KEGG   PATHWAY: rno00310
Entry
rno00310                    Pathway                                
Name
Lysine degradation - Rattus norvegicus (rat)
Class
Metabolism; Amino acid metabolism
Pathway map
rno00310  Lysine degradation
rno00310

Module
rno_M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA [PATH:rno00310]
Other DBs
GO: 0006554
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
100169747  Phykpl; 5-phosphohydroxy-L-lysine phospho-lyase [KO:K18202] [EC:4.2.3.134]
100359816  Setd1b; histone-lysine N-methyltransferase SETD1B isoform X1 [KO:K11422] [EC:2.1.1.354]
100361623  Kmt5al2; N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
100361710  Setdb2; histone-lysine N-methyltransferase SETDB2 isoform X1 [KO:K18494] [EC:2.1.1.355]
100362634  Kmt2d; lysine methyltransferase 2D [KO:K09187] [EC:2.1.1.354]
100366024  Prdm16; PR/SET domain 16 [KO:K22410] [EC:2.1.1.367]
100909949  Kmt5al1; N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
102550344  Kmt2b; lysine methyltransferase 2B [KO:K14959] [EC:2.1.1.354]
113965  Hadh; hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor [KO:K00022] [EC:1.1.1.35]
116552  Plod1; procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 precursor [KO:K00473] [EC:1.14.11.4]
140547  Echs1; enoyl-CoA hydratase, mitochondrial precursor [KO:K07511] [EC:4.2.1.17]
170670  Hadha; trifunctional enzyme subunit alpha, mitochondrial precursor [KO:K07515] [EC:4.2.1.17 1.1.1.211]
170898  Tmlhe; trimethyllysine dioxygenase, mitochondrial [KO:K00474] [EC:1.14.11.8]
171142  Ehhadh; peroxisomal bifunctional enzyme [KO:K07514] [EC:4.2.1.17 1.1.1.35 5.3.3.8]
25014  Acat1; acetyl-CoA acetyltransferase, mitochondrial precursor [KO:K00626] [EC:2.3.1.9]
288346  Kmt5al3; N-lysine methyltransferase KMT5A-like [KO:K11428] [EC:2.1.1.361]
288583  Plod3; multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 precursor [KO:K13646] [EC:1.14.11.4 2.4.1.50 2.4.1.66]
289081  Colgalt2; procollagen galactosyltransferase 2 precursor [KO:K11703] [EC:2.4.1.50]
289372  Smyd2; N-lysine methyltransferase SMYD2 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
290637  Colgalt1; procollagen galactosyltransferase 1 precursor [KO:K11703] [EC:2.4.1.50]
290831  Nsd3; histone-lysine N-methyltransferase NSD3 [KO:K11425] [EC:2.1.1.370 2.1.1.371]
291450  Aldh7a1; alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
29416  Aadat; kynurenine/alpha-aminoadipate aminotransferase, mitochondrial [KO:K00825] [EC:2.6.1.7 2.6.1.39]
294924  Mecom; histone-lysine N-methyltransferase MECOM [KO:K04462] [EC:2.1.1.367]
29539  Aldh2; aldehyde dehydrogenase, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
296925  Aass; alpha-aminoadipic semialdehyde synthase, mitochondrial precursor [KO:K14157] [EC:1.5.1.8 1.5.1.9]
297333  Smyd1; histone-lysine N-methyltransferase SMYD1 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
298079  Aldh1b1; aldehyde dehydrogenase X, mitochondrial precursor [KO:K00128] [EC:1.2.1.3]
298942  Dld; dihydrolipoyl dehydrogenase, mitochondrial precursor [KO:K00382] [EC:1.8.1.4]
299201  Dlst; dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [KO:K00658] [EC:2.3.1.61]
299521  Camkmt; calmodulin-lysine N-methyltransferase [KO:K18826] [EC:2.1.1.60]
300723  Hykk; hydroxylysine kinase [KO:K18201] [EC:2.7.1.81]
300901  Plod2; procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 2 precursor [KO:K13645] [EC:1.14.11.4]
302553  Suv39h1; histone-lysine N-methyltransferase SUV39H1 isoform 1 [KO:K11419] [EC:2.1.1.355]
303272  Pipox; peroxisomal sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
303547  Ezh1; histone-lysine N-methyltransferase EZH1 [KO:K17451] [EC:2.1.1.356]
306764  Nsd1; histone-lysine N-methyltransferase, H3 lysine-36 specific [KO:K15588] [EC:2.1.1.357]
307305  Prdm6; putative histone-lysine N-methyltransferase PRDM6 isoform X1 [KO:K20795] [EC:2.1.1.361]
308100  Acat2; acetyl-CoA acetyltransferase, cytosolic [KO:K00626] [EC:2.3.1.9]
308345  Kmt5c; histone-lysine N-methyltransferase KMT5C [KO:K11429] [EC:2.1.1.362]
310638  Ash1l; histone-lysine N-methyltransferase ASH1L [KO:K06101] [EC:2.1.1.354]
311968  Kmt2e; inactive histone-lysine N-methyltransferase 2E [KO:K09189] [EC:2.1.1.354]
312299  Ezh2; histone-lysine N-methyltransferase EZH2 [KO:K11430] [EC:2.1.1.356]
313678  Prdm2; PR domain zinc finger protein 2 [KO:K11432] [EC:2.1.1.355]
315606  Kmt2a; histone-lysine N-methyltransferase 2A isoform 1 [KO:K09186] [EC:2.1.1.354]
316013  Setd2; histone-lysine N-methyltransferase SETD2 [KO:K11423] [EC:2.1.1.359]
361272  Dhtkd1; 2-oxoadipate dehydrogenase complex component E1 [KO:K15791] [EC:1.2.4.-]
361688  Kmt5b; histone-lysine N-methyltransferase KMT5B [KO:K11429] [EC:2.1.1.362]
361798  Ehmt2; histone-lysine N-methyltransferase EHMT2 [KO:K11420] [EC:2.1.1.355]
362078  Ehmt1; histone-lysine N-methyltransferase EHMT1 isoform 1 [KO:K11420] [EC:2.1.1.355]
362831  Dot1l; histone-lysine N-methyltransferase, H3 lysine-79 specific [KO:K11427] [EC:2.1.1.360]
364785  Suv39h2; histone-lysine N-methyltransferase SUV39H2 [KO:K11419] [EC:2.1.1.355]
364975  Gcdh; glutaryl-CoA dehydrogenase, mitochondrial [KO:K00252] [EC:1.3.8.6]
365096  Acat2l1; acetyl-CoA acetyltransferase, cytosolic-like isoform X1 [KO:K00626] [EC:2.3.1.9]
365155  Prdm9; histone-lysine N-methyltransferase PRDM9 [KO:K20796] [EC:2.1.1.354]
498295  Smyd3; histone-lysine N-methyltransferase SMYD3 [KO:K11426] [EC:2.1.1.354 2.1.1.357]
500281  Setmar; histone-lysine N-methyltransferase SETMAR [KO:K11433] [EC:2.1.1.357]
502710  Kmt2c; histone-lysine N-methyltransferase 2C isoform X11 [KO:K09188] [EC:2.1.1.354]
64040  Aldh9a1; 4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
64564  Bbox1; gamma-butyrobetaine dioxygenase [KO:K00471] [EC:1.14.11.1]
65183  Aldh3a2; aldehyde dehydrogenase family 3 member A2 [KO:K00128] [EC:1.2.1.3]
680537  Nsd2; histone-lysine N-methyltransferase NSD2 [KO:K11424] [EC:2.1.1.357]
689820  Kmt5a; N-lysine methyltransferase KMT5A isoform 1 [KO:K11428] [EC:2.1.1.361]
689883  Setdb1; histone-lysine N-methyltransferase SETDB1 [KO:K11421] [EC:2.1.1.366]
689954  Setd7; histone-lysine N-methyltransferase SETD7 [KO:K11431] [EC:2.1.1.364]
Compound
C00024  Acetyl-CoA
C00026  2-Oxoglutarate
C00037  Glycine
C00042  Succinate
C00047  L-Lysine
C00068  Thiamin diphosphate
C00136  Butanoyl-CoA
C00164  Acetoacetate
C00322  2-Oxoadipate
C00332  Acetoacetyl-CoA
C00408  L-Pipecolate
C00431  5-Aminopentanoate
C00449  N6-(L-1,3-Dicarboxypropyl)-L-lysine
C00450  (S)-2,3,4,5-Tetrahydropyridine-2-carboxylate
C00487  Carnitine
C00489  Glutarate
C00527  Glutaryl-CoA
C00739  D-Lysine
C00877  Crotonoyl-CoA
C00956  L-2-Aminoadipate
C00990  5-Aminopentanamide
C01087  (R)-2-Hydroxyglutarate
C01142  (3S)-3,6-Diaminohexanoate
C01144  (S)-3-Hydroxybutanoyl-CoA
C01149  4-Trimethylammoniobutanal
C01181  4-Trimethylammoniobutanoate
C01186  (3S,5S)-3,5-Diaminohexanoate
C01211  Procollagen 5-hydroxy-L-lysine
C01259  (3S)-3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
C01672  Cadaverine
C02188  Protein lysine
C02727  N6-Acetyl-L-lysine
C03087  5-Acetamidopentanoate
C03196  (S)-2-Hydroxyglutarate
C03239  6-Amino-2-oxohexanoate
C03273  5-Oxopentanoate
C03366  5-Phosphooxy-L-lysine
C03656  (S)-5-Amino-3-oxohexanoic acid
C03793  N6,N6,N6-Trimethyl-L-lysine
C04020  D-Lysopine
C04076  L-2-Aminoadipate 6-semialdehyde
C04092  Delta1-Piperideine-2-carboxylate
C04487  5-(D-Galactosyloxy)-L-lysine-procollagen
C05161  (2R,5S)-2,5-Diaminohexanoate
C05231  L-3-Aminobutyryl-CoA
C05544  Protein N6-methyl-L-lysine
C05545  Protein N6,N6-dimethyl-L-lysine
C05546  Protein N6,N6,N6-trimethyl-L-lysine
C05548  6-Acetamido-2-oxohexanoate
C05825  2-Amino-5-oxohexanoate
C06157  [Dihydrolipoyllysine-residue succinyltransferase] S-glutaryldihydrolipoyllysine
C12455  5-Aminopentanal
C15972  Enzyme N6-(lipoyl)lysine
C15973  Enzyme N6-(dihydrolipoyl)lysine
C16741  L-Hydroxylysine
C22667  4-Carboxy-1-hydroxybutyryl-ThPP
Reference
PMID:11802770
  Authors
Vaz FM, Wanders RJ.
  Title
Carnitine biosynthesis in mammals.
  Journal
Biochem J 361:417-29 (2002)
DOI:10.1042/bj3610417
Reference
PMID:1682209
  Authors
Large PJ, Robertson A.
  Title
The route of lysine breakdown in Candida tropicalis.
  Journal
FEMS Microbiol Lett 66:209-13 (1991)
DOI:10.1111/j.1574-6968.1990.tb03998.x
Related
pathway
rno00020  Citrate cycle (TCA cycle)
rno00780  Biotin metabolism
KO pathway
ko00310   

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