KEGG   PATHWAY: pkl05202
Entry
pkl05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Pipistrellus kuhlii (Kuhl's pipistrelle)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
pkl05202  Transcriptional misregulation in cancer
pkl05202

Organism
Pipistrellus kuhlii (Kuhl's pipistrelle) [GN:pkl]
Gene
118714829  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
118711224  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
118728102  MPO; myeloperoxidase isoform X1 [KO:K10789] [EC:1.11.2.2]
118711341  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
118718683  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
118705602  HDAC2; histone deacetylase 2 isoform X1 [KO:K06067] [EC:3.5.1.98]
118723755  HDAC1; histone deacetylase 1 isoform X1 [KO:K06067] [EC:3.5.1.98]
118728514  SIN3A; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
118704686  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
118720508  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
118709891  PER2; period circadian protein homolog 2 isoform X1 [KO:K02633]
118712855  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
118711536  CD14; monocyte differentiation antigen CD14 isoform X1 [KO:K04391]
118731522  integrin alpha-M-like [KO:K06461]
118721121  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
118726294  junction plakoglobin isoform X1 [KO:K10056]
118728971  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
118732278  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
118728720  CCNA1; cyclin-A1 [KO:K06627]
118725924  CCNA2; cyclin-A2 isoform X1 [KO:K06627]
118725286  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
118718007  BCL2A1; bcl-2-related protein A1 isoform X1 [KO:K02162]
118713363  ZBTB16; zinc finger and BTB domain-containing protein 16 isoform X1 [KO:K10055]
118718671  MYC; myc proto-oncogene protein [KO:K04377]
118729124  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
118710897  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
118721742  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
118711976  WNT16; protein Wnt-16 [KO:K01558]
118730120  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
118704469  DEFA5; LOW QUALITY PROTEIN: defensin-5 [KO:K05230]
118711780  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
118726101  granzyme H-like isoform X1 [KO:K01353] [EC:3.4.21.79]
118726108  granzyme B(G,H)-like isoform X1 [KO:K01353] [EC:3.4.21.79]
118726126  LOW QUALITY PROTEIN: granzyme B-like [KO:K01353] [EC:3.4.21.79]
118726137  granzyme B-like isoform X1 [KO:K01353] [EC:3.4.21.79]
118710551  KMT2A; histone-lysine N-methyltransferase 2A isoform X1 [KO:K09186] [EC:2.1.1.354]
118727003  AFF1; AF4/FMR2 family member 1 isoform X1 [KO:K15184]
118706678  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
118730218  CCNT1; cyclin-T1 isoform X1 [KO:K15188]
118709085  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
118731191  MLLT1; protein ENL isoform X1 [KO:K15187]
118716620  MLLT3; protein AF-9 isoform X1 [KO:K15187]
118711157  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
118712962  LMO2; rhombotin-2 isoform X1 [KO:K15612]
118727940  LOW QUALITY PROTEIN: pre-B-cell leukemia transcription factor 3-like [KO:K15610]
118704417  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
118705191  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
118710903  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
118729535  LOW QUALITY PROTEIN: Krueppel-like factor 3 [KO:K15605]
118707792  KLF3; Krueppel-like factor 3 [KO:K15605]
118702809  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
118727864  HOXA9; homeobox protein Hox-A9 isoform X1 [KO:K21950]
118727860  HOXA10; homeobox protein Hox-A10 [KO:K17443]
118719199  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
118728371  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
118712118  lysine-specific demethylase 6A-like isoform X1 [KO:K11447] [EC:1.14.11.68]
118731696  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
118705193  SUPT3H; transcription initiation protein SPT3 homolog isoform X1 [KO:K11313]
118725618  PROM1; prominin-1 [KO:K06532]
118730455  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
118704767  BMP2K; BMP-2-inducible protein kinase isoform X1 [KO:K08854] [EC:2.7.11.1]
118704316  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
118729119  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
118714318  CDK14; cyclin-dependent kinase 14 isoform X1 [KO:K08821] [EC:2.7.11.22]
118717446  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
118727866  HOXA11; homeobox protein Hox-A11 [KO:K21951]
118717163  SIX1; homeobox protein SIX1 [KO:K15614]
118717150  SIX4; homeobox protein SIX4 isoform X1 [KO:K15615]
118718355  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
118724553  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
118710938  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
118722055  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
118716590  FUT8; alpha-(1,6)-fucosyltransferase isoform X1 [KO:K00717] [EC:2.4.1.68]
118711117  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
118718970  TLX1; T-cell leukemia homeobox protein 1 [KO:K09340]
118708811  BCL11B; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
118718914  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
118710354  LYL1; protein lyl-1 [KO:K15604]
118719296  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
118706009  pre T-cell antigen receptor alpha-like [KO:K06056]
118706010  pre T-cell antigen receptor alpha-like [KO:K06056]
118717396  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
118728810  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
118712461  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
118716109  TRAF1; TNF receptor-associated factor 1 isoform X1 [KO:K03172]
118707390  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
118723527  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
118707886  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
118724928  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
118720563  MAF; transcription factor Maf isoform X1 [KO:K09035]
118730162  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
118707171  NSD2; histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
118716594  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase NSD2-like [KO:K11424] [EC:2.1.1.357]
118711489  histone H3.3 type 1-like [KO:K11253]
118727357  histone H3.1 [KO:K11253]
118727359  histone H3.1 isoform X1 [KO:K11253]
118727360  histone H3.1 [KO:K11253]
118727361  histone H3.1 [KO:K11253]
118727438  uncharacterized protein LOC118727438 [KO:K11253]
118727675  histone H3.3A [KO:K11253]
118704648  histone H3.3A [KO:K11253]
118721163  histone H3-like [KO:K11253]
118721140  histone H3 [KO:K11253]
118716317  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
118717643  PAX8; paired box protein Pax-8 [KO:K09293]
118715228  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
118707032  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
118705657  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
118721741  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
118721777  PRCC; proline-rich protein PRCC [KO:K13105]
118731761  TFE3; transcription factor E3 isoform X1 [KO:K09105]
118705573  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
118723981  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
118723863  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
118719125  PLAU; urokinase-type plasminogen activator isoform X1 [KO:K01348] [EC:3.4.21.73]
118730564  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
118713270  stromelysin-1-like [KO:K01394] [EC:3.4.24.17]
118707740  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
118727701  ZEB1; zinc finger E-box-binding homeobox 1 isoform X1 [KO:K09299]
118727965  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
118723460  SPINT1; kunitz-type protease inhibitor 1 isoform X1 [KO:K15619]
118714240  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
118726429  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
118723329  ETV5; ETS translocation variant 5 isoform X1 [KO:K15593]
118721487  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
118721297  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
118726567  DDX5; probable ATP-dependent RNA helicase DDX5 isoform X1 [KO:K12823] [EC:5.6.2.7]
118717058  MYCN; N-myc proto-oncogene protein [KO:K09109]
118716611  MAX; protein max isoform X1 [KO:K04453]
118729242  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
118718637  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
118726809  TP53; cellular tumor antigen p53 [KO:K04451]
118731315  BMI1; polycomb complex protein BMI-1 isoform X1 [KO:K11459]
118728518  SP1; transcription factor Sp1 [KO:K04684]
118723679  ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500]
118721515  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
118726508  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
118714967  MEN1; menin isoform X1 [KO:K14970]
118725343  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
118726400  LOW QUALITY PROTEIN: RNA-binding protein EWS-like [KO:K13209]
118725391  FLI1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
118729152  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118718092  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
118715431  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
118727846  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
118709607  FEV; protein FEV isoform X1 [KO:K09437]
118728931  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
118708085  cyclic AMP-dependent transcription factor ATF-1-like [KO:K09053]
118718760  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589]
118712974  ATM; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
118715010  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
118713347  WT1; Wilms tumor protein isoform X1 [KO:K09234]
118715966  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
118730561  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
118703776  BAIAP3; BAI1-associated protein 3 isoform X1 [KO:K15621]
118731741  TSPAN7; tetraspanin-7 [KO:K06571]
118722540  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
118716257  NR4A3; nuclear receptor subfamily 4 group A member 3 isoform X1 [KO:K08559]
118726319  TAF15; TATA-binding protein-associated factor 2N isoform X1 [KO:K14651]
118704936  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
118730280  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
118707905  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
118714203  IL6; interleukin-6 [KO:K05405]
118722416  NFKBIZ; NF-kappa-B inhibitor zeta isoform X1 [KO:K14242]
118703354  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
118706879  RELA; transcription factor p65 isoform X1 [KO:K04735]
118709059  CXCL8; interleukin-8 [KO:K10030]
118723482  PAX7; paired box protein Pax-7 isoform X1 [KO:K09381]
118709793  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
118730644  FOXO1; forkhead box protein O1 [KO:K07201]
118719986  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
118729025  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
118708631  mitochondrial ribosome-associated GTPase 2 isoform X1 [KO:K15623]
118707895  SS18; protein SSXT isoform X1 [KO:K15623]
118731795  putative protein SSX6 [KO:K15624]
118704916  NUPR1; nuclear protein 1 [KO:K15626]
118704502  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
118711705  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
118731305  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
118723504  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
118708686  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
118712174  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
118705679  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
118713534  DDB2; DNA damage-binding protein 2 isoform X1 [KO:K10140]
118703506  POLK; DNA polymerase kappa isoform X1 [KO:K03511] [EC:2.7.7.7]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
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Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
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Blood 101:3681-6 (2003)
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Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
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Blood 97:2798-807 (2001)
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Best Pract Res Clin Haematol 16:1-13 (2003)
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
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Curr Opin Genet Dev 19:82-91 (2009)
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Biochim Biophys Acta 1796:201-15 (2009)
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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The MYCN oncogene and differentiation in neuroblastoma.
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MYCN oncoprotein targets and their therapeutic potential.
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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PMID:19472090
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
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Related
pathway
pkl04115  p53 signaling pathway
pkl05211  Renal cell carcinoma
pkl05215  Prostate cancer
pkl05216  Thyroid cancer
pkl05221  Acute myeloid leukemia
KO pathway
ko05202   
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