KEGG   PATHWAY: phi04148
Entry
phi04148                    Pathway                                
Name
Efferocytosis - Pseudopodoces humilis (Tibetan ground-tit)
Class
Cellular Processes; Transport and catabolism
Pathway map
phi04148  Efferocytosis
phi04148

Organism
Pseudopodoces humilis (Tibetan ground-tit) [GN:phi]
Gene
102104322  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
102112480  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
102107523  PANX1; pannexin-1 [KO:K03443]
102112618  P2RY2; P2Y purinoceptor 2 [KO:K04269]
102112428  P2RY6; P2Y purinoceptor 6 [KO:K04272]
102111713  P2Y purinoceptor 12 [KO:K04298]
102106754  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
102113554  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
102111464  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
102112452  ABCA1; ATP-binding cassette sub-family A member 1 isoform X2 [KO:K05641]
102113780  ABCA7; ATP-binding cassette sub-family A member 7 [KO:K05641]
102108864  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
102106429  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 [KO:K06059] [EC:3.4.24.86]
102110765  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [KO:K06704] [EC:3.4.24.81]
102101171  fractalkine-like [KO:K05508]
102105231  CX3C chemokine receptor 1 [KO:K04192]
102111394  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
102114296  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102105250  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
102099564  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
102101745  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X2 [KO:K09097]
102100643  EPO; erythropoietin [KO:K05437]
102110768  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
102102818  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102110457  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
102104364  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
102099900  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
102099140  MFGE8; lactadherin isoform X1 [KO:K17253]
102111314  GAS6; growth arrest-specific protein 6 [KO:K05464]
102100429  MERTK; tyrosine-protein kinase Mer isoform X1 [KO:K05117] [EC:2.7.10.1]
102111827  CD36; platelet glycoprotein 4 [KO:K06259]
102103663  THBS1; thrombospondin-1 [KO:K16857]
102110075  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102102285  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102105209  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
102103262  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
102112129  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
102103159  DNMT3A; DNA (cytosine-5)-methyltransferase 3A [KO:K17398] [EC:2.1.1.37]
102101211  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
102112781  TGFB1; transforming growth factor beta-1 [KO:K13375]
102112747  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
102107999  sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
102112361  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
102112061  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102104633  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X6 [KO:K04515] [EC:2.7.11.17]
102108054  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X8 [KO:K04515] [EC:2.7.11.17]
102104310  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X3 [KO:K04515] [EC:2.7.11.17]
102110009  MAPK12; mitogen-activated protein kinase 12 isoform X2 [KO:K04441] [EC:2.7.11.24]
102109820  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
102110807  mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102111004  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
102106065  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102112541  ALOX5; arachidonate 5-lipoxygenase isoform X1 [KO:K00461] [EC:1.13.11.34]
102100835  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102108567  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102114558  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102113493  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102108932  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
102100959  ANO6; anoctamin-6 [KO:K19500]
102106697  ANO3; anoctamin-3 [KO:K19498]
102107224  ANO4; anoctamin-4 [KO:K19499]
102109690  ANO5; anoctamin-5 isoform X1 [KO:K19480]
102111472  ANO9; anoctamin-9 [KO:K19503]
102100029  BSG; basigin [KO:K06535]
102107681  XKR8; XK-related protein 8 [KO:K26813]
102111317  XKR9; XK-related protein 9 [KO:K26814]
102104217  XKR7; XK-related protein 7 [KO:K26811]
102104806  XKR4; LOW QUALITY PROTEIN: XK-related protein 4 [KO:K26811]
102103509  XKR6; XK-related protein 6 [KO:K26811]
102103842  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
102105284  ATP8A2; phospholipid-transporting ATPase IB isoform X1 [KO:K14802] [EC:7.6.2.1]
102109610  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
102111315  ATP11A; probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
102111642  ATP11B; probable phospholipid-transporting ATPase IF isoform X2 [KO:K26934] [EC:7.6.2.1]
102112470  TMEM30A; cell cycle control protein 50A [KO:K26935]
102114361  PROS1; vitamin K-dependent protein S isoform X1 [KO:K03908]
102112204  ITGAV; integrin alpha-V [KO:K06487]
102114571  ITGB3; integrin beta-3 [KO:K06493]
102106421  ITGB5; integrin beta-5 [KO:K06588]
102113157  AXL; tyrosine-protein kinase receptor UFO [KO:K05115] [EC:2.7.10.1]
102105122  TYRO3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
102111128  ADGRB1; brain-specific angiogenesis inhibitor 1 [KO:K04596]
102103134  T-cell immunoglobulin and mucin domain-containing protein 4 isoform X1 [KO:K26936]
102114425  hepatitis A virus cellular receptor 1 homolog isoform X1 [KO:K20413]
102100531  STAB1; stabilin-1 [KO:K19020]
102107792  STAB2; stabilin-2 [KO:K19013]
102104319  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
102099890  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
102102631  CRKL; crk-like protein [KO:K04438]
102102139  CRK; adapter molecule crk isoform X1 [KO:K04438]
102111809  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
102102389  DOCK1; dedicator of cytokinesis protein 1 isoform X2 [KO:K13708]
102111634  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
102103092  disintegrin and metalloproteinase domain-containing protein 9 [KO:K06834] [EC:3.4.24.-]
102100556  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
102108188  CALR; calreticulin [KO:K08057]
102105876  C1QA; complement C1q subcomponent subunit A [KO:K03986]
102105506  C1QB; complement C1q subcomponent subunit B [KO:K03987]
102105689  C1QC; complement C1q subcomponent subunit C isoform X1 [KO:K03988]
102101426  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
102109620  MEGF10; multiple epidermal growth factor-like domains protein 10 [KO:K24068]
102109531  MEGF11; multiple epidermal growth factor-like domains protein 11 [KO:K24068]
102114607  SCARF1; scavenger receptor class F member 1 [KO:K24318]
102112957  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
102104415  RAB17; ras-related protein Rab-17 [KO:K07909]
102107036  RAB5A; ras-related protein Rab-5A [KO:K07887]
102100332  RAB5B; ras-related protein Rab-5B [KO:K07888]
102100820  RAB5C; ras-related protein Rab-5C [KO:K07889]
102107873  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
102105206  VPS8; vacuolar protein sorting-associated protein 8 homolog isoform X2 [KO:K20178]
102112582  VPS11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
102108196  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
102103243  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
102099951  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
102111219  RAB14; ras-related protein Rab-14 [KO:K07881]
102106802  VPS39; vam6/Vps39-like protein [KO:K20183]
102103754  VPS41; vacuolar protein sorting-associated protein 41 homolog [KO:K20184]
102111705  RAB7A; ras-related protein Rab-7a [KO:K07897]
102104479  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
106628281  LOW QUALITY PROTEIN: lysosomal amino acid transporter 1 homolog [KO:K23678]
102101353  PQLC2; lysosomal amino acid transporter 1 homolog [KO:K23678]
102106292  ARG2; arginase-2, mitochondrial [KO:K01476] [EC:3.5.3.1]
102105119  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
102109333  cholesterol 25-hydroxylase-like protein [KO:K10223] [EC:1.14.99.38]
102102616  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
102113251  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
102103127  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
102105403  carnitine O-palmitoyltransferase 1, muscle isoform-like [KO:K19523] [EC:2.3.1.21]
102113007  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
102101980  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
102114683  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
102105573  IL10; interleukin-10 [KO:K05443]
102101390  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
102102806  LIPA; lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
102101762  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
102107076  lipase member K-like [KO:K01052] [EC:3.1.1.13]
102104657  PLA2G15; group XV phospholipase A2 isoform X1 [KO:K06129] [EC:3.1.1.5]
102113514  PPARD; peroxisome proliferator-activated receptor delta isoform X1 [KO:K04504]
102105889  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 isoform X1 [KO:K07299]
102110654  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
102101880  SGK1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
102105129  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
106627996  CD24; signal transducer CD24 [KO:K06469]
102103143  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
102106054  signal-regulatory protein beta-1 isoform 3-like [KO:K06551]
102106440  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1 [KO:K06551]
102110203  PTPN6; tyrosine-protein phosphatase non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
102103197  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
phi00010  Glycolysis / Gluconeogenesis
phi04140  Autophagy - animal
phi04145  Phagosome
KO pathway
ko04148   
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