KEGG   PATHWAY: stru04350
Entry
stru04350                   Pathway                                
Name
TGF-beta signaling pathway - Salmo trutta (river trout)
Description
The transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species ranging from worms and insects to mammals. A wide spectrum of cellular functions such as proliferation, apoptosis, differentiation and migration are regulated by TGF-beta family members. TGF-beta family member binds to the Type II receptor and recruits Type I, whereby Type II receptor phosphorylates and activates Type I. The Type I receptor, in turn, phosphorylates receptor-activated Smads ( R-Smads: Smad1, Smad2, Smad3, Smad5, and Smad8). Once phosphorylated, R-Smads associate with the co-mediator Smad, Smad4, and the heteromeric complex then translocates into the nucleus. In the nucleus, Smad complexes activate specific genes through cooperative interactions with other DNA-binding and coactivator (or co-repressor) proteins.
Class
Environmental Information Processing; Signal transduction
Pathway map
stru04350  TGF-beta signaling pathway
stru04350

Other DBs
GO: 0007179
Organism
Salmo trutta (river trout) [GN:stru]
Gene
115163617  chordin-like [KO:K04657]
115206509  chordin-like [KO:K04657]
115153496  nog; noggin [KO:K04658]
115170737  noggin-2-like [KO:K04658]
115171429  noggin-3-like [KO:K04658]
115159967  noggin-2-like [KO:K04658]
115200864  noggin-3-like [KO:K04658]
115200970  noggin-2-like [KO:K04658]
115202581  noggin-3-like [KO:K04658]
115150629  neuroblastoma suppressor of tumorigenicity 1-like isoform X1 [KO:K19558]
115207785  neuroblastoma suppressor of tumorigenicity 1-like [KO:K19558]
115183654  grem2; gremlin-2 isoform X1 [KO:K23318]
115193686  gremlin-2-like [KO:K23318]
115175123  gremlin-1-like [KO:K23318]
115153272  gremlin-2-like [KO:K23318]
115162371  gremlin-1-like [KO:K23318]
115172652  gremlin-1-like [KO:K23318]
115156939  gremlin-1-like [KO:K23318]
115175127  thrombospondin-1-like [KO:K16857]
115162365  thrombospondin-1-like [KO:K16857]
115156330  thrombospondin-1-like [KO:K16857]
115172646  thrombospondin-1-like [KO:K16857]
115179983  decorin-like [KO:K04660]
115199091  decorin-like [KO:K04660]
115150319  fibromodulin-like [KO:K08121]
115208113  fibromodulin-like [KO:K08121]
115174540  left-right determination factor 2-like [KO:K04668]
115162734  left-right determination factor 2-like [KO:K04668]
115167266  left-right determination factor 2-like [KO:K04668]
115165046  follistatin-A isoform X1 [KO:K04661]
115159161  follistatin-A-like isoform X1 [KO:K04661]
115149388  follistatin-A-like [KO:K04661]
115200639  follistatin-A-like isoform X1 [KO:K04661]
115174481  bone morphogenetic protein 2-like [KO:K21283]
115162980  bone morphogenetic protein 4-like [KO:K21283]
115163233  bone morphogenetic protein 2-like [KO:K21283]
115156427  bone morphogenetic protein 2-like [KO:K21283]
115173509  bone morphogenetic protein 2-like [KO:K21283]
115205939  LOW QUALITY PROTEIN: bone morphogenetic protein 2-like [KO:K21283]
115162164  bone morphogenetic protein 4-like [KO:K04662]
115172445  bone morphogenetic protein 4-like [KO:K04662]
115149905  bone morphogenetic protein 7-like [KO:K16620]
115195598  bmp6; bone morphogenetic protein 6 [KO:K16620]
115155625  inhibin beta B chain-like [KO:K22687]
115160962  inhibin beta B chain-like [KO:K22687]
115179607  inhibin beta B chain-like [KO:K22687]
115151072  inhibin beta C chain-like [KO:K22687]
115207339  inhibin beta B chain-like [KO:K22687]
115196012  inhibin beta B chain-like [KO:K22687]
115169857  serotransferrin-1 isoform X1 [KO:K14736]
115169858  serotransferrin-2-like isoform X1 [KO:K14736]
115153430  bone morphogenetic protein 5-like [KO:K04663]
115201596  bone morphogenetic protein 5-like [KO:K04663]
115168387  bone morphogenetic protein 7-like [KO:K16621]
115166148  bone morphogenetic protein 7-like [KO:K16621]
115150812  bone morphogenetic protein 7-like [KO:K16621]
115207619  bone morphogenetic protein 7-like [KO:K16621]
115176172  bone morphogenetic protein 8B-like isoform X1 [KO:K16622]
115173475  bone morphogenetic protein 8B-like isoform X1 [KO:K16622]
115149895  gdf5; growth/differentiation factor 5 [KO:K04664]
115208439  growth/differentiation factor 5-like [KO:K04664]
115175969  growth/differentiation factor 6-A-like [KO:K20012]
115177367  growth/differentiation factor 6-A-like [KO:K20012]
115173192  growth/differentiation factor 6-B-like [KO:K20012]
115162717  growth/differentiation factor 6-A-like [KO:K20013]
115172450  growth/differentiation factor 6-A-like [KO:K20013]
115158261  amh; muellerian-inhibiting factor [KO:K04665]
115181896  interferon gamma 1-like [KO:K04687]
115184184  interferon gamma 1-like isoform X1 [KO:K04687]
115174125  tumor necrosis factor-like [KO:K03156]
115175311  tumor necrosis factor-like [KO:K03156]
115167052  thrombospondin type-1 domain-containing protein 4-like isoform X1 [KO:K23377]
115203270  thrombospondin type-1 domain-containing protein 4-like isoform X1 [KO:K23377]
115193820  latent-transforming growth factor beta-binding protein 1-like isoform X1 [KO:K19559]
115153174  ltbp1; latent-transforming growth factor beta-binding protein 1 isoform X1 [KO:K19559]
115154758  transforming growth factor beta-1 proprotein-like [KO:K13375]
115206692  transforming growth factor beta-1 proprotein-like [KO:K13375]
115204365  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
115168917  transforming growth factor beta-2 proprotein-like [KO:K13376]
115175550  transforming growth factor beta-2 proprotein-like [KO:K13376]
115177416  transforming growth factor beta-2 proprotein-like [KO:K13376]
115205573  transforming growth factor beta-2 proprotein-like isoform X1 [KO:K13376]
115175155  transforming growth factor beta-3 proprotein-like [KO:K13377]
115162330  transforming growth factor beta-3 proprotein-like [KO:K13377]
115172613  transforming growth factor beta-3 proprotein-like [KO:K13377]
115151907  transforming growth factor beta-3 proprotein-like [KO:K13377]
115170185  inhba; inhibin beta A chain [KO:K04667]
115154063  inhibin beta A chain-like [KO:K04667]
115156586  inhibin beta A chain-like [KO:K04667]
115195860  inhibin beta A chain-like [KO:K04667]
115190191  nodal homolog 2-A-like [KO:K04666]
115152734  nodal homolog 2-A-like [KO:K04666]
115164055  nodal homolog 2-A-like [KO:K04666]
115202745  nodal homolog 2-A-like [KO:K04666]
115200187  nodal homolog 2-A-like [KO:K04666]
115193873  bone morphogenetic protein receptor type-1A-like isoform X1 [KO:K04673] [EC:2.7.11.30]
115153130  bone morphogenetic protein receptor type-1A-like isoform X1 [KO:K04673] [EC:2.7.11.30]
115164992  bmpr1b; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
115159366  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
115149215  bone morphogenetic protein receptor type-1B-like [KO:K13578] [EC:2.7.11.30]
115156083  acvr1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
115160701  activin receptor type-1-like isoform X1 [KO:K04675] [EC:2.7.11.30]
115179357  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
115196161  activin receptor type-1-like [KO:K04675] [EC:2.7.11.30]
115161448  bone morphogenetic protein receptor type-2-like [KO:K04671] [EC:2.7.11.30]
115184541  bone morphogenetic protein receptor type-2-like [KO:K04671] [EC:2.7.11.30]
115156264  bone morphogenetic protein receptor type-2-like [KO:K04671] [EC:2.7.11.30]
115155533  activin receptor type-2A-like [KO:K04670] [EC:2.7.11.30]
115160846  activin receptor type-2A-like [KO:K04670] [EC:2.7.11.30]
115179829  activin receptor type-2A-like isoform X1 [KO:K04670] [EC:2.7.11.30]
115195962  activin receptor type-2A isoform X1 [KO:K04670] [EC:2.7.11.30]
115180224  hemojuvelin-like [KO:K23100]
115176778  hemojuvelin-like [KO:K23100]
115166817  neogenin-like isoform X1 [KO:K06766]
115203507  neogenin-like [KO:K06766]
115189365  transferrin receptor protein 2-like [KO:K23910]
115170147  transferrin receptor protein 1-like [KO:K06503]
115151496  transferrin receptor protein 1-like isoform X1 [KO:K06503]
115195465  transferrin receptor protein 1-like isoform X1 [KO:K06503]
115192640  repulsive guidance molecule A-like [KO:K23096]
115158236  repulsive guidance molecule A-like isoform X1 [KO:K23096]
115151984  repulsive guidance molecule A-like isoform X1 [KO:K23096]
115196766  repulsive guidance molecule A-like [KO:K23096]
115164398  RGM domain family member B-like [KO:K06847]
115200248  RGM domain family member B-like isoform X1 [KO:K06847]
115169694  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
115157085  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
115149427  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
115195639  TGF-beta receptor type-1-like isoform X1 [KO:K04674] [EC:2.7.11.30]
115176037  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
115155646  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
115160989  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
115173307  TGF-beta receptor type-2-like [KO:K04388] [EC:2.7.11.30]
115207067  epithelial membrane protein 3-like [KO:K26257]
115166046  epithelial membrane protein 3-like [KO:K26257]
115150919  epithelial membrane protein 3-like [KO:K26257]
115148590  transforming growth factor beta activator LRRC32-like [KO:K26316]
115154061  transforming growth factor beta activator LRRC32-like isoform X1 [KO:K26316]
115187321  transforming growth factor beta activator LRRC32-like isoform X1 [KO:K26316]
115195360  transforming growth factor beta activator LRRC33-like isoform X1 [KO:K26317]
115152954  transforming growth factor beta activator LRRC33-like [KO:K26317]
115167839  activin receptor type-1B-like isoform X1 [KO:K13567] [EC:2.7.11.30]
115165502  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
115150572  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
115207835  activin receptor type-1B-like [KO:K13567] [EC:2.7.11.30]
115157595  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
115150309  activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
115195559  activin receptor type-2B-like [KO:K13596] [EC:2.7.11.30]
115156084  acvr1c; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
115160699  activin receptor type-1C-like [KO:K13568] [EC:2.7.11.30]
115153825  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
115195897  BMP and activin membrane-bound inhibitor homolog [KO:K10162]
115191790  mothers against decapentaplegic homolog 1-like isoform X1 [KO:K04676]
115194736  smad1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
115202239  mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
115167106  mothers against decapentaplegic homolog 5-like isoform X1 [KO:K16790]
115205737  mothers against decapentaplegic homolog 5 isoform X1 [KO:K16790]
115204638  smad9; mothers against decapentaplegic homolog 9 isoform X1 [KO:K16791]
115164783  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
115199870  mothers against decapentaplegic homolog 2-like isoform X1 [KO:K04500]
115192958  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
115166794  mothers against decapentaplegic homolog 3 [KO:K23605]
115164984  smad4; LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4 [KO:K04501]
115173628  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115175837  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115176558  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115159360  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115180008  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115149222  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
115199711  mothers against decapentaplegic homolog 4-like [KO:K04501]
115182703  mothers against decapentaplegic homolog 6-like [KO:K04677]
115166793  mothers against decapentaplegic homolog 6-like [KO:K04677]
115203655  mothers against decapentaplegic homolog 6-like [KO:K04677]
115159099  smad7; mothers against decapentaplegic homolog 7 isoform X1 [KO:K19631]
115183943  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115188858  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115188928  E3 ubiquitin-protein ligase SMURF1-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115171382  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115178351  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115201867  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
115208608  E3 ubiquitin-protein ligase SMURF2-like isoform X1 [KO:K04678] [EC:2.3.2.26]
115157629  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
115158016  zinc finger FYVE domain-containing protein 9-like isoform X1 [KO:K04679]
115169225  zfyve9; zinc finger FYVE domain-containing protein 9 [KO:K04679]
115159881  zinc finger FYVE domain-containing protein 16-like isoform X1 [KO:K04679]
115151576  zinc finger FYVE domain-containing protein 9-like [KO:K04679]
115203804  zinc finger FYVE domain-containing protein 16-like isoform X1 [KO:K04679]
115171287  RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
115199956  RING-box protein 1 isoform X1 [KO:K03868] [EC:2.3.2.32]
115152091  cullin-1-like [KO:K03347]
115169709  cullin-1 [KO:K03347]
115157067  cullin-1-like [KO:K03347]
115154025  S-phase kinase-associated protein 1 [KO:K03094]
115148560  S-phase kinase-associated protein 1 [KO:K03094]
115165075  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
115192138  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115170800  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115200671  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
115168240  rho-related GTP-binding protein RhoA-C [KO:K04513]
115168296  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
115165260  rho-related GTP-binding protein RhoA-C-like [KO:K04513]
115165905  rho-related GTP-binding protein RhoA-C-like isoform X1 [KO:K04513]
115166252  rho-related GTP-binding protein RhoA-B [KO:K04513]
115150994  rho-related GTP-binding protein RhoA-D [KO:K04513]
115150254  transforming protein RhoA-like [KO:K04513]
115208179  transforming protein RhoA-like [KO:K04513]
115169563  rho-associated protein kinase 1-like isoform X1 [KO:K04514] [EC:2.7.11.1]
115157216  rho-associated protein kinase 1-like isoform X1 [KO:K04514] [EC:2.7.11.1]
115162918  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform-like [KO:K03456]
115205876  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
115154024  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
115160075  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
115167379  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
115167649  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
115148561  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
115203777  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
115205700  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like isoform X1 [KO:K04382] [EC:3.1.3.16]
115191963  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
115154330  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
115163489  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
115148872  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
115206403  ribosomal protein S6 kinase beta-1-like isoform X1 [KO:K04688] [EC:2.7.11.1]
115202102  ribosomal protein S6 kinase beta-2-like isoform X1 [KO:K04688] [EC:2.7.11.1]
115177216  hepcidin [KO:K23106]
115168624  DNA-binding protein inhibitor ID-1-like [KO:K04680]
115165962  DNA-binding protein inhibitor ID-1-like [KO:K04680]
115150821  DNA-binding protein inhibitor ID-1-like [KO:K04680]
115207607  DNA-binding protein inhibitor ID-1-like [KO:K04680]
115174985  DNA-binding protein inhibitor ID-2-like [KO:K17693]
115162537  id2; DNA-binding protein inhibitor ID-2 [KO:K17693]
115172833  DNA-binding protein inhibitor ID-2-like [KO:K17693]
115195175  DNA-binding protein inhibitor ID-2-like [KO:K17693]
115189001  DNA-binding protein inhibitor ID-4-like [KO:K17695]
115189002  DNA-binding protein inhibitor ID-4-like [KO:K17695]
115208414  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
115152244  e2f4; transcription factor E2F4 [KO:K04682]
115167192  transcription factor E2F4-like [KO:K04682]
115156777  transcription factor E2F5-like isoform X1 [KO:K04682]
115203140  transcription factor E2F4-like [KO:K04682]
115197458  transcription factor E2F4-like [KO:K04682]
115155887  transcription factor Dp-1-like isoform X1 [KO:K04683]
115179526  transcription factor Dp-1-like [KO:K04683]
115179527  transcription factor Dp-1-like [KO:K04683]
115161278  transcription factor Dp-1-like isoform X1 [KO:K04683]
115152698  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
115171283  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115171774  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115178827  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115147398  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115206430  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115201319  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
115199931  histone acetyltransferase p300-like [KO:K04498] [EC:2.3.1.48]
115207322  sp1; transcription factor Sp1 isoform X1 [KO:K04684]
115157517  ski-like protein isoform X1 [KO:K18499]
115169298  ski-like protein [KO:K18499]
115168950  ski; ski oncogene [KO:K26503]
115150928  ski oncogene-like [KO:K26503]
115165372  ski oncogene-like [KO:K26503]
115166830  paired amphipathic helix protein Sin3a-like isoform X1 [KO:K11644]
115203496  paired amphipathic helix protein Sin3a-like isoform X1 [KO:K11644]
115197166  sin3a; paired amphipathic helix protein Sin3a isoform X1 [KO:K11644]
115174133  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
115176317  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
115162437  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
115172722  probable histone deacetylase 1-B [KO:K06067] [EC:3.5.1.98]
115194183  histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
115154316  nuclear receptor corepressor 1-like isoform X1 [KO:K04650]
115148853  nuclear receptor corepressor 1-like [KO:K04650]
115154337  homeobox protein AKR-like isoform X1 [KO:K19383]
115195825  homeobox protein AKR-like [KO:K19383]
115150174  homeobox protein AKR-like isoform X1 [KO:K19553]
115208296  homeobox protein TGIF1-like [KO:K19553]
115154720  transcriptional regulator Myc-like [KO:K04377]
115156503  myc; myc proto-oncogene protein [KO:K04377]
115195764  transcriptional regulator Myc [KO:K04377]
115208402  transcriptional regulator Myc-2-like [KO:K04377]
115151122  transcriptional regulator Myc-2-like [KO:K04377]
115191708  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
115170833  pituitary homeobox 2-like isoform X1 [KO:K04686]
115205119  pituitary homeobox 2 isoform X1 [KO:K04686]
Compound
C14819  Fe3+
Reference
PMID:12809600
  Authors
Shi Y, Massague J.
  Title
Mechanisms of TGF-beta signaling from cell membrane to the nucleus.
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pathway
stru04010  MAPK signaling pathway
stru04110  Cell cycle
stru04120  Ubiquitin mediated proteolysis
stru04210  Apoptosis
KO pathway
ko04350   
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