Entry
Name
Cytokine-cytokine receptor interaction - Miniopterus natalensis (Natal long-fingered bat)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
mna04060 Cytokine-cytokine receptor interaction
Organism
Miniopterus natalensis (Natal long-fingered bat) [GN:
mna ]
Gene
107525060 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
107525448 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
107525711 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
107525739 EBI3; LOW QUALITY PROTEIN: interleukin-27 subunit beta [KO:K24476 ]
107525752 TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477 ]
107526929 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
107527134 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
107527297 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
107528723 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
107529000 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
107530196 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
107530220 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
107530873 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
107531354 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
107531533 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
107531534 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
107532703 IL1R2; LOW QUALITY PROTEIN: interleukin-1 receptor type 2 [KO:K04387 ]
107532895 IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070 ]
107533181 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B isoform X1 [KO:K05148 ]
107533523 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
107533654 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
107533922 TNFRSF14; tumor necrosis factor receptor superfamily member 14 [KO:K05152 ]
107535578 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
107535579 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
107535808 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
107536816 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
107538338 TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160 ]
107538341 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
107539187 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
107539194 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
107541712 BMP8A; LOW QUALITY PROTEIN: bone morphogenetic protein 8A [KO:K16622 ]
107542574 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
107543257 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
107543690 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
107543700 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
107543743 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
107543787 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
107543794 TNFSF18; tumor necrosis factor ligand superfamily member 18 isoform X1 [KO:K05479 ]
107543958 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
107543972 LTBR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
107544039 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
107544337 IL27RA; LOW QUALITY PROTEIN: interleukin-27 receptor subunit alpha [KO:K19598 ]
107544615 TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475 ]
107544616 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
107545016 CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059 ]
107545409 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway