KEGG   PATHWAY: pcw04151
Entry
pcw04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Phascolarctos cinereus (koala)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
pcw04151  PI3K-Akt signaling pathway
pcw04151

Other DBs
GO: 0043491
Organism
Phascolarctos cinereus (koala) [GN:pcw]
Gene
110192126  FGF8; fibroblast growth factor 8 [KO:K04358]
110192294  VTN; vitronectin [KO:K06251]
110192449  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
110192705  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
110192821  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
110192877  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
110192878  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
110193052  LPAR4; LOW QUALITY PROTEIN: lysophosphatidic acid receptor 4 [KO:K04275]
110193058  FGF16; fibroblast growth factor 16 [KO:K04358]
110193352  KRAS; GTPase KRas isoform X1 [KO:K07827]
110193513  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
110193602  PKN3; LOW QUALITY PROTEIN: serine/threonine-protein kinase N3 [KO:K23692]
110193996  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
110194004  NR4A1; LOW QUALITY PROTEIN: nuclear receptor subfamily 4 group A member 1 [KO:K04465]
110194038  ITGA5; integrin alpha-5 [KO:K06484]
110194074  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
110194271  TP53; cellular tumor antigen p53 [KO:K04451]
110194373  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
110194558  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
110194580  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
110194600  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110194741  COL4A5; collagen alpha-5(IV) chain [KO:K06237]
110194823  RPS6; 40S ribosomal protein S6 [KO:K02991]
110194908  [KO:K04382] [EC:3.1.3.16]
110195321  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
110195377  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
110195466  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
110195467  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
110195494  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
110195533  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
110195563  RELA; transcription factor p65 isoform X1 [KO:K04735]
110195785  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
110195790  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
110195834  FGF9; fibroblast growth factor 9 [KO:K04358]
110195906  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
110196285  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
110196387  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
110196671  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
110196697  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
110196698  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
110196805  ANGPT1; LOW QUALITY PROTEIN: angiopoietin-1 [KO:K05465]
110196970  TNR; tenascin-R isoform X1 [KO:K06252]
110197002  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
110197010  TNN; tenascin-N isoform X1 [KO:K06252]
110197115  FGF4; fibroblast growth factor 4 [KO:K04358]
110197122  FGF19; fibroblast growth factor 19 [KO:K22603]
110197133  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
110197149  FGF3; fibroblast growth factor 3 [KO:K04358]
110197171  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
110197190  INS; insulin [KO:K04526]
110197222  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
110197331  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
110197339  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
110197389  PSPN; persephin [KO:K25416]
110197417  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110197487  NRTN; neurturin [KO:K25414]
110197489  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
110197976  THBS2; LOW QUALITY PROTEIN: thrombospondin-2 [KO:K04659]
110198108  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
110198231  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
110198384  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
110198393  CHAD; chondroadherin [KO:K06248]
110198480  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
110198617  EPHA2; LOW QUALITY PROTEIN: ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
110198683  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
110198824  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
110198828  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
110198842  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
110198888  TSC1; hamartin [KO:K07206]
110198932  LAMC3; laminin subunit gamma-3 [KO:K06247]
110198993  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
110199192  IL7; interleukin-7 isoform X1 [KO:K05431]
110199207  MTOR; LOW QUALITY PROTEIN: serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
110199211  [KO:K05415]
110199212  [KO:K05415]
110199213  [KO:K05415]
110199216  [KO:K05415]
110199218  [KO:K05415]
110199230  [KO:K05414]
110199240  [KO:K05414]
110199247  [KO:K05414]
110199249  [KO:K05414]
110199250  [KO:K05414]
110199251  [KO:K05414]
110199253  [KO:K05414]
110199254  [KO:K05414]
110199255  [KO:K05414]
110199313  TNXB; tenascin-X isoform X1 [KO:K06252]
110199423  ATF6B; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
110199476  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
110199935  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
110199966  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
110200147  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
110200157  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
110200158  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
110200217  ARTN; artemin [KO:K25415]
110200243  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
110200253  IRS1; insulin receptor substrate 1 [KO:K16172]
110200330  MTCP1; protein p13 MTCP-1 [KO:K16837]
110200334  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
110200415  FGF17; LOW QUALITY PROTEIN: fibroblast growth factor 17 [KO:K04358]
110200602  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
110201024  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
110201183  [KO:K05414]
110201199  [KO:K05414]
110201202  [KO:K05414]
110201203  [KO:K05414]
110201241  FGF20; fibroblast growth factor 20 [KO:K04358]
110201274  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
110201281  VEGFA; vascular endothelial growth factor A [KO:K05448]
110201331  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
110201388  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
110201451  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
110201505  COL2A1; collagen alpha-1(II) chain [KO:K19719]
110201572  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
110201716  ITGAV; integrin alpha-V [KO:K06487]
110201937  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
110201965  RHEB; GTP-binding protein Rheb [KO:K07208]
110202027  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
110202309  [KO:K07828]
110202312  FGF7; fibroblast growth factor 7 [KO:K04358]
110202405  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 isoform X1 [KO:K04544]
110202413  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
110202430  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
110202713  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110202719  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
110202795  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
110202831  EPO; erythropoietin [KO:K05437]
110202873  THBS1; thrombospondin-1 [KO:K16857]
110202946  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
110202954  HRAS; GTPase HRas isoform X1 [KO:K02833]
110203042  AKT1; LOW QUALITY PROTEIN: RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
110203090  ITGA9; integrin alpha-9 [KO:K06585]
110203184  [KO:K05096] [EC:2.7.10.1]
110203252  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
110203289  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
110203364  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
110203410  [KO:K07828]
110203411  [KO:K07828]
110203426  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
110203666  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
110204454  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
110204577  [KO:K01596] [EC:4.1.1.32]
110204582  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
110204813  GNB5; LOW QUALITY PROTEIN: guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
110204892  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
110204990  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
110205141  PCK1; LOW QUALITY PROTEIN: phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
110205178  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
110205189  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
110205364  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
110205475  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
110205653  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
110205661  HSP90B1; endoplasmin [KO:K09487]
110205706  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
110205742  IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069]
110205795  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
110205802  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
110205943  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110206299  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
110206350  CSF3R; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor receptor [KO:K05061]
110206594  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
110206842  LAMC1; laminin subunit gamma-1 [KO:K05635]
110206843  LAMC2; laminin subunit gamma-2 [KO:K06246]
110206931  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
110206952  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
110206961  MAGI2; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 isoform X1 [KO:K05629]
110206985  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
110207004  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
110207016  LAMB1; laminin subunit beta-1 [KO:K05636]
110207433  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
110207491  RBL2; LOW QUALITY PROTEIN: retinoblastoma-like protein 2 [KO:K16332]
110207577  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
110207578  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
110207589  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
110207627  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
110208073  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
110208137  ITGB5; integrin beta-5 [KO:K06588]
110208200  PPP2R3A; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
110208219  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
110208321  PGF; placenta growth factor [KO:K16859]
110208451  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
110208793  PRL; prolactin [KO:K05439]
110208858  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
110208905  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
110208909  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
110209064  [KO:K06238]
110209065  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
110209067  COL6A6; collagen alpha-6(VI) chain isoform X1 [KO:K06238]
110209152  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
110209198  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
110209293  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
110209301  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
110209582  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
110209686  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
110209849  SPP1; osteopontin [KO:K06250]
110209854  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
110209863  AREG; LOW QUALITY PROTEIN: amphiregulin [KO:K09782]
110209873  IBSP; bone sialoprotein 2 [KO:K06253]
110209874  EREG; proepiregulin isoform X1 [KO:K09784]
110209930  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
110209937  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
110209968  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
110210692  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
110210894  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
110210908  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
110210914  [KO:K05084] [EC:2.7.10.1]
110210989  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
110211045  MDM2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
110211245  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
110211357  TLR4; toll-like receptor 4 [KO:K10160]
110211363  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
110211398  ANGPT4; LOW QUALITY PROTEIN: angiopoietin-4 [KO:K05467]
110211412  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
110211478  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
110211575  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
110211588  ATF2; cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
110211727  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
110211774  SOS2; son of sevenless homolog 2 [KO:K03099]
110211797  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
110211817  IL4; interleukin-4 [KO:K05430]
110211866  [KO:K04289]
110211956  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
110211962  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
110211977  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
110211993  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
110211994  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
110212045  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
110212110  EFNA1; ephrin-A1 [KO:K05462]
110212119  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
110212146  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
110212192  PPP2R2C; LOW QUALITY PROTEIN: protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
110212245  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
110212412  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
110212616  YWHAQ; 14-3-3 protein theta [KO:K16197]
110212739  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
110212842  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
110212886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
110212891  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
110213049  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
110213063  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
110213115  IL6; interleukin-6 [KO:K05405]
110213181  KITLG; kit ligand isoform X1 [KO:K05461]
110213449  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
110213489  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
110213633  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
110213688  PDGFC; platelet-derived growth factor C [KO:K05450]
110213728  VWF; von Willebrand factor [KO:K03900]
110213789  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
110213860  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
110213879  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
110213885  GYS2; glycogen [starch] synthase, liver isoform X1 [KO:K00693] [EC:2.4.1.11]
110213919  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
110214163  GNG14; uncharacterized LOC105372280 homolog [KO:K04347]
110214171  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
110214297  [KO:K06856]
110214304  [KO:K06856]
110214315  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
110214461  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
110214629  PRLR; LOW QUALITY PROTEIN: prolactin receptor [KO:K05081]
110214692  PHLPP1; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
110214720  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
110214751  BCL2; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
110214849  [KO:K05130]
110214853  IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
110214886  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
110214934  OSMR; LOW QUALITY PROTEIN: oncostatin-M-specific receptor subunit beta [KO:K05057]
110214961  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
110215066  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
110215167  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110215262  YWHAH; 14-3-3 protein eta [KO:K16198]
110215327  FGF10; fibroblast growth factor 10 [KO:K04358]
110215344  OSM; oncostatin-M isoform X1 [KO:K05418]
110215414  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
110215430  PIK3AP1; LOW QUALITY PROTEIN: phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
110215432  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
110215551  FLT1; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
110215617  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
110215704  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
110215726  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
110215729  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
110215806  CSF3; granulocyte colony-stimulating factor [KO:K05423]
110215826  COL1A1; collagen alpha-1(I) chain [KO:K06236]
110215837  [KO:K05438]
110215841  ITGA3; integrin alpha-3 [KO:K06482]
110215860  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
110215866  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
110215904  ITGB3; integrin beta-3 [KO:K06493]
110215985  VEGFC; vascular endothelial growth factor C [KO:K05449]
110216083  MYC; myc proto-oncogene protein [KO:K04377]
110216101  GHR; growth hormone receptor [KO:K05080]
110216252  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
110216282  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
110216530  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
110216589  F2R; proteinase-activated receptor 1 [KO:K03914]
110216602  THBS4; thrombospondin-4 [KO:K04659]
110216702  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
110216720  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
110216795  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
110216814  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
110216959  [KO:K06243]
110216962  LAMB2; laminin subunit beta-2 [KO:K06243]
110216984  [KO:K02583]
110217257  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
110217565  COL1A2; collagen alpha-2(I) chain [KO:K06236]
110217679  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
110217882  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
110218186  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
110218307  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
110218309  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
110218605  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
110218646  FGF6; fibroblast growth factor 6 [KO:K04358]
110218698  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
110218707  CDKN1B; cyclin-dependent kinase inhibitor 1B isoform X1 [KO:K06624]
110218759  FGF23; fibroblast growth factor 23 [KO:K22428]
110218851  [KO:K04289]
110219058  [KO:K13304] [EC:2.7.11.1]
110219182  NRAS; GTPase NRas [KO:K07828]
110219266  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
110219284  NGF; beta-nerve growth factor [KO:K02582]
110219298  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
110219415  FN1; fibronectin isoform X1 [KO:K05717]
110219692  FGF21; fibroblast growth factor 21 [KO:K22429]
110219700  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
110219774  GYS1; LOW QUALITY PROTEIN: glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
110219910  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
110219961  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
110220506  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
110220737  ITGB6; integrin beta-6 [KO:K06589]
110220894  FGF1; fibroblast growth factor 1 [KO:K18496]
110221208  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
110221241  YWHAG; LOW QUALITY PROTEIN: 14-3-3 protein gamma [KO:K16198]
110221483  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
110221618  JAK2; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
110221658  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
110221680  ITGA4; integrin alpha-4 [KO:K06483]
110221859  CD19; B-lymphocyte antigen CD19 [KO:K06465]
110221918  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110221943  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
110221953  TSC2; LOW QUALITY PROTEIN: tuberin [KO:K07207]
110221981  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
110222026  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
110222135  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
110222446  VEGFD; vascular endothelial growth factor D [KO:K05449]
110222633  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
110222677  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
110222728  LAMB3; laminin subunit beta-3 [KO:K06244]
110222892  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
110222927  FOXO3; forkhead box protein O3 [KO:K09408]
110222958  FGF2; fibroblast growth factor 2 [KO:K18497]
110223001  [KO:K05429]
110223036  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
110223042  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
110223279  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
110223284  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
110223345  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
110223395  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
110223419  COMP; cartilage oligomeric matrix protein [KO:K04659]
110223453  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
110223501  EFNA2; ephrin-A2 [KO:K05462]
110223520  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
110223533  FGF22; fibroblast growth factor 22 [KO:K04358]
110224036  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
pcw00010  Glycolysis / Gluconeogenesis
pcw04010  MAPK signaling pathway
pcw04012  ErbB signaling pathway
pcw04062  Chemokine signaling pathway
pcw04064  NF-kappa B signaling pathway
pcw04068  FoxO signaling pathway
pcw04110  Cell cycle
pcw04115  p53 signaling pathway
pcw04150  mTOR signaling pathway
pcw04210  Apoptosis
pcw04370  VEGF signaling pathway
pcw04510  Focal adhesion
pcw04620  Toll-like receptor signaling pathway
pcw04630  JAK-STAT signaling pathway
pcw04662  B cell receptor signaling pathway
pcw04910  Insulin signaling pathway
KO pathway
ko04151   

DBGET integrated database retrieval system