threonine-protein kinase D1 isoform X1 [KO:K06070] [EC:2.7.11.13]
103249709  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103263213  PLD1; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
103276554  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
103262848  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
103272922  HIF1A; hypoxia-inducible factor 1-alpha isoform X2 [KO:K08268]
103251386  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
103262949  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
103252292  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
103263178  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
103251005  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
Compound
C00001  H2O
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00007  Oxygen
C00019  S-Adenosyl-L-methionine
C00021  S-Adenosyl-L-homocysteine
C00023  Iron
C00027  Hydrogen peroxide
C00051  Glutathione
C00070  Copper
C00084  Acetaldehyde
C00127  Glutathione disulfide
C00146  Phenol
C00291  Nickel
C00469  Ethanol
C00472  p-Benzoquinone
C00530  Hydroquinone
C00704  Superoxide
C00951  Estradiol-17beta
C01407  Benzene
C01413  Cadmium
C01782  Benzene oxide
C02389  p-Benzosemiquinone
C02575  Pentachlorophenol
C02814  Benzene-1,2,4-triol
C03434  Tetrachlorohydroquinone
C03622  N-Hydroxy-4-aminobiphenyl
C04623  DDT
C05301  2-Hydroxyestradiol
C05309  Semiquinone
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06268  Chromium
C06269  Arsenic
C06696  Lead
C07294  Methylarsonate
C07295  Methanearsonous acid
C07308  Cacodylate
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C10998  4-Aminobiphenyl
C14209  4-Hydroxy-17beta-estradiol
C14850  Benzo[a]pyrene-7,8-oxide
C14852  Benzo[a]pyrene-7,8-dihydrodiol
C16038  2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
C16844  Hydroxyl radical
C18205  2,2',4,4'-Tetrabromodiphenyl ether
C18933  Chloranil
C19171  Cobalt
C20300  Dimethylarsinous acid
C20316  4-Nitrosobiphenyl
C20319  Hydronitroxide radical
C22355  Benzo[a]pyrene-7,8-diol
C22356  Benzo[a]pyrene-7,8-dione
C22357  17beta-Estradiol-2,3-quinone
C22381  Reactive oxygen species
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Redox toxicology of environmental chemicals causing oxidative stress.
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Related
pathway
csyr00190  Oxidative phosphorylation
csyr00980  Metabolism of xenobiotics by cytochrome P450
csyr04010  MAPK signaling pathway
csyr04064  NF-kappa B signaling pathway
csyr04066  HIF-1 signaling pathway
csyr04151  PI3K-Akt signaling pathway
csyr04370  VEGF signaling pathway
csyr05207  Chemical carcinogenesis - receptor activation
csyr05211  Renal cell carcinoma
csyr05215  Prostate cancer
csyr05219  Bladder cancer
csyr05221  Acute myeloid leukemia
csyr05222  Small cell lung cancer
csyr05223  Non-small cell lung cancer
csyr05224  Breast cancer
csyr05225  Hepatocellular carcinoma
KO pathway
ko05208   
LinkDB

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