KEGG   PATHWAY: mamb04217
Entry
mamb04217                   Pathway                                
Name
Necroptosis - Megalobrama amblycephala (Wuchang bream)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
mamb04217  Necroptosis
mamb04217

Organism
Megalobrama amblycephala (Wuchang bream) [GN:mamb]
Gene
125274751  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
125244232  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
125264677  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
125266535  traf2a; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
125266915  LOW QUALITY PROTEIN: TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
125267992  traf2b; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
125255103  uncharacterized protein LOC125255103 [KO:K09849]
125250625  ripk1l; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
125253483  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
125259069  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
125263552  rbck1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
125264973  shrprbck1r; LOW QUALITY PROTEIN: ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
125251677  E3 ubiquitin-protein ligase RNF31 [KO:K11974] [EC:2.3.2.31]
125251285  si:dkey-181m9.8; uncharacterized protein si:dkey-181m9.8 [KO:K11974] [EC:2.3.2.31]
125250449  sharpin; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K20894]
125264867  si:ch211-189a15.5; uncharacterized protein si:ch211-189a15.5 [KO:K17595]
125254433  spata2l; spermatogenesis associated 2-like [KO:K17595]
125259906  spata2; LOW QUALITY PROTEIN: spermatogenesis-associated protein 2 [KO:K17595]
125264294  si:cabz01101003.1; ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
125265064  cylda; LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD [KO:K08601] [EC:3.4.19.12]
125273991  cyldl; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
125265402  fadd; protein FADD [KO:K02373]
125266561  casp22; caspase-22 [KO:K04398] [EC:3.4.22.61]
125274320  casp8l1; caspase 8, apoptosis-related cysteine peptidase, like 1 isoform X1 [KO:K04398] [EC:3.4.22.61]
125274321  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
125268421  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
125269841  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
125257039  cflara; CASP8 and FADD-like apoptosis regulator a [KO:K04724]
125269848  CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
125264282  ripk3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
125257067  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
125252343  camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
125262414  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
125272496  camk2d2; calcium/calmodulin-dependent protein kinase type II delta 2 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
125265885  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain isoform X1 [KO:K04515] [EC:2.7.11.17]
125266459  camk2b1; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
125255303  camk2g1; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma 1 isoform X1 [KO:K04515] [EC:2.7.11.17]
125276818  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
125270154  slc25a6; ADP/ATP translocase 3 [KO:K05863]
125258732  slc25a5; ADP/ATP translocase 2 [KO:K05863]
125272556  slc25a4; ADP/ATP translocase 1 [KO:K05863]
125267772  si:dkey-251i10.1; ADP/ATP translocase 3 [KO:K05863]
125258910  ppid; peptidyl-prolyl cis-trans isomerase D isoform X1 [KO:K05864] [EC:5.2.1.8]
125252917  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
125255500  voltage-dependent anion-selective channel protein 2-like [KO:K15040]
125276634  vdac2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
125262510  zgc:56235; voltage-dependent anion-selective channel protein 2-like [KO:K15041]
125279676  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
125255828  glud1b; glutamate dehydrogenase 1b [KO:K00261] [EC:1.4.1.3]
125276829  glud1a; glutamate dehydrogenase 1a [KO:K00261] [EC:1.4.1.3]
125253222  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
125253223  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
125273848  glulb; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
125250860  glula; glutamate-ammonia ligase (glutamine synthase) a [KO:K01915] [EC:6.3.1.2]
125264482  pygmb; phosphorylase, glycogen, muscle b [KO:K00688] [EC:2.4.1.1]
125252697  pygma; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
125268797  pygb; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
125277313  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
125252240  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125252441  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125255077  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125277047  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125258190  zgc:56095; ferritin, lower subunit-like [KO:K00522] [EC:1.16.3.1]
125261789  ferritin, lower subunit-like [KO:K00522] [EC:1.16.3.1]
125264407  fth1a; ferritin, heavy polypeptide 1a [KO:K00522] [EC:1.16.3.1]
125248020  fth1b; ferritin, heavy polypeptide 1b [KO:K00522] [EC:1.16.3.1]
125277052  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
125277059  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
125277066  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
125277071  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
125277078  ferritin, middle subunit-like [KO:K00522] [EC:1.16.3.1]
125261869  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125261870  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125262001  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125278200  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
125245073  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125246655  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266030  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266031  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266034  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
125266162  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266251  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266252  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266253  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266254  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266255  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266256  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266257  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266258  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266259  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266261  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266268  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266277  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266278  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266279  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266336  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125250122  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
125268789  pla2g4f.2; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
125268790  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
125263730  capn1b; calpain-1 catalytic subunit b [KO:K01367] [EC:3.4.22.52]
125252746  si:dkeyp-50d11.2; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
125265358  capn1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
125276706  capn1a; calpain 1, (mu/I) large subunit a [KO:K01367] [EC:3.4.22.52]
125269037  calpain-1 catalytic subunit-like isoform X1 [KO:K01367] [EC:3.4.22.52]
125269039  si:ch211-202f3.3; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
125263723  capn2l; calpain 2, (m/II) large subunit, like [KO:K03853] [EC:3.4.22.53]
125263724  capn8; calpain-8 [KO:K03853] [EC:3.4.22.53]
125263725  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
125263726  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
125263728  calpain-2 catalytic subunit-like [KO:K03853] [EC:3.4.22.53]
125263731  capn2b; calpain 2, (m/II) large subunit b [KO:K03853] [EC:3.4.22.53]
125276707  capn2a; calpain 2, (m/II) large subunit a [KO:K03853] [EC:3.4.22.53]
125258602  smpd1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
125247600  mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
125267223  pgam5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
125246774  dnm1l; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
125280367  si:dkey-32e23.4; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
125242861  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
125242858  caspa; caspase a [KO:K01370] [EC:3.4.22.36]
125271030  caspase b-like [KO:K01370] [EC:3.4.22.36]
125271512  caspase b-like [KO:K01370] [EC:3.4.22.36]
125262403  interleukin-1 beta-like [KO:K04519]
125262404  interleukin-1 beta-like [KO:K04519]
125255231  chmp2a; charged multivesicular body protein 2a [KO:K12191]
125269929  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
125272254  chmp2bb; charged multivesicular body protein 2b [KO:K12192]
125268974  chmp3; charged multivesicular body protein 3 [KO:K12193]
125261572  charged multivesicular body protein 4c [KO:K12194]
125262802  charged multivesicular body protein 4c [KO:K12194]
125273567  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
125258002  chmp4c; charged multivesicular body protein 4c [KO:K24782]
125263778  chmp6a; charged multivesicular body protein 6 [KO:K12195]
125255314  chmp6b; charged multivesicular body protein 6 [KO:K12195]
125247106  vps4a; vacuolar protein sorting-associated protein 4A isoform X1 [KO:K12196]
125251478  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
125251779  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
125247275  chmp1a; charged multivesicular body protein 1a [KO:K12197]
125266575  chmp1b; charged multivesicular body protein 1b [KO:K12197]
125250507  chmp5a; charged multivesicular body protein 5 [KO:K12198]
125261390  chmp5b; charged multivesicular body protein 5 [KO:K12198]
125280413  chmp7; charged multivesicular body protein 7 isoform X1 [KO:K15053]
125254727  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
125249530  hmgb1b; high mobility group protein B1b [KO:K10802]
125261279  hmgb1a; high mobility group protein B1a [KO:K10802]
125258532  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
125266562  tnfsf10l4; tumor necrosis factor (ligand) superfamily, member 10 like 4 [KO:K04721]
125266505  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
125279072  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125268751  fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
125272663  ifnphi1; interferon phi 1 isoform X1 [KO:K05414]
125250057  ifnphi3; interferon phi 3 [KO:K05414]
125268605  uncharacterized protein LOC125268605 [KO:K05414]
125245511  ifng1; interferon gamma 1 isoform X1 [KO:K04687]
125269711  crfb2; cytokine receptor family member b2 [KO:K05131]
125277488  interferon gamma receptor 1-like [KO:K05132]
125271771  ifngr1; interferon gamma receptor 1 [KO:K05132]
125273972  jak1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
125250111  tyrosine-protein kinase JAK1-like [KO:K11217] [EC:2.7.10.2]
125252489  jak2a; tyrosine-protein kinase JAK2a [KO:K04447] [EC:2.7.10.2]
125267577  jak2b; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
125280636  tyrosine-protein kinase JAK2-like isoform X1 [KO:K11218] [EC:2.7.10.2]
125268759  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
125270612  stat1b; signal transducer and activator of transcription 1b [KO:K11220]
125254061  stat1a; signal transducer and activator of transcription 1a isoform X1 [KO:K11220]
125273698  stat2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
125279525  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
125270610  stat4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
125279545  stat5a; signal transducer and activator of transcription 5A [KO:K11224]
125255293  stat5b; LOW QUALITY PROTEIN: signal transducer and activator of transcription 5B [KO:K11224]
125259594  stat6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
125255446  irf9; interferon regulatory factor 9 [KO:K04693]
125276480  interferon-induced, double-stranded RNA-activated protein kinase-like isoform X1 [KO:K16195] [EC:2.7.11.1]
125276481  interferon-induced, double-stranded RNA-activated protein kinase-like isoform X1 [KO:K16195] [EC:2.7.11.1]
125276617  toll-like receptor 4 [KO:K10160]
125276618  tlr4bb; toll-like receptor 4b, duplicate b isoform X1 [KO:K10160]
125276619  toll-like receptor 4 [KO:K10160]
125263270  ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
125272563  tlr3; toll-like receptor 3 [KO:K05401]
125260822  usp21; ubiquitin carboxyl-terminal hydrolase 21 [KO:K21634] [EC:3.4.19.12]
125259046  sqstm1; sequestosome-1 [KO:K14381]
125278538  hsp90ab1; heat shock protein HSP 90-beta [KO:K04079]
125278599  hsp90aa1.2; heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 isoform X1 [KO:K04079]
125278600  hsp90aa1.1; heat shock protein HSP 90-alpha 1 [KO:K04079]
125277485  tnfaip3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
125278426  poly [ADP-ribose] polymerase 1-like [KO:K24070] [EC:2.4.2.30]
125254700  bida; BH3 interacting domain death agonist [KO:K04726]
125272083  baxa; BCL2 associated X, apoptosis regulator a [KO:K02159]
125265753  zgc:153993; apoptosis regulator BAX isoform X1 [KO:K02159]
125277032  baxb; BCL2 associated X, apoptosis regulator b isoform X1 [KO:K02159]
125266557  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
125258318  histone H2A-like [KO:K11251]
125262140  histone H2A [KO:K11251]
125262407  histone H2A.V [KO:K11251]
125262679  histone H2AX-like [KO:K11251]
125264158  histone H2A-like [KO:K11251]
125264199  histone H2A-like [KO:K11251]
125252954  core histone macro-H2A.1 [KO:K11251]
125265260  histone H2A-like [KO:K11251]
125265262  histone H2A-like [KO:K11251]
125265348  histone H2A-like [KO:K11251]
125265349  histone H2A-like [KO:K11251]
125246607  histone H2A-like [KO:K11251]
125246608  histone H2A-like [KO:K11251]
125246609  histone H2A-like [KO:K11251]
125246610  histone H2A-like [KO:K11251]
125246611  histone H2A-like [KO:K11251]
125246612  histone H2A-like [KO:K11251]
125246613  histone H2A-like [KO:K11251]
125246614  histone H2A-like [KO:K11251]
125246615  histone H2A-like [KO:K11251]
125246616  histone H2A-like [KO:K11251]
125246617  histone H2A-like [KO:K11251]
125246618  histone H2A-like [KO:K11251]
125246619  histone H2A-like [KO:K11251]
125253777  histone H2A-like [KO:K11251]
125253778  histone H2A-like [KO:K11251]
125253779  histone H2A-like [KO:K11251]
125265605  histone H2A.Z [KO:K11251]
125265643  histone H2A-like [KO:K11251]
125265645  histone H2A-like [KO:K11251]
125265646  histone H2A-like [KO:K11251]
125273028  histone H2A, sperm [KO:K11251]
125247293  histone H2A-like [KO:K11251]
125247294  histone H2A-like [KO:K11251]
125247295  histone H2A-like [KO:K11251]
125247351  histone H2A-like [KO:K11251]
125247352  histone H2A [KO:K11251]
125265903  histone H2A-like [KO:K11251]
125265904  histone H2A-like [KO:K11251]
125265905  histone H2A-like [KO:K11251]
125265906  histone H2A-like [KO:K11251]
125254334  histone H2A-like [KO:K11251]
125254401  histone H2A-like [KO:K11251]
125254590  histone H2A-like [KO:K11251]
125254591  histone H2A-like [KO:K11251]
125247980  histone H2A-like [KO:K11251]
125254670  histone H2A-like [KO:K11251]
125266767  histone H2AX [KO:K11251]
125267352  histone H2A.V [KO:K11251]
125249345  histone H2A-like [KO:K11251]
125276682  core histone macro-H2A.2 [KO:K11251]
125262417  ppiab; LOW QUALITY PROTEIN: peptidylprolyl isomerase Ab (cyclophilin A) [KO:K03767] [EC:5.2.1.8]
125262418  peptidyl-prolyl cis-trans isomerase-like [KO:K03767] [EC:5.2.1.8]
125279920  ppiaa; peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
125258583  bcl2a; apoptosis regulator Bcl-2a isoform X1 [KO:K02161]
125251012  bcl2b; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
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Related
pathway
mamb00250  Alanine, aspartate and glutamate metabolism
mamb04210  Apoptosis
KO pathway
ko04217   
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