KEGG   PATHWAY: pprm04144
Entry
pprm04144                   Pathway                                
Name
Endocytosis - Pimephales promelas (fathead minnow)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
pprm04144  Endocytosis
pprm04144

Other DBs
GO: 0006897
Organism
Pimephales promelas (fathead minnow) [GN:pprm]
Gene
120464082  arf6b; ADP-ribosylation factor 6b [KO:K07941]
120491988  arf6a; ADP-ribosylation factor 6a [KO:K07941]
120474613  pip5k1bb; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
120482607  pip5k1ba; phosphatidylinositol-4-phosphate 5-kinase, type I, beta a [KO:K00889] [EC:2.7.1.68]
120483653  pip5k1aa; phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a [KO:K00889] [EC:2.7.1.68]
120486719  pip5k1ca; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
120471295  pip5k1cb; phosphatidylinositol-4-phosphate 5-kinase, type I, gamma b [KO:K00889] [EC:2.7.1.68]
120495035  pip5k1ab; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
120470379  pip5kl1; phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1 [KO:K13712] [EC:2.7.1.68]
120482485  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
120466845  si:ch211-168k14.2; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
120469975  pld2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
120488208  pld1b; phospholipase D1 [KO:K01115] [EC:3.1.4.4]
120479123  dynamin-3-like isoform X1 [KO:K01528] [EC:3.6.5.5]
120471617  dnm1a; dynamin-1a isoform X1 [KO:K01528] [EC:3.6.5.5]
120472089  dnm1b; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
120489706  dnm2a; dynamin-3 isoform X1 [KO:K23484] [EC:3.6.5.5]
120487565  dnm2b; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
120478312  clta; clathrin light chain A [KO:K04644]
120482352  cltb; clathrin light chain B isoform X1 [KO:K04645]
120489653  cltcl1; clathrin heavy chain 1 isoform X1 [KO:K04646]
120482610  cltca; clathrin, heavy chain a (Hc) isoform X1 [KO:K04646]
120478624  cltcb; clathrin, heavy chain b (Hc) isoform X1 [KO:K04646]
120489849  ap2a1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
120471826  ap2b1; AP-2 complex subunit beta [KO:K11825]
120482051  ap2m1a; AP-2 complex subunit mu-A isoform X1 [KO:K11826]
120459977  ap2m1b; AP-2 complex subunit mu-B isoform X1 [KO:K11826]
120478893  ap2s1; AP-2 complex subunit sigma [KO:K11827]
120460028  ehd2b; EH domain-containing protein 2b [KO:K12469]
120471783  ehd2a; EH domain-containing protein 2 isoform X1 [KO:K12469]
120482409  tgfbr1a; TGF-beta receptor type-1a [KO:K04674] [EC:2.7.11.30]
120475734  tgfbr1b; TGF-beta receptor type-1b [KO:K04674] [EC:2.7.11.30]
120461610  tgfbr2l; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120462277  tgfbr2b; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
120482292  zfyve9a; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
120466879  zfyve9b; zinc finger FYVE domain-containing protein 9 isoform X1 [KO:K04679]
120483059  zfyve16; zinc finger FYVE domain-containing protein 16 isoform X1 [KO:K04679]
120482166  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
120491009  smad3a; mothers against decapentaplegic homolog 3a [KO:K23605]
120460054  mothers against decapentaplegic homolog 3-like [KO:K23605]
120487810  smad3b; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 3b [KO:K23605]
120479508  tfr1a; transferrin receptor 1a [KO:K06503]
120488440  tfr1b; transferrin receptor 1b [KO:K06503]
120463339  epidermal growth factor receptor-like isoform X1 [KO:K04361] [EC:2.7.10.1]
120488261  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
120493762  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120479337  fgfr2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
120479581  fgfr3; LOW QUALITY PROTEIN: fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
120484884  fgfr4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
120469797  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
120487871  igf1ra; insulin-like growth factor 1a receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
120478520  cbl; E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
120481818  cblb; E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K22517] [EC:2.3.2.27]
120484535  E3 ubiquitin-protein ligase CBL-like [KO:K22518] [EC:2.3.2.27]
120484536  E3 ubiquitin-protein ligase CBL-like [KO:K22518] [EC:2.3.2.27]
120488312  sh3kbp1; SH3 domain-containing kinase-binding protein 1 isoform X1 [KO:K12470]
120482460  sh3gl1a; SH3-domain GRB2-like 1a isoform X1 [KO:K11247]
120482500  sh3gl1b; SH3-domain GRB2-like 1b isoform X1 [KO:K11247]
120459025  sh3gl3b; endophilin-A3b [KO:K11247]
120470383  sh3gl3a; endophilin-A3a isoform X1 [KO:K11247]
120495117  sh3gl2a; SH3 domain containing GRB2 like 2a, endophilin A1 [KO:K11247]
120463314  sh3gl2b; SH3 domain containing GRB2 like 2b, endophilin A1 [KO:K11247]
120482389  sh3glb1b; endophilin-B1b isoform X1 [KO:K11248]
120488146  sh3glb1a; endophilin-B1a isoform X1 [KO:K11248]
120473999  endophilin-B2-like [KO:K21269]
120490256  sh3glb2a; endophilin-B2a isoform X1 [KO:K21269]
120470250  sh3glb2b; endophilin-B2b isoform X1 [KO:K21269]
120482676  amph; amphiphysin isoform X1 [KO:K12562]
120491472  bin1b; myc box-dependent-interacting protein 1b isoform X1 [KO:K12562]
120487234  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
120481565  epn3a; epsin-3 isoform X1 [KO:K12471]
120489412  epn2; epsin-2 isoform X1 [KO:K12471]
120483636  epn1b; epsin-1 [KO:K12471]
120459865  epn3b; epsin-3 [KO:K12471]
120484432  epn1a; epsin-1 isoform X1 [KO:K12471]
120481839  eps15; epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
120474934  eps15l1b; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
120486327  eps15l1a; epidermal growth factor receptor substrate 15-like 1 isoform X1 [KO:K12472]
120482348  sparta; spartin a isoform X1 [KO:K19366]
120478861  spartb; spartin b isoform X1 [KO:K19366]
120487661  nedd4a; E3 ubiquitin-protein ligase NEDD4a isoform X1 [KO:K10591] [EC:2.3.2.26]
120490835  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
120476934  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
120469276  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
120463376  rnf41; E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
120493851  itcha; itchy E3 ubiquitin protein ligase a isoform X1 [KO:K05632] [EC:2.3.2.26]
120481003  itchb; itchy E3 ubiquitin protein ligase b [KO:K05632] [EC:2.3.2.26]
120489455  smurf1; E3 ubiquitin-protein ligase SMURF1 isoform X1 [KO:K04678] [EC:2.3.2.26]
120462253  smurf2; E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
120467778  NEDD4-like E3 ubiquitin-protein ligase WWP1 [KO:K05633] [EC:2.3.2.26]
120489183  low-density lipoprotein receptor-like [KO:K12473]
120467911  ldlrb; low-density lipoprotein receptor [KO:K12473]
120485036  ldlrap1a; low density lipoprotein receptor adapter protein 1a isoform X1 [KO:K12474]
120493659  si:dkey-71h2.2; low density lipoprotein receptor adapter protein 1-B isoform X1 [KO:K12474]
120479745  ldlrap1b; low density lipoprotein receptor adapter protein 1b isoform X1 [KO:K12474]
120469717  dab2; disabled homolog 2 isoform X1 [KO:K12475]
120461693  si:ch211-204c21.1; disabled homolog 2 isoform X1 [KO:K12475]
120477494  C-C chemokine receptor type 5 [KO:K04180]
120487020  cxcr2; C-X-C chemokine receptor type 1 [KO:K05050]
120487304  C-X-C chemokine receptor type 1 [KO:K05050]
120467152  cxcr4b; C-X-C chemokine receptor type 4b [KO:K04189]
120491643  cxcr4a; C-X-C chemokine receptor type 4a [KO:K04189]
120483236  grk7a; rhodopsin kinase grk7a [KO:K00909] [EC:2.7.11.14]
120459072  grk1a; rhodopsin kinase GRK1 [KO:K00909] [EC:2.7.11.14]
120460023  grk7b; rhodopsin kinase grk7-b [KO:K00909] [EC:2.7.11.14]
120472285  grk1b; rhodopsin kinase GRK1b [KO:K00909] [EC:2.7.11.14]
120482724  grk3; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
120474871  grk5l; G protein-coupled receptor kinase 5 isoform X1 [KO:K08291] [EC:2.7.11.16]
120482238  grk6; G protein-coupled receptor kinase 6 [KO:K08291] [EC:2.7.11.16]
120482766  grk5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
120478313  grk4; G protein-coupled receptor kinase 4 isoform X1 [KO:K08291] [EC:2.7.11.16]
120482358  arrb2a; arrestin, beta 2a isoform X1 [KO:K04439]
120475752  arrb1; beta-arrestin-1 [KO:K04439]
120470263  arrb2b; arrestin, beta 2b isoform X1 [KO:K04439]
120469264  wasla; WASP like actin nucleation promoting factor a isoform X1 [KO:K23612]
120489670  actr2a; actin-related protein 2-A [KO:K17260]
120492421  actr2b; actin-related protein 2-B [KO:K17260]
120469994  zgc:101810; actin-related protein 2-A [KO:K17260]
120475851  actr3b; actin-related protein 3B isoform X1 [KO:K18584]
120487155  actr3; actin-related protein 3 [KO:K18584]
120489649  zgc:86896; actin-related protein 2/3 complex subunit 1A [KO:K05757]
120490300  arpc1a; actin-related protein 2/3 complex subunit 1A [KO:K05757]
120490301  arpc1b; actin-related protein 2/3 complex subunit 1B [KO:K05757]
120487096  arpc2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
120490685  actin-related protein 2/3 complex subunit 3-B [KO:K05756]
120490756  actin-related protein 2/3 complex subunit 3-B [KO:K05756]
120491503  arpc4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
120480618  arpc4l; actin related protein 2/3 complex, subunit 4, like [KO:K05755]
120482727  arpc5a; actin-related protein 2/3 complex subunit 5a [KO:K05754]
120469740  arpc5lb; actin related protein 2/3 complex, subunit 5-like, b [KO:K05754]
120494122  arpc5b; actin-related protein 2/3 complex subunit 5b [KO:K05754]
120473506  arpc5la; actin related protein 2/3 complex, subunit 5-like, a [KO:K05754]
120483713  WAS/WASL-interacting protein family member 3-like [KO:K19475]
120491410  wipf1b; WAS/WASL-interacting protein family member 1 [KO:K19475]
120459819  wipf1a; LOW QUALITY PROTEIN: WAS/WASL-interacting protein family member 1a [KO:K19475]
120468924  wipf2a; WAS/WASL-interacting protein family member 2 [KO:K19475]
120485627  wipf2b; WAS/WASL-interacting protein family member 2b [KO:K19475]
120489406  heat shock cognate 70 kDa protein-like [KO:K03283]
120489416  heat shock cognate 70 kDa protein-like [KO:K03283]
120489688  heat shock 70 kDa protein [KO:K03283]
120490127  heat shock 70 kDa protein-like [KO:K03283]
120490129  hsp70.3; heat shock cognate 70-kd protein, tandem duplicate 3 [KO:K03283]
120490266  heat shock 70 kDa protein-like [KO:K03283]
120483031  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
120469115  hspa1b; heat shock 70 kDa protein 1B [KO:K03283]
120478686  hsc70; heat shock cognate 71 kDa protein [KO:K03283]
120493118  dnajc6; putative tyrosine-protein phosphatase auxilin isoform X1 [KO:K09526]
120469205  washc4; WASH complex subunit 4 [KO:K18465]
120462176  washc5; WASH complex subunit 5 [KO:K18464]
120479338  washc2c; WASH complex subunit 2 isoform X1 [KO:K18462]
120464864  wash1; WASH complex subunit 1 [KO:K18461]
120477030  washc3; WASH complex subunit 3 [KO:K18463]
120484080  capza1b; F-actin-capping protein subunit alpha-1b [KO:K10364]
120494031  capza1a; F-actin-capping protein subunit alpha-1a [KO:K10364]
120486524  capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
120490684  vps29; vacuolar protein sorting-associated protein 29 isoform X1 [KO:K18467]
120489332  vps26b; vacuolar protein sorting-associated protein 26B [KO:K18466]
120482684  vps26bl; vacuolar protein sorting-associated protein 26B-like [KO:K18466]
120479759  vps26a; vacuolar protein sorting-associated protein 26A [KO:K18466]
120493633  vps35; vacuolar protein sorting-associated protein 35 [KO:K18468]
120493518  snx3; sorting nexin-3 [KO:K17918]
120494631  snx12; sorting nexin-12 isoform X1 [KO:K17918]
120484863  usp8; ubiquitin carboxyl-terminal hydrolase 8 [KO:K11839] [EC:3.4.19.12]
120474213  stambpa; STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
120481368  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
120481400  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
120481340  ras-related protein rab7-like [KO:K07897]
120480617  rab7a; ras-related protein Rab-7a [KO:K07897]
120480718  si:dkey-13a21.4; ras-related protein Rab-7a [KO:K07897]
120488221  zgc:100918; ras-related protein rab7 [KO:K07897]
120481206  ras-related protein rab7-like [KO:K07897]
120473044  hgs; hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]
120461527  stam2; signal transducing adapter molecule 2 [KO:K04705]
120464894  tsg101b; tumor susceptibility gene 101 protein [KO:K12183]
120473338  tsg101a; tumor susceptibility 101a [KO:K12183]
120465329  multivesicular body subunit 12B-like isoform X1 [KO:K12186]
120465331  multivesicular body subunit 12B-like [KO:K12186]
120466746  mvb12a; multivesicular body subunit 12A [KO:K12186]
120485336  mvb12bb; multivesicular body subunit 12Bb isoform X1 [KO:K12186]
120485340  vps28; vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
120482110  vps37bb; VPS37B subunit of ESCRT-I b [KO:K12185]
120492057  vps37c; vacuolar protein sorting-associated protein 37C [KO:K12185]
120470059  vps37ba; VPS37B subunit of ESCRT-I a [KO:K12185]
120478717  vacuolar protein sorting-associated protein 37C-like [KO:K12185]
120472079  vps37d; vacuolar protein sorting-associated protein 37D [KO:K12185]
120481294  vps37a; vacuolar protein sorting-associated protein 37A [KO:K12185]
120463932  snf8; vacuolar-sorting protein SNF8 isoform X1 [KO:K12188]
120482170  vps36; vacuolar protein-sorting-associated protein 36 [KO:K12190]
120468969  vps25; vacuolar protein-sorting-associated protein 25 [KO:K12189]
120474713  chmp6b; charged multivesicular body protein 6 [KO:K12195]
120489182  charged multivesicular body protein 6 isoform X1 [KO:K12195]
120474854  chmp4bb; charged multivesicular body protein 4c [KO:K12194]
120493938  chmp4ba; charged multivesicular body protein 4b [KO:K12194]
120475862  chmp4c; charged multivesicular body protein 4c [KO:K24782]
120475720  chmp3; charged multivesicular body protein 3 [KO:K12193]
120474501  charged multivesicular body protein 2a [KO:K12191]
120474526  chmp2a; charged multivesicular body protein 2a [KO:K12191]
120461423  chmp2bb; charged multivesicular body protein 2b [KO:K12192]
120487283  chmp2ba; charged multivesicular body protein 2Ba [KO:K12192]
120481237  chmp7; charged multivesicular body protein 7 [KO:K15053]
120482482  vps4b; vacuolar protein sorting-associated protein 4B isoform X1 [KO:K12196]
120468024  vps4a; vacuolar protein sorting-associated protein 4A [KO:K12196]
120486497  vacuolar protein sorting-associated protein 4B-like [KO:K12196]
120493771  vta1; vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
120478375  chmp1a; charged multivesicular body protein 1a [KO:K12197]
120470243  chmp1b; charged multivesicular body protein 1b [KO:K12197]
120481794  chmp5a; charged multivesicular body protein 5 [KO:K12198]
120477660  chmp5b; charged multivesicular body protein 5 [KO:K12198]
120492645  ist1; IST1 homolog isoform X1 [KO:K19476]
120485158  programmed cell death 6-interacting protein isoform X1 [KO:K12200]
120469869  maspardin [KO:K19367]
120469870  maspardin [KO:K19367]
120493802  cation-independent mannose-6-phosphate receptor-like [KO:K06564]
120493804  cation-independent mannose-6-phosphate receptor-like [KO:K06564]
120475508  snx2; sorting nexin-2 [KO:K17917]
120490987  snx1b; sorting nexin-1 [KO:K17917]
120477745  snx1a; sorting nexin-1a [KO:K17917]
120463945  snx5; sorting nexin-5 [KO:K17920]
120475802  sorting nexin-6-like [KO:K17920]
120491496  si:dkey-28n18.9; sorting nexin-5 [KO:K17920]
120468968  sorting nexin-5-like [KO:K17920]
120480690  sorting nexin-6 [KO:K17920]
120463324  src; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
120464885  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
120473360  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
120462286  il2rb; interleukin-2 receptor subunit beta [KO:K05069]
120475010  il2rgb; interleukin 2 receptor, gamma b [KO:K05070]
120482795  il2rga; interleukin 2 receptor, gamma a [KO:K05070]
120473952  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
120473953  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
120483844  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
120483860  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
120493692  rhoca; ras homolog family member Ca [KO:K04513]
120486480  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
120483303  zinc-alpha-2-glycoprotein-like [KO:K06751]
120483603  H-2 class I histocompatibility antigen, Q9 alpha chain [KO:K06751]
120476273  rtbdn; retbindin [KO:K13649]
120478254  folr; folate receptor [KO:K13649]
120459090  cav1; caveolin-1 [KO:K06278]
120459091  cav2; caveolin-2 [KO:K12958]
120462894  zgc:158296; caveolin-2 [KO:K12958]
120480744  zgc:172270; caveolin-2 [KO:K12958]
120491672  cav3; caveolin-3 [KO:K12959]
120493755  ehd3; EH domain-containing protein 3 [KO:K12476]
120477640  ehd4; EH domain-containing protein 4 [KO:K12477]
120462022  eea1; early endosome antigen 1 [KO:K12478]
120491156  rab5ab; RAB5A, member RAS oncogene family, b [KO:K07887]
120483794  rab5aa; RAB5A, member RAS oncogene family, a [KO:K07887]
120486535  rab5b; ras-related protein Rab-5B [KO:K07888]
120489695  rab5c; ras-related protein Rab-5C [KO:K07889]
120472052  rabep1; rab GTPase-binding effector protein 1 isoform X1 [KO:K12480]
120481324  rabenosyn-5 [KO:K12481]
120480019  rab4a; ras-related protein Rab-4A [KO:K07879]
120460700  rufy1; RUN and FYVE domain-containing protein 1 [KO:K12482]
120479528  rufy2; RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
120476447  ehd1b; EH domain-containing protein 1b [KO:K12483]
120460822  ehd1a; EH domain-containing protein 1a [KO:K12483]
120485329  vps45; vacuolar protein sorting-associated protein 45 [KO:K12479]
120461524  sorting nexin-4-like [KO:K17919]
120461590  sorting nexin-4-like [KO:K17919]
120481789  rab31; ras-related protein Rab-31 [KO:K07891]
120493955  rab22a; ras-related protein Rab-22A [KO:K07891]
120460293  rab10; ras-related protein Rab-10 [KO:K07903]
120460884  rab8a; ras-related protein Rab-8A [KO:K07901]
120489491  rab35b; ras-related protein Rab-35b [KO:K07876]
120489786  si:dkey-16l2.16; ras-related protein Rab-35 [KO:K07876]
120471647  rab35a; ras-related protein Rab-35 [KO:K07876]
120481435  rab11al; RAB11a, member RAS oncogene family, like [KO:K07904]
120493784  rab11a; ras-related protein Rab-11A [KO:K07904]
120491786  rab11bb; RAB11B, member RAS oncogene family, b isoform X1 [KO:K07905]
120486500  rab11ba; RAB11B, member RAS oncogene family, a [KO:K07905]
120474228  rab11fip1b; LOW QUALITY PROTEIN: titin homolog [KO:K12484]
120461099  uncharacterized protein LOC120461099 isoform X1 [KO:K12484]
120486512  rab11fip1a; rab11 family-interacting protein 1 [KO:K12484]
120479541  rab11 family-interacting protein 2 [KO:K12484]
120479761  rab11fip5a; uncharacterized protein rab11fip5a isoform X1 [KO:K12484]
120488234  zfyve27; protrudin isoform X1 [KO:K19368]
120464564  kif5ab; kinesin heavy chain [KO:K10396]
120474750  kif5bb; kinesin-1 heavy chain [KO:K10396]
120475092  kif5aa; kinesin family member 5Aa [KO:K10396]
120467184  kif5c; kinesin heavy chain [KO:K10396]
120495478  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
120495479  kinesin-1 heavy chain-like isoform X1 [KO:K10396]
120489635  rab11fip4a; rab11 family-interacting protein 4A isoform X1 [KO:K12485]
120471133  rab11fip4b; rab11 family-interacting protein 4B isoform X1 [KO:K12485]
120479776  rab11fip3; rab11 family-interacting protein 3 isoform X1 [KO:K12485]
120492272  pard3aa; partitioning defective 3 homolog [KO:K04237]
120495320  pard3ab; LOW QUALITY PROTEIN: par-3 family cell polarity regulator alpha, b [KO:K04237]
120484521  pard6ga; par-6 family cell polarity regulator gamma a [KO:K06093]
120485396  pard6gb; par-6 family cell polarity regulator gamma b [KO:K06093]
120487816  pard6a; partitioning defective 6 homolog alpha [KO:K06093]
120463612  pard6b; partitioning defective 6 homolog beta [KO:K06093]
120482077  prkcz; protein kinase C zeta type isoform X1 [KO:K18952] [EC:2.7.11.13]
120465129  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
120484761  cdc42l; cell division cycle 42, like [KO:K04393]
120463350  cdc42l2; cell division cycle 42 like 2 isoform X1 [KO:K04393]
120480475  cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120485018  smap2; stromal membrane-associated protein 2 isoform X1 [KO:K12486]
120485413  stromal membrane-associated protein 2-like [KO:K12486]
120479463  stromal membrane-associated protein 1-like isoform X1 [KO:K12486]
120479652  stromal membrane-associated protein 1-like [KO:K12486]
120472372  git1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
120482542  git2b; ARF GTPase-activating protein GIT2b isoform X1 [KO:K12487]
120469623  git2a; ARF GTPase-activating protein GIT2a isoform X1 [KO:K12487]
120482155  asap1a; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1a isoform X1 [KO:K12488]
120476016  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like isoform X1 [KO:K12488]
120493539  asap2b; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2b [KO:K12488]
120486818  LOW QUALITY PROTEIN: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
120486821  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2-like [KO:K12488]
120480534  asap3; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12488]
120480640  unm_sa1614; arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
120469760  acap1; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 [KO:K12489]
120461382  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like isoform X1 [KO:K12489]
120470816  zgc:162872; BAR_ACAPs and ArfGap_ACAP domain-containing protein [KO:K12489]
120463429  acap3a; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12489]
120473408  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like [KO:K12489]
120473410  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3-like isoform X1 [KO:K12489]
120478236  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
120470113  arap1a; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
120473632  arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K18439]
120477290  zmp:0000000660; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 [KO:K18440]
120460878  arap3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
120466997  agap1; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 isoform X1 [KO:K12491]
120486083  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K12491]
120488161  agap3; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12491]
120463265  LOW QUALITY PROTEIN: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2-like [KO:K17848]
120460906  arfgap1; ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
120459974  arfgap2; ADP-ribosylation factor GTPase-activating protein 2 isoform X1 [KO:K12493]
120478361  arfgap3; ADP-ribosylation factor GTPase-activating protein 3 [KO:K12493]
120474775  uncharacterized protein LOC120474775 [KO:K12494]
120482354  psd3l; PH and SEC7 domain-containing protein 3 [KO:K12494]
120460964  psd2; PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
120479527  psda; LOW QUALITY PROTEIN: uncharacterized protein psda [KO:K12494]
120472164  PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
120464816  iqsec3b; LOW QUALITY PROTEIN: IQ motif and SEC7 domain-containing protein 3 [KO:K12495]
120469150  IQ motif and SEC7 domain-containing protein 2 isoform X1 [KO:K12495]
120477161  iqsec3a; IQ motif and SEC7 domain-containing protein 3 isoform X1 [KO:K12495]
120479059  iqsec1a; IQ motif and Sec7 domain ArfGEF 1a isoform X1 [KO:K12495]
120479371  iqsec2b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
120480367  iqsec1b; IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
120481536  cyth3b; cytohesin-3 isoform X1 [KO:K18441]
120474664  cyth1b; LOW QUALITY PROTEIN: cytohesin-1b [KO:K18441]
120490681  cyth3a; cytohesin-3 [KO:K18441]
120476202  cytohesin-1 isoform X1 [KO:K18441]
120476203  cytohesin-1-like [KO:K18441]
120467940  cyth4b; cytohesin 4b isoform X1 [KO:K18441]
120462660  cyth2; cytohesin-2 isoform X1 [KO:K18441]
120489160  cyth4a; cytohesin-3 [KO:K18441]
120475963  arfgef1; brefeldin A-inhibited guanine nucleotide-exchange protein 1 isoform X1 [KO:K18442]
120463353  arfgef2; brefeldin A-inhibited guanine nucleotide-exchange protein 2 [KO:K18442]
120479412  gbf1; Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
120489401  arf2a; ADP-ribosylation factor 2a [KO:K07937]
120468718  arf1; ADP-ribosylation factor 1 [KO:K07937]
120488029  arf2b; ADP-ribosylation factor 2b [KO:K07937]
120491645  arf3b; ADP-ribosylation factor 3b [KO:K07938]
120463644  arf3a; ADP-ribosylation factor 3a isoform X1 [KO:K07938]
120464823  arf5; ADP-ribosylation factor 5 [KO:K07939]
120464824  ADP-ribosylation factor 4-like [KO:K07939]
120480279  ADP-ribosylation factor 4-like [KO:K07939]
120480297  ADP-ribosylation factor 4-like [KO:K07939]
120480756  ADP-ribosylation factor 4-like [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
pprm04060  Cytokine-cytokine receptor interaction
pprm04070  Phosphatidylinositol signaling system
pprm04130  SNARE interactions in vesicular transport
pprm04142  Lysosome
pprm04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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