Entry Name Small cell lung cancer - Phascolarctos cinereus (koala)
Description Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.
Class Human Diseases; Cancer: specific typesBRITE hierarchy
Pathway map Disease Organism Phascolarctos cinereus (koala) [GN:
pcw ]
Gene 110195907 GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402 ]
110197222 COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237 ]
110198716 ZBTB17; zinc finger and BTB domain-containing protein 17 isoform X1 [KO:K10500 ]
110199476 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
110204454 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
110205196 BIRC7; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 7 [KO:K16061 ]
110208219 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
110209293 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
110209686 NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580 ]
110211967 CKS1B; cyclin-dependent kinases regulatory subunit 1 isoform X1 [KO:K02219 ]
110212964 GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402 ]
110216530 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
110217257 CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625 ]
110218707 CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624 ]
110221734 APAF1; LOW QUALITY PROTEIN: apoptotic protease-activating factor 1 [KO:K02084 ]
110223395 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
110223449 GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402 ]
110223919 DDB2; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140 ]
Compound C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Osada H, Takahashi T.
Title Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
Journal Reference Authors Yokota J, Nishioka M, Tani M, Kohno T.
Title Genetic alterations responsible for metastatic phenotypes of lung cancer cells.
Journal Reference Authors Sanchez-Cespedes M.
Title Dissecting the genetic alterations involved in lung carcinogenesis.
Journal Reference Authors Mitsuuchi Y, Testa JR.
Title Cytogenetics and molecular genetics of lung cancer.
Journal Reference Authors Kaye FJ.
Title Molecular biology of lung cancer.
Journal Reference Authors Panani AD, Roussos C.
Title Cytogenetic and molecular aspects of lung cancer.
Journal Reference Authors Altucci L, Gronemeyer H.
Title The promise of retinoids to fight against cancer.
Journal Reference Authors Virmani AK, Rathi A, Zochbauer-Muller S, Sacchi N, Fukuyama Y, Bryant D, Maitra A, Heda S, Fong KM, Thunnissen F, Minna JD, Gazdar AF.
Title Promoter methylation and silencing of the retinoic acid receptor-beta gene in lung carcinomas.
Journal Reference Authors Sartorius UA, Krammer PH.
Title Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines.
Journal Reference Authors Adhikary S, Eilers M.
Title Transcriptional regulation and transformation by Myc proteins.
Journal Reference Authors Spruck C, Strohmaier H, Watson M, Smith AP, Ryan A, Krek TW, Reed SI.
Title A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.
Journal Reference Authors Buttery RC, Rintoul RC, Sethi T.
Title Small cell lung cancer: the importance of the extracellular matrix.
Journal Reference Authors Yamada KM, Araki M.
Title Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis.
Journal J Cell Sci 114:2375-82 (2001)
Reference Authors Rintoul RC, Sethi T.
Title The role of extracellular matrix in small-cell lung cancer.
Journal Reference Authors Ekedahl J, Joseph B, Grigoriev MY, Muller M, Magnusson C, Lewensohn R, Zhivotovsky B.
Title Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells.
Journal Reference Authors Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF.
Title Apoptosis and lung cancer: a review.
Journal Reference Authors Weyhenmeyer B, Murphy AC, Prehn JH, Murphy BM
Title Targeting the anti-apoptotic Bcl-2 family members for the treatment of cancer.
Journal Exp Oncol 34:192-9 (2012)
Related KO pathway
