KEGG   PATHWAY: xma05168
Entry
xma05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Xiphophorus maculatus (southern platyfish)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
xma05168  Herpes simplex virus 1 infection
xma05168

Organism
Xiphophorus maculatus (southern platyfish) [GN:xma]
Gene
102225449  tumor necrosis factor-like [KO:K05468]
102225273  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
111608550  uncharacterized protein LOC111608550 [KO:K05477]
102220194  tnfrsf14; tumor necrosis factor receptor superfamily member 14 [KO:K05152]
111608032  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K05152]
111609649  tumor necrosis factor receptor superfamily member 5-like isoform X1 [KO:K05152]
111609653  tumor necrosis factor receptor superfamily member 5-like [KO:K05152]
111609892  tumor necrosis factor receptor superfamily member 5-like [KO:K05152]
111606209  proprotein convertase subtilisin/kexin type 5-like [KO:K05152]
102233408  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
102217350  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
102227944  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
102223773  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102226088  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
102221657  inhibitor of nuclear factor kappa-B kinase subunit alpha-like isoform X1 [KO:K04467] [EC:2.7.11.10]
102233509  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
102228531  nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
102217801  NF-kappa-B inhibitor alpha-like [KO:K04734]
102218233  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
102219636  transcription factor p65-like isoform X1 [KO:K04735]
102228638  birc2; baculoviral IAP repeat-containing protein 2 isoform X2 [KO:K16060]
102219032  nectin1; nectin-1 isoform X5 [KO:K06081]
102238052  nectin-1-like [KO:K06081]
102231310  nectin-2-like isoform X1 [KO:K06531]
102222444  nectin-2-like isoform X1 [KO:K06531]
102232688  ptpn11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102223330  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
102234716  integrin alpha-5-like [KO:K06484]
102222515  integrin alpha-5 [KO:K06484]
102221802  integrin beta-3 [KO:K06493]
102227385  itgb3; integrin beta-3 [KO:K06493]
102227098  proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
102227197  proto-oncogene tyrosine-protein kinase Src isoform X4 [KO:K05704] [EC:2.7.10.2]
102238337  card9; caspase recruitment domain-containing protein 9 isoform X1 [KO:K12794]
102228854  interferon regulatory factor 3-like isoform X1 [KO:K05411]
102219062  tp53; cellular tumor antigen p53 [KO:K04451]
102235663  complement C3-like [KO:K03990]
102229911  c5; complement C5 [KO:K03994]
102222311  cfp; properdin [KO:K15412]
102226787  toll-like receptor 2 type-2 [KO:K10159]
102227045  toll-like receptor 2 type-1 [KO:K10159]
102230797  toll-like receptor 2 type-2 isoform X1 [KO:K10159]
102234764  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
102220023  irf7; interferon regulatory factor 7 isoform X2 [KO:K09447]
102217195  tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
102229375  TIR domain-containing adapter molecule 1-like [KO:K05842]
102235789  irak4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
102231075  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
102220826  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102226534  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
102232287  mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
102220462  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
102236763  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
106700093  interleukin-1 beta isoform X1 [KO:K04519]
102231459  interleukin-1 beta [KO:K04519]
111610322  interleukin-1 beta-like [KO:K04519]
102231253  tumor necrosis factor-like isoform X1 [KO:K03156]
111609466  tumor necrosis factor-like [KO:K03156]
111612051  interleukin-12 subunit alpha-like [KO:K05406]
102220212  interleukin-12 subunit beta-like [KO:K05425]
102220488  interleukin-12 subunit beta-like [KO:K05425]
102226505  interleukin-12 subunit beta-like [KO:K05425]
102237624  ifih1; interferon-induced helicase C domain-containing protein 1 isoform X1 [KO:K12647] [EC:5.6.2.6]
102221226  mavs; mitochondrial antiviral-signaling protein [KO:K12648]
102234631  traf3; TNF receptor-associated factor 3 [KO:K03174]
102228722  inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
102227107  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
106699651  interferon a3-like [KO:K05414]
111609837  interferon a3-like [KO:K05414]
106700431  interferon a3-like [KO:K05414]
106699738  cyclic GMP-AMP synthase-like [KO:K17834] [EC:2.7.7.86]
102238245  cgas; cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
102235680  tmem173; stimulator of interferon genes protein [KO:K12654]
102232527  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102219385  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
102229527  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
102233529  serine/threonine-protein phosphatase alpha-2 isoform [KO:K06269] [EC:3.1.3.16]
102223696  serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like [KO:K06269] [EC:3.1.3.16]
102230984  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
102234726  eif2ak1; eukaryotic translation initiation factor 2-alpha kinase 1 isoform X4 [KO:K16194] [EC:2.7.11.1]
102232776  interferon-induced, double-stranded RNA-activated protein kinase-like [KO:K16195] [EC:2.7.11.1]
102220027  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
102234794  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
102218618  eif2s1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
102235528  eif2b1; translation initiation factor eIF-2B subunit alpha [KO:K03239]
102224563  eif2b2; translation initiation factor eIF-2B subunit beta [KO:K03754]
102216379  eif2b3; translation initiation factor eIF-2B subunit gamma [KO:K03241]
102220520  eif2b4; translation initiation factor eIF-2B subunit delta isoform X2 [KO:K03680]
102234298  eif2b5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
102220785  hcfc1; host cell factor 1 [KO:K14966]
102230815  host cell factor 1 isoform X1 [KO:K14966]
102227032  hcfc2; host cell factor 2 [KO:K27390]
102222180  POU domain, class 2, transcription factor 2-like [KO:K09364]
102230530  pou2f2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
102230786  pou2f1; POU domain, class 2, transcription factor 1 isoform X1 [KO:K09364]
102224283  pou2f3; POU domain, class 2, transcription factor 3 [KO:K09364]
102219036  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
102232586  suppressor of cytokine signaling 3 [KO:K04696]
102216753  suppressor of cytokine signaling 3-like [KO:K04696]
102225542  jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
102232564  tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
102225755  signal transducer and activator of transcription 1-like [KO:K11220]
102237914  signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
102236235  signal transducer and activator of transcription 1-alpha/beta [KO:K11221]
102232232  irf9; interferon regulatory factor 9 [KO:K04693]
102238297  uncharacterized protein LOC102238297 [KO:K09228]
102234262  zinc finger protein 11-like [KO:K09228]
111608706  zinc finger protein 585A-like [KO:K09228]
102230471  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
102226835  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111608388  uncharacterized protein LOC111608388 [KO:K09228]
102227867  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
102232043  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102217614  zinc finger protein 184-like [KO:K09228]
102219431  zinc finger protein 420-like [KO:K09228]
102223843  zinc finger protein 431-like [KO:K09228]
102222918  zinc finger protein 497-like isoform X2 [KO:K09228]
102219170  zinc finger protein OZF-like [KO:K09228]
106699732  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111608861  zinc finger protein 37-like [KO:K09228]
102221437  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102235368  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102235506  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102229377  zinc finger protein 208-like [KO:K09228]
106700102  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
106700144  zinc finger protein OZF-like [KO:K09228]
111610415  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
102221175  oocyte zinc finger protein XlCOF6-like isoform X1 [KO:K09228]
102223429  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
106699817  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102222408  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102221969  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
102223442  zinc finger protein OZF-like [KO:K09228]
102223955  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
102233705  zinc finger protein 501-like [KO:K09228]
111609630  zinc finger protein 570-like [KO:K09228]
111610444  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
111610488  zinc finger protein 845-like isoform X1 [KO:K09228]
102217360  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111610489  zinc finger protein OZF-like [KO:K09228]
111610565  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
106699898  zinc finger protein 26-like [KO:K09228]
111609741  zinc finger protein 2-like [KO:K09228]
102232322  zinc finger protein Xfin-like [KO:K09228]
111610297  zinc finger protein 658B-like isoform X1 [KO:K09228]
111609888  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
102233629  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
102228516  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
111609893  zinc finger protein OZF-like [KO:K09228]
102228637  zinc finger protein OZF-like [KO:K09228]
102230734  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102228377  zinc finger protein 595-like [KO:K09228]
106699810  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
102233858  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
106699806  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102229687  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
111609894  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
102235155  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
106699978  zinc finger protein OZF-like isoform X1 [KO:K09228]
102235609  gastrula zinc finger protein XlCGF52.1-like [KO:K09228]
102235460  oocyte zinc finger protein XlCOF6-like [KO:K09228]
102229532  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
102236113  zinc finger protein 501-like [KO:K09228]
102221208  zinc finger protein 420-like isoform X1 [KO:K09228]
111611950  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111611951  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
102233208  zinc finger protein OZF-like isoform X1 [KO:K09228]
111611952  zinc finger protein OZF-like [KO:K09228]
102232785  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
106700275  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111612081  zinc finger protein 345-like isoform X1 [KO:K09228]
102233345  zinc finger protein OZF-like [KO:K09228]
102234213  zinc finger protein 91-like [KO:K09228]
102224751  zinc finger protein OZF-like [KO:K09228]
106699812  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
111609925  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
106699811  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
102218376  gastrula zinc finger protein XlCGF58.1-like [KO:K09228]
102223944  oocyte zinc finger protein XlCOF6-like [KO:K09228]
102224976  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
106700115  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111610430  zinc finger protein OZF-like [KO:K09228]
102223177  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
111610840  zinc finger protein 70-like isoform X1 [KO:K09228]
102235099  zinc finger protein 84-like [KO:K09228]
102216852  gastrula zinc finger protein XlCGF52.1-like isoform X1 [KO:K09228]
102224523  zinc finger protein 37-like isoform X1 [KO:K09228]
102224779  zinc finger protein 329-like [KO:K09228]
111611181  gastrula zinc finger protein XlCGF8.2DB-like [KO:K09228]
106700186  zinc finger protein OZF-like [KO:K09228]
111610299  zinc finger protein 420-like [KO:K09228]
111610398  zinc finger protein 879-like [KO:K09228]
102234980  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102231200  zinc finger protein OZF-like [KO:K09228]
102225983  oocyte zinc finger protein XlCOF6-like [KO:K09228]
106699900  zinc finger protein OZF-like [KO:K09228]
102217188  oocyte zinc finger protein XlCOF6-like [KO:K09228]
102225282  oocyte zinc finger protein XlCOF6.1-like [KO:K09228]
102224716  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111606501  zinc finger protein 234-like [KO:K09228]
102231786  gastrula zinc finger protein XlCGF57.1-like isoform X3 [KO:K09228]
102235664  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102227348  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102230207  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111606770  zinc finger and SCAN domain-containing protein 2-like isoform X1 [KO:K09228]
111606771  zinc finger protein OZF-like isoform X1 [KO:K09228]
102227228  zinc finger protein 2-like [KO:K09228]
102233964  zinc finger protein 11-like [KO:K09228]
102234373  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
111608713  zinc finger protein 664-like isoform X1 [KO:K09228]
111608770  zinc finger protein OZF-like [KO:K09228]
111608774  zinc finger protein OZF-like [KO:K09228]
102221715  uncharacterized protein LOC102221715 [KO:K09228]
106700085  zinc finger protein 227-like [KO:K09228]
102238346  gastrula zinc finger protein XlCGF7.1-like isoform X2 [KO:K09228]
102224102  zinc finger protein 37-like isoform X2 [KO:K09228]
106699979  zinc finger protein OZF-like [KO:K09228]
111608865  zinc finger protein 134-like [KO:K09228]
106700176  zinc finger protein OZF-like [KO:K09228]
111608871  zinc finger protein 391-like [KO:K09228]
106700174  gastrula zinc finger protein XlCGF28.1-like [KO:K09228]
111608873  zinc finger protein 391-like [KO:K09228]
111608874  zinc finger protein 664-like [KO:K09228]
111608875  zinc finger protein 32-like [KO:K09228]
111605770  zinc finger protein 135-like isoform X1 [KO:K09228]
111608876  zinc finger protein 32-like [KO:K09228]
111608877  zinc finger protein 32-like [KO:K09228]
111608879  zinc finger and SCAN domain-containing protein 2-like [KO:K09228]
111608881  zinc finger protein 239-like [KO:K09228]
102223680  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111606247  zinc finger protein 271-like [KO:K09228]
106699662  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
111608188  uncharacterized protein LOC111608188 [KO:K09228]
102221754  zinc finger protein 835-like [KO:K09228]
102234256  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111609627  zinc finger protein 883-like isoform X1 [KO:K09228]
106700392  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102228951  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
106700346  zinc finger protein OZF-like [KO:K09228]
102220139  zinc finger protein 501-like [KO:K09228]
102234207  zinc finger protein OZF-like [KO:K09228]
102218838  zinc finger protein OZF-like isoform X1 [KO:K09228]
111609631  zinc finger protein OZF-like [KO:K09228]
111609765  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111609637  zinc finger and SCAN domain-containing protein 21-like [KO:K09228]
111609819  zinc finger protein 551-like [KO:K09228]
111609887  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
106699813  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
106699809  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102231257  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
102227917  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
102235281  gastrula zinc finger protein XlCGF46.1-like isoform X1 [KO:K09228]
102227092  gastrula zinc finger protein XlCGF46.1-like isoform X1 [KO:K09228]
102230993  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102229422  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
106699591  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
106700294  zinc finger protein 260-like [KO:K09228]
111611170  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111611179  zinc finger protein OZF-like [KO:K09228]
102226210  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
102231772  zinc finger protein 883-like [KO:K09228]
102218284  zinc finger protein 771 [KO:K09228]
111612083  zinc finger protein OZF-like [KO:K09228]
102217661  uncharacterized protein LOC102217661 [KO:K09228]
111611851  zinc finger protein 583-like isoform X1 [KO:K09228]
102234513  zinc finger protein 11-like [KO:K09228]
102218224  zinc finger protein 3 homolog [KO:K09228]
106700371  zinc finger protein OZF-like [KO:K09228]
106700273  gastrula zinc finger protein XlCGF57.1-like isoform X1 [KO:K09228]
111612045  oocyte zinc finger protein XlCOF20-like [KO:K09228]
102218330  zinc finger protein OZF-like isoform X1 [KO:K09228]
102234993  gastrula zinc finger protein XlCGF57.1-like [KO:K09228]
111606263  endothelial zinc finger protein induced by tumor necrosis factor alpha-like [KO:K09228]
102232344  zinc finger protein 2-like [KO:K09228]
111608870  gastrula zinc finger protein XlCGF26.1-like [KO:K09228]
111608864  zinc finger protein 239-like [KO:K09228]
102225433  uncharacterized protein LOC102225433 [KO:K05132]
102216665  interferon gamma receptor 1-like [KO:K05132]
102230010  tyrosine-protein kinase JAK2-like [KO:K04447] [EC:2.7.10.2]
102224189  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
102237505  death domain-associated protein 6-like isoform X1 [KO:K02308]
102217160  tap1; antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
102218472  antigen peptide transporter 2-like [KO:K05654] [EC:7.4.2.14]
102236923  antigen peptide transporter 2-like isoform X2 [KO:K05654] [EC:7.4.2.14]
102237532  tapasin-like [KO:K08058]
102232044  protein disulfide-isomerase A3-like [KO:K08056] [EC:5.3.4.1]
102224000  pdia3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
102217437  calreticulin-like [KO:K08057]
102220809  calreticulin-like [KO:K08057]
102223722  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
102225479  LOW QUALITY PROTEIN: major histocompatibility complex class I-related gene protein-like [KO:K06751]
102233148  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
102230961  H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
102228868  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102229128  RT1 class I histocompatibility antigen, AA alpha chain-like isoform X1 [KO:K06751]
102219761  H-2 class I histocompatibility antigen, Q9 alpha chain-like [KO:K06751]
102224240  HLA class I histocompatibility antigen, B-38 alpha chain-like isoform X1 [KO:K06751]
102221188  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
102220021  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102223985  H-2 class I histocompatibility antigen, Q9 alpha chain-like isoform X1 [KO:K06751]
102232511  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
102223409  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102223660  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102217443  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102224183  hereditary hemochromatosis protein-like [KO:K06751]
102223924  major histocompatibility complex class I-related gene protein-like [KO:K06751]
111610621  major histocompatibility complex class I-related gene protein-like [KO:K06751]
102224690  major histocompatibility complex class I-related gene protein-like isoform X1 [KO:K06751]
102228633  beta-2-microglobulin-like [KO:K08055]
102228909  beta-2-microglobulin-like [KO:K08055]
102219346  HLA class II histocompatibility antigen, DQ beta 2 chain-like precursor [KO:K06752]
102237122  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
102223319  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
102225334  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
102236725  H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752]
102229989  H-2 class II histocompatibility antigen, A-Q alpha chain-like [KO:K06752]
102225679  mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752]
102236986  H-2 class II histocompatibility antigen, E-S beta chain isoform X1 [KO:K06752]
106700297  HLA class II histocompatibility antigen, DRB1-14 beta chain-like [KO:K06752]
102225594  HLA class II histocompatibility antigen, DQ beta 1 chain-like [KO:K06752]
102234492  cd74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
102225882  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102226157  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
102231707  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
102218230  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
102230257  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102236577  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
102216923  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102226265  pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
102216436  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
102235425  phosphatidylinositol 3-kinase regulatory subunit alpha-like isoform X1 [KO:K02649]
102233436  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
102225808  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102237954  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102224082  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102232504  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
102237756  hamartin-like [KO:K07206]
102219029  hamartin-like isoform X1 [KO:K07206]
102219500  tsc2; tuberin isoform X1 [KO:K07207]
102234512  GTP-binding protein Rheb [KO:K07208]
102223809  rheb; GTP-binding protein Rheb [KO:K07208]
102220301  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
102237234  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
102218543  eukaryotic translation initiation factor 4E-binding protein 3-like [KO:K07205]
102231493  SRSF protein kinase 1-like isoform X1 [KO:K15409] [EC:2.7.11.1]
102217850  srpk1; SRSF protein kinase 1 isoform X1 [KO:K15409] [EC:2.7.11.1]
102236359  serine/arginine-rich splicing factor 1 isoform X2 [KO:K12890]
102228051  serine/arginine-rich splicing factor 1A [KO:K12890]
102229452  srsf2; serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
102226051  serine/arginine-rich splicing factor 3 [KO:K12892]
102229957  serine/arginine-rich splicing factor 3-like [KO:K12892]
102234962  serine/arginine-rich splicing factor 5 [KO:K12893]
102235184  serine/arginine-rich splicing factor 4-like [KO:K12893]
102234146  srsf5; serine/arginine-rich splicing factor 5 [KO:K12893]
102221465  serine/arginine-rich splicing factor 6 [KO:K12893]
102223839  serine/arginine-rich splicing factor 7-like isoform X1 [KO:K12896]
102230756  srsf7; serine/arginine-rich splicing factor 7 [KO:K12896]
102220370  serine/arginine-rich splicing factor 9-like [KO:K21123]
102222705  nxf1; nuclear RNA export factor 1 [KO:K14284]
102220164  THO complex subunit 4 [KO:K12881]
102217946  THO complex subunit 4-like isoform X1 [KO:K12881]
102222747  tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
102224562  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
102232209  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
102237252  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
102228470  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
102230597  fadd; FAS-associated death domain protein [KO:K02373]
111608841  caspase-8-like [KO:K04398] [EC:3.4.22.61]
102236921  caspase-8-like [KO:K04398] [EC:3.4.22.61]
102237850  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
102237443  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
111605875  uncharacterized protein LOC111605875 [KO:K04726]
102229835  apoptosis regulator BAX-like isoform X1 [KO:K02159]
102238210  apoptosis regulator BAX-like [KO:K02159]
106700271  apoptosis regulator BAX-like [KO:K02159]
111611010  bad; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
102223266  bcl2; apoptosis regulator Bcl-2 [KO:K02161]
102221560  bcl-2-like protein 1 [KO:K04570]
102221225  bcl2l1; bcl-2-like protein 1 [KO:K04570]
102228435  cytochrome c-b [KO:K08738]
102224281  cytochrome c [KO:K08738]
102220895  apaf1; apoptotic protease-activating factor 1 isoform X2 [KO:K02084]
102226741  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
102224433  caspase-3 [KO:K02187] [EC:3.4.22.56]
102227213  caspase-3-like [KO:K02187] [EC:3.4.22.56]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:E23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
xma03040  Spliceosome
xma03050  Proteasome
xma04115  p53 signaling pathway
xma04210  Apoptosis
xma04620  Toll-like receptor signaling pathway
xma04622  RIG-I-like receptor signaling pathway
KO pathway
ko05168   
LinkDB

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