KEGG   PATHWAY: pyu04140
Entry
pyu04140                    Pathway                                
Name
Autophagy - animal - Puma yagouaroundi (jaguarundi)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
pyu04140  Autophagy - animal
pyu04140

Other DBs
GO: 0006914
Organism
Puma yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009809  GABARAPL2; gamma-aminobutyric acid receptor-associated protein-like 2 isoform X1 [KO:K08341]
121009907  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
121010371  VPS33A; vacuolar protein sorting-associated protein 33A isoform X1 [KO:K20182]
121010458  CAMKK2; calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
121010516  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121010520  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
121010556  ATG12; ubiquitin-like protein ATG12 isoform X1 [KO:K08336]
121010704  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
121010934  [KO:K10802]
121010943  RAB8A; ras-related protein Rab-8A [KO:K07901]
121011002  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121011025  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
121011444  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121012283  TP53INP2; tumor protein p53-inducible nuclear protein 2 isoform X1 [KO:K21247]
121012286  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
121012341  BCL2L1; bcl-2-like protein 1 [KO:K04570]
121012415  VPS16; vacuolar protein sorting-associated protein 16 homolog isoform X1 [KO:K20180]
121012862  SUPT20H; transcription factor SPT20 homolog isoform X1 [KO:K21245]
121013456  STX7; syntaxin-7 isoform X1 [KO:K08488]
121013659  ATG10; ubiquitin-like-conjugating enzyme ATG10 isoform X1 [KO:K17888]
121013980  ATG4D; cysteine protease ATG4D isoform X1 [KO:K08342] [EC:3.4.22.-]
121014090  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121014128  [KO:K17606]
121014135  [KO:K01365] [EC:3.4.22.15]
121014161  CTSV; cathepsin L2 [KO:K01365] [EC:3.4.22.15]
121014190  [KO:K01365] [EC:3.4.22.15]
121014191  [KO:K01365] [EC:3.4.22.15]
121014192  DAPK1; death-associated protein kinase 1 isoform X1 [KO:K08803] [EC:2.7.11.1]
121014195  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
121014311  ATG4B; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
121014409  ATG16L1; autophagy-related protein 16-1 isoform X1 [KO:K17890]
121014485  IRS1; insulin receptor substrate 1 [KO:K16172]
121014807  OPTN; optineurin isoform X1 [KO:K19946]
121014850  PRKCQ; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
121014969  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121014983  [KO:K10435]
121014984  BECN2; beclin-2 [KO:K08334]
121015103  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
121015111  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121015275  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
121015327  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
121015817  SMCR8; guanine nucleotide exchange protein SMCR8 [KO:K23611]
121015838  ULK2; serine/threonine-protein kinase ULK2 isoform X1 [KO:K08269] [EC:2.7.11.1]
121016026  [KO:K08341]
121016283  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
121016570  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121016847  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
121016944  YKT6; synaptobrevin homolog YKT6 [KO:K08516]
121017530  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
121017634  [KO:K17445]
121018030  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
121018107  WDR45B; WD repeat domain phosphoinositide-interacting protein 3 isoform X1 [KO:K22991]
121018181  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
121018786  RRAS; ras-related protein R-Ras isoform X1 [KO:K07829]
121018803  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
121019101  RAB1A; ras-related protein Rab-1A [KO:K07874]
121019164  VAMP8; vesicle-associated membrane protein 8 isoform X1 [KO:K08512]
121019662  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
121019674  TSC2; tuberin isoform X1 [KO:K07207]
121019680  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
121020585  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121021042  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121021440  DAPK3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
121021465  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
121021482  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
121021726  RAB7B; ras-related protein Rab-7b isoform X1 [KO:K07898]
121022226  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
121022539  RAB7A; ras-related protein Rab-7a [KO:K07897]
121022644  MTMR3; myotubularin-related protein 3 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
121022734  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
121022826  HRAS; GTPase HRas isoform X1 [KO:K02833]
121022935  RHEB; GTP-binding protein Rheb [KO:K07208]
121022953  ATG9B; autophagy-related protein 9B isoform X1 [KO:K17907]
121023018  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121023035  SNAP29; synaptosomal-associated protein 29 [KO:K08509]
121023683  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
121023814  ATG2A; autophagy-related protein 2 homolog A isoform X1 [KO:K17906]
121023947  BAD; bcl2-associated agonist of cell death [KO:K02158]
121023963  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
121023965  INS; insulin [KO:K04526]
121024217  IRS2; insulin receptor substrate 2 [KO:K07187]
121024295  [KO:K01365] [EC:3.4.22.15]
121024519  [KO:K21245]
121024682  [KO:K16185]
121024832  RAB39B; ras-related protein Rab-39B [KO:K07925]
121024997  [KO:K02977]
121025239  IGBP1; immunoglobulin-binding protein 1 [KO:K17606]
121025434  LAMP2; lysosome-associated membrane glycoprotein 2 [KO:K06528]
121025718  IRS4; LOW QUALITY PROTEIN: insulin receptor substrate 4 [KO:K17446]
121025767  ATG4A; cysteine protease ATG4A [KO:K08342] [EC:3.4.22.-]
121025915  WDR45; WD repeat domain phosphoinositide-interacting protein 4 isoform X1 [KO:K22991]
121026147  [KO:K02977]
121026251  [KO:K01365] [EC:3.4.22.15]
121026350  [KO:K01365] [EC:3.4.22.15]
121026362  [KO:K01365] [EC:3.4.22.15]
121026893  RRAGC; ras-related GTP-binding protein C [KO:K16186]
121027009  CTSB; cathepsin B isoform X1 [KO:K01363] [EC:3.4.22.1]
121027050  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
121027198  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
121027239  ATG4C; cysteine protease ATG4C isoform X1 [KO:K08342] [EC:3.4.22.-]
121027378  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121027417  SH3GLB1; endophilin-B1 isoform X1 [KO:K11248]
121027738  NRAS; GTPase NRas [KO:K07828]
121028561  TAX1BP1; tax1-binding protein 1 isoform X1 [KO:K21347]
121028920  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
121029203  [KO:K10802]
121029508  RAB33B; ras-related protein Rab-33B [KO:K07920]
121029776  RRAGD; ras-related GTP-binding protein D [KO:K16186]
121029788  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
121029845  ATG5; autophagy protein 5 isoform X1 [KO:K08339]
121030608  TANK; TRAF family member-associated NF-kappa-B activator [KO:K12650]
121030685  GORASP2; Golgi reassembly-stacking protein 2 [KO:K26797]
121030906  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
121031096  ATG9A; autophagy-related protein 9A [KO:K17907]
121031803  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
121031872  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
121031936  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
121032009  ZFYVE1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
121032262  ATG2B; autophagy-related protein 2 homolog B isoform X1 [KO:K17906]
121032358  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121032687  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
121032947  [KO:K10802]
121032982  EPG5; ectopic P granules protein 5 homolog [KO:K23883]
121032993  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
121033019  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121033111  WDFY3; WD repeat and FYVE domain-containing protein 3 isoform X1 [KO:K22262]
121033478  GORASP1; Golgi reassembly-stacking protein 1 isoform X1 [KO:K26797]
121033661  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
121033726  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
121033733  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121034018  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121034502  RRAGA; ras-related GTP-binding protein A [KO:K16185]
121034547  C9orf72; guanine nucleotide exchange C9orf72 homolog [KO:K23609]
121034743  STX17; syntaxin-17 [KO:K08491]
121034964  [KO:K07897]
121035151  TSC1; hamartin isoform X1 [KO:K07206]
121035497  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
121036235  ATG3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
121036371  RUBCN; run domain Beclin-1-interacting and cysteine-rich domain-containing protein isoform X1 [KO:K19330]
121036680  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
121036765  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
121036923  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121037403  BNIP3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
121037443  PRAP1; proline-rich acidic protein 1 [KO:K21250]
121037679  LAMP1; lysosome-associated membrane glycoprotein 1 [KO:K06528]
121038271  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
121038547  ATG101; autophagy-related protein 101 [KO:K19730]
121038626  [KO:K10802]
121038809  KRAS; GTPase KRas isoform X1 [KO:K07827]
121038952  GABARAPL1; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
121039241  ATG16L2; protein Atg16l2 isoform X1 [KO:K20868]
121039299  UVRAG; UV radiation resistance-associated gene protein isoform X1 [KO:K21249]
121039795  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
121040822  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
121041241  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121041251  ATG7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
121041285  MTMR14; myotubularin-related protein 14 isoform X1 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
121041326  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121041490  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
121041529  VPS18; vacuolar protein sorting-associated protein 18 homolog isoform X1 [KO:K20181]
121041560  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
121041817  DAPK2; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
121041863  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
121042474  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121042910  DEPTOR; DEP domain-containing mTOR-interacting protein [KO:K20402]
121043466  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
121043470  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 isoform X1 [KO:K17985]
121043535  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
121043998  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
121044324  BIRC6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
121044477  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
121044690  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
121044694  VMP1; vacuole membrane protein 1 isoform X1 [KO:K21248]
121044716  MTMR4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
121044832  CALCOCO2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
121045044  BECN1; beclin-1 isoform X1 [KO:K08334]
121045060  NBR1; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
pyu04010  MAPK signaling pathway
pyu04141  Protein processing in endoplasmic reticulum
pyu04142  Lysosome
pyu04150  mTOR signaling pathway
pyu04152  AMPK signaling pathway
pyu04910  Insulin signaling pathway
KO pathway
ko04140   

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