KEGG   PATHWAY: mthb05415
Entry
mthb05415                   Pathway                                
Name
Diabetic cardiomyopathy - Macaca thibetana thibetana (Pere David's macaque)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
mthb05415  Diabetic cardiomyopathy
mthb05415

Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126959708  solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
126939701  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
126956904  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
126934018  glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X1 [KO:K00820] [EC:2.6.1.16]
126962427  calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
126955622  calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
126956598  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
126950160  calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
126943251  troponin I, cardiac muscle isoform X1 [KO:K12044]
126942683  ryanodine receptor 2 isoform X1 [KO:K04962]
126952106  cardiac phospholamban [KO:K05852]
126931431  sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
126944432  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
126939937  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
126931105  transcription factor Sp1 isoform X1 [KO:K04684]
126942065  angiotensinogen isoform X1 [KO:K09821]
126939551  renin [KO:K01380] [EC:3.4.23.15]
126959477  chymase [KO:K01329] [EC:3.4.21.39]
126944386  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
126953221  advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
126946357  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
126950372  neutrophil cytosol factor 1 [KO:K08011]
126944340  cytochrome b-245 light chain isoform X1 [KO:K08009]
126940149  neutrophil cytosol factor 2 isoform X1 [KO:K08010]
126963740  neutrophil cytosol factor 4 isoform X1 [KO:K08012]
126954326  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
126950508  ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
126963767  ras-related C3 botulinum toxin substrate 2 [KO:K07860]
126947490  type-1 angiotensin II receptor [KO:K04166]
126955390  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
126935358  transcription factor p65 isoform X1 [KO:K04735]
126952773  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
126952775  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
126929437  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
126929447  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
126954697  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126963142  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126956917  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126945112  72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
126963805  matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
126949926  collagen alpha-2(I) chain isoform X1 [KO:K06236]
126939864  collagen alpha-1(I) chain isoform X1 [KO:K06236]
126933167  collagen alpha-1(III) chain [KO:K19720]
126941768  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
126948495  transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
126959539  transforming growth factor beta-3 proprotein [KO:K13377]
126951242  platelet glycoprotein 4 [KO:K06259]
126963592  peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
126929429  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
126949933  pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
126939874  pyruvate dehydrogenase kinase, isozyme 2 isoform X1 [KO:K00898] [EC:2.7.11.2]
126946719  pyruvate dehydrogenase kinase, isozyme 3 [KO:K00898] [EC:2.7.11.2]
126938340  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
126948783  protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
126937038  serine/threonine-protein phosphatase 2A activator isoform X1 [KO:K17605]
126931492  serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
126933834  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
126935389  serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
126935841  cathepsin D [KO:K01379] [EC:3.4.23.5]
126951757  protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
126962177  carnitine O-palmitoyltransferase 2, mitochondrial [KO:K08766] [EC:2.3.1.21]
126935873  insulin isoform X1 [KO:K04526]
126942469  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
126932885  insulin receptor substrate 1 [KO:K16172]
126947557  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
126952893  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
126948170  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
126961422  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
126956531  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
126942202  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
126963336  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
126943096  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
126959416  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126942032  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
126952739  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
126949239  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
126930517  glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
126943552  glycogen [starch] synthase, muscle isoform X1 [KO:K00693] [EC:2.4.1.11]
126940500  TBC1 domain family member 4 isoform X1 [KO:K17902]
126946894  LOW QUALITY PROTEIN: mitochondrial pyruvate carrier 1-like protein [KO:K22138]
126953778  mitochondrial pyruvate carrier 1 [KO:K22138]
126932543  mitochondrial pyruvate carrier 2-like [KO:K22139]
126958710  mitochondrial pyruvate carrier 2-like [KO:K22139]
126941736  mitochondrial pyruvate carrier 2 isoform X1 [KO:K22139]
126954291  LOW QUALITY PROTEIN: pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial [KO:K00161] [EC:1.2.4.1]
126933527  LOW QUALITY PROTEIN: pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial-like [KO:K00161] [EC:1.2.4.1]
126946404  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial [KO:K00161] [EC:1.2.4.1]
126948828  pyruvate dehydrogenase E1 component subunit beta, mitochondrial [KO:K00162] [EC:1.2.4.1]
126947324  NADH-ubiquinone oxidoreductase chain 5-like [KO:K03883] [EC:7.1.1.2]
126935373  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
126930135  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial-like [KO:K03943] [EC:7.1.1.2]
126941129  NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
126950655  NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
126932207  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
126946139  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
126941467  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
126957346  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
126950258  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
126942379  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
126942872  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126943346  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 isoform X1 [KO:K03947]
126944267  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126956821  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
126930414  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
126962403  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126956036  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126949986  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
126963966  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126945886  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126958389  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126960684  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
126949375  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
126938104  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
126949807  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
126960621  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
126953759  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
126963639  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 isoform X1 [KO:K03950]
126942854  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
126937961  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
126931739  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
126932556  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
126937587  acyl carrier protein, mitochondrial-like [KO:K03955]
126944402  acyl carrier protein, mitochondrial [KO:K03955]
126951198  acyl carrier protein, mitochondrial-like [KO:K03955]
126942837  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
126932729  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11-like [KO:K03956]
126930310  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
126942362  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
126959705  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
126948765  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1-like [KO:K03957]
126949662  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
126932125  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
126934097  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126958757  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126934260  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
126949249  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
126939064  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
126935141  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
126948391  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
126937431  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
126942449  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
126963088  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
126944751  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
126939420  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126950876  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126934694  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
126961397  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
126944752  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
126930302  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial-like [KO:K11351]
126945660  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
126932178  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
126935729  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
126935957  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial-like [KO:K03935] [EC:7.1.1.2]
126936392  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
126945830  NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial-like [KO:K03936] [EC:7.1.1.2]
126956863  NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform X1 [KO:K03937]
126938277  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126963401  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126960994  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 isoform X1 [KO:K03938]
126961122  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
126957428  NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
126942790  NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
126935402  NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
126954622  NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
126935701  NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
126956207  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
126957442  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
126955714  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
126961462  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126936808  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
126962850  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
126956192  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
126950253  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126961220  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
126935807  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
126930673  LOW QUALITY PROTEIN: cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
126943623  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
126960981  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
126948676  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
126944495  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
126954785  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
126961549  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
126937178  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
126934429  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
126960839  cytochrome b-c1 complex subunit 7 [KO:K00417]
126954793  cytochrome b-c1 complex subunit 8-like [KO:K00418]
126956035  cytochrome b-c1 complex subunit 8 [KO:K00418]
126963991  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
126942883  cytochrome b-c1 complex subunit 10 [KO:K00420]
126944333  cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [KO:K02263]
126964308  cytochrome c oxidase subunit 4 isoform 2, mitochondrial isoform X1 [KO:K02263]
126934981  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
126959142  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
126960028  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
126936073  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
126956094  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
126934339  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
126944266  cytochrome c oxidase subunit 6A2, mitochondrial [KO:K02266]
126946802  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
126943264  cytochrome c oxidase subunit 6B2 [KO:K02267]
126939820  cytochrome c oxidase subunit 6B1-like [KO:K02267]
126941943  cytochrome c oxidase subunit 6B1 [KO:K02267]
126954498  cytochrome c oxidase subunit 6C [KO:K02268]
126961151  cytochrome c oxidase subunit 6C [KO:K02268]
126946168  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
126934205  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
126946829  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
126951565  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
126952142  cytochrome c oxidase subunit 7A2, mitochondrial isoform X1 [KO:K02270]
126942121  cytochrome c oxidase subunit 7A1, mitochondrial isoform X1 [KO:K02270]
126955253  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
126946324  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
126942189  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
126930116  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126943807  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126956722  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126938620  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126957169  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126957397  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
126958011  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126933618  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
126946671  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126958869  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126952688  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126960733  cytochrome c oxidase subunit 7C, mitochondrial-like [KO:K02272]
126959711  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
126935615  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
126941410  ATP synthase subunit alpha, mitochondrial [KO:K02132]
126930379  ATP synthase subunit beta, mitochondrial isoform X1 [KO:K02133] [EC:7.1.2.2]
126962920  ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
126942994  ATP synthase subunit delta, mitochondrial isoform X1 [KO:K02134]
126929356  ATP synthase subunit epsilon, mitochondrial [KO:K02135]
126930054  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
126955326  ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
126951623  LOW QUALITY PROTEIN: ATP synthase F(0) complex subunit B1, mitochondrial-like [KO:K02127]
126954576  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126942840  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126930915  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126931179  ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
126963773  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
126932708  ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
126964152  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
126939892  ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
126940287  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
126959053  ATP synthase F(0) complex subunit C3, mitochondrial-like [KO:K02128]
126949063  ATP synthase F(0) complex subunit C2, mitochondrial-like [KO:K02128]
126954618  ATP synthase subunit d, mitochondrial-like [KO:K02138]
126939263  ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
126934985  ATP synthase subunit d, mitochondrial-like [KO:K02138]
126933171  ATP synthase subunit O, mitochondrial-like [KO:K02137]
126950727  ATP synthase subunit O, mitochondrial [KO:K02137]
126950759  ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
126956005  voltage-dependent anion-selective channel protein 1 [KO:K05862]
126962446  voltage-dependent anion-selective channel protein 2 [KO:K15040]
126960768  voltage-dependent anion-selective channel protein 3 [KO:K15041]
126955617  ADP/ATP translocase 4 isoform X1 [KO:K05863]
126955724  ADP/ATP translocase 1 [KO:K05863]
126946121  ADP/ATP translocase 2 [KO:K05863]
126946856  ADP/ATP translocase 3 [KO:K05863]
126947143  ADP/ATP translocase 3 [KO:K05863]
126962461  peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
126943319  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
126951570  nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
126930446  glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
126932591  glyceraldehyde-3-phosphate dehydrogenase-like [KO:K00134] [EC:1.2.1.12]
126935666  poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
126945462  glucose-6-phosphate 1-dehydrogenase isoform X1 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
126961776  glutathione reductase, mitochondrial isoform X1 [KO:K00383] [EC:1.8.1.7]
126938052  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
126946646  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
126941494  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
126957972  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
126964414  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
126959796  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
126964415  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
126935554  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
126938330  LOW QUALITY PROTEIN: angiotensin-converting enzyme-like protein Ace3 [KO:K01283] [EC:3.4.15.1]
126939540  angiotensin-converting enzyme isoform X1 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
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  Authors
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  Title
Of mice and men: models and mechanisms of diabetic cardiomyopathy.
  Journal
Basic Res Cardiol 114:2 (2018)
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Reference
PMID:24462787
  Authors
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Diabetic cardiomyopathy: mechanisms and new treatment strategies targeting antioxidant signaling pathways.
  Journal
Pharmacol Ther 142:375-415 (2014)
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Reference
PMID:28231848
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Cardiovasc Diabetol 16:28 (2017)
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Reference
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Nat Rev Cardiol 17:585-607 (2020)
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Reference
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Int J Mol Sci 20:E2833 (2019)
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Reference
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  Title
Emerging Actors in Diabetic Cardiomyopathy: Heartbreaker Biomarkers or Therapeutic Targets?
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Trends Pharmacol Sci 39:452-467 (2018)
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Reference
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Diabetic Cardiomyopathy: An Immunometabolic Perspective.
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Front Endocrinol (Lausanne) 8:72 (2017)
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Reference
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Chong CR, Clarke K, Levelt E
  Title
Metabolic Remodeling in Diabetic Cardiomyopathy.
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Cardiovasc Res 113:422-430 (2017)
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Reference
PMID:11742414
  Authors
Brownlee M
  Title
Biochemistry and molecular cell biology of diabetic complications.
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Nature 414:813-20 (2001)
DOI:10.1038/414813a
Reference
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  Authors
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  Title
Established and Emerging Mechanisms of Diabetic Cardiomyopathy.
  Journal
J Lipid Atheroscler 8:26-47 (2019)
DOI:10.12997/jla.2019.8.1.26
Reference
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  Authors
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  Title
Diabetic cardiomyopathy revisited.
  Journal
Circulation 115:3213-23 (2007)
DOI:10.1161/CIRCULATIONAHA.106.679597
Reference
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  Authors
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  Title
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Biochim Biophys Acta Mol Basis Dis 1864:1949-1959 (2018)
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  Authors
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Molecular and metabolic mechanisms of cardiac dysfunction in diabetes.
  Journal
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Reference
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  Authors
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  Title
Diabetic cardiomyopathy: understanding the molecular and cellular basis to progress in diagnosis and treatment.
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Reference
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  Authors
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  Title
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  Journal
Front Physiol 7:125 (2016)
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Reference
PMID:33276047
  Authors
Randhawa VK, Dhanvantari S, Connelly K
  Title
How Diabetes and Heart Failure Modulate Each Other and Condition Management.
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Can J Cardiol S0828-282X(20)31115-6 (2020)
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Reference
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  Authors
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World J Diabetes 10:490-510 (2019)
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  Title
Cardiac-specific suppression of NF-kappaB signaling prevents diabetic cardiomyopathy via inhibition of the renin-angiotensin system.
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My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy.
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Reference
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Vascular endothelial dysfunction, a major mediator in diabetic cardiomyopathy.
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Reference
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The pathogenesis of myocardial fibrosis in the setting of diabetic cardiomyopathy.
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J Am Coll Cardiol 47:693-700 (2006)
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Int J Mol Sci 21:E970 (2020)
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Related
pathway
mthb00010  Glycolysis / Gluconeogenesis
mthb00020  Citrate cycle (TCA cycle)
mthb00190  Oxidative phosphorylation
mthb00520  Amino sugar and nucleotide sugar metabolism
mthb03320  PPAR signaling pathway
mthb04071  Sphingolipid signaling pathway
mthb04150  mTOR signaling pathway
mthb04210  Apoptosis
mthb04260  Cardiac muscle contraction
mthb04350  TGF-beta signaling pathway
mthb04614  Renin-angiotensin system
mthb04910  Insulin signaling pathway
mthb04930  Type II diabetes mellitus
mthb04931  Insulin resistance
mthb04933  AGE-RAGE signaling pathway in diabetic complications
mthb04940  Type I diabetes mellitus
KO pathway
ko05415   
LinkDB

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