KEGG   PATHWAY: pcw04510
Entry
pcw04510                    Pathway                                
Name
Focal adhesion - Phascolarctos cinereus (koala)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pcw04510  Focal adhesion
pcw04510

Other DBs
GO: 0005925
Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110192294  VTN; vitronectin [KO:K06251]
110192462  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
110192705  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
110192821  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
110193513  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110193669  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
110194038  ITGA5; integrin alpha-5 [KO:K06484]
110194074  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
110194600  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110194741  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
110195467  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110195486  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
110195533  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
110195740  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
110195785  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
110195967  FLNB; filamin-B isoform X1 [KO:K27392]
110196103  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
110196697  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
110196698  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
110196726  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
110196829  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
110196868  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
110196970  TNR; tenascin-R isoform X1 [KO:K06252]
110197010  TNN; tenascin-N isoform X1 [KO:K06252]
110197059  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
110197071  [KO:K12757]
110197087  MYL12B; myosin regulatory light chain 12B [KO:K12757]
110197171  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110197222  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
110197377  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
110197976  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
110198108  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
110198318  EMP2; epithelial membrane protein 2 [KO:K26256]
110198393  CHAD; chondroadherin [KO:K06248]
110198538  [KO:K06279]
110198828  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
110198842  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
110198895  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
110198932  LAMC3; laminin subunit gamma-3 [KO:K06247]
110198948  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
110199079  CAV3; caveolin-3 [KO:K12959]
110199313  TNXB; tenascin-X isoform X1 [KO:K06252]
110199476  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
110199935  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110199966  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
110200147  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110200158  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110200243  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
110200343  FLNA; filamin-A isoform X1 [KO:K04437]
110200481  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
110200954  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
110201031  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
110201281  VEGFA; vascular endothelial growth factor A [KO:K05448]
110201388  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
110201423  TLN1; LOW QUALITY PROTEIN: talin-1 [KO:K06271]
110201503  SHC4; SHC-transforming protein 4 isoform X1 [KO:K17449]
110201505  COL2A1; collagen alpha-1(II) chain [KO:K19719]
110201572  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110201716  ITGAV; integrin alpha-V [KO:K06487]
110202246  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
110202355  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
110202375  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
110202713  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110202873  THBS1; thrombospondin-1 [KO:K16857]
110202942  CAV2; caveolin-2 [KO:K12958]
110202945  CAV1; caveolin-1 isoform X1 [KO:K06278]
110202946  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110202954  HRAS; GTPase HRas isoform X1 [KO:K02833]
110203042  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110203090  ITGA9; integrin alpha-9 [KO:K06585]
110203184  [KO:K05096] [EC:2.7.10.1]
110203289  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110203322  VASP; vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
110203451  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
110204454  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110204892  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110204990  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110205178  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
110205189  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
110205369  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
110205475  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110205536  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
110205635  [KO:K05692]
110205653  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
110205706  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
110205748  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
110205795  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110205896  PARVB; beta-parvin isoform X1 [KO:K06275]
110205897  PARVG; gamma-parvin isoform X1 [KO:K06275]
110205943  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110206033  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
110206299  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
110206410  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
110206445  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
110206842  LAMC1; laminin subunit gamma-1 [KO:K05635]
110206843  LAMC2; laminin subunit gamma-2 [KO:K06246]
110206931  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
110206952  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
110206985  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
110207016  LAMB1; laminin subunit beta-1 [KO:K05636]
110207445  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
110207655  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
110208060  PAK5; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
110208073  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110208127  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
110208137  ITGB5; integrin beta-5 [KO:K06588]
110208178  PAK2; serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
110208219  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110208321  PGF; placenta growth factor [KO:K16859]
110208858  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
110209064  [KO:K06238]
110209065  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
110209067  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
110209121  CTNNB1; LOW QUALITY PROTEIN: catenin beta-1 [KO:K02105]
110209198  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
110209293  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110209670  [KO:K04513]
110209710  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
110209849  SPP1; osteopontin [KO:K06250]
110209873  IBSP; bone sialoprotein 2 [KO:K06253]
110210302  [KO:K05736] [EC:2.7.11.1]
110210535  PAK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
110210894  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
110211041  RAP1B; ras-related protein Rap-1b [KO:K07836]
110211245  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
110211363  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
110211455  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
110211575  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
110211774  SOS2; son of sevenless homolog 2 [KO:K03099]
110211956  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
110211965  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
110212948  JUN; transcription factor AP-1 [KO:K04448]
110213049  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
110213174  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
110213688  PDGFC; platelet-derived growth factor C [KO:K05450]
110213728  VWF; von Willebrand factor [KO:K03900]
110214034  [KO:K05692]
110214622  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
110214751  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
110214961  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
110215022  [KO:K16060]
110215023  [KO:K16060]
110215167  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110215191  CRKL; crk-like protein [KO:K04438]
110215414  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
110215432  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
110215514  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
110215551  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110215729  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110215826  COL1A1; collagen alpha-1(I) chain [KO:K06236]
110215841  ITGA3; integrin alpha-3 [KO:K06482]
110215866  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
110215904  ITGB3; integrin beta-3 [KO:K06493]
110215985  VEGFC; vascular endothelial growth factor C [KO:K05449]
110216123  ZYX; zyxin isoform X1 [KO:K06273]
110216339  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
110216530  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110216602  THBS4; thrombospondin-4 [KO:K04659]
110216678  [KO:K00889] [EC:2.7.1.68]
110216702  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110216709  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
110216721  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
110216905  RHOA; transforming protein RhoA [KO:K04513]
110216959  [KO:K06243]
110216962  LAMB2; laminin subunit beta-2 [KO:K06243]
110217565  COL1A2; collagen alpha-2(I) chain [KO:K06236]
110217679  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
110217767  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
110218220  ACTG1; actin, cytoplasmic 2 [KO:K05692]
110218260  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
110218307  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110218605  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
110218645  EMP1; epithelial membrane protein 1 [KO:K26255]
110218698  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110218764  RAP1A; ras-related protein Rap-1A [KO:K04353]
110218825  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
110218909  PARVA; alpha-parvin isoform X1 [KO:K06275]
110219266  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
110219298  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
110219415  FN1; fibronectin isoform X1 [KO:K05717]
110219617  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
110219818  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
110219961  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
110220182  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
110220276  ARHGAP5; rho GTPase-activating protein 5 [KO:K13709]
110220704  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
110220737  ITGB6; integrin beta-6 [KO:K06589]
110220840  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
110221051  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
110221306  MYL10; myosin regulatory light chain 10 [KO:K12756]
110221420  VCL; vinculin isoform X1 [KO:K05700]
110221680  ITGA4; integrin alpha-4 [KO:K06483]
110221918  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110221981  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110222129  CRK; adapter molecule crk isoform X1 [KO:K04438]
110222446  VEGFD; vascular endothelial growth factor D [KO:K05449]
110222728  LAMB3; laminin subunit beta-3 [KO:K06244]
110222837  PXN; paxillin isoform X1 [KO:K05760]
110222880  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
110222892  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
110223114  ACTB; actin, cytoplasmic 1 [KO:K05692]
110223139  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform isoform X1 [KO:K12758]
110223395  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110223419  COMP; cartilage oligomeric matrix protein [KO:K04659]
110223483  SHC2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
110223716  PAK6; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
110223827  SHC3; SHC-transforming protein 3 [KO:K17448]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pcw04010  MAPK signaling pathway
pcw04060  Cytokine-cytokine receptor interaction
pcw04070  Phosphatidylinositol signaling system
pcw04110  Cell cycle
pcw04151  PI3K-Akt signaling pathway
pcw04310  Wnt signaling pathway
pcw04512  ECM-receptor interaction
pcw04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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