KEGG   PATHWAY: mcf04148
Entry
mcf04148                    Pathway                                
Name
Efferocytosis - Macaca fascicularis (crab-eating macaque)
Class
Cellular Processes; Transport and catabolism
Pathway map
mcf04148  Efferocytosis
mcf04148

Organism
Macaca fascicularis (crab-eating macaque) [GN:mcf]
Gene
102144182  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
102127213  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
102118885  CASP1; caspase-1 [KO:K01370] [EC:3.4.22.36]
102132936  PANX1; pannexin-1 [KO:K03443]
102123171  P2RY2; P2Y purinoceptor 2 [KO:K04269]
102125133  P2RY6; P2Y purinoceptor 6 [KO:K04272]
102122720  P2RY12; P2Y purinoceptor 12 [KO:K04298]
101926057  SPHK1; sphingosine kinase 1 isoform X2 [KO:K04718] [EC:2.7.1.91]
102116114  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
102127318  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
101926332  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
102117645  ABCA1; phospholipid-transporting ATPase ABCA1 isoform X2 [KO:K05641]
102115816  GPR132; probable G-protein coupled receptor 132 isoform X1 [KO:K08426]
102116784  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
101925715  ADAM10; LOW QUALITY PROTEIN: disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
102117496  CX3CL1; fractalkine isoform X1 [KO:K05508]
101925250  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
102136960  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
102133233  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102136724  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102125274  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X2 [KO:K17334]
101866092  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
102118770  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
101925524  EPO; erythropoietin precursor [KO:K05437]
102138718  EPOR; erythropoietin receptor [KO:K05079]
102119008  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
102145011  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102116996  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
102129932  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
102120453  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
102133330  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
102134091  MFGE8; lactadherin [KO:K17253]
102133887  GAS6; growth arrest-specific protein 6 isoform X1 [KO:K05464]
102143798  MERTK; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
101926577  CD36; platelet glycoprotein 4 [KO:K06259]
102130245  THBS1; thrombospondin-1 [KO:K16857]
102141214  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102140855  dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
102143028  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102121812  PTGER2; prostaglandin E2 receptor EP2 subtype isoform X1 [KO:K04259]
101865027  PTGER4; prostaglandin E2 receptor EP4 subtype isoform X1 [KO:K04261]
102123287  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
102141699  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X2 [KO:K05870]
102129546  TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375]
101867165  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102114913  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X2 [KO:K05853] [EC:7.2.2.10]
101867359  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
101926613  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102126681  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101865637  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101866326  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
101867352  MAPK13; mitogen-activated protein kinase 13 isoform X2 [KO:K04441] [EC:2.7.11.24]
101926770  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102134421  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
101867305  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
102131033  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X2 [KO:K04443] [EC:2.7.11.1]
102132853  ALOX5; polyunsaturated fatty acid 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
102124513  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
102137290  LOW QUALITY PROTEIN: polyunsaturated fatty acid (12S)/(13S)-lipoxygenase, epidermal-type-like [KO:K00460] [EC:1.13.11.33]
102118860  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102122216  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102136160  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102115345  DUSP16; dual specificity protein phosphatase 16 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102121929  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102139955  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102115746  ANO6; anoctamin-6 isoform X1 [KO:K19500]
101865236  ANO3; anoctamin-3 isoform X2 [KO:K19498]
102114977  ANO4; anoctamin-4 isoform X1 [KO:K19499]
102145190  ANO5; anoctamin-5 isoform X1 [KO:K19480]
102141451  ANO7; anoctamin-7 isoform X2 [KO:K19501]
102119631  ANO9; anoctamin-9 isoform X1 [KO:K19503]
102121721  BSG; basigin isoform X1 [KO:K06535]
102144353  XKR8; XK-related protein 8 [KO:K26813]
102132974  XKR9; XK-related protein 9 [KO:K26814]
102146761  XKR7; XK-related protein 7 [KO:K26811]
107130617  XKR4; XK-related protein 4 [KO:K26811]
102137797  XKR6; XK-related protein 6 [KO:K26811]
102145170  ATP8A1; phospholipid-transporting ATPase IA isoform X2 [KO:K14802] [EC:7.6.2.1]
102145479  ATP8A2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
101925402  ATP11B; phospholipid-transporting ATPase IF isoform X1 [KO:K26934] [EC:7.6.2.1]
102114806  ATP11A; phospholipid-transporting ATPase IH isoform X3 [KO:K26934] [EC:7.6.2.1]
102116390  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
102120490  TMEM30A; cell cycle control protein 50A [KO:K26935]
101865088  PROS1; vitamin K-dependent protein S isoform X1 [KO:K03908]
102116249  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
102117791  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
102123619  ITGB5; integrin beta-5 [KO:K06588]
102126361  AXL; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
102135978  TYRO3; tyrosine-protein kinase receptor TYRO3 [KO:K05116] [EC:2.7.10.1]
102129770  ADGRB1; adhesion G protein-coupled receptor B1 isoform X1 [KO:K04596]
102140672  TIMD4; T-cell immunoglobulin and mucin domain-containing protein 4 isoform X1 [KO:K26936]
102141332  HAVCR1; hepatitis A virus cellular receptor 1 isoform X3 [KO:K20413]
102141722  HAVCR2; hepatitis A virus cellular receptor 2 [KO:K20414]
102121124  AGER; advanced glycosylation end product-specific receptor [KO:K19722]
102122730  STAB1; stabilin-1 isoform X1 [KO:K19020]
102137090  STAB2; stabilin-2 isoform X3 [KO:K19013]
101925550  PTK2; focal adhesion kinase 1 isoform X6 [KO:K05725] [EC:2.7.10.2]
102114845  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
102122623  CRKL; crk-like protein [KO:K04438]
101865065  CRK; adapter molecule crk isoform X1 [KO:K04438]
101925562  ELMO1; engulfment and cell motility protein 1 isoform X2 [KO:K12366]
102131974  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
101866593  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102134837  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
102119780  ADAM9; disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
102121336  CALR; calreticulin [KO:K08057]
107126479  C1QA; complement C1q subcomponent subunit A [KO:K03986]
102139434  C1QB; complement C1q subcomponent subunit B [KO:K03987]
102130549  C1QC; complement C1q subcomponent subunit C isoform X1 [KO:K03988]
102119582  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
102124212  MEGF10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
102133447  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X8 [KO:K24068]
102146351  SCARF1; scavenger receptor class F member 1 isoform X1 [KO:K24318]
102120990  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X3 [KO:K23285]
102124977  RAB17; ras-related protein Rab-17 isoform X1 [KO:K07909]
102144117  RAB5A; ras-related protein Rab-5A [KO:K07887]
101865961  RAB5B; ras-related protein Rab-5B [KO:K07888]
102116190  RAB5C; ras-related protein Rab-5C [KO:K07889]
102133230  ras-related protein Rab-5C-like [KO:K07889]
102132918  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
101866098  VPS8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
102126928  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
102126359  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
101926226  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
101926604  VPS33A; vacuolar protein sorting-associated protein 33A isoform X2 [KO:K20182]
102123446  RAB14; ras-related protein Rab-14 [KO:K07881]
102146451  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
102126362  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
102143515  RAB7A; ras-related protein Rab-7a [KO:K07897]
102137760  RAB7B; ras-related protein Rab-7b isoform X4 [KO:K07898]
102142794  SLC66A1; lysosomal amino acid transporter 1 homolog isoform X5 [KO:K23678]
102131487  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
101866868  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
102141093  antizyme inhibitor 2-like isoform X1 [KO:K01581] [EC:4.1.1.17]
101865394  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
102131529  ornithine decarboxylase-like [KO:K01581] [EC:4.1.1.17]
102142173  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
102122176  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
101867045  NR1H2; oxysterols receptor LXR-beta isoform X1 [KO:K08535]
101926183  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform [KO:K08765] [EC:2.3.1.21]
101866032  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
102134440  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform isoform X10 [KO:K19524] [EC:2.3.1.21]
102132017  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
102133631  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
102134009  SIRT1; NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
102132310  PBX1; pre-B-cell leukemia transcription factor 1 isoform X4 [KO:K09355]
102133450  IL10; interleukin-10 [KO:K05443]
101926160  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
101925346  PLA2G15; phospholipase A2 group XV isoform X2 [KO:K06129] [EC:3.1.1.5]
102125360  PPARD; peroxisome proliferator-activated receptor delta isoform X2 [KO:K04504]
102144217  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
101866764  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
101866184  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
102139846  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
101867055  CD24; signal transducer CD24 isoform X2 [KO:K06469]
102117792  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
102125591  SIGLEC10; sialic acid-binding Ig-like lectin 10 isoform X1 [KO:K06749]
102138723  signal-regulatory protein gamma [KO:K06551]
102141933  signal-regulatory protein beta-1-like [KO:K06551]
101926317  SIRPA; tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1 [KO:K06551]
102133910  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X2 [KO:K05697] [EC:3.1.3.48]
102129572  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X2 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
mcf00010  Glycolysis / Gluconeogenesis
mcf04140  Autophagy - animal
mcf04145  Phagosome
KO pathway
ko04148   
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