KEGG   PATHWAY: lco04217
Entry
lco04217                    Pathway                                
Name
Necroptosis - Larimichthys crocea (large yellow croaker)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
lco04217  Necroptosis
lco04217

Organism
Larimichthys crocea (large yellow croaker) [GN:lco]
Gene
104931067  tumor necrosis factor [KO:K03156]
104931068  tumor necrosis factor-like [KO:K03156]
104933337  tumor necrosis factor-like [KO:K03156]
104929001  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
104930371  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
104930866  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
104939546  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
104925037  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
104936671  TNF receptor-associated factor 5 [KO:K09849]
104931522  ripk1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
104934542  inhibitor of apoptosis protein [KO:K16060]
104938662  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
104922306  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
104922367  ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
104939164  rnf31; E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
104932664  E3 ubiquitin-protein ligase RNF31 isoform X1 [KO:K11974] [EC:2.3.2.31]
104939449  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
104931528  sharpin [KO:K20894]
104935915  uncharacterized protein LOC104935915 [KO:K17595]
104925099  spata2; spermatogenesis-associated protein 2 [KO:K17595]
104938143  spata2l; spermatogenesis-associated protein 2-like protein [KO:K17595]
104934191  ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
104933539  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
104917650  cyld; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
104939366  ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
104933825  FAS-associated death domain protein [KO:K02373]
104938225  caspase-8 [KO:K04398] [EC:3.4.22.61]
104938227  caspase-8 [KO:K04398] [EC:3.4.22.61]
104924422  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
104928804  cflar; CASP8 and FADD-like apoptosis regulator [KO:K04724]
104936986  receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
104937235  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
104935860  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
104931702  camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
104925006  calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
104920649  calcium/calmodulin-dependent protein kinase type II delta chain isoform X1 [KO:K04515] [EC:2.7.11.17]
104936335  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515] [EC:2.7.11.17]
104921044  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
104924351  calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X4 [KO:K04515] [EC:2.7.11.17]
109141357  slc25a4; ADP/ATP translocase 1 [KO:K05863]
104931197  ADP/ATP translocase 2 [KO:K05863]
104931565  ADP/ATP translocase 3 [KO:K05863]
104932578  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
104931727  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
104930544  voltage-dependent anion-selective channel protein 2 [KO:K15040]
104930678  voltage-dependent anion-selective channel protein 2 [KO:K15040]
104921660  voltage-dependent anion-selective channel protein 2 isoform X2 [KO:K15041]
104934930  voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15041]
104936703  glutamate dehydrogenase, mitochondrial [KO:K00261] [EC:1.4.1.3]
104922307  glutamate dehydrogenase, mitochondrial [KO:K00261] [EC:1.4.1.3]
104918286  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
104930883  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
109139234  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
104938237  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
104935669  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
104936496  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
104926477  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
104922720  mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
104924269  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
104928586  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
109137480  ferritin, lower subunit-like [KO:K00522] [EC:1.16.3.1]
104919244  ferritin, heavy subunit [KO:K00522] [EC:1.16.3.1]
104931113  ferritin, middle subunit [KO:K00522] [EC:1.16.3.1]
104928844  ferritin, heavy subunit [KO:K00522] [EC:1.16.3.1]
104929913  cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
104921829  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104929914  cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
104935254  cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
104932304  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
104934901  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
104918347  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
104939931  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
104939929  calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
104934898  calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
104934897  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
104934896  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
104918327  calpain-2 catalytic subunit isoform X2 [KO:K03853] [EC:3.4.22.53]
104918337  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
104923818  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
104934603  mlkl; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
104920909  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
104931148  dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
104940665  dynamin-1-like protein isoform X2 [KO:K17065] [EC:3.6.5.5]
104933661  dynamin-1-like protein isoform X2 [KO:K17065] [EC:3.6.5.5]
104924727  apoptosis-associated speck-like protein containing a CARD isoform X1 [KO:K12799]
109142120  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
104924732  caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
104923462  interleukin-1 beta [KO:K04519]
104933433  chmp2a; charged multivesicular body protein 2a [KO:K12191]
104923836  chmp2b; charged multivesicular body protein 2b [KO:K12192]
109136651  chmp3; charged multivesicular body protein 3 [KO:K12193]
104937184  charged multivesicular body protein 4b isoform X2 [KO:K12194]
104933698  LOW QUALITY PROTEIN: charged multivesicular body protein 4b [KO:K12194]
104936175  chmp4b; charged multivesicular body protein 4b [KO:K12194]
104929570  chmp4c; charged multivesicular body protein 4c [KO:K24782]
104940299  charged multivesicular body protein 6 [KO:K12195]
104937338  chmp6; charged multivesicular body protein 6 [KO:K12195]
104919108  vacuolar protein sorting-associated protein 4B [KO:K12196]
104937186  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
104918295  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
104920599  charged multivesicular body protein 1b-2 [KO:K12197]
104940072  charged multivesicular body protein 1b [KO:K12197]
104937183  chmp1a; charged multivesicular body protein 1a [KO:K12197]
104925293  charged multivesicular body protein 5 [KO:K12198]
104937440  chmp7; charged multivesicular body protein 7 [KO:K15053]
104929767  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X2 [KO:K04982] [EC:2.7.11.1]
104939928  hmgb1; high mobility group protein B1 [KO:K10802]
104920041  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104939189  tumor necrosis factor ligand superfamily member 10 [KO:K04721]
104936786  tumor necrosis factor receptor superfamily member 10B-like precursor [KO:K04722]
104939559  tumor necrosis factor receptor superfamily member 10B isoform X3 [KO:K04722]
104917990  tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
104926008  tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
104929632  tumor necrosis factor receptor superfamily member 26 isoform X1 [KO:K04390]
109139382  interferon a3 [KO:K05414]
109138476  interferon a3-like [KO:K05414]
104932498  uncharacterized protein LOC104932498 [KO:K05131]
104931539  ifngr1l; interferon gamma receptor 1-like precursor [KO:K05132]
104918512  interferon gamma receptor 1-like isoform X1 [KO:K05132]
109139938  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
104923637  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
104918982  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
104927912  tyrosine-protein kinase JAK2 [KO:K11218] [EC:2.7.10.2]
109142264  tyk2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
104926239  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
104920795  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
104931961  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11221]
104925957  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
104920796  stat4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
104925974  signal transducer and activator of transcription 5B isoform X2 [KO:K11224]
104938972  signal transducer and activator of transcription 5B [KO:K11224]
104932951  signal transducer and activator of transcription 6 [KO:K11225]
104939165  LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
104918202  uncharacterized protein LOC104918202 [KO:K16195] [EC:2.7.11.1]
104924828  TIR domain-containing adapter molecule 1 [KO:K05842]
104917775  tlr3; toll-like receptor 3 precursor [KO:K05401]
104933236  ubiquitin carboxyl-terminal hydrolase 21-like [KO:K21634] [EC:3.4.19.12]
104938308  sqstm1; sequestosome-1 [KO:K14381]
104924694  heat shock protein HSP 90-alpha 1 [KO:K04079]
104924933  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
109136649  heat shock protein HSP 90-alpha isoform X1 [KO:K04079]
104928434  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
104921986  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
104933823  apoptosis regulator BAX [KO:K02159]
104923927  apoptosis regulator BAX [KO:K02159]
104927165  apoptosis regulator BAX isoform X2 [KO:K02159]
104934644  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
109137669  LOW QUALITY PROTEIN: histone H2A-beta, sperm [KO:K11251]
104939743  histone H2A [KO:K11251]
104939800  histone H2A [KO:K11251]
104935112  histone H2A [KO:K11251]
104936495  core histone macro-H2A.2 [KO:K11251]
104936813  late histone H2A.2.2 [KO:K11251]
104923457  histone H2A.V [KO:K11251]
104934515  histone H2AX [KO:K11251]
104935534  late histone H2A.L3 [KO:K11251]
104921797  histone H2A [KO:K11251]
104927203  histone H2A.Z [KO:K11251]
104939690  histone H2A [KO:K11251]
104939726  histone H2A [KO:K11251]
109138248  histone H2A [KO:K11251]
104935310  histone H2A [KO:K11251]
104924243  core histone macro-H2A.1 isoform X1 [KO:K11251]
104932847  histone H2A [KO:K11251]
104934128  peptidyl-prolyl cis-trans isomerase [KO:K03767] [EC:5.2.1.8]
104934127  peptidyl-prolyl cis-trans isomerase [KO:K03767] [EC:5.2.1.8]
104936527  peptidyl-prolyl cis-trans isomerase isoform X1 [KO:K03767] [EC:5.2.1.8]
104918293  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
104939569  apoptosis regulator Bcl-2-like [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
  Authors
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
lco00250  Alanine, aspartate and glutamate metabolism
lco04210  Apoptosis
KO pathway
ko04217   
LinkDB

DBGET integrated database retrieval system