KEGG   PATHWAY: gab04120
Entry
gab04120                    Pathway                                
Name
Ubiquitin mediated proteolysis - Gossypium arboreum (tree cotton)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
gab04120  Ubiquitin mediated proteolysis
gab04120

Other DBs
GO: 0016567
Organism
Gossypium arboreum (tree cotton) [GN:gab]
Gene
108453253  polyubiquitin [KO:K08770]
108451830  polyubiquitin-like [KO:K08770]
108483306  polyubiquitin-like [KO:K08770]
108451831  polyubiquitin-like [KO:K08770]
108464014  polyubiquitin [KO:K08770]
108451832  polyubiquitin [KO:K08770]
108481202  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
108472962  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
108454470  ubiquitin-60S ribosomal protein L40 [KO:K02927]
108454587  ubiquitin-60S ribosomal protein L40 [KO:K02927]
108454635  ubiquitin-60S ribosomal protein L40 [KO:K02927]
108479650  ubiquitin-40S ribosomal protein S27a [KO:K02977]
108470443  ubiquitin-40S ribosomal protein S27a [KO:K02977]
108489409  ubiquitin-40S ribosomal protein S27a [KO:K02977]
108469927  ubiquitin-40S ribosomal protein S27a [KO:K02977]
108457788  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
108482973  ubiquitin-activating enzyme E1 1-like [KO:K03178] [EC:6.2.1.45]
108486204  ubiquitin-activating enzyme E1 1-like isoform X1 [KO:K03178] [EC:6.2.1.45]
108482929  ubiquitin-activating enzyme E1 1-like isoform X1 [KO:K03178] [EC:6.2.1.45]
108463154  ubiquitin-activating enzyme E1 1-like [KO:K03178] [EC:6.2.1.45]
108479462  SUMO-activating enzyme subunit 1B-1-like [KO:K10684] [EC:6.2.1.45]
108459357  SUMO-activating enzyme subunit 1B-1-like [KO:K10684] [EC:6.2.1.45]
108479684  SUMO-activating enzyme subunit 2 [KO:K10685] [EC:6.2.1.45]
108476333  SUMO-activating enzyme subunit 2-like [KO:K10685] [EC:6.2.1.45]
108454051  NEDD8-activating enzyme E1 catalytic subunit [KO:K10686] [EC:6.2.1.64]
108470299  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
108473867  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
108479699  ubiquitin-conjugating enzyme E2 2 [KO:K10573] [EC:2.3.2.23]
108479801  ubiquitin-conjugating enzyme E2 2-like [KO:K10573] [EC:2.3.2.23]
108481453  ubiquitin-conjugating enzyme E2 20 [KO:K06688] [EC:2.3.2.23]
108458184  probable ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
108452004  probable ubiquitin-conjugating enzyme E2 C [KO:K06688] [EC:2.3.2.23]
108476244  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
108480013  ubiquitin-conjugating enzyme E2 10-like [KO:K06689] [EC:2.3.2.23]
108470759  ubiquitin-conjugating enzyme E2 28-like [KO:K06689] [EC:2.3.2.23]
108469808  ubiquitin-conjugating enzyme E2 10-like [KO:K06689] [EC:2.3.2.23]
108479608  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
108479982  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
108467495  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
108476341  ubiquitin-conjugating enzyme E2 28 [KO:K06689] [EC:2.3.2.23]
108472439  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
108487200  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
108477114  ubiquitin-conjugating enzyme E2 10-like [KO:K06689] [EC:2.3.2.23]
108489758  ubiquitin-conjugating enzyme E2-17 kDa-like isoform X1 [KO:K06689] [EC:2.3.2.23]
108455911  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
108450336  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
108457467  ubiquitin-conjugating enzyme E2-17 kDa-like [KO:K06689] [EC:2.3.2.23]
108457646  ubiquitin-conjugating enzyme E2-17 kDa [KO:K06689] [EC:2.3.2.23]
108466137  ubiquitin-conjugating enzyme E2 10-like [KO:K06689] [EC:2.3.2.23]
108452081  ubiquitin-conjugating enzyme E2 11-like isoform X1 [KO:K06689] [EC:2.3.2.23]
108453970  ubiquitin-conjugating enzyme E2 10 [KO:K06689] [EC:2.3.2.23]
108487031  constitutive photomorphogenesis protein 10 isoform X1 [KO:K20217] [EC:2.3.2.23]
108483708  ubiquitin-conjugating enzyme E2 13 [KO:K10575] [EC:2.3.2.23]
108484625  ubiquitin-conjugating enzyme E2 7 [KO:K10575] [EC:2.3.2.23]
108459600  ubiquitin-conjugating enzyme E2 7-like [KO:K10575] [EC:2.3.2.23]
108451977  ubiquitin-conjugating enzyme E2 7 isoform X1 [KO:K10575] [EC:2.3.2.23]
108480401  ubiquitin-conjugating enzyme E2 5-like [KO:K10576] [EC:2.3.2.23]
108474089  ubiquitin-conjugating enzyme E2 4-like [KO:K10576] [EC:2.3.2.23]
108467624  ubiquitin-conjugating enzyme E2 4 [KO:K10576] [EC:2.3.2.23]
108485846  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
108454881  ubiquitin-conjugating enzyme E2-23 kDa-like [KO:K10576] [EC:2.3.2.23]
108481173  SUMO-conjugating enzyme SCE1-like [KO:K10577]
108474073  SUMO-conjugating enzyme SCE1 [KO:K10577]
108452370  SUMO-conjugating enzyme SCE1-like isoform X1 [KO:K10577]
108452065  SUMO-conjugating enzyme SCE1-like [KO:K10577]
108456657  ubiquitin-conjugating enzyme E2 32 [KO:K10578] [EC:2.3.2.23]
108487021  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
108487020  ubiquitin-conjugating enzyme E2 32-like [KO:K10578] [EC:2.3.2.23]
108486987  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
108486569  ubiquitin-conjugating enzyme E2 34-like [KO:K04554] [EC:2.3.2.23]
108478380  ubiquitin-conjugating enzyme E2 27-like [KO:K04649] [EC:2.3.2.23]
108476655  ubiquitin-conjugating enzyme E2 27 [KO:K04649] [EC:2.3.2.23]
108485579  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
108479783  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
108476831  NEDD8-conjugating enzyme Ubc12 [KO:K10579] [EC:2.3.2.34]
108465036  NEDD8-conjugating enzyme Ubc12-like [KO:K10579] [EC:2.3.2.34]
108470741  ubiquitin-conjugating enzyme E2 35 [KO:K10580] [EC:2.3.2.23]
108480379  ubiquitin-conjugating enzyme E2 36-like isoform X1 [KO:K10580] [EC:2.3.2.23]
108482243  ubiquitin-conjugating enzyme E2 36-like [KO:K10580] [EC:2.3.2.23]
108461275  ubiquitin-conjugating enzyme E2 36-like [KO:K10580] [EC:2.3.2.23]
108450720  ubiquitin-conjugating enzyme E2 36-like [KO:K10580] [EC:2.3.2.23]
108475896  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
108470392  probable ubiquitin-conjugating enzyme E2 26 isoform X1 [KO:K10581] [EC:2.3.2.24]
108483580  probable ubiquitin-conjugating enzyme E2 25 isoform X1 [KO:K10581] [EC:2.3.2.24]
108489657  probable ubiquitin-conjugating enzyme E2 24 isoform X1 [KO:K10581] [EC:2.3.2.24]
108484013  probable ubiquitin-conjugating enzyme E2 24 [KO:K10581] [EC:2.3.2.24]
108482225  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
108456106  putative ubiquitin-conjugating enzyme E2 38 [KO:K10581] [EC:2.3.2.24]
108460544  probable ubiquitin-conjugating enzyme E2 23 isoform X1 [KO:K10581] [EC:2.3.2.24]
108474144  ubiquitin-conjugating enzyme E2 22 [KO:K10583] [EC:2.3.2.23]
108480366  probable ubiquitin-conjugating enzyme E2 18 isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
108477213  probable ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
108470168  probable ubiquitin-conjugating enzyme E2 16 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
108454520  probable ubiquitin-conjugating enzyme E2 18 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
108467019  E3 ubiquitin-protein ligase UPL7 isoform X1 [KO:K10588] [EC:2.3.2.26]
108489253  E3 ubiquitin-protein ligase UPL6-like [KO:K10589] [EC:2.3.2.26]
108457292  E3 ubiquitin-protein ligase UPL6-like isoform X1 [KO:K10589] [EC:2.3.2.26]
108480325  E3 ubiquitin-protein ligase UPL3-like [KO:K10590] [EC:2.3.2.26]
108479247  E3 ubiquitin-protein ligase UPL3-like [KO:K10590] [EC:2.3.2.26]
108466926  E3 ubiquitin-protein ligase UPL3-like [KO:K10590] [EC:2.3.2.26]
108489361  E3 ubiquitin-protein ligase UPL4 [KO:K10590] [EC:2.3.2.26]
108451788  E3 ubiquitin-protein ligase UPL2-like [KO:K10592] [EC:2.3.2.26]
108452797  E3 ubiquitin-protein ligase UPL2-like [KO:K10592] [EC:2.3.2.26]
108482654  E3 ubiquitin-protein ligase UPL1 isoform X1 [KO:K10592] [EC:2.3.2.26]
108457009  probable ubiquitin conjugation factor E4 [KO:K10597] [EC:2.3.2.27]
108470431  E3 ubiquitin-protein ligase CHIP-like isoform X1 [KO:K09561] [EC:2.3.2.27]
108466437  E3 ubiquitin-protein ligase CHIP-like isoform X1 [KO:K09561] [EC:2.3.2.27]
108479975  peptidyl-prolyl cis-trans isomerase CYP65 [KO:K10598] [EC:5.2.1.8]
108476195  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
108480868  pre-mRNA-processing factor 19 homolog 1-like isoform X1 [KO:K10599] [EC:2.3.2.27]
108457269  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
108455268  pre-mRNA-processing factor 19-like [KO:K10599] [EC:2.3.2.27]
108473357  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
108476700  E3 ubiquitin-protein ligase SINAT3 [KO:K04506] [EC:2.3.2.27]
108482293  E3 ubiquitin-protein ligase SINAT2 isoform X1 [KO:K04506] [EC:2.3.2.27]
108470780  E3 ubiquitin-protein ligase SINA-like 10 [KO:K04506] [EC:2.3.2.27]
108456772  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
108487311  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
108487491  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
108467842  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
108454141  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
108461533  E3 ubiquitin-protein ligase SINAT2-like [KO:K04506] [EC:2.3.2.27]
108463997  E3 ubiquitin-protein ligase SINAT3-like isoform X1 [KO:K04506] [EC:2.3.2.27]
108464695  E3 ubiquitin-protein ligase SINAT2 [KO:K04506] [EC:2.3.2.27]
108453854  E3 ubiquitin-protein ligase SINAT5-like [KO:K04506] [EC:2.3.2.27]
108473881  E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
108454940  WD repeat-containing protein RUP2-like [KO:K10143] [EC:2.3.2.27]
108458445  E3 ubiquitin-protein ligase COP1-like [KO:K10143] [EC:2.3.2.27]
108485753  WD repeat-containing protein RUP2-like [KO:K10143] [EC:2.3.2.27]
108480829  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
108478238  E3 ubiquitin-protein ligase MIEL1 isoform X1 [KO:K10144] [EC:2.3.2.27]
108457966  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
108474656  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
108484295  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
108463797  E3 ubiquitin-protein ligase MIEL1-like [KO:K10144] [EC:2.3.2.27]
108470077  E4 SUMO-protein ligase PIAL2-like [KO:K04706] [EC:2.3.2.-]
108467800  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like isoform X1 [KO:K10601] [EC:2.3.2.27]
108457241  ERAD-associated E3 ubiquitin-protein ligase HRD1B-like [KO:K10601] [EC:2.3.2.27]
108469135  E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
108468083  RING-box protein 1a [KO:K03868] [EC:2.3.2.32]
108469121  RING-box protein 1a-like [KO:K03868] [EC:2.3.2.32]
108488019  RING-box protein 1-like [KO:K03868] [EC:2.3.2.32]
108489532  cullin-1-like [KO:K03347]
108479602  cullin-1 [KO:K03347]
108483524  cullin-1-like [KO:K03347]
108456884  cullin-1-like [KO:K03347]
108481325  uncharacterized protein LOC108481325 [KO:K03094]
108481621  SKP1-like protein 14 [KO:K03094]
108478959  SKP1-like protein 1B [KO:K03094]
108479581  SKP1-like protein 1A [KO:K03094]
108468845  SKP1-like protein 14 [KO:K03094]
108487755  SKP1-like protein 11 [KO:K03094]
108459225  SKP1-like protein 1B [KO:K03094]
108460734  SKP1-like protein 1A [KO:K03094]
108460755  SKP1-like protein 1B [KO:K03094]
108480402  F-box protein SKP2A-like [KO:K03875]
108476028  F-box protein SKP2A [KO:K03875]
108464200  F-box protein SKP2B-like [KO:K03875]
108482206  LOW QUALITY PROTEIN: transcription elongation factor B polypeptide 1 [KO:K03872]
108484137  transcription elongation factor B polypeptide 1-like [KO:K03872]
108467701  uncharacterized protein LOC108467701 [KO:K03873]
108482781  cullin-3A [KO:K03869]
108460606  cullin-3A-like isoform X1 [KO:K03869]
108452976  cullin-3A-like [KO:K03869]
108489638  cullin-4-like [KO:K10609]
108486440  cullin-4-like [KO:K10609]
108460847  cullin-4-like isoform X1 [KO:K10609]
108475900  DNA damage-binding protein 1a [KO:K10610]
108484537  protein DAMAGED DNA-BINDING 2 [KO:K10140]
108450388  DNA excision repair protein ERCC-8 [KO:K10570]
108470678  light-mediated development protein DET1 isoform X1 [KO:K10571]
108451225  anaphase-promoting complex subunit 11 [KO:K03358]
108464370  anaphase-promoting complex subunit 2 [KO:K03349]
108482701  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
108456785  cell division cycle 20.2, cofactor of APC complex-like isoform X1 [KO:K03363]
108456786  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
108454608  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
108450770  cell division cycle 20.2, cofactor of APC complex-like [KO:K03363]
108480438  protein FIZZY-RELATED 2-like [KO:K03364]
108489229  protein FIZZY-RELATED 3 isoform X1 [KO:K03364]
108469285  protein FIZZY-RELATED 2-like [KO:K03364]
108454565  protein FIZZY-RELATED 2 [KO:K03364]
108467041  anaphase-promoting complex subunit 1 [KO:K03348]
108481004  cell division cycle protein 27 homolog B-like isoform X1 [KO:K03350]
108484017  cell division cycle protein 27 homolog B-like [KO:K03350]
108461205  cell division cycle protein 27 homolog B-like [KO:K03350]
108487443  anaphase-promoting complex subunit 4 isoform X1 [KO:K03351]
108473800  anaphase-promoting complex subunit 5 [KO:K03352]
108480745  anaphase-promoting complex subunit 6 isoform X1 [KO:K03353]
108460553  anaphase-promoting complex subunit 7 [KO:K03354]
108461211  anaphase-promoting complex subunit 8 [KO:K03355]
108470203  anaphase-promoting complex subunit 10 isoform X1 [KO:K03357]
108461556  anaphase-promoting complex subunit 13 [KO:K12456]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
gab03050  Proteasome
KO pathway
ko04120   
LinkDB

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