KEGG   PATHWAY: pprl04210
Entry
pprl04210                   Pathway                                
Name
Apoptosis - Poeciliopsis prolifica (blackstripe livebearer)
Description
Apoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled by numerous interrelating processes. The 'extrinsic' pathway involves stimulation of members of the tumor necrosis factor (TNF) receptor subfamily, such as TNFRI, CD95/Fas or TRAILR (death receptors), located at the cell surface, by their specific ligands, such as TNF-alpha, FasL or TRAIL, respectively. The 'intrinsic' pathway is activated mainly by non-receptor stimuli, such as DNA damage, ER stress, metabolic stress, UV radiation or growth-factor deprivation. The central event in the 'intrinsic' pathway is the mitochondrial outer membrane permeabilization (MOMP), which leads to the release of cytochrome c. These two pathways converge at the level of effector caspases, such as caspase-3 and caspase-7. The third major pathway is initiated by the constituents of cytotoxic granules (e.g. Perforin and Granzyme B) that are released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Granzyme B, similarly to the caspases, cleaves its substrates after aspartic acid residues, suggesting that this protease has the ability to activate members of the caspase family directly. It is the balance between the pro-apoptotic and anti-apoptotic signals that eventually determines whether cells will undergo apoptosis, survive or proliferate. TNF family of ligands activates anti-apoptotic or cell-survival signals as well as apoptotic signals. NGF and Interleukin-3 promotes the survival, proliferation and differentiation of neurons or hematopoietic cells, respectively. Withdrawal of these growth factors leads to cell death, as described above.
Class
Cellular Processes; Cell growth and death
Pathway map
pprl04210  Apoptosis
pprl04210

Other DBs
GO: 0006915
Organism
Poeciliopsis prolifica (blackstripe livebearer) [GN:pprl]
Gene
129351094  [KO:K04396] [EC:3.4.22.59]
129351171  [KO:K04379]
129351172  [KO:K04379]
129351186  [KO:K01363] [EC:3.4.22.1]
129351238  parp1; poly [ADP-ribose] polymerase 1 [KO:K24070]
129351621  hdr; hematopoietic death receptor isoform X1 [KO:K04722]
129351631  [KO:K03173] [EC:2.3.2.27]
129352302  birc5a; baculoviral IAP repeat-containing protein 5a [KO:K08731]
129352377  [KO:K00922] [EC:2.7.1.153]
129352487  [KO:K02159]
129352553  map3k14a; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
129352556  [KO:K02159]
129352803  tnfa; tumor necrosis factor a (TNF superfamily, member 2) [KO:K03156]
129352937  [KO:K04960]
129353038  [KO:K04402]
129353093  [KO:K04958]
129353137  ctsz; cathepsin Z [KO:K08568] [EC:3.4.18.1]
129353196  fadd; protein FADD [KO:K02373]
129353226  zgc:153993; apoptosis regulator BAX [KO:K02159]
129353527  [KO:K12641]
129353737  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
129353750  [KO:K04958]
129353957  [KO:K08738]
129354121  [KO:K01379] [EC:3.4.23.5]
129354296  [KO:K07374]
129354336  [KO:K02580]
129354427  [KO:K04960]
129354669  lmnb2; lamin-B2 [KO:K07611]
129354903  tp53; cellular tumor antigen p53 [KO:K04451]
129355050  [KO:K04448]
129355352  lmnb1; lamin-B1 [KO:K07611]
129355722  parp3; protein mono-ADP-ribosyltransferase PARP3 [KO:K10798] [EC:2.4.2.-]
129356041  [KO:K03853] [EC:3.4.22.53]
129356380  [KO:K01379] [EC:3.4.23.5]
129356397  [KO:K01367] [EC:3.4.22.52]
129356790  [KO:K28005]
129356935  [KO:K00922] [EC:2.7.1.153]
129358214  [KO:K04570]
129358476  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
129358542  pidd1; p53-induced death domain-containing protein 1 [KO:K10130]
129358753  septin4b; LOW QUALITY PROTEIN: septin 4b [KO:K16943]
129359095  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129359132  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
129359151  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
129359227  [KO:K07374]
129359386  ctsc; dipeptidyl peptidase 1 [KO:K01275] [EC:3.4.14.1]
129359538  fas; tumor necrosis factor receptor superfamily member 26 [KO:K04390]
129359549  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
129359619  [KO:K01367] [EC:3.4.22.52]
129359660  capn8; calpain-8 isoform X1 [KO:K03853] [EC:3.4.22.53]
129359661  [KO:K03853] [EC:3.4.22.53]
129359743  ctsh; pro-cathepsin H [KO:K01366] [EC:3.4.22.16]
129359791  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
129360005  [KO:K16341]
129360331  [KO:K04389]
129360357  [KO:K04389]
129360606  [KO:K08568] [EC:3.4.18.1]
129360609  [KO:K08568] [EC:3.4.18.1]
129360611  nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
129360642  [KO:K01374] [EC:3.4.22.42]
129360644  [KO:K01374] [EC:3.4.22.42]
129360854  casp10; caspase-8 [KO:K04398] [EC:3.4.22.61]
129360882  tuba8l3; LOW QUALITY PROTEIN: tubulin, alpha 8 like 3 [KO:K07374]
129361070  [KO:K02833]
129361229  [KO:K01353] [EC:3.4.21.79]
129361287  [KO:K08738]
129361293  [KO:K07374]
129361294  [KO:K07374]
129361332  [KO:K01353] [EC:3.4.21.79]
129361527  [KO:K04724]
129361690  casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
129361695  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
129361914  [KO:K04448]
129361940  bcl2b; apoptosis regulator Bcl-2 [KO:K02161]
129362038  [KO:K02649]
129362051  [KO:K00922] [EC:2.7.1.153]
129362253  ripk1l; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
129362322  [KO:K04398] [EC:3.4.22.61]
129362327  gadd45aa; growth arrest and DNA-damage-inducible, alpha, a isoform X1 [KO:K04402]
129362518  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
129362822  ctsf; cathepsin F [KO:K01373] [EC:3.4.22.41]
129362835  [KO:K02187] [EC:3.4.22.56]
129362905  xiap; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
129363186  actb2; actin, cytoplasmic 2 isoform X1 [KO:K05692]
129363290  zgc:55558; GTPase KRas [KO:K07827]
129363354  csf2rb; cytokine receptor common subunit beta [KO:K04738]
129363526  napsa; napsin-A [KO:K01379] [EC:3.4.23.5]
129363741  [KO:K08852] [EC:2.7.11.1 3.1.26.-]
129363822  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129363883  atf4b; activating transcription factor 4b [KO:K04374]
129363942  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
129363981  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
129364094  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
129364907  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
129365107  kras; GTPase KRas isoform X1 [KO:K07827]
129365183  fosaa; protein c-Fos [KO:K04379]
129365197  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129365275  [KO:K04721]
129365634  nfkbiab; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b [KO:K04734]
129365662  [KO:K04402]
129365801  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129365858  [KO:K02649]
129365887  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
129365913  [KO:K05692]
129365938  gadd45ga; growth arrest and DNA-damage-inducible, gamma a [KO:K04402]
129365972  [KO:K01365] [EC:3.4.22.15]
129365990  endog; endonuclease G, mitochondrial [KO:K01173]
129366009  [KO:K01365] [EC:3.4.22.15]
129366180  dab2ipa; LOW QUALITY PROTEIN: disabled homolog 2-interacting protein [KO:K19901]
129366251  prf1.5; perforin 1.5 [KO:K07818]
129366457  traf2b; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
129366819  atf4a; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
129367122  [KO:K07818]
129367190  [KO:K07818]
129368162  chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
129368276  [KO:K04466] [EC:2.7.11.25]
129368293  [KO:K04397] [EC:3.4.22.60]
129368462  birc2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
129368638  aifm1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
129369271  nfkbiaa; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a [KO:K04734]
129369796  [KO:K10522]
129369797  [KO:K10522]
129370166  tuba5; tubulin alpha 5 [KO:K07374]
129370284  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
129370914  ntrk1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
129370974  si:ch211-1i11.3; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129370977  mcl1b; induced myeloid leukemia cell differentiation protein Mcl-1b [KO:K02539]
129371013  ctsk; cathepsin K [KO:K01371] [EC:3.4.22.38]
129371019  [KO:K01368] [EC:3.4.22.27]
129371227  casp2; caspase-2 isoform X1 [KO:K02186] [EC:3.4.22.55]
129371233  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
129371690  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
129371764  bcl2l1; bcl-2-like protein 1 [KO:K04570]
129371780  casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
129371839  dffb; DNA fragmentation factor subunit beta isoform X1 [KO:K02311] [EC:3.-.-.-]
129371932  [KO:K07374]
129372285  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
129372351  ngfa; neurotrophin-7 [KO:K02582]
129372384  dffa; DNA fragmentation factor subunit alpha isoform X1 [KO:K02310]
129372499  birc5b; baculoviral IAP repeat-containing protein 5b [KO:K08731]
129372535  si:ch211-112c15.8; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
129372835  ngfb; nerve growth factor [KO:K02582]
129373309  badb; BCL2 associated agonist of cell death b isoform X1 [KO:K02158]
129373494  septin4a; septin 4a isoform X1 [KO:K16943]
129373728  [KO:K07818]
129373729  [KO:K07818]
129374084  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
129374116  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
129374135  ptpn13; tyrosine-protein phosphatase non-receptor type 13 isoform X1 [KO:K02374]
129374289  [KO:K03173] [EC:2.3.2.27]
129374293  tnfrsfa; tumor necrosis factor receptor superfamily, member a [KO:K04722]
129374297  [KO:K19901]
129374319  [KO:K07374]
129374530  [KO:K10798] [EC:2.4.2.-]
129374535  [KO:K10798] [EC:2.4.2.-]
129374773  [KO:K08669] [EC:3.4.21.108]
129374849  [KO:K01367] [EC:3.4.22.52]
129374867  ctsl.1; cathepsin L.1 [KO:K01365] [EC:3.4.22.15]
129375187  ctss1; cathepsin S, ortholog 1 [KO:K01371] [EC:3.4.22.38]
129375228  eif2s1b; eukaryotic translation initiation factor 2 subunit 1b [KO:K03237]
129375300  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
129375625  apaf1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
129375788  [KO:K12641]
129375859  daxx; death domain-associated protein 6 [KO:K02308]
129376040  gadd45ba; growth arrest and DNA-damage-inducible, beta a [KO:K04402]
129376319  faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
129376464  [KO:K01353] [EC:3.4.21.79]
129376621  [KO:K01353] [EC:3.4.21.79]
129376675  [KO:K01353] [EC:3.4.21.79]
129376705  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
129376856  casp3a; caspase-3a [KO:K02187] [EC:3.4.22.56]
129376935  actb1; actin, cytoplasmic 1 isoform X1 [KO:K05692]
129376985  [KO:K07374]
129376986  [KO:K07374]
129376994  [KO:K07374]
129377040  [KO:K07374]
129377123  [KO:K02649]
129377132  [KO:K07374]
129377287  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
129377405  cts12; procathepsin L [KO:K01365] [EC:3.4.22.15]
129377482  [KO:K04440] [EC:2.7.11.24]
129377784  pdpk1b; 3-phosphoinositide dependent protein kinase 1b [KO:K06276] [EC:2.7.11.1]
129377971  [KO:K28005]
129377997  [KO:K08568] [EC:3.4.18.1]
129378132  [KO:K00922] [EC:2.7.1.153]
129378345  rela; transcription factor p65 isoform X1 [KO:K04735]
129378374  jun; transcription factor AP-1 [KO:K04448]
129378559  [KO:K08738]
129378707  [KO:K07374]
129378922  tnfsf10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
129379152  [KO:K02649]
129379432  capn1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
129379679  gadd45ab; growth arrest and DNA-damage-inducible, alpha, b [KO:K04402]
129379829  [KO:K04397] [EC:3.4.22.60]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C00319  Sphingosine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:26615431
  Authors
Savitskaya MA, Onishchenko GE
  Title
Mechanisms of Apoptosis.
  Journal
Biochemistry (Mosc) 80:1393-417 (2015)
DOI:10.1134/S0006297915110012
Reference
PMID:23803157
  Authors
Schleich K, Lavrik IN
  Title
Mathematical modeling of apoptosis.
  Journal
Cell Commun Signal 11:44 (2013)
DOI:10.1186/1478-811X-11-44
Reference
PMID:15654015
  Authors
Lavrik I, Golks A, Krammer PH
  Title
Death receptor signaling.
  Journal
J Cell Sci 118:265-7 (2005)
DOI:10.1242/jcs.01610
Reference
PMID:15725726
  Authors
Jin Z, El-Deiry WS
  Title
Overview of cell death signaling pathways.
  Journal
Cancer Biol Ther 4:139-63 (2005)
DOI:10.4161/cbt.4.2.1508
Reference
PMID:15322527
  Authors
Benn SC, Woolf CJ
  Title
Adult neuron survival strategies--slamming on the brakes.
  Journal
Nat Rev Neurosci 5:686-700 (2004)
DOI:10.1038/nrn1477
Reference
PMID:12838338
  Authors
Orrenius S, Zhivotovsky B, Nicotera P
  Title
Regulation of cell death: the calcium-apoptosis link.
  Journal
Nat Rev Mol Cell Biol 4:552-65 (2003)
DOI:10.1038/nrm1150
Reference
PMID:19148180
  Authors
Clarke P, Tyler KL
  Title
Apoptosis in animal models of virus-induced disease.
  Journal
Nat Rev Microbiol 7:144-55 (2009)
DOI:10.1038/nrmicro2071
Reference
PMID:22429822
  Authors
Wen X, Lin ZQ, Liu B, Wei YQ
  Title
Caspase-mediated programmed cell death pathways as potential therapeutic targets in cancer.
  Journal
Cell Prolif 45:217-24 (2012)
DOI:10.1111/j.1365-2184.2012.00814.x
Reference
PMID:25526085
  Authors
Shalini S, Dorstyn L, Dawar S, Kumar S
  Title
Old, new and emerging functions of caspases.
  Journal
Cell Death Differ 22:526-39 (2015)
DOI:10.1038/cdd.2014.216
Reference
PMID:15601572
  Authors
Philchenkov A
  Title
Caspases: potential targets for regulating cell death.
  Journal
J Cell Mol Med 8:432-44 (2004)
DOI:10.1111/j.1582-4934.2004.tb00468.x
Reference
PMID:9894605
  Authors
Stroh C, Schulze-Osthoff K
  Title
Death by a thousand cuts: an ever increasing list of caspase substrates.
  Journal
Cell Death Differ 5:997-1000 (1998)
DOI:10.1038/sj.cdd.4400451
Reference
PMID:23070002
  Authors
Safa AR
  Title
c-FLIP, a master anti-apoptotic regulator.
  Journal
Exp Oncol 34:176-84 (2012)
Reference
PMID:18304445
  Authors
Jeong SY, Seol DW
  Title
The role of mitochondria in apoptosis.
  Journal
BMB Rep 41:11-22 (2008)
DOI:10.5483/bmbrep.2008.41.1.011
Reference
PMID:20533903
  Authors
Parsons MJ, Green DR
  Title
Mitochondria in cell death.
  Journal
Essays Biochem 47:99-114 (2010)
DOI:10.1042/bse0470099
Reference
PMID:15719025
  Authors
Strasser A
  Title
The role of BH3-only proteins in the immune system.
  Journal
Nat Rev Immunol 5:189-200 (2005)
DOI:10.1038/nri1568
Reference
PMID:24278747
  Authors
Schonthal AH
  Title
Endoplasmic reticulum stress: its role in disease and novel prospects for therapy.
  Journal
Scientifica (Cairo) 2012:857516 (2012)
DOI:10.6064/2012/857516
Reference
PMID:21145844
  Authors
Malhi H, Kaufman RJ
  Title
Endoplasmic reticulum stress in liver disease.
  Journal
J Hepatol 54:795-809 (2011)
DOI:10.1016/j.jhep.2010.11.005
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:16397578
  Authors
Wu J, Kaufman RJ
  Title
From acute ER stress to physiological roles of the Unfolded Protein Response.
  Journal
Cell Death Differ 13:374-84 (2006)
DOI:10.1038/sj.cdd.4401840
Reference
PMID:21914490
  Authors
Repnik U, Stoka V, Turk V, Turk B
  Title
Lysosomes and lysosomal cathepsins in cell death.
  Journal
Biochim Biophys Acta 1824:22-33 (2012)
DOI:10.1016/j.bbapap.2011.08.016
Reference
PMID:22465226
  Authors
Cesen MH, Pegan K, Spes A, Turk B
  Title
Lysosomal pathways to cell death and their therapeutic applications.
  Journal
Exp Cell Res 318:1245-51 (2012)
DOI:10.1016/j.yexcr.2012.03.005
Reference
PMID:26231733
  Authors
Dashzeveg N, Yoshida K
  Title
Cell death decision by p53 via control of the mitochondrial membrane.
  Journal
Cancer Lett 367:108-12 (2015)
DOI:10.1016/j.canlet.2015.07.019
Reference
PMID:22075987
  Authors
Bouchier-Hayes L, Green DR
  Title
Caspase-2: the orphan caspase.
  Journal
Cell Death Differ 19:51-7 (2012)
DOI:10.1038/cdd.2011.157
Reference
PMID:18238895
  Authors
Baptiste-Okoh N, Barsotti AM, Prives C
  Title
A role for caspase 2 and PIDD in the process of p53-mediated apoptosis.
  Journal
Proc Natl Acad Sci U S A 105:1937-42 (2008)
DOI:10.1073/pnas.0711800105
Reference
PMID:12949498
  Authors
Aggarwal BB
  Title
Signalling pathways of the TNF superfamily: a double-edged sword.
  Journal
Nat Rev Immunol 3:745-56 (2003)
DOI:10.1038/nri1184
Reference
PMID:14737178
  Authors
Steelman LS, Pohnert SC, Shelton JG, Franklin RA, Bertrand FE, McCubrey JA.
  Title
JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.
  Journal
Leukemia 18:189-218 (2004)
DOI:10.1038/sj.leu.2403241
Reference
PMID:9916983
  Authors
Dragovich T, Rudin CM, Thompson CB
  Title
Signal transduction pathways that regulate cell survival and cell death.
  Journal
Oncogene 17:3207-13 (1998)
DOI:10.1038/sj.onc.1202587
Reference
PMID:11520933
  Authors
Sofroniew MV, Howe CL, Mobley WC
  Title
Nerve growth factor signaling, neuroprotection, and neural repair.
  Journal
Annu Rev Neurosci 24:1217-81 (2001)
DOI:10.1146/annurev.neuro.24.1.1217
Reference
PMID:24769728
  Authors
Kristiansen M, Ham J
  Title
Programmed cell death during neuronal development: the sympathetic neuron model.
  Journal
Cell Death Differ 21:1025-35 (2014)
DOI:10.1038/cdd.2014.47
Reference
PMID:18208375
  Authors
Logue SE, Martin SJ
  Title
Caspase activation cascades in apoptosis.
  Journal
Biochem Soc Trans 36:1-9 (2008)
DOI:10.1042/BST0360001
Reference
PMID:19770840
  Authors
Boivin WA, Cooper DM, Hiebert PR, Granville DJ
  Title
Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma.
  Journal
Lab Invest 89:1195-220 (2009)
DOI:10.1038/labinvest.2009.91
Reference
PMID:20075940
  Authors
Cullen SP, Brunet M, Martin SJ
  Title
Granzymes in cancer and immunity.
  Journal
Cell Death Differ 17:616-23 (2010)
DOI:10.1038/cdd.2009.206
Reference
PMID:36652128
  Authors
Liu K, Lan D, Li C, Liu S, Dai X, Song T, Wang X, Kong Q, He Z, Tan J, Zhang J
  Title
A double-edged sword: role of apoptosis repressor with caspase recruitment domain (ARC) in tumorigenesis and ischaemia/reperfusion (I/R) injury.
  Journal
Apoptosis 28:313-325 (2023)
DOI:10.1007/s10495-022-01802-4
Related
pathway
pprl04010  MAPK signaling pathway
pprl04020  Calcium signaling pathway
pprl04115  p53 signaling pathway
pprl04141  Protein processing in endoplasmic reticulum
KO pathway
ko04210   

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