KEGG   PATHWAY: mna04510
Entry
mna04510                    Pathway                                
Name
Focal adhesion - Miniopterus natalensis (Natal long-fingered bat)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
mna04510  Focal adhesion
mna04510

Other DBs
GO: 0005925
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:mna]
Gene
107539184  COL1A1; collagen alpha-1(I) chain [KO:K06236]
107541704  COL1A2; collagen alpha-2(I) chain [KO:K06236]
107528223  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
107530382  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
107530384  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
107526032  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
107526046  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
107525529  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
107525530  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
107536231  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
107536232  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
107546062  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
107546063  collagen alpha-4(VI) chain-like [KO:K06238]
107546119  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
107530028  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
107529178  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
107523880  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
107531189  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
107530937  LAMA2; laminin subunit alpha-2 [KO:K05637]
107535878  LAMA1; laminin subunit alpha-1 [KO:K05637]
107529572  LAMA5; laminin subunit alpha-5 [KO:K06240]
107535921  laminin subunit alpha-3-like [KO:K06240]
107535922  laminin subunit alpha-3-like [KO:K06240]
107540693  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
107526620  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
107529446  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
107529447  laminin subunit beta-2-like [KO:K06243]
107532931  LAMB3; laminin subunit beta-3 [KO:K06244]
107526629  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
107546271  LAMC1; laminin subunit gamma-1 [KO:K05635]
107546249  LAMC2; laminin subunit gamma-2 [KO:K06246]
107524677  LAMC3; laminin subunit gamma-3 [KO:K06247]
107529842  CHAD; chondroadherin [KO:K06248]
107542305  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
107543012  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
107543851  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
107535067  THBS4; thrombospondin-4 [KO:K04659]
107535388  COMP; cartilage oligomeric matrix protein [KO:K04659]
107537025  THBS2; thrombospondin-2 [KO:K04659]
107524737  FN1; fibronectin isoform X1 [KO:K05717]
107537117  SPP1; osteopontin [KO:K06250]
107528756  VTN; vitronectin [KO:K06251]
107543746  TNN; tenascin-N [KO:K06252]
107543769  TNR; tenascin-R [KO:K06252]
107535445  TNC; tenascin [KO:K06252]
107538944  TNXB; tenascin-X [KO:K06252]
107544091  VWF; von Willebrand factor [KO:K03900]
107537112  IBSP; bone sialoprotein 2 [KO:K06253]
107526271  integrin alpha-1-like [KO:K06480]
107527140  ITGA2; integrin alpha-2 [KO:K06481]
107528854  ITGA2B; integrin alpha-IIb [KO:K06476]
107539175  ITGA3; integrin alpha-3 [KO:K06482]
107546708  ITGA4; integrin alpha-4 [KO:K06483]
107541067  ITGA5; integrin alpha-5 [KO:K06484]
107530895  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
107538226  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
107530252  ITGA8; integrin alpha-8 [KO:K06584]
107529098  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
107525841  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
107536679  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
107525073  ITGB1; integrin beta-1 [KO:K05719]
107530883  ITGB3; integrin beta-3 [KO:K06493]
107536630  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
107527350  ITGB5; integrin beta-5 [KO:K06588]
107523936  ITGB6; integrin beta-6 [KO:K06589]
107528299  ITGB7; integrin beta-7 [KO:K06590]
107540309  ITGB8; integrin beta-8 [KO:K06591]
107525432  EMP2; epithelial membrane protein 2 [KO:K26256]
107543141  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
107531241  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
107527538  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
107532411  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
107534373  EGF; pro-epidermal growth factor [KO:K04357]
107545147  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
107536886  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
107539800  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
107533829  PGF; placenta growth factor isoform X1 [KO:K16859]
107541939  VEGFC; vascular endothelial growth factor C [KO:K05449]
107529497  FIGF; vascular endothelial growth factor D [KO:K05449]
107527167  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
107532710  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
107535230  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
107527774  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
107532764  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
107525996  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
107534361  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
107528437  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
107528536  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
107529006  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
107525295  EMP1; epithelial membrane protein 1 [KO:K26255]
107542143  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
107540055  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
107534406  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
107529450  RHOA; transforming protein RhoA [KO:K04513]
107531488  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
107535907  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
107542396  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
107529566  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
107524124  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
107542067  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
107544330  myosin regulatory light polypeptide 9 [KO:K12755]
107542167  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
107526566  MYL10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
107535889  myosin regulatory light chain 12B [KO:K12757]
107535890  myosin regulatory light polypeptide 9 [KO:K12757]
107541481  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
107534692  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
107533957  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
107529564  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
107526828  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
107536013  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
107541310  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
107542256  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
107535858  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
107527759  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
107539122  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
107538124  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
107525631  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
107539076  ACTG1; actin, cytoplasmic 2 [KO:K05692]
107537600  ACTB; actin, cytoplasmic 1 [KO:K05692]
107541035  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
107543584  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
107532204  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
107545701  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
107544935  TLN1; talin-1 [KO:K06271]
107533761  TLN2; talin-2 [KO:K06271]
107545550  FLNA; filamin-A [KO:K04437]
107531471  FLNB; filamin-B [KO:K27392]
107528505  PXN; paxillin isoform X1 [KO:K05760]
107540507  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
107523764  ZYX; zyxin [KO:K06273]
107536769  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
107545822  VCL; vinculin isoform X1 [KO:K05700]
107534848  PARVG; gamma-parvin [KO:K06275]
107534855  PARVB; beta-parvin [KO:K06275]
107535314  PARVA; alpha-parvin [KO:K06275]
107533364  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
107542383  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
107528331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107534199  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
107527219  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
107524266  CTNNB1; catenin beta-1 [KO:K02105]
107538300  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
107544745  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
107540426  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
107533206  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
107532628  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
107538463  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
107541106  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
107526728  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
107529317  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
107535325  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
107543303  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
107525716  VAV1; proto-oncogene vav [KO:K05730]
107524668  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
107541170  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
107537179  guanine nucleotide exchange factor VAV3 [KO:K05730]
107537599  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
107545262  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
107539040  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
107524443  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
107527275  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
107525908  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
107544471  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
107536364  PAK7; serine/threonine-protein kinase PAK 7 [KO:K05736] [EC:2.7.11.1]
107543032  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
107538414  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
107540891  cell division control protein 42 homolog [KO:K04393]
107524660  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
107535608  CRK; adapter molecule crk isoform X1 [KO:K04438]
107530545  CRKL; crk-like protein [KO:K04438]
107535162  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
107524638  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
107545324  RAP1A; ras-related protein Rap-1A [KO:K04353]
107526932  RAP1B; ras-related protein Rap-1b [KO:K07836]
107537133  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
107527953  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
107528432  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
107536966  JUN; transcription factor AP-1 [KO:K04448]
107531103  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
107528537  CAV1; caveolin-1 [KO:K06278]
107528527  CAV2; caveolin-2 [KO:K12958]
107534781  CAV3; caveolin-3 [KO:K12959]
107540684  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
107543890  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
107538554  SHC2; SHC-transforming protein 2 [KO:K17447]
107529164  SHC3; SHC-transforming protein 3 [KO:K17448]
107535558  SHC4; LOW QUALITY PROTEIN: SHC-transforming protein 4 [KO:K17449]
107536618  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
107525851  SOS2; son of sevenless homolog 2 [KO:K03099]
107541780  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
107542351  HRAS; GTPase HRas isoform X1 [KO:K02833]
107534729  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
107533801  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
107541504  MAPK3; LOW QUALITY PROTEIN: mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
107530451  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
107541393  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
107537434  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
107538904  CCND2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
107536896  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
107532417  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
107532418  baculoviral IAP repeat-containing protein 3-like [KO:K16060]
107524984  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
107539805  BAD; bcl2-associated agonist of cell death [KO:K02158]
107545431  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
mna04010  MAPK signaling pathway
mna04060  Cytokine-cytokine receptor interaction
mna04070  Phosphatidylinositol signaling system
mna04110  Cell cycle
mna04151  PI3K-Akt signaling pathway
mna04310  Wnt signaling pathway
mna04512  ECM-receptor interaction
mna04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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