KEGG   PATHWAY: mgp04810
Entry
mgp04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Meleagris gallopavo (turkey)
Class
Cellular Processes; Cell motility
Pathway map
mgp04810  Regulation of actin cytoskeleton
mgp04810

Other DBs
GO: 0030036
Organism
Meleagris gallopavo (turkey) [GN:mgp]
Gene
100541536  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
109363681  lysophosphatidic acid receptor 1-B-like [KO:K04289]
100550166  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100539306  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100547557  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100549677  CXCL12; stromal cell-derived factor 1 [KO:K10031]
100541154  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100549057  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
100543186  F2R; proteinase-activated receptor 1 [KO:K03914]
100540225  INS; insulin [KO:K04526]
100543460  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
104913334  fibroblast growth factor 1-like [KO:K18496]
100551381  fibroblast growth factor 1-like [KO:K18496]
100550388  FGF2; fibroblast growth factor 2 [KO:K18497]
100539058  FGF18; fibroblast growth factor 18 [KO:K04358]
100548838  FGF6; fibroblast growth factor 6 [KO:K04358]
100540381  FGF3; fibroblast growth factor 3 [KO:K04358]
100550193  FGF16; fibroblast growth factor 16 [KO:K04358]
100550759  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
100538626  FGF20; fibroblast growth factor 20 [KO:K04358]
100540464  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
104910684  FGF5; fibroblast growth factor 5 [KO:K04358]
104911992  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
100540226  FGF4; fibroblast growth factor 4 [KO:K22603]
100549914  FGF23; fibroblast growth factor 23 [KO:K22428]
100545955  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100542930  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100547981  PDGFC; platelet-derived growth factor C [KO:K05450]
100543088  PDGFD; LOW QUALITY PROTEIN: platelet-derived growth factor D [KO:K05450]
100541093  INSRR; LOW QUALITY PROTEIN: insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
100543252  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100547498  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100540905  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100543461  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100544316  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
100542010  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100550611  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
100551213  FN1; fibronectin [KO:K05717]
104914876  integrin alpha-1-like [KO:K06480]
104916711  integrin alpha-IIb-like [KO:K06476]
100545328  ITGA4; integrin alpha-4 [KO:K06483]
100538428  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100550013  LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
100546503  integrin alpha-8 [KO:K06584]
100538631  ITGA9; integrin alpha-9 [KO:K06585]
100547226  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
100541922  ITGAV; integrin alpha-V [KO:K06487]
100551464  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100543565  ITGB2; integrin beta-2 [KO:K06464]
100540307  ITGB3; integrin beta-3 [KO:K06493]
100544044  ITGB4; integrin beta-4 isoform X4 [KO:K06525]
104911802  integrin beta-5 [KO:K06588]
100548345  ITGB6; integrin beta-6 [KO:K06589]
100540683  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
104912678  KNG1; kininogen-1 [KO:K03898]
116216168  BDKRB1; B1 bradykinin receptor [KO:K03915]
100542846  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03916]
100538353  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100548586  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100549620  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
100542687  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100538532  C5; complement C5 [KO:K03994]
104914855  C6; complement component C6 [KO:K03995]
100546320  C7; complement component C7 [KO:K03996]
100547483  C8A; complement component C8 alpha chain [KO:K03997]
100547639  C8B; complement component C8 beta chain [KO:K03998]
104913649  C8G; complement component C8 gamma chain [KO:K03999]
100550659  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100540964  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
100539211  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100545127  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X3 [KO:K05722]
104913032  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
100543321  LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
100550512  CRK; adapter molecule crk [KO:K04438]
100538907  CRKL; crk-like protein [KO:K04438]
100544294  dedicator of cytokinesis protein 1-like [KO:K13708]
100547597  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100542624  son of sevenless homolog 1 [KO:K03099]
100540230  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100546858  HRAS; GTPase HRas [KO:K02833]
100151750  KRAS; GTPase KRas [KO:K07827]
104914532  NRAS; GTPase NRas [KO:K07828]
100547062  RRAS2; ras-related protein R-Ras2 [KO:K07830]
100544446  MRAS; ras-related protein M-Ras [KO:K07831]
100547020  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
100543492  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100546867  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100549888  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100549239  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100548237  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100541220  VAV2; guanine nucleotide exchange factor VAV2 isoform X3 [KO:K05730]
100539361  guanine nucleotide exchange factor VAV3 [KO:K05730]
104912296  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
104915730  proto-oncogene vav-like [KO:K05730]
100540208  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
100550268  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
100541264  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100543421  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X2 [KO:K04368] [EC:2.7.12.2]
100551337  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X2 [KO:K04369] [EC:2.7.12.2]
100543845  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100545672  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100539659  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100541155  RGCC; regulator of cell cycle RGCC [KO:K26108]
100548723  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
104916818  ARHGAP35; LOW QUALITY PROTEIN: rho GTPase-activating protein 35 [KO:K05732]
100547488  RHOA; transforming protein RhoA [KO:K04513]
100548156  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100547045  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
100544672  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100546318  CDC42; cell division control protein 42 homolog isoform X2 [KO:K04393]
100541412  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100539360  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
100540875  PAK4; serine/threonine-protein kinase PAK 4 isoform X2 [KO:K05734] [EC:2.7.11.1]
100547824  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
100543151  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
100538686  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
100539446  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
100538826  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100543918  MYLK4; myosin light chain kinase family member 4 isoform X3 [KO:K00907] [EC:2.7.11.18]
100538449  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
100542497  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100547989  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
100551067  MYLK3; myosin light chain kinase 3 isoform X2 [KO:K00907] [EC:2.7.11.18]
104914090  neurofilament heavy polypeptide-like [KO:K00907] [EC:2.7.11.18]
100544698  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100546973  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100550782  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100539276  PPP1R12A; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12A [KO:K06270]
100545452  protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
104914452  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
100547128  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100549745  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100539263  MYL10; myosin regulatory light chain 10 [KO:K12756]
100548741  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
100548894  myosin regulatory light chain 2, smooth muscle minor isoform isoform X2 [KO:K12757]
100551398  MYH9; myosin-9 [KO:K10352]
100542649  MYH11; myosin-11 isoform X1 [KO:K10352]
100545901  MYH10; myosin-10 isoform X1 [KO:K10352]
100539769  DIAPH2; protein diaphanous homolog 2 isoform X2 [KO:K05741]
100008573  SLC9A1; LOW QUALITY PROTEIN: sodium/hydrogen exchanger 1 [KO:K05742]
100540819  PIP5K1B; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
100543434  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma [KO:K00889] [EC:2.7.1.68]
100542814  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
100551336  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
100543719  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
100544400  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
100550102  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
100548509  LIMK2; LIM domain kinase 2 isoform X3 [KO:K05744] [EC:2.7.11.1]
100551247  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
100550206  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
100547100  ENAH; LOW QUALITY PROTEIN: protein enabled homolog [KO:K05746]
100542107  WASL; LOW QUALITY PROTEIN: neural Wiskott-Aldrich syndrome protein [KO:K23612]
100545294  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
100541932  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
109363687  CYFIP1; LOW QUALITY PROTEIN: cytoplasmic FMR1-interacting protein 1 [KO:K05749]
100545969  NCKAP1L; nck-associated protein 1-like [KO:K05750]
100541002  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
100543472  ABI2; abl interactor 2 isoform X1 [KO:K05751]
100544489  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
100538720  ACTR2; actin-related protein 2 [KO:K17260]
100545482  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
100538994  ACTR3; actin-related protein 3 [KO:K18584]
100539832  ARPC1B; actin-related protein 2/3 complex subunit 1B isoform X1 [KO:K05757]
100539675  ARPC1A; actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
100541974  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
100539007  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100540489  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
104913721  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100542800  actin, cytoplasmic type 5 [KO:K05692]
100303677  ACTB; actin, cytoplasmic 1 [KO:K05692]
100544583  actin, cytoplasmic 2-like [KO:K05692]
100544644  PFN3; profilin-3 [KO:K05759]
100545777  PFN4; profilin-4 isoform X1 [KO:K05759]
100549018  PFN2; profilin-2 isoform X1 [KO:K05759]
100544102  PXN; paxillin isoform X1 [KO:K05760]
100546943  EZR; ezrin [KO:K08007]
100549813  RDX; LOW QUALITY PROTEIN: radixin [KO:K05762]
100549523  MSN; moesin isoform X1 [KO:K05763]
100539160  thymosin beta-12 [KO:K05764]
100549265  CFL2; cofilin-2 [KO:K05765]
100544732  SSH2; LOW QUALITY PROTEIN: protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100551427  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
104916913  SSH3; protein phosphatase Slingshot homolog 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100302597  VCL; vinculin [KO:K05700]
100550295  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
100543341  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
100547544  GSN; gelsolin isoform X1 [KO:K05768]
100543828  LOW QUALITY PROTEIN: adseverin-like [KO:K05768]
100539916  ACTN1; alpha-actinin-1 isoform X3 [KO:K05699]
104915165  adenomatous polyposis coli protein [KO:K02085]
100544685  APC2; LOW QUALITY PROTEIN: adenomatous polyposis coli protein 2 [KO:K02085]
100544917  rho guanine nucleotide exchange factor 4 [KO:K05769]
100547204  spermatogenesis-associated protein 13 [KO:K05769]
104909282  uncharacterized protein LOC104909282 [KO:K05769]
104917573  uncharacterized protein LOC104917573 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
mgp04010  MAPK signaling pathway
mgp04510  Focal adhesion
mgp04520  Adherens junction
KO pathway
ko04810   
LinkDB

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