KEGG   PATHWAY: hoc04820
Entry
hoc04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Hemiscyllium ocellatum (epaulette shark)
Class
Cellular Processes; Cell motility
Pathway map
hoc04820  Cytoskeleton in muscle cells
hoc04820

Organism
Hemiscyllium ocellatum (epaulette shark) [GN:hoc]
Gene
132830996  collagen alpha-1(I) chain-like isoform X1 [KO:K06236]
132815701  col1a2; collagen alpha-2(I) chain [KO:K06236]
132817149  collagen alpha-1(I) chain-like [KO:K19720]
132835991  collagen alpha-1(V) chain-like isoform X1 [KO:K19721]
132832897  collagen alpha-1(V) chain-like [KO:K19721]
132819201  collagen alpha-1(XXIV) chain [KO:K19721]
132819213  collagen alpha-1(XI) chain-like [KO:K19721]
132825922  collagen alpha-1(XXVII) chain-like isoform X1 [KO:K19721]
132825971  collagen alpha-1(V) chain-like isoform X1 [KO:K19721]
132817150  col5a2b; collagen alpha-2(V) chain [KO:K19721]
132830075  col9a2; collagen alpha-2(IX) chain [KO:K08131]
132823021  col9a3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
132806937  col9a1b; collagen, type IX, alpha 1b [KO:K08131]
132815241  collagen alpha-1(IX) chain-like [KO:K08131]
132824869  decorin-like [KO:K04660]
132828162  decorin-like isoform X1 [KO:K04660]
132817645  collagen alpha-3(VI) chain-like [KO:K06238]
132817207  collagen alpha-3(VI) chain isoform X1 [KO:K06238]
132817265  col6a2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
132817266  col6a1; collagen alpha-1(VI) chain [KO:K06238]
132818146  thbs1b; thrombospondin-1 [KO:K16857]
132805616  thbs3a; thrombospondin-3a [KO:K04659]
132822367  thbs4a; thrombospondin-4a isoform X1 [KO:K04659]
132819653  thrombospondin-2-like [KO:K04659]
132829152  comp; cartilage oligomeric matrix protein [KO:K04659]
132834735  fibrillin-1-like isoform X1 [KO:K06825]
132825797  fibrillin-2-like isoform X1 [KO:K23342]
132828871  fbn2b; fibrillin-2b [KO:K23342]
132816367  collagen alpha-6(IV) chain-like isoform X1 [KO:K06237]
132816368  collagen alpha-1(IV) chain-like [KO:K06237]
132820379  col4a6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
132820381  col4a5; collagen alpha-5(IV) chain [KO:K06237]
132821661  collagen alpha-4(IV) chain-like [KO:K06237]
132821747  collagen alpha-5(IV) chain-like [KO:K06237]
132822322  fbln2; fibulin-2 isoform X1 [KO:K17307]
132824967  fbln1; fibulin-1 isoform X1 [KO:K17307]
132833496  hspg2; basement membrane-specific heparan sulfate proteoglycan core protein isoform X1 [KO:K06255]
132833982  nid1a; nidogen-1 [KO:K06826]
132818302  nid2a; uncharacterized protein nid2a isoform X1 [KO:K06826]
132817267  fibronectin-like isoform X1 [KO:K05717]
132834804  syndecan-1-like [KO:K06257]
132815475  sdc2; syndecan-2 [KO:K16336]
132829938  syndecan-3-like [KO:K16337]
132823007  sdc4; syndecan-4 [KO:K16338]
132833782  agrn; agrin isoform X1 [KO:K06254]
132815115  desmocollin-2-like [KO:K07601]
132815113  desmoglein-2-like [KO:K07597]
132815114  cadherin-2-like [KO:K07597]
132824888  plakophilin-2-like isoform X1 [KO:K12642]
132831013  junction plakoglobin-like [KO:K10056]
132813460  desmoplakin-like isoform X1 [KO:K10381]
132829888  vimentin-like [KO:K07606]
132823896  type III intermediate filament-like [KO:K07606]
132815779  glial fibrillary acidic protein-like [KO:K07606]
132815780  type III intermediate filament-like [KO:K07606]
132805601  zgc:172323; desmin [KO:K07610]
132817712  desmin-like [KO:K07610]
132832896  lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
132815086  lama1; laminin subunit alpha-1 [KO:K05637]
132810559  itga1; integrin alpha-1 [KO:K06480]
132810713  itga2.2; integrin alpha-2 [KO:K06481]
132831019  itga3b; integrin alpha-3b [KO:K06482]
132817503  itga4; integrin alpha-4 [KO:K06483]
132805742  integrin alpha-5-like [KO:K06484]
132817116  integrin alpha-6-like [KO:K06485]
132805812  integrin alpha-7-like isoform X1 [KO:K06583]
132830713  integrin alpha-8-like [KO:K06584]
132815769  itga8; integrin alpha-8 [KO:K06584]
132812346  itga9; integrin alpha-9 [KO:K06585]
132805507  itga10; integrin alpha-10 [KO:K06586]
132834389  itga11a; integrin alpha-11a isoform X1 [KO:K06587]
132817146  itgav; integrin alpha-V [KO:K06487]
132815812  integrin beta-1-like [KO:K05719]
132816136  integrin beta-1-like isoform X1 [KO:K05719]
132830920  integrin beta-3-like [KO:K06493]
132827702  itgb4; integrin beta-4 isoform X1 [KO:K06525]
132817070  itgb5; integrin beta-5 [KO:K06588]
132817082  itgb6; integrin beta-6 isoform X1 [KO:K06589]
132815934  itgb8; integrin beta-8 [KO:K06591]
132805537  tln1; talin-1 isoform X1 [KO:K06271]
132834837  talin-2 isoform X1 [KO:K06271]
132834896  vinculin isoform X1 [KO:K05700]
132814614  alpha-actinin-2 [KO:K21073]
132819689  alpha-actinin-2-like [KO:K21073]
132815054  actin, cytoplasmic type 5-like isoform X1 [KO:K05692]
132815056  actin, cytoplasmic type 5-like isoform X1 [KO:K05692]
132815057  actin-3-like [KO:K05692]
132815131  actin, non-muscle 6.2-like [KO:K05692]
132815132  actin, non-muscle 6.2 [KO:K05692]
132815133  actin, non-muscle 6.2-like [KO:K05692]
132825506  actb2; actin, cytoplasmic 2 [KO:K05692]
132828025  actin, cytoplasmic type 5 [KO:K05692]
132815134  actin, non-muscle 6.2-like [KO:K05692]
132822402  dag1; dystroglycan [KO:K06265]
132831040  epsilon-sarcoglycan-like isoform X1 [KO:K12565]
132815697  sgce; epsilon-sarcoglycan isoform X1 [KO:K27061]
132815372  sgcb; beta-sarcoglycan isoform X1 [KO:K12566]
132823451  sgcd; delta-sarcoglycan [KO:K12563]
132816787  sgcg; gamma-sarcoglycan [KO:K12564]
132815088  zeta-sarcoglycan [KO:K27062]
132826947  sspn; sarcospan [KO:K22194]
132821029  dmd; dystrophin isoform X1 [KO:K10366]
132823030  snta1; alpha-1-syntrophin [KO:K24063]
132812930  sntb1; beta-1-syntrophin [KO:K24064]
132823841  sntb2; beta-2-syntrophin isoform X1 [KO:K24064]
132814490  dtna; dystrobrevin alpha isoform X1 [KO:K26998]
132826696  flncb; filamin-C isoform X1 [KO:K27393]
132810202  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
132821070  sodium/potassium-transporting ATPase subunit alpha [KO:K01539] [EC:7.2.2.13]
132835145  sodium/potassium-transporting ATPase subunit beta-2-like isoform X1 [KO:K01540]
132820121  protein ATP1B4-like [KO:K01540]
132821067  sodium/potassium-transporting ATPase subunit beta-1-like [KO:K01540]
132821415  atp1b3a; sodium/potassium-transporting ATPase subunit beta-3a isoform X1 [KO:K01540]
132826204  ank3b; ankyrin-3 isoform X1 [KO:K09259]
132825936  sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
132836640  spectrin beta chain, non-erythrocytic 4-like [KO:K06115]
132818037  sptbn5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
132819767  sptbn1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
132836360  spectrin beta chain, non-erythrocytic 1-like isoform X1 [KO:K23932]
132824279  csrp3; cysteine and glycine-rich protein 3 [KO:K09377]
132828410  csrp1a; cysteine and glycine-rich protein 1a isoform X1 [KO:K09377]
132823041  myosin-7-like [KO:K24220]
132815876  myosin-7B-like [KO:K24220]
132827661  myosin-1B [KO:K24220]
132827662  myosin-4-like [KO:K24220]
132827664  myosin-4-like [KO:K24220]
132827666  myosin-4-like [KO:K24220]
132827990  myosin-2-like [KO:K24220]
132831254  myosin-9-like isoform X1 [KO:K10352]
132827645  myosin-10 isoform X1 [KO:K10352]
132825314  myosin-11-like isoform X1 [KO:K10352]
132817288  myosin light chain 1, skeletal muscle isoform-like isoform X1 [KO:K05738]
132815047  myosin light chain 3-like [KO:K12749]
132831022  myl4; myosin light chain 4 [KO:K12750]
132827118  myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
132833455  myosin light chain 5-like [KO:K12753]
132837052  myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
132822971  myosin regulatory light polypeptide 9 [KO:K12755]
132824838  mybpc1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
132831484  mybpc2a; myosin binding protein Ca isoform X1 [KO:K12558]
132824336  myosin-binding protein C, cardiac-type-like [KO:K12568]
132828249  myosin-binding protein H-like [KO:K24494]
132836344  actin, alpha cardiac muscle 1-like [KO:K12314]
132818173  actin, alpha cardiac muscle 1 [KO:K12314]
132822102  troponin C, slow skeletal and cardiac muscles [KO:K05865]
132828407  troponin I, slow skeletal muscle-like isoform X1 [KO:K10371]
132826619  troponin I, slow skeletal muscle-like [KO:K10371]
132826620  troponin I, slow skeletal muscle-like [KO:K10371]
132831195  troponin T, slow skeletal muscle-like [KO:K10372]
132822703  troponin C, skeletal muscle-like [KO:K12042]
132822891  troponin C, skeletal muscle-like isoform X1 [KO:K12042]
132824416  troponin I, fast skeletal muscle-like [KO:K12043]
132824413  troponin T, fast skeletal muscle isoforms-like isoform X1 [KO:K12046]
132826621  troponin T, fast skeletal muscle isoforms-like [KO:K12046]
132828116  tnnt2a; troponin T type 2a (cardiac) [KO:K12045]
132834645  tropomyosin alpha-1 chain isoform X1 [KO:K10373]
132806133  tropomyosin alpha-1 chain-like isoform X1 [KO:K10373]
132805620  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
132829072  tropomyosin alpha-1 chain isoform X1 [KO:K10375]
132817615  titin-like [KO:K12567] [EC:2.7.11.1]
132823205  myot; myotilin isoform X1 [KO:K19875]
132830819  telethonin-like [KO:K19879]
132830876  telethonin-like [KO:K19879]
132815173  telethonin-like [KO:K19879]
132816591  synaptopodin-2-like isoform X1 [KO:K24066]
132817034  neb; nebulin isoform X1 [KO:K18267]
132816115  nebl; nebulette isoform X1 [KO:K25865]
132834921  myozenin-1-like [KO:K26050]
132823292  myozenin-2 [KO:K26050]
132816603  myoz2b; myozenin-2b [KO:K26050]
132822262  PDZ and LIM domain protein 3-like isoform X1 [KO:K23353]
132835113  pdlim1; PDZ and LIM domain protein 1 [KO:K23353]
132836902  pdlim2; PDZ and LIM domain protein 2 isoform X1 [KO:K23353]
132823443  PDZ and LIM domain protein 4-like isoform X1 [KO:K23353]
132822491  F-actin-capping protein subunit alpha-2-like [KO:K10364]
132824921  F-actin-capping protein subunit alpha-2 [KO:K10364]
132828307  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
132833822  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
132815065  xin actin-binding repeat-containing protein 1-like [KO:K27381]
132817346  xirp2b; xin actin-binding repeat-containing protein 2 [KO:K27381]
132826297  nrap; nebulin-related-anchoring protein isoform X1 [KO:K24421]
132826194  mypn; myopalladin isoform X1 [KO:K22028]
132833451  pdlim5a; PDZ and LIM domain protein 5a isoform X1 [KO:K19867]
132834941  ldb3a; LIM domain-binding protein 3a [KO:K19867]
132823385  pdlim7; PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
132834165  tmod2; tropomodulin-2 [KO:K10370]
132829313  tmod1; tropomodulin-1 isoform X1 [KO:K10370]
132820345  fhl1a; four and a half LIM domains protein 1a [KO:K14365]
132832338  four and a half LIM domains protein 2-like isoform X1 [KO:K14380]
132816440  four and a half LIM domains protein 2 [KO:K14380]
132830134  fhl3a; four and a half LIM domains protein 3 [KO:K24414]
132822141  lmod3; leiomodin-3 isoform X1 [KO:K22030]
132824764  leiomodin-2-like [KO:K22030]
132828194  leiomodin-1-like [KO:K22030]
132826438  ankrd1b; ankyrin repeat domain-containing protein 1b [KO:K21433]
132826521  ankyrin repeat domain-containing protein 2-like [KO:K21434]
132831037  formin-like protein 1 isoform X1 [KO:K23957]
132805861  formin-like protein 3 [KO:K23957]
132817097  formin-like protein 2 isoform X1 [KO:K23957]
132817928  inf2; inverted formin-2 [KO:K23958]
132818320  LOW QUALITY PROTEIN: inverted formin-2-like [KO:K23958]
132831168  daam2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
132818275  daam1a; disheveled-associated activator of morphogenesis 1 [KO:K04512]
132823514  protein diaphanous homolog 1-like [KO:K05741]
132820465  diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
132816349  protein diaphanous homolog 3-like [KO:K05745]
132819346  fmn2b; formin-2 [KO:K02184]
132829893  myom3; myomesin-3 [KO:K24495]
132807427  myom2b; myomesin-2 [KO:K24495]
132814914  myom1b; myomesin-1 isoform X1 [KO:K24495]
132833805  eno1a; enolase 1a, (alpha) isoform X1 [KO:K01689] [EC:4.2.1.11]
132835352  beta-enolase [KO:K01689] [EC:4.2.1.11]
132816691  ank2b; ankyrin-2b [KO:K09255]
132836790  creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
132806841  trim54; tripartite motif-containing protein 54 isoform X1 [KO:K10653]
132815272  trim55a; tripartite motif-containing protein 55a isoform X1 [KO:K10654]
132830168  E3 ubiquitin-protein ligase TRIM63-like [KO:K10655] [EC:2.3.2.27]
132824460  AMP deaminase 3-like isoform X1 [KO:K01490] [EC:3.5.4.6]
132828346  AMP deaminase 2-like isoform X1 [KO:K01490] [EC:3.5.4.6]
132828444  ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
132817707  obscurin-like [KO:K17531] [EC:2.7.11.1]
132816236  obscnb; obscurin [KO:K17531] [EC:2.7.11.1]
132836295  calpain-11-like isoform X1 [KO:K08573] [EC:3.4.22.54]
132818086  calpain-3-like isoform X1 [KO:K08573] [EC:3.4.22.54]
132815908  plectin-like [KO:K10388]
132818456  syne3; nesprin-3 isoform X1 [KO:K21761]
132819864  nesprin-1-like isoform X1 [KO:K19326]
132818445  nesprin-2-like isoform X1 [KO:K19346]
132831321  sun2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
132825370  SUN domain-containing protein 1-like isoform X1 [KO:K19347]
132822048  transmembrane protein 43-like [KO:K27488]
132830341  lbr; delta(14)-sterol reductase LBR isoform X1 [KO:K19532] [EC:1.3.1.70]
132834223  lamin-L(III)-like [KO:K12641]
132823786  lmnb1; lamin-B1 [KO:K07611]
132828890  lmnb2; lamin-B2 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
hoc04512  ECM-receptor interaction
hoc04814  Motor proteins
KO pathway
ko04820   
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