KEGG   PATHWAY: emc05168
Entry
emc05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Eublepharis macularius (Leopard gecko)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
emc05168  Herpes simplex virus 1 infection
emc05168

Organism
Eublepharis macularius (Leopard gecko) [GN:emc]
Gene
129346528  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
129344828  TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
129341859  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
129331658  TRAF5; TNF receptor-associated factor 5 [KO:K09849]
129342159  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129332264  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
129345981  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129324997  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
129336994  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
129336549  RELA; transcription factor p65 [KO:K04735]
129325802  inhibitor of apoptosis protein-like [KO:K16060]
129342021  NECTIN1; nectin-1 [KO:K06081]
129343342  NECTIN2; nectin-2 isoform X1 [KO:K06531]
129340172  PILRA; paired immunoglobulin-like type 2 receptor alpha isoform X1 [KO:K15411]
129341211  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
129345105  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
129346292  ITGA5; integrin alpha-5 [KO:K06484]
129338738  ITGB3; integrin beta-3 [KO:K06493]
129329995  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
129334283  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
129341934  CARD9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
129338317  IRF3; LOW QUALITY PROTEIN: interferon regulatory factor 3 [KO:K05411]
129340394  TP53; cellular tumor antigen p53 [KO:K04451]
129346041  C3; LOW QUALITY PROTEIN: complement C3 [KO:K03990]
129342632  C5; complement C5 [KO:K03994]
129346563  CFP; properdin [KO:K15412]
129337116  TLR2; toll-like receptor 2 [KO:K10159]
129337671  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
129324796  IRF7; interferon regulatory factor 7 [KO:K09447]
129337119  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
129330873  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
129335648  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
129346112  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
129323951  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
129326227  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
129336319  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
129334528  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
129342322  interleukin-1 beta-like [KO:K04519]
129337334  IL6; interleukin-6 [KO:K05405]
129328847  TNF; tumor necrosis factor [KO:K03156]
129327588  IL12B; interleukin-12 subunit beta [KO:K05425]
129334781  RIGI; antiviral innate immune response receptor RIG-I [KO:K12646] [EC:5.6.2.6]
129325086  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
129324633  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
129335877  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
129335154  interferon alpha-3-like [KO:K05414]
129335155  interferon omega-1-like [KO:K05414]
129335156  interferon omega-1-like [KO:K05414]
129335157  interferon omega-1-like [KO:K05414]
129335158  interferon omega-1-like [KO:K05414]
129339358  CGAS; cyclic GMP-AMP synthase isoform X1 [KO:K17834] [EC:2.7.7.86]
129333581  STING1; stimulator of interferon genes protein [KO:K12654]
129329374  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129323844  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
129341454  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
129338531  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X1 [KO:K16194] [EC:2.7.11.1]
129325820  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
129337398  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
129325282  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
129325143  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
129341553  EIF2B1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
129323647  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
129330943  EIF2B3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
129337828  EIF2B4; translation initiation factor eIF-2B subunit delta [KO:K03680]
129332623  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
129331346  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
129346016  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
129336189  HCFC2; host cell factor 2 [KO:K27390]
129342000  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
129343292  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
129326507  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
129325744  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
129325815  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
129328279  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
129340151  suppressor of cytokine signaling 3-like [KO:K04696]
129330016  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
129346015  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
129323801  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
129328133  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
129340727  IRF9; interferon regulatory factor 9 [KO:K04693]
129327672  zinc finger protein 34-like [KO:K09228]
129327710  zinc finger protein 345-like [KO:K09228]
129327739  zinc finger protein 260-like [KO:K09228]
129327749  zinc finger protein 93-like [KO:K09228]
129327758  zinc finger protein 660-like [KO:K09228]
129327759  zinc finger protein 665-like [KO:K09228]
129327760  zinc finger protein 345-like [KO:K09228]
129327772  zinc finger protein 420-like [KO:K09228]
129327774  zinc finger protein 501-like [KO:K09228]
129327780  zinc finger protein 665-like [KO:K09228]
129327790  zinc finger protein 436-like [KO:K09228]
129327793  zinc finger protein 420-like [KO:K09228]
129327794  zinc finger protein OZF-like [KO:K09228]
129327805  zinc finger protein 271-like [KO:K09228]
129327823  uncharacterized protein LOC129327823 [KO:K09228]
129327832  zinc finger protein 3-like [KO:K09228]
129327833  zinc finger protein 420-like [KO:K09228]
129327835  zinc finger protein 430-like [KO:K09228]
129327839  zinc finger protein 420-like [KO:K09228]
129327843  zinc finger protein 883-like [KO:K09228]
129327845  zinc finger protein OZF-like [KO:K09228]
129327851  zinc finger protein 345-like [KO:K09228]
129327852  zinc finger protein 345-like [KO:K09228]
129327853  zinc finger protein 420-like [KO:K09228]
129327856  zinc finger protein 345-like [KO:K09228]
129327857  zinc finger protein 239-like [KO:K09228]
129327860  zinc finger protein ZFP2-like [KO:K09228]
129327877  LOW QUALITY PROTEIN: zinc finger protein 160-like [KO:K09228]
129327898  zinc finger protein 345-like [KO:K09228]
129327900  zinc finger protein ZFP2-like [KO:K09228]
129327912  zinc finger protein 883-like [KO:K09228]
129327951  LOW QUALITY PROTEIN: zinc finger protein 850-like [KO:K09228]
129327953  zinc finger protein 665-like [KO:K09228]
129327972  zinc finger protein OZF-like [KO:K09228]
129327975  LOW QUALITY PROTEIN: zinc finger protein 726-like [KO:K09228]
129327982  zinc finger protein 85-like [KO:K09228]
129327986  zinc finger protein 420-like [KO:K09228]
129327990  zinc finger protein 679-like [KO:K09228]
129327993  zinc finger protein 420-like [KO:K09228]
129327994  zinc finger protein 345-like [KO:K09228]
129327999  zinc finger protein 665-like [KO:K09228]
129328000  zinc finger protein ZFP2-like [KO:K09228]
129328001  zinc finger protein 675-like [KO:K09228]
129328005  zinc finger protein 420-like [KO:K09228]
129328007  zinc finger protein ZFP2-like [KO:K09228]
129328008  zinc finger protein 665-like [KO:K09228]
129328009  zinc finger protein 665-like [KO:K09228]
129328012  zinc finger protein 501-like [KO:K09228]
129328016  zinc finger protein 420-like [KO:K09228]
129328026  zinc finger protein ZFP2-like [KO:K09228]
129328027  zinc finger protein 420-like [KO:K09228]
129328031  zinc finger protein 665-like [KO:K09228]
129328053  zinc finger protein 501-like [KO:K09228]
129328054  zinc finger protein 345-like [KO:K09228]
129328055  zinc finger protein 345-like [KO:K09228]
129339429  zinc finger protein 729-like [KO:K09228]
129339544  zinc finger protein 420-like [KO:K09228]
129328083  zinc finger protein 501-like [KO:K09228]
129328094  zinc finger protein 239-like [KO:K09228]
129328118  zinc finger protein 420-like isoform X1 [KO:K09228]
129328171  zinc finger protein 665-like [KO:K09228]
129328173  zinc finger protein 664-like isoform X1 [KO:K09228]
129328174  zinc finger protein 501-like [KO:K09228]
129328244  zinc finger protein 883-like [KO:K09228]
129328292  zinc finger protein 260-like [KO:K09228]
129333963  zinc finger protein 883-like [KO:K09228]
129328360  zinc finger protein 501-like [KO:K09228]
129328442  zinc finger protein 721-like [KO:K09228]
129328455  zinc finger protein 665-like isoform X1 [KO:K09228]
129328456  zinc finger protein 883-like [KO:K09228]
129328459  zinc finger protein 883-like isoform X1 [KO:K09228]
129328464  zinc finger protein 345-like [KO:K09228]
129328466  zinc finger protein 883-like isoform X1 [KO:K09228]
129328471  zinc finger protein OZF-like [KO:K09228]
129328474  zinc finger protein 501-like [KO:K09228]
129328476  zinc finger protein 664-like [KO:K09228]
129328478  zinc finger protein 239-like isoform X1 [KO:K09228]
129328669  zinc finger protein 850-like [KO:K09228]
129328671  zinc finger protein 420-like [KO:K09228]
129328676  zinc finger protein 420-like [KO:K09228]
129328677  zinc finger protein 420-like isoform X1 [KO:K09228]
129328681  zinc finger protein 345-like [KO:K09228]
129328687  zinc finger protein 345-like [KO:K09228]
129328692  zinc finger protein 420-like isoform X1 [KO:K09228]
129334637  zinc finger protein 501-like [KO:K09228]
129328695  zinc finger protein 331-like isoform X1 [KO:K09228]
129328696  zinc finger protein ZFP2-like isoform X1 [KO:K09228]
129328702  zinc finger protein 345-like [KO:K09228]
129328710  zinc finger protein 160-like [KO:K09228]
129328721  zinc finger protein 383-like isoform X1 [KO:K09228]
129328727  zinc finger protein OZF-like [KO:K09228]
129328733  zinc finger protein 501-like [KO:K09228]
129328734  zinc finger protein 501-like [KO:K09228]
129328735  zinc finger protein OZF-like [KO:K09228]
129328738  zinc finger protein 501-like [KO:K09228]
129328741  zinc finger protein 501-like [KO:K09228]
129328746  zinc finger protein 664-like isoform X1 [KO:K09228]
129328747  zinc finger protein 502-like [KO:K09228]
129328757  LOW QUALITY PROTEIN: zinc finger protein 493-like [KO:K09228]
129328758  zinc finger protein 271-like [KO:K09228]
129328759  zinc finger protein 420-like [KO:K09228]
129328762  zinc finger protein 420-like [KO:K09228]
129328763  zinc finger protein 420-like [KO:K09228]
129328764  zinc finger protein 420-like [KO:K09228]
129328789  zinc finger protein 883-like isoform X1 [KO:K09228]
129328790  zinc finger protein 773-like [KO:K09228]
129328792  zinc finger protein OZF-like [KO:K09228]
129328798  zinc finger protein 239-like [KO:K09228]
129328799  zinc finger protein 773-like isoform X1 [KO:K09228]
129328862  zinc finger protein 883-like isoform X1 [KO:K09228]
129329011  zinc finger protein 501-like [KO:K09228]
129346436  zinc finger protein 664-like [KO:K09228]
129329040  zinc finger protein 420-like [KO:K09228]
129329041  zinc finger protein 345-like isoform X1 [KO:K09228]
129329043  zinc finger protein 345-like [KO:K09228]
129329044  zinc finger protein 883-like [KO:K09228]
129329045  zinc finger protein 665-like [KO:K09228]
129329046  zinc finger protein 345-like [KO:K09228]
129329072  zinc finger protein 271-like isoform X1 [KO:K09228]
129329109  zinc finger protein 43-like [KO:K09228]
129329114  zinc finger protein 345-like [KO:K09228]
129329117  zinc finger protein 420-like isoform X1 [KO:K09228]
129329120  zinc finger protein 420-like [KO:K09228]
129329121  zinc finger protein 665-like [KO:K09228]
129329122  zinc finger protein 260-like isoform X1 [KO:K09228]
129329123  zinc finger protein 345-like isoform X1 [KO:K09228]
129329124  zinc finger protein 420-like [KO:K09228]
129329126  zinc finger protein 501-like isoform X1 [KO:K09228]
129329127  zinc finger protein 260-like isoform X1 [KO:K09228]
129329129  zinc finger protein 665-like [KO:K09228]
129329130  zinc finger protein 85-like [KO:K09228]
129329132  zinc finger protein 345-like [KO:K09228]
129329133  zinc finger protein 883-like [KO:K09228]
129329134  zinc finger protein 883-like [KO:K09228]
129329135  zinc finger protein 93-like [KO:K09228]
129329136  zinc finger protein ZFP2-like [KO:K09228]
129329138  zinc finger protein OZF-like [KO:K09228]
129329150  zinc finger protein 420-like [KO:K09228]
129329155  zinc finger protein OZF-like isoform X1 [KO:K09228]
129329173  zinc finger protein 85-like [KO:K09228]
129329186  zinc finger protein 300-like isoform X1 [KO:K09228]
129329370  zinc finger protein 345-like [KO:K09228]
129329372  zinc finger protein 34-like [KO:K09228]
129329373  zinc finger protein 883-like isoform X1 [KO:K09228]
129329379  zinc finger protein 883-like isoform X1 [KO:K09228]
129329385  zinc finger protein 345-like [KO:K09228]
129329388  zinc finger protein 345-like [KO:K09228]
129340961  zinc finger protein 34-like [KO:K09228]
129323697  zinc finger protein 420-like isoform X1 [KO:K09228]
129323698  zinc finger protein 345-like [KO:K09228]
129329404  zinc finger protein 251-like isoform X1 [KO:K09228]
129329406  zinc finger protein 501-like [KO:K09228]
129329410  zinc finger protein 501-like [KO:K09228]
129329413  zinc finger protein OZF-like [KO:K09228]
129324281  zinc finger protein 585A-like [KO:K09228]
129324286  zinc finger protein 665-like [KO:K09228]
129324287  zinc finger protein 345-like [KO:K09228]
129324290  zinc finger protein OZF-like [KO:K09228]
129324298  zinc finger protein 665-like [KO:K09228]
129329989  zinc finger protein 883-like isoform X1 [KO:K09228]
129337376  zinc finger protein 250-like [KO:K09228]
129337524  zinc finger protein 398-like [KO:K09228]
129343273  zinc finger protein 345-like [KO:K09228]
129337665  ZNF282; zinc finger protein 282 [KO:K09228]
129337693  zinc finger protein 135-like isoform X1 [KO:K09228]
129337870  zinc finger protein 586-like isoform X1 [KO:K09228]
129337998  zinc finger protein 777-like [KO:K09228]
129338001  zinc finger protein 660-like [KO:K09228]
129338002  gastrula zinc finger protein XlCGF26.1-like isoform X1 [KO:K09228]
129338010  zinc finger protein 501-like [KO:K09228]
129338212  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
129338214  zinc finger protein 883-like [KO:K09228]
129338217  zinc finger protein 436-like [KO:K09228]
129338221  zinc finger protein 845-like [KO:K09228]
129338226  zinc finger protein 585A-like [KO:K09228]
129338515  zinc finger protein ZFP2-like [KO:K09228]
129326901  zinc finger protein 501-like [KO:K09228]
129326936  zinc finger protein 420-like [KO:K09228]
129326967  zinc finger protein 420-like [KO:K09228]
129326984  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
129326989  zinc finger protein 664-like [KO:K09228]
129326991  zinc finger protein 501-like [KO:K09228]
129327008  zinc finger protein ZFP2-like [KO:K09228]
129327014  zinc finger protein 665-like [KO:K09228]
129327061  zinc finger protein 93-like [KO:K09228]
129327062  zinc finger protein ZFP2-like [KO:K09228]
129327063  zinc finger protein 883-like [KO:K09228]
129327064  zinc finger protein 883-like [KO:K09228]
129327066  zinc finger protein 883-like [KO:K09228]
129327068  zinc finger protein 883-like isoform X1 [KO:K09228]
129327069  zinc finger protein 883-like [KO:K09228]
129327072  zinc finger protein 883-like [KO:K09228]
129327075  zinc finger protein 883-like [KO:K09228]
129327080  zinc finger protein OZF-like isoform X1 [KO:K09228]
129327082  zinc finger protein 883-like [KO:K09228]
129327083  zinc finger protein 883-like [KO:K09228]
129327084  zinc finger protein 154-like [KO:K09228]
129327089  zinc finger protein 501-like [KO:K09228]
129327090  zinc finger protein 501-like [KO:K09228]
129327095  zinc finger protein 543-like isoform X1 [KO:K09228]
129327100  zinc finger protein 239-like [KO:K09228]
129327105  zinc finger protein 665-like [KO:K09228]
129327122  zinc finger protein 184-like [KO:K09228]
129327130  zinc finger protein 883-like [KO:K09228]
129327136  zinc finger protein 260-like isoform X1 [KO:K09228]
129327140  zinc finger protein ZFP2-like [KO:K09228]
129327141  zinc finger protein 420-like [KO:K09228]
129327147  zinc finger protein 260-like [KO:K09228]
129327148  zinc finger protein 345-like [KO:K09228]
129327149  zinc finger protein 883-like [KO:K09228]
129327153  zinc finger protein 420-like [KO:K09228]
129327160  zinc finger protein OZF-like isoform X1 [KO:K09228]
129327165  zinc finger protein 879-like [KO:K09228]
129327171  zinc finger protein 345-like [KO:K09228]
129327172  zinc finger protein 271-like [KO:K09228]
129327190  zinc finger protein 420-like [KO:K09228]
129327195  zinc finger protein ZFP2-like [KO:K09228]
129327196  zinc finger protein 883-like [KO:K09228]
129327198  zinc finger protein 470-like [KO:K09228]
129327202  zinc finger protein 665-like [KO:K09228]
129327203  zinc finger protein OZF-like isoform X1 [KO:K09228]
129327208  zinc finger protein 239-like [KO:K09228]
129327245  zinc finger protein 420-like [KO:K09228]
129327248  zinc finger protein 883-like [KO:K09228]
129327249  zinc finger protein 665-like [KO:K09228]
129338647  zinc finger protein 3-like [KO:K09228]
129327251  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
129327253  zinc finger protein 883-like [KO:K09228]
129327254  zinc finger protein 883-like [KO:K09228]
129327255  zinc finger protein 883-like [KO:K09228]
129327256  zinc finger protein 883-like [KO:K09228]
129327257  zinc finger protein 420-like isoform X1 [KO:K09228]
129327258  zinc finger protein 665-like [KO:K09228]
129327259  zinc finger protein 260-like [KO:K09228]
129327260  zinc finger protein 737-like [KO:K09228]
129327261  zinc finger protein ZFP2-like isoform X1 [KO:K09228]
129327262  zinc finger protein 665-like [KO:K09228]
129327264  zinc finger protein 501-like [KO:K09228]
129327265  zinc finger protein 501-like isoform X1 [KO:K09228]
129327266  zinc finger protein 501-like [KO:K09228]
129327267  zinc finger protein 501-like isoform X1 [KO:K09228]
129327268  zinc finger protein 501-like isoform X1 [KO:K09228]
129327270  zinc finger protein 501-like [KO:K09228]
129327346  zinc finger protein 664-like isoform X1 [KO:K09228]
129327405  zinc finger protein 501-like isoform X1 [KO:K09228]
129327406  zinc finger protein 501-like [KO:K09228]
129327431  zinc finger protein 436-like isoform X1 [KO:K09228]
129327438  zinc finger protein OZF-like isoform X1 [KO:K09228]
129327445  zinc finger protein 271-like isoform X1 [KO:K09228]
129327446  zinc finger protein 271-like [KO:K09228]
129327447  zinc finger protein 260-like [KO:K09228]
129327449  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
129328793  zinc finger protein CKR1-like [KO:K09228]
129340536  zinc finger protein 883-like [KO:K09228]
129338938  zinc finger protein 665-like [KO:K09228]
129335334  interferon gamma-like [KO:K04687]
129323728  IFNGR1; interferon gamma receptor 1 [KO:K05132]
129325489  IFNGR2; interferon gamma receptor 2 [KO:K05133]
129334950  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
129345462  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
129345655  protein PML-like isoform X1 [KO:K10054] [EC:2.3.2.-]
129328742  tapasin-like [KO:K08058]
129345363  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
129346157  CALR; calreticulin [KO:K08057]
129330010  calreticulin-like [KO:K08057]
129330216  CALR3; calreticulin-3 isoform X1 [KO:K08057]
129328479  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
129327209  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
129327210  major histocompatibility complex class I-related gene protein-like [KO:K06751]
129327212  class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
129345368  B2M; beta-2-microglobulin [KO:K08055]
129327984  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328039  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
129328040  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328041  rano class II histocompatibility antigen, A beta chain-like [KO:K06752]
129328043  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328044  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328045  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328487  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
129328493  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328494  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
129328495  H-2 class II histocompatibility antigen, E-S beta chain-like isoform X1 [KO:K06752]
129328497  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328498  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328499  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328500  HLA class II histocompatibility antigen, DM beta chain [KO:K06752]
129328502  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
129328503  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
129328504  HLA class II histocompatibility antigen, DR alpha chain-like isoform X1 [KO:K06752]
129328506  HLA class II histocompatibility antigen, DM alpha chain [KO:K06752]
129328507  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129328508  HLA class II histocompatibility antigen, DR alpha chain-like isoform X1 [KO:K06752]
129328509  SLA class II histocompatibility antigen, DQ haplotype C beta chain-like [KO:K06752]
129328511  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
129327021  HLA class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
129327024  H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752]
129327434  HLA class II histocompatibility antigen, DR alpha chain-like isoform X1 [KO:K06752]
129327479  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
129340355  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [KO:K00922] [EC:2.7.1.153]
129331860  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129332202  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129345006  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
129334239  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129329994  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
129331257  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
129323978  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129329530  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129342846  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129342094  TSC1; hamartin isoform X1 [KO:K07206]
129340080  TSC2; tuberin isoform X1 [KO:K07207]
129337580  RHEB; GTP-binding protein Rheb [KO:K07208]
129344458  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
129342005  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
129330526  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
129344501  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
129328280  SRSF2; serine/arginine-rich splicing factor 2 [KO:K12891]
129330070  SRSF3; serine/arginine-rich splicing factor 3 [KO:K12892]
129323779  serine/arginine-rich splicing factor 5-like isoform X1 [KO:K12893]
129324134  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
129330156  SRSF6; serine/arginine-rich splicing factor 6 [KO:K12893]
129343384  SRSF4; serine/arginine-rich splicing factor 4 [KO:K12893]
129333552  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
129341049  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
129338668  NXF1; nuclear RNA export factor 1 [KO:K14284]
129328259  ALYREF; THO complex subunit 4 [KO:K12881]
129331288  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129332301  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
129345538  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
129343981  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
129340065  FAS-associated death domain protein-like [KO:K02373]
129323679  FADD; LOW QUALITY PROTEIN: FAS-associated death domain protein [KO:K02373]
129335339  BID; BH3-interacting domain death agonist [KO:K04726]
129340239  apoptosis regulator BAX-like isoform X1 [KO:K02159]
129340438  BAX; apoptosis regulator BAX [KO:K02159]
129330550  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
129340405  BAD; bcl2-associated agonist of cell death [KO:K02158]
129333903  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
129330607  BCL2L1; bcl-2-like protein 1 [KO:K04570]
129324533  cytochrome c, somatic-like [KO:K08738]
129337229  cytochrome c [KO:K08738]
129336555  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
129345045  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
129337174  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
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Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
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Semin Immunopathol 31:207-21 (2009)
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Reference
PMID:20221426
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MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
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Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
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Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
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PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
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Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
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J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
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J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
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Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
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Virol J 13:38 (2016)
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Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
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Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
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Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
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J Virol 92:e00099-17 (2018)
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Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
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Expert Rev Neurother 9:505-17 (2009)
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Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
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Trends Biochem Sci 28:294-304 (2003)
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Reference
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Fleming SB
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Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
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Vaccines (Basel) 4:E23 (2016)
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Reference
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Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
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J Virol 78:6282-6 (2004)
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Reference
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Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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J Virol 87:10244-54 (2013)
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Reference
PMID:21994592
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Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
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Viruses 1:1240-64 (2009)
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Reference
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  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
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Curr Opin Immunol 23:96-103 (2011)
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Reference
PMID:12960333
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Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
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J Immunol 171:3075-83 (2003)
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Reference
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  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
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Virology 479-480:568-77 (2015)
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Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
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J Virol 91:e00295-17 (2017)
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Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
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Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
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J Virol 78:4389-96 (2004)
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Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
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Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
emc03040  Spliceosome
emc03050  Proteasome
emc04115  p53 signaling pathway
emc04210  Apoptosis
emc04620  Toll-like receptor signaling pathway
emc04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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