KEGG   PATHWAY: pon05415
Entry
pon05415                    Pathway                                
Name
Diabetic cardiomyopathy - Pongo abelii (Sumatran orangutan)
Description
Diabetic cardiomyopathy has been defined as left ventricular dysfunction that occurs among patients with diabetes mellitus independent of a recognized cause such as coronary artery disease or hypertension. The pathogenesis of diabetic cardiomyopathy broadly involves hyperglycemia, increased circulating fatty acids, and insulin resistance contributing to reactive oxygen species (ROS) generation, mitochondrial dysfunction, impaired calcium metabolism, Renin-Angiotensin System (RAS) activation, and altered substrate metabolism. These effects result in cardiac fibrosis, hypertrophy, cardiomyocyte death, contractile dysfunction, endothelial cell damage and eventually heart failure. In the process of cardiac fibrosis, cardiac fibroblasts are the final effector cell.
Class
Human Diseases; Cardiovascular disease
Pathway map
pon05415  Diabetic cardiomyopathy
pon05415

Organism
Pongo abelii (Sumatran orangutan) [GN:pon]
Gene
100173447  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100456448  SLC2A4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
100173251  GFPT2; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 [KO:K00820] [EC:2.6.1.16]
100433102  GFPT1; glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 isoform X3 [KO:K00820] [EC:2.6.1.16]
100433531  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
100172212  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
100462386  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100436747  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
100173211  TNNI3; troponin I, cardiac muscle [KO:K12044]
100173051  RYR2; ryanodine receptor 2 [KO:K04962]
112133783  PLN; cardiac phospholamban [KO:K05852]
100446409  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3 [KO:K05853] [EC:7.2.2.10]
100453755  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100459692  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100440745  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
100458106  AGT; angiotensinogen [KO:K09821]
100435070  REN; renin [KO:K01380] [EC:3.4.23.15]
100432060  CMA1; chymase isoform X1 [KO:K01329] [EC:3.4.21.39]
100439900  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100443859  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
100459132  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
100442050  NCF1; neutrophil cytosol factor 1 [KO:K08011]
100456737  cytochrome b-245 light chain [KO:K08009]
100174692  NCF2; neutrophil cytosol factor 2 [KO:K08010]
100456695  NCF4; neutrophil cytosol factor 4 isoform X2 [KO:K08012]
100443271  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100431483  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100461588  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100461595  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100456049  RELA; transcription factor p65 [KO:K04735]
100449269  MAPK14; mitogen-activated protein kinase 14 isoform X2 [KO:K04441] [EC:2.7.11.24]
100449853  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
100437263  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
100438358  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100174482  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100459133  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100437424  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100451667  MMP2; 72 kDa type IV collagenase [KO:K01398] [EC:3.4.24.24]
100455867  MMP9; LOW QUALITY PROTEIN: matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
100438152  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
100439107  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100457897  COL3A1; collagen alpha-1(III) chain [KO:K19720]
100459982  TGFB1; transforming growth factor beta-1 [KO:K13375]
100461291  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
100433208  TGFB3; transforming growth factor beta-3 [KO:K13377]
100462480  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
100454169  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
100444942  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
100462571  PDK3; pyruvate dehydrogenase kinase, isozyme 3 isoform X1 [KO:K00898] [EC:2.7.11.2]
100174113  PDK2; pyruvate dehydrogenase kinase, isozyme 2 [KO:K00898] [EC:2.7.11.2]
100435148  PDK4; pyruvate dehydrogenase kinase, isozyme 4 [KO:K00898] [EC:2.7.11.2]
100434355  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
100452668  PRKCD; protein kinase C delta type isoform X1 [KO:K06068] [EC:2.7.11.13]
100171871  PTPA; serine/threonine-protein phosphatase 2A activator [KO:K17605]
100173410  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100459799  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100458223  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100172401  CTSD; cathepsin D precursor [KO:K01379] [EC:3.4.23.5]
100174126  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
100442465  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
100451422  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
100442255  IRS1; insulin receptor substrate 1 [KO:K16172]
100432846  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100453779  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103889133  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100174298  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100173589  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
100437617  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100171828  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100454279  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100448114  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100442100  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100456786  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
100447772  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
100452879  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
100172871  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
100172313  TBC1D4; TBC1 domain family member 4 isoform X1 [KO:K17902]
100443375  MPC1L; mitochondrial pyruvate carrier 1-like protein [KO:K22138]
100449626  MPC1; mitochondrial pyruvate carrier 1 [KO:K22138]
100173880  MPC2; mitochondrial pyruvate carrier 2 [KO:K22139]
100174745  PDHA1; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor [KO:K00161] [EC:1.2.4.1]
100443483  PDHA2; pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial isoform X1 [KO:K00161] [EC:1.2.4.1]
100171772  PDHB; pyruvate dehydrogenase E1 component subunit beta, mitochondrial precursor [KO:K00162] [EC:1.2.4.1]
808473  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
808478  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
808479  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
808481  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
808477  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
808484  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
808476  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
100454954  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
100432094  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
100458281  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
100173751  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
100173647  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
100454965  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
112130077  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
100432301  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
100444005  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100440996  cytochrome c oxidase subunit NDUFA4-like [KO:K03948]
112134886  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
100459464  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
100172232  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
100433299  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
100448660  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
100451328  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
100443232  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
100172726  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
100174681  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial precursor [KO:K03953]
100173536  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
100939986  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
100434362  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 isoform X1 [KO:K03956]
100447619  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
100456804  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
100173590  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
100442655  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
100431339  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
100173492  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
103890345  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
100442174  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
100172329  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
100440533  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 isoform X2 [KO:K03963]
100174138  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial precursor [KO:K03964]
100437450  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
100171671  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
112129455  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
100461106  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
100172962  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor [KO:K03934] [EC:7.1.1.2]
100461547  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
100446873  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
100172316  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor [KO:K03937]
100173291  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
100443000  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
112129629  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
100437218  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
100437121  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial isoform X1 [KO:K03939]
100173971  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial precursor [KO:K03940] [EC:7.1.1.2]
100172255  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial precursor [KO:K03941] [EC:7.1.1.2]
100174556  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
100455802  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
100173631  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor [KO:K00234] [EC:1.3.5.1]
100446843  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
100437700  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
100936632  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
100172275  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
100459356  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
808483  CYTB; cytochrome b [KO:K00412]
100451363  cytochrome c1, heme protein, mitochondrial [KO:K00413]
100452425  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
100456655  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
100451861  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
103889540  cytochrome b-c1 complex subunit 2, mitochondrial-like isoform X1 [KO:K00415]
100450040  cytochrome b-c1 complex subunit 6, mitochondrial isoform X2 [KO:K00416]
100172279  UQCRB; cytochrome b-c1 complex subunit 7 [KO:K00417]
100173822  UQCRQ; cytochrome b-c1 complex subunit 8 [KO:K00418]
100173591  UCRC; ubiquinol-cytochrome c reductase complex (7.2 kD) [KO:K00419]
100173092  UQCR; cytochrome b-c1 complex subunit 10 [KO:K00420]
808480  COX3; cytochrome c oxidase subunit III [KO:K02262]
808482  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
808475  COX2; cytochrome c oxidase subunit II [KO:K02261]
100448759  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
100173464  COX4I1; cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
100459812  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
100461926  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
100431194  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
100171718  COX5B; cytochrome c oxidase subunit 5B, mitochondrial precursor [KO:K02265]
100439561  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
100172268  COX6A2; cytochrome c oxidase subunit 6A2, mitochondrial precursor [KO:K02266]
103892145  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
100451317  cytochrome c oxidase subunit 6B2 [KO:K02267]
100172105  COX6B1; cytochrome c oxidase subunit 6B1 [KO:K02267]
100172239  COX6C; cytochrome c oxidase subunit 6C [KO:K02268]
100434042  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
100462105  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
100172849  COX7B; cytochrome c oxidase subunit 7B, mitochondrial precursor [KO:K02271]
100451432  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
100174116  COX7C; cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
112134903  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
100172325  COX8A; cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
100450286  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
100173854  ATP5F1A; ATP synthase subunit alpha, mitochondrial precursor [KO:K02132]
100457861  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
100447834  ATP5F1C; ATP synthase subunit gamma, mitochondrial [KO:K02136]
100461440  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
103888842  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
112128617  uncharacterized protein LOC112128617 [KO:K02135]
808485  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
100171475  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial precursor [KO:K02127]
100450621  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
100171455  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial precursor [KO:K02128]
100172599  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial precursor [KO:K02128]
100440784  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
100172045  ATP5PO; ATP synthase subunit O, mitochondrial precursor [KO:K02137]
100172310  ATP5PF; ATP synthase-coupling factor 6, mitochondrial precursor [KO:K02131]
808474  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
100460133  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100456290  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100174591  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100437258  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100432368  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100173820  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100445977  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100445983  ADP/ATP translocase 3-like [KO:K05863]
100445991  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100451563  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
100447953  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
100172694  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
100461666  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
100449143  G6PD; glucose-6-phosphate 1-dehydrogenase isoform X2 [KO:K00036] [EC:1.1.1.49 1.1.1.363]
100437026  GSR; glutathione reductase, mitochondrial [KO:K00383] [EC:1.8.1.7]
100450864  TGFBR1; TGF-beta receptor type-1 isoform X2 [KO:K04674] [EC:2.7.11.30]
100459236  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
100173357  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
100448249  SMAD3; mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
100458716  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
100460060  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
100434502  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
100461961  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
100453403  ACE; angiotensin-converting enzyme [KO:K01283] [EC:3.4.15.1]
100453767  LOW QUALITY PROTEIN: angiotensin-converting enzyme-like protein Ace3 [KO:K01283] [EC:3.4.15.1]
Compound
C00001  H2O
C00002  ATP
C00005  NADPH
C00006  NADP+
C00022  Pyruvate
C00024  Acetyl-CoA
C00027  Hydrogen peroxide
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00051  Glutathione
C00076  Calcium cation
C00085  D-Fructose 6-phosphate
C00092  D-Glucose 6-phosphate
C00095  D-Fructose
C00118  D-Glyceraldehyde 3-phosphate
C00127  Glutathione disulfide
C00162  Fatty acid
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C00236  3-Phospho-D-glyceroyl phosphate
C00318  L-Carnitine
C00352  D-Glucosamine 6-phosphate
C00369  Starch
C00533  Nitric oxide
C00546  Methylglyoxal
C00704  Superoxide
C00794  D-Sorbitol
C00873  Angiotensin I
C02135  Angiotensin II
C02843  Long-chain acyl-CoA
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06156  alpha-D-Glucosamine 1-phosphate
C16844  Hydroxyl radical
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
C22310  Fructose 3-phosphate
C22311  3-Deoxyglucosone
Reference
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Related
pathway
pon00010  Glycolysis / Gluconeogenesis
pon00020  Citrate cycle (TCA cycle)
pon00190  Oxidative phosphorylation
pon00520  Amino sugar and nucleotide sugar metabolism
pon03320  PPAR signaling pathway
pon04071  Sphingolipid signaling pathway
pon04150  mTOR signaling pathway
pon04210  Apoptosis
pon04260  Cardiac muscle contraction
pon04350  TGF-beta signaling pathway
pon04614  Renin-angiotensin system
pon04910  Insulin signaling pathway
pon04930  Type II diabetes mellitus
pon04931  Insulin resistance
pon04933  AGE-RAGE signaling pathway in diabetic complications
pon04940  Type I diabetes mellitus
KO pathway
ko05415   
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