KEGG   PATHWAY: tfn04510
Entry
tfn04510                    Pathway                                
Name
Focal adhesion - Trachypithecus francoisi (Francois's langur)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
tfn04510  Focal adhesion
tfn04510

Other DBs
GO: 0005925
Organism
Trachypithecus francoisi (Francois's langur) [GN:tfn]
Gene
117062427  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117062530  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
117062719  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
117063510  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
117063511  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
117063724  [KO:K04393]
117064051  [KO:K06240]
117064083  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
117064107  [KO:K12757]
117064108  MYL12B; myosin regulatory light chain 12B [KO:K12757]
117064126  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
117064366  FLNA; LOW QUALITY PROTEIN: filamin-A [KO:K04437]
117064804  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
117064910  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
117065100  ITGA1; LOW QUALITY PROTEIN: integrin alpha-1 [KO:K06480]
117065104  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
117065206  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117065386  THBS4; thrombospondin-4 [KO:K04659]
117065429  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
117065596  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
117065701  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
117066362  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
117066678  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
117066689  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
117066827  ACTG1; actin, cytoplasmic 2 [KO:K05692]
117066881  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
117067088  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
117067204  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
117067210  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
117067220  CHAD; chondroadherin [KO:K06248]
117067396  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117067460  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
117067614  VTN; vitronectin [KO:K06251]
117067958  CRK; adapter molecule crk isoform X1 [KO:K04438]
117068468  PAK5; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
117068620  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
117068731  MYL9; myosin regulatory light polypeptide 9 isoform X1 [KO:K12755]
117068749  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
117069038  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
117069054  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
117069324  PGF; placenta growth factor isoform X1 [KO:K16859]
117069415  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
117069667  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
117069839  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
117070036  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117070145  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
117070310  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
117070448  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
117070473  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
117070553  TLN2; talin-2 isoform X1 [KO:K06271]
117070688  SHC4; SHC-transforming protein 4 [KO:K17449]
117070877  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
117070884  THBS1; thrombospondin-1 [KO:K16857]
117071286  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117072297  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117072359  ZYX; zyxin isoform X1 [KO:K06273]
117072545  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
117072550  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
117072614  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117072632  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
117072646  MYL10; myosin regulatory light chain 10 isoform X1 [KO:K12756]
117072721  ACTB; actin, cytoplasmic 1 [KO:K05692]
117072853  LAMB4; laminin subunit beta-4 isoform X1 [KO:K06245]
117073298  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
117073359  LAMC3; laminin subunit gamma-3 [KO:K06247]
117073371  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
117073436  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
117073439  CAV1; caveolin-1 isoform X1 [KO:K06278]
117073440  CAV2; caveolin-2 isoform X1 [KO:K12958]
117073498  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
117073506  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117073594  COL1A2; collagen alpha-2(I) chain [KO:K06236]
117073672  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
117074462  LAMC2; laminin subunit gamma-2 [KO:K06246]
117074614  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
117074670  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
117074894  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
117074900  COMP; cartilage oligomeric matrix protein [KO:K04659]
117075022  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
117075160  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
117075174  TNN; tenascin-N isoform X1 [KO:K06252]
117075199  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
117075364  LAMB3; laminin subunit beta-3 [KO:K06244]
117075463  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
117075738  PPP1R12B; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12B [KO:K12329]
117075753  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
117076028  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
117076049  TNR; tenascin-R isoform X1 [KO:K06252]
117076331  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117076369  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117076589  VAV1; proto-oncogene vav [KO:K05730]
117076850  LAMC1; laminin subunit gamma-1 [KO:K05635]
117077479  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
117077500  XIAP; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
117077535  COL4A5; LOW QUALITY PROTEIN: collagen alpha-5(IV) chain [KO:K06237]
117077572  VEGFD; vascular endothelial growth factor D [KO:K05449]
117078318  COL4A6; LOW QUALITY PROTEIN: collagen alpha-6(IV) chain [KO:K06237]
117078321  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
117078804  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
117079459  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
117079787  PARVA; alpha-parvin isoform X1 [KO:K06275]
117080013  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
117080066  BIRC3; baculoviral IAP repeat-containing protein 3 isoform X1 [KO:K16060]
117080067  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
117080254  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
117080423  [KO:K04375]
117080612  BAD; bcl2-associated agonist of cell death [KO:K02158]
117081027  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
117081297  LAMB2; laminin subunit beta-2 [KO:K06243]
117081433  RHOA; transforming protein RhoA [KO:K04513]
117081518  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
117081589  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
117081688  HRAS; GTPase HRas isoform X1 [KO:K02833]
117081956  [KO:K05692]
117082160  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
117082194  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
117082715  VCL; vinculin isoform X1 [KO:K05700]
117082864  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
117083051  FLNB; LOW QUALITY PROTEIN: filamin-B [KO:K27392]
117083152  [KO:K05692]
117083193  CAV3; caveolin-3 [KO:K12959]
117083269  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117083385  ITGB5; integrin beta-5 [KO:K06588]
117083396  MYLK; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
117083458  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
117083761  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117083793  [KO:K06276] [EC:2.7.11.1]
117083878  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
117083938  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
117084122  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
117084197  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
117084198  [KO:K06238]
117084453  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
117084479  [KO:K04366] [EC:2.7.11.1]
117085006  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
117085338  SPP1; osteopontin [KO:K06250]
117085339  IBSP; bone sialoprotein 2 [KO:K06253]
117085362  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
117085601  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
117085606  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
117085754  [KO:K04392]
117085785  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
117086074  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
117086157  VEGFC; vascular endothelial growth factor C [KO:K05449]
117086614  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
117086699  [KO:K00889] [EC:2.7.1.68]
117086983  TNXB; LOW QUALITY PROTEIN: tenascin-X [KO:K06252]
117087209  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
117087278  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
117087428  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
117087485  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117087606  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117087642  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
117087736  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
117088057  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
117089305  PXN; paxillin isoform X1 [KO:K05760]
117089402  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K12756]
117089406  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
117089531  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
117089688  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
117089777  RAP1B; ras-related protein Rap-1b [KO:K07836]
117089974  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
117089991  ITGA5; integrin alpha-5 [KO:K06484]
117090048  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
117090217  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
117090481  EMP1; epithelial membrane protein 1 [KO:K26255]
117090655  VWF; von Willebrand factor [KO:K03900]
117090678  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
117090727  [KO:K06274]
117091405  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
117091457  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
117091710  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
117091723  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
117091956  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117091985  JUN; transcription factor AP-1 [KO:K04448]
117092482  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
117092503  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
117092662  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117092796  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
117093160  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117093348  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117094336  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
117094375  [KO:K05692]
117094430  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
117094436  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
117094564  FN1; fibronectin isoform X1 [KO:K05717]
117094753  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
117094777  ITGA4; integrin alpha-4 [KO:K06483]
117094852  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
117094959  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
117095609  [KO:K06269] [EC:3.1.3.16]
117095874  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
117095877  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
117096344  PARVG; gamma-parvin isoform X1 [KO:K06275]
117096346  PARVB; beta-parvin isoform X1 [KO:K06275]
117096471  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
117096627  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117096632  CRKL; crk-like protein [KO:K04438]
117096863  THBS2; thrombospondin-2 [KO:K04659]
117096942  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
117096947  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
117097545  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
117097659  EMP2; epithelial membrane protein 2 [KO:K26256]
117097913  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
117098366  SHC3; SHC-transforming protein 3 [KO:K17448]
117098499  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
117098609  [KO:K07836]
117098771  TNC; tenascin isoform X1 [KO:K06252]
117099000  TLN1; talin-1 isoform X1 [KO:K06271]
117099200  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
117099723  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
tfn04010  MAPK signaling pathway
tfn04060  Cytokine-cytokine receptor interaction
tfn04070  Phosphatidylinositol signaling system
tfn04110  Cell cycle
tfn04151  PI3K-Akt signaling pathway
tfn04310  Wnt signaling pathway
tfn04512  ECM-receptor interaction
tfn04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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