KEGG   PATHWAY: eai05415
Entry
eai05415                    Pathway                                
Name
Diabetic cardiomyopathy - Equus asinus (ass)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
eai05415  Diabetic cardiomyopathy
eai05415

Organism
Equus asinus (ass) [GN:eai]
Gene
106847800  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
106844181  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 isoform X1 [KO:K07191]
106828330  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 [KO:K00820] [EC:2.6.1.16]
106843727  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
106843233  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
106843543  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
106822866  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
106838495  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
106840925  TNNI3; troponin I, cardiac muscle [KO:K12044]
106834687  RYR2; ryanodine receptor 2 isoform X4 [KO:K04962]
106847013  PLN; cardiac phospholamban [KO:K05852]
106825678  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
106829100  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
106842285  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
106835289  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
106844922  AGT; angiotensinogen [KO:K09821]
106822997  REN; renin isoform X1 [KO:K01380] [EC:3.4.23.15]
106823831  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106831014  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
106825146  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
106840982  NCF1; neutrophil cytosol factor 1 [KO:K08011]
106828257  cytochrome b-245 light chain [KO:K08009]
106836994  NCF2; neutrophil cytosol factor 2 [KO:K08010]
106837573  NCF4; neutrophil cytosol factor 4 [KO:K08012]
106840518  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
106837585  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
106829436  AGTR1; type-1 angiotensin II receptor [KO:K04166]
106825951  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
106833569  RELA; transcription factor p65 isoform X1 [KO:K04735]
106824547  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
106824582  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
106846005  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
106846006  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
106839421  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
106831384  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106843729  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106822484  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
106843045  MMP9; matrix metalloproteinase-9 isoform X1 [KO:K01403] [EC:3.4.24.35]
106826321  COL1A1; collagen alpha-1(I) chain precursor [KO:K06236]
106838933  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
106838698  COL3A1; collagen alpha-1(III) chain [KO:K19720]
106843812  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
106836714  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
106830938  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
106833451  CD36; platelet glycoprotein 4 [KO:K06259]
106845979  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
106846020  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
106838924  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
106826450  PDK2; pyruvate dehydrogenase kinase, isozyme 2 [KO:K00898] [EC:2.7.11.2]
106824116  PDK3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
106835567  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106822994  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
106845415  PTPA; serine/threonine-protein phosphatase 2A activator [KO:K17605]
106842216  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
106837075  serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
106833503  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
106824102  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
106845213  PRKCZ; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
106833186  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
106844524  INSR; insulin receptor isoform X2 [KO:K04527] [EC:2.7.10.1]
106827854  IRS1; insulin receptor substrate 1 [KO:K16172]
106838100  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106829313  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106836695  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106840141  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
106822593  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
106824993  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
106845897  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106835457  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106839597  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106843289  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106836676  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
106829188  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
106825573  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
106838266  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
106843092  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
106822614  MPC1L; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
106842062  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
106841555  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
106826760  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
106835514  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
106848658  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
808061  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808059  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808060  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808055  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808056  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808058  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808057  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
106833485  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
106828659  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
106829925  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
106845129  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
106823773  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
106840869  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X2 [KO:K03947]
106848374  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
106832994  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
106834450  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
106829331  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
106829867  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
106848494  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
106844493  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X5 [KO:K03951]
106837867  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
106831495  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
106832206  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
106846147  NDUFAB1; acyl carrier protein, mitochondrial isoform X2 [KO:K03955]
106832748  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
106831170  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
106825466  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 isoform X1 [KO:K11353]
106825375  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
106842621  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
106823500  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
106823734  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
106829307  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
106841469  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
106844306  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X2 [KO:K03963]
106846749  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
106839361  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
106836226  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
106847989  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
106828149  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
106827589  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
106844019  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial isoform X1 [KO:K03936] [EC:7.1.1.2]
106843348  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
106830578  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X2 [KO:K03938]
106835886  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
106834185  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X2 [KO:K03940] [EC:7.1.1.2]
106844280  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
106838418  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
106842890  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
106835869  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
106827983  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
106827584  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
106840217  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
106834965  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
808065  CYTB; cytochrome b [KO:K00412]
106841912  cytochrome c1, heme protein, mitochondrial [KO:K00413]
106830662  cytochrome b-c1 complex subunit 1, mitochondrial isoform X1 [KO:K00414]
106841746  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
106822600  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
106835419  cytochrome b-c1 complex subunit 7 [KO:K00417]
106841008  cytochrome b-c1 complex subunit 8 [KO:K00418]
106827325  cytochrome b-c1 complex subunit 9 [KO:K00419]
106834176  cytochrome b-c1 complex subunit 10 [KO:K00420]
808054  COX3; cytochrome c oxidase subunit III [KO:K02262]
808066  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
808064  COX2; cytochrome c oxidase subunit II [KO:K02261]
106829176  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
106833711  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X2 [KO:K02263]
106831275  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
106842542  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
106831875  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
106844790  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
106829247  cytochrome c oxidase subunit 6B1 [KO:K02267]
106842364  cytochrome c oxidase subunit 6C [KO:K02268]
123285498  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6C-like [KO:K02268]
106842554  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
106848636  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
106841238  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
106846922  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
106841203  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
106833641  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
123286886  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
106823353  ATP5F1A; ATP synthase subunit alpha, mitochondrial [KO:K02132]
106832969  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
106831232  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
106834227  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
106824394  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
808063  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
106828604  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
106828058  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
106837906  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
106826529  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
106830277  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
106832829  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
106842470  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
808062  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
106834658  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
106837945  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1-like [KO:K05862]
106843557  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
106828962  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
106841502  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
106842512  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
106830087  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
106829894  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
106828596  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
106840859  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
106823361  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
106827217  glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
106847293  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
106843424  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
106846372  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
106826649  G6PD; glucose-6-phosphate 1-dehydrogenase [KO:K00036] [EC:1.1.1.49 1.1.1.363]
106824458  GSR; LOW QUALITY PROTEIN: glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
106842924  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
106830994  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
106831216  SMAD2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
106840608  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
106823182  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
106823191  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
106835172  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
106833627  PLCB3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
106835520  angiotensin-converting enzyme isoform X5 [KO:K01283] [EC:3.4.15.1]
106835568  LOW QUALITY PROTEIN: angiotensin-converting enzyme-like protein Ace3 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
PMID:30443826
  Authors
Riehle C, Bauersachs J
  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
DOI:10.1007/s00395-018-0711-0
Reference
PMID:24462787
  Authors
Huynh K, Bernardo BC, McMullen JR, Ritchie RH
  Title
Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
DOI:10.1016/j.pharmthera.2014.01.003
Reference
PMID:28231848
  Authors
Lorenzo-Almoros A, Tunon J, Orejas M, Cortes M, Egido J, Lorenzo O
  Title
Diagnostic approaches for diabetic cardiomyopathy.
  Journal
Cardiovasc Diabetol 16:28 (2017)
DOI:10.1186/s12933-017-0506-x
Reference
PMID:32080423
  Authors
Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L
  Title
Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence.
  Journal
Nat Rev Cardiol 17:585-607 (2020)
DOI:10.1038/s41569-020-0339-2
Reference
PMID:31212580
  Authors
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Related
pathway
eai00010  Glycolysis / Gluconeogenesis
eai00020  Citrate cycle (TCA cycle)
eai00190  Oxidative phosphorylation
eai00520  Amino sugar and nucleotide sugar metabolism
eai03320  PPAR signaling pathway
eai04071  Sphingolipid signaling pathway
eai04150  mTOR signaling pathway
eai04210  Apoptosis
eai04260  Cardiac muscle contraction
eai04350  TGF-beta signaling pathway
eai04614  Renin-angiotensin system
eai04910  Insulin signaling pathway
eai04930  Type II diabetes mellitus
eai04931  Insulin resistance
eai04933  AGE-RAGE signaling pathway in diabetic complications
eai04940  Type I diabetes mellitus
KO pathway
ko05415   
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