KEGG   PATHWAY: pcoq05202
Entry
pcoq05202                   Pathway                                
Name
Transcriptional misregulation in cancer - Propithecus coquereli (Coquerel's sifaka)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
pcoq05202  Transcriptional misregulation in cancer
pcoq05202

Organism
Propithecus coquereli (Coquerel's sifaka) [GN:pcoq]
Gene
105804942  BCL2L1; bcl-2-like protein 1 [KO:K04570]
105805206  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
105805387  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
105805517  PROM1; prominin-1 [KO:K06532]
105805631  [KO:K11253]
105805634  [KO:K11253]
105805653  [KO:K11253]
105805675  [KO:K11253]
105805676  [KO:K11253]
105805701  [KO:K11253]
105805720  [KO:K11253]
105805725  [KO:K11253]
105806045  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105806103  REL; proto-oncogene c-Rel isoform X1 [KO:K09254]
105806153  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
105806281  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
105806416  RXRG; retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
105806444  CD86; T-lymphocyte activation antigen CD86 [KO:K05413]
105806461  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
105806571  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
105806665  PBX3; pre-B-cell leukemia transcription factor 3 isoform X1 [KO:K15610]
105806746  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
105806777  [KO:K11253]
105806852  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
105806898  ERG; transcriptional regulator ERG isoform X1 [KO:K09435]
105807125  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
105807166  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
105807261  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
105807294  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
105807338  HOXA11; homeobox protein Hox-A11 [KO:K21951]
105807368  HOXA10; homeobox protein Hox-A10 [KO:K17443]
105807369  HOXA9; homeobox protein Hox-A9 [KO:K21950]
105807417  PTCRA; pre T-cell antigen receptor alpha [KO:K06056]
105807601  H3F3C; histone H3.3C [KO:K11253]
105807869  LYL1; protein lyl-1 [KO:K15604]
105808047  BCL6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
105808070  [KO:K11253]
105808152  [KO:K11253]
105808188  SS18; protein SSXT [KO:K15623]
105808246  ETV5; ETS translocation variant 5 [KO:K15593]
105808352  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
105808390  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
105808446  TSPAN7; tetraspanin-7 [KO:K06571]
105808489  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105808587  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
105808757  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
105808773  FEV; protein FEV [KO:K09437]
105809060  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
105809115  MLF1; myeloid leukemia factor 1 isoform X1 [KO:K15622]
105809316  BAX; apoptosis regulator BAX [KO:K02159]
105809783  RUNX1T1; protein CBFA2T1 isoform X1 [KO:K10053]
105809892  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
105809929  FOXO1; forkhead box protein O1 [KO:K07201]
105810131  CCNA1; cyclin-A1 [KO:K06627]
105810189  EWSR1; RNA-binding protein EWS isoform X1 [KO:K13209]
105810344  BMI1; polycomb complex protein BMI-1 isoform X1 [KO:K11459]
105810395  H3F3A; histone H3.3 isoform X1 [KO:K11253]
105810508  KLF3; Krueppel-like factor 3 isoform X1 [KO:K15605]
105810553  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
105810741  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
105811004  HDAC2; LOW QUALITY PROTEIN: histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
105811046  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
105811078  DDB2; DNA damage-binding protein 2 [KO:K10140]
105811217  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
105811277  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
105811283  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
105811323  MYC; myc proto-oncogene protein [KO:K04377]
105811620  [KO:K05230]
105811621  [KO:K05230]
105811622  [KO:K05230]
105811966  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
105811977  MLLT1; protein ENL isoform X1 [KO:K15187]
105812194  ETV7; LOW QUALITY PROTEIN: transcription factor ETV7 [KO:K03211]
105812249  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105812488  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
105812560  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
105812697  [KO:K11253]
105812702  AFF1; AF4/FMR2 family member 1 isoform X1 [KO:K15184]
105812752  GZMB; granzyme B [KO:K01353] [EC:3.4.21.79]
105812777  [KO:K06643] [EC:2.3.2.27]
105813080  BAIAP3; BAI1-associated protein 3 isoform X1 [KO:K15621]
105813423  PTK2; focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
105813456  MAF; transcription factor Maf [KO:K09035]
105813680  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
105813869  TAF15; TATA-binding protein-associated factor 2N [KO:K14651]
105813986  PER2; period circadian protein homolog 2 isoform X1 [KO:K02633]
105814175  [KO:K10784]
105814323  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
105814517  SPINT1; kunitz-type protease inhibitor 1 isoform X1 [KO:K15619]
105814567  WT1; Wilms tumor protein isoform X1 [KO:K09234]
105814611  LMO2; rhombotin-2 isoform X1 [KO:K15612]
105814651  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
105814728  [KO:K04570]
105814785  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
105814960  BCL11B; B-cell lymphoma/leukemia 11B isoform X1 [KO:K22046]
105815122  IGF1; insulin-like growth factor I [KO:K05459]
105815145  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
105815267  CCNA2; cyclin-A2 [KO:K06627]
105815387  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
105815792  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
105816094  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
105816292  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform X1 [KO:K00069] [EC:1.1.1.141]
105816296  FLI1; Friend leukemia integration 1 transcription factor isoform X1 [KO:K09436]
105816363  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
105816779  TFE3; transcription factor E3 [KO:K09105]
105817148  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105817162  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
105817226  NFKBIZ; NF-kappa-B inhibitor zeta [KO:K14242]
105817394  MYCN; N-myc proto-oncogene protein [KO:K09109]
105817781  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
105817934  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
105817935  [KO:K06590]
105817995  [KO:K11253]
105818033  BMP2K; BMP-2-inducible protein kinase [KO:K08854] [EC:2.7.11.1]
105818043  SP1; transcription factor Sp1 isoform X1 [KO:K04684]
105818086  CCNT1; cyclin-T1 [KO:K15188]
105818548  SS18L1; calcium-responsive transactivator isoform X1 [KO:K15623]
105818634  CEBPB; CCAAT/enhancer-binding protein beta [KO:K10048]
105818800  ZEB1; zinc finger E-box-binding homeobox 1 [KO:K09299]
105819019  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
105819191  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
105819233  KMT2A; histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
105819395  TP53; cellular tumor antigen p53 [KO:K04451]
105819508  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
105819521  ETV6; transcription factor ETV6 isoform X1 [KO:K03211]
105819524  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
105819695  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
105819734  FUT8; alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
105819760  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
105819774  SIX1; homeobox protein SIX1 isoform X1 [KO:K15614]
105819819  SIX4; homeobox protein SIX4 isoform X1 [KO:K15615]
105819899  MAX; protein max isoform X1 [KO:K04453]
105820012  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
105820262  JUP; junction plakoglobin [KO:K10056]
105820328  PAX8; paired box protein Pax-8 isoform X1 [KO:K09293]
105820882  [KO:K11253]
105820929  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C isoform X1 [KO:K11449] [EC:1.14.11.-]
105820959  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
105821018  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
105821206  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
105821207  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
105821583  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
105821673  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
105821684  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105821782  [KO:K06498]
105821881  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105821883  PRCC; proline-rich protein PRCC [KO:K13105]
105821917  [KO:K11253]
105822134  ETV4; ETS translocation variant 4 isoform X1 [KO:K15592]
105822157  [KO:K01394] [EC:3.4.24.17]
105822182  ATM; LOW QUALITY PROTEIN: serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
105822245  [KO:K01394] [EC:3.4.24.17]
105822267  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
105822276  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
105822279  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
105822445  IL6; interleukin-6 [KO:K05405]
105822622  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
105822670  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
105822769  [KO:K06856]
105822820  CXCL8; interleukin-8 [KO:K10030]
105822999  SMAD1; mothers against decapentaplegic homolog 1 [KO:K04676]
105823014  BCL2A1; bcl-2-related protein A1 [KO:K02162]
105823018  ARNT2; aryl hydrocarbon receptor nuclear translocator 2 [KO:K15589]
105823085  [KO:K06461]
105823099  NUPR1; nuclear protein 1 [KO:K15626]
105823163  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
105823715  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
105824036  CD14; monocyte differentiation antigen CD14 [KO:K04391]
105824217  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
105824294  TLX1; T-cell leukemia homeobox protein 1 isoform X1 [KO:K09340]
105824343  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
105824396  RUNX1; runt-related transcription factor 1 [KO:K08367]
105824715  H3F3B; histone H3.3 [KO:K11253]
105824950  ZBTB17; LOW QUALITY PROTEIN: zinc finger and BTB domain-containing protein 17 [KO:K10500]
105825293  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
105825363  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
105825510  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
105825941  [KO:K06856]
105826213  WHSC1; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
105826431  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
105826550  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
105826653  RUNX2; runt-related transcription factor 2 isoform X1 [KO:K09278]
105826654  SUPT3H; transcription initiation protein SPT3 homolog [KO:K11313]
105826705  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
105826811  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
105826882  [KO:K09381]
105826993  MLLT3; protein AF-9 [KO:K15187]
105827383  RELA; transcription factor p65 isoform X1 [KO:K04735]
105827468  MEN1; menin isoform X1 [KO:K14970]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
PMID:12670461
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
  Journal
Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8
Reference
PMID:14998494
  Authors
Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM
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Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
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Cancer Cell 5:191-9 (2004)
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The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
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Blood 117:211-20 (2011)
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PMID:19059936
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Haematologica 94:78-86 (2009)
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Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).
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Leuk Lymphoma 34:25-33 (1999)
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PMID:10784387
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The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
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Leuk Lymphoma 36:435-45 (2000)
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Oncogenic gene fusions in epithelial carcinomas.
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Curr Opin Genet Dev 19:82-91 (2009)
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Translocations in epithelial cancers.
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Biochim Biophys Acta 1796:201-15 (2009)
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Reddi HV, McIver B, Grebe SK, Eberhardt NL
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The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
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Endocrinology 148:932-5 (2007)
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The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
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Exp Cell Res 315:2399-409 (2009)
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Nat Rev Cancer 8:497-511 (2008)
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An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
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Cancer Cell 17:443-54 (2010)
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TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
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PLoS One 6:e21650 (2011)
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ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
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Mol Endocrinol 21:1835-46 (2007)
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Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
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Cancer Res 68:73-80 (2008)
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The MYCN oncogene and differentiation in neuroblastoma.
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Semin Cancer Biol 21:256-66 (2011)
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PMID:20153925
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MYCN oncoprotein targets and their therapeutic potential.
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Cancer Lett 293:144-57 (2010)
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PMID:15644444
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The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
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Proc Natl Acad Sci U S A 102:731-6 (2005)
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Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
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Oncogene 29:2681-90 (2010)
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p53 is a direct transcriptional target of MYCN in neuroblastoma.
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Cancer Res 70:1377-88 (2010)
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N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
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J Biol Chem 282:12503-16 (2007)
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A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
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Cancer Res 71:404-12 (2011)
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Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.
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Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
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Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
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Curr Mol Med 8:805-15 (2008)
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Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.
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Endocr J 56:887-95 (2009)
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In search of tumor suppressing functions of menin.
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Mol Cell Endocrinol 265-266:34-41 (2007)
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PMID:15826838
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Fusion oncogenes in tumor development.
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Semin Cancer Biol 15:236-43 (2005)
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PMID:12527902
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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
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Oncogene 22:1-9 (2003)
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PMID:18648544
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IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
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PLoS One 3:e2634 (2008)
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Cancer Lett 254:1-10 (2007)
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Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
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Int J Clin Exp Pathol 3:338-47 (2010)
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Advances in Ewing's sarcoma research: where are we now and what lies ahead?
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Cancer Res 69:7140-50 (2009)
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PMID:12527906
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Oncogene 22:41-9 (2003)
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PMID:15826834
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The EWS-WT1 gene fusion in desmoplastic small round cell tumor.
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Semin Cancer Biol 15:197-205 (2005)
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The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.
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J Pathol 217:83-93 (2009)
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The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.
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Int J Cancer 122:2446-53 (2008)
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Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
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Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.
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Int J Cancer 115:556-60 (2005)
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PMID:18850010
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The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
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Oncogene 28:270-8 (2009)
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Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
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Mol Cancer 9:257 (2010)
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PMID:18457914
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PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
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Cancer Lett 270:10-8 (2008)
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Reference
PMID:11863357
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Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
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Genomics 79:278-84 (2002)
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Reference
PMID:17101797
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Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T
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The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
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Mol Cell Biol 27:1348-55 (2007)
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PMID:19472090
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Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Lim do H, Yoo KH, Choi YL
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Expression of MET in alveolar soft part sarcoma.
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Med Oncol 27:459-65 (2010)
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PMID:21779514
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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
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Genes Cancer 2:466-74 (2011)
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Reference
PMID:21765642
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Suzuki K, Matsubara H
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Recent advances in p53 research and cancer treatment.
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J Biomed Biotechnol 2011:978312 (2011)
DOI:10.1155/2011/978312
Related
pathway
pcoq04115  p53 signaling pathway
pcoq05211  Renal cell carcinoma
pcoq05215  Prostate cancer
pcoq05216  Thyroid cancer
pcoq05221  Acute myeloid leukemia
KO pathway
ko05202   

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