KEGG   PATHWAY: acat04020
Entry
acat04020                   Pathway                                
Name
Calcium signaling pathway - Aquarana catesbeiana (American bullfrog)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
acat04020  Calcium signaling pathway
acat04020

Other DBs
GO: 0019722
Organism
Aquarana catesbeiana (American bullfrog) [GN:acat]
Gene
141101823  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
141101829  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
141102426  [KO:K04958]
141102610  [KO:K04958]
141102624  [KO:K05865]
141102722  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
141102734  MST1; hepatocyte growth factor-like protein [KO:K23441]
141102750  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
141102756  OXTR; oxytocin receptor [KO:K04229]
141102859  [KO:K15040]
141102934  CAMK1; calcium/calmodulin-dependent protein kinase type 1 [KO:K08794] [EC:2.7.11.17]
141103086  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
141103118  HRH1; histamine H1 receptor [KO:K04149]
141103206  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
141103260  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
141103286  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
141103587  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
141103719  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
141103721  MCOLN2; mucolipin-2 [KO:K04993]
141103736  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
141103741  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
141103770  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
141103804  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
141103824  [KO:K04635]
141104518  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
141104769  [KO:K08043] [EC:4.6.1.1]
141104935  TBXA2R; thromboxane A2 receptor [KO:K04264]
141105212  [KO:K04211]
141105763  ADRB1; beta-1 adrenergic receptor [KO:K04141]
141105951  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
141105961  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
141106039  HTR7; 5-hydroxytryptamine receptor 7 [KO:K04163]
141106050  [KO:K05840]
141106052  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
141106086  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
141106112  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
141106146  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
141106216  VDAC2; non-selective voltage-gated ion channel VDAC2 [KO:K15040]
141106225  PPIF; LOW QUALITY PROTEIN: peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
141106234  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
141106248  [KO:K05869] [EC:2.7.11.17]
141106317  P2RX3; P2X purinoceptor 3 [KO:K05217]
141106590  [KO:K04809]
141106712  [KO:K08774]
141107233  FGF5; fibroblast growth factor 5 [KO:K04358]
141107653  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
141107762  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
141107769  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
141107972  [KO:K04198]
141107984  CYSLTR1; LOW QUALITY PROTEIN: cysteinyl leukotriene receptor 1 [KO:K04322]
141107988  HTR2C; 5-hydroxytryptamine receptor 2C [KO:K04157]
141108086  SLC25A5; ADP/ATP translocase 2 isoform X1 [KO:K05863]
141108162  [KO:K05096] [EC:2.7.10.1]
141108269  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
141108358  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
141108498  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
141108799  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
141108862  FGF16; fibroblast growth factor 16 [KO:K04358]
141109033  [KO:K07190]
141109832  [KO:K04266]
141110076  FGF21; fibroblast growth factor 21 [KO:K22429]
141110267  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
141110283  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
141110445  TACR3; neuromedin-K receptor [KO:K04224]
141110782  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
141110911  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
141110934  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
141110940  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
141111054  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
141111362  FGF2; fibroblast growth factor 2 [KO:K18497]
141111984  TPCN2; two pore channel protein 2 [KO:K14077]
141112180  EDNRA; endothelin-1 receptor [KO:K04197]
141112291  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
141112310  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
141112353  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
141112484  [KO:K05849]
141112486  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
141112676  PDGFC; platelet-derived growth factor C [KO:K05450]
141112700  [KO:K04282]
141112758  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
141112779  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
141112825  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
141112948  FGF3; fibroblast growth factor 3 [KO:K04358]
141112950  FGF4; fibroblast growth factor 4 [KO:K04358]
141112951  FGF19; fibroblast growth factor 19 [KO:K22603]
141113218  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
141113266  TNNC2; troponin C, skeletal muscle isoform X1 [KO:K12042]
141113325  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [KO:K01116] [EC:3.1.4.11]
141113504  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
141113547  VEGFC; vascular endothelial growth factor C [KO:K05449]
141113908  NFATC2; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
141113950  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
141113954  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
141114046  NTSR1; neurotensin receptor type 1 [KO:K04211]
141114091  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
141114110  [KO:K04282]
141114191  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
141114197  [KO:K00907] [EC:2.7.11.18]
141114227  [KO:K03914]
141114265  [KO:K02677] [EC:2.7.11.13]
141114430  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
141114469  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
141114970  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
141115002  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
141115363  [KO:K03914]
141116334  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
141116425  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
141116440  CALM1; calmodulin-1 [KO:K02183]
141116560  [KO:K03914]
141116676  STIM2; stromal interaction molecule 2 [KO:K18196]
141116711  CCKAR; cholecystokinin receptor type A [KO:K04194]
141116733  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
141116996  CASQ1; calsequestrin-1 [KO:K23468]
141117131  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
141117138  [KO:K01242] [EC:3.2.2.6 2.4.99.20]
141117231  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
141117245  [KO:K03916]
141117333  DRD5; D(1B) dopamine receptor [KO:K05840]
141117483  [KO:K03916]
141117570  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
141118604  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
141119514  [KO:K04150]
141120399  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
141120730  [KO:K04163]
141122543  [KO:K03914]
141124037  [KO:K03914]
141124045  [KO:K03914]
141124046  [KO:K03914]
141124047  [KO:K03914]
141124056  [KO:K03914]
141124164  FGF20; fibroblast growth factor 20 [KO:K04358]
141126652  [KO:K04194]
141126906  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
141126996  PDGFD; platelet-derived growth factor D [KO:K05450]
141127011  SLN; sarcolipin [KO:K22642]
141127013  [KO:K22642]
141127125  [KO:K03914]
141127131  [KO:K03914]
141127159  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
141127197  FGF9; fibroblast growth factor 9 [KO:K04358]
141127209  [KO:K03914]
141127215  [KO:K03914]
141127275  [KO:K03914]
141127280  [KO:K03914]
141127286  [KO:K03914]
141127325  PDE1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
141127473  [KO:K15040]
141127475  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
141127555  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
141127564  [KO:K04166]
141127646  EDNRB; endothelin receptor type B [KO:K04198]
141128021  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
141128022  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
141128028  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
141128254  [KO:K03914]
141128272  [KO:K03914]
141128397  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
141128466  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
141128561  TFEB; transcription factor EB isoform X1 [KO:K15590]
141128598  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
141128638  ITPR3; inositol 1,4,5-trisphosphate-gated calcium channel ITPR3 isoform X1 [KO:K04960]
141128766  PTAFR; platelet-activating factor receptor isoform X1 [KO:K04279]
141128864  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
141128984  ORAI2; protein orai-2 isoform X1 [KO:K16057]
141128989  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
141129092  ADORA2B; adenosine receptor A2b [KO:K04267]
141129105  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
141129118  GRPR; gastrin-releasing peptide receptor [KO:K04169]
141129127  VEGFD; vascular endothelial growth factor D [KO:K05449]
141129249  [KO:K03914]
141129526  CASQ2; calsequestrin-2 [KO:K23445]
141129993  AVPR1B; vasopressin V1b receptor [KO:K04227]
141131191  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
141131218  CALML4; calmodulin-like protein 4 [KO:K02183]
141131301  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
141131412  FGF7; fibroblast growth factor 7 [KO:K04358]
141131496  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
141131802  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
141131833  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
141131968  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
141132131  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
141132161  AVPR1A; vasopressin V1a receptor isoform X1 [KO:K04226]
141132258  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
141132287  HRH2; histamine H2 receptor [KO:K04150]
141132294  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
141132311  ADRB2; beta-2 adrenergic receptor [KO:K04142]
141132329  DRD1; D(1A) dopamine receptor [KO:K04144]
141132348  FGF1; fibroblast growth factor 1 [KO:K18496]
141132418  VDAC1; non-selective voltage-gated ion channel VDAC1 isoform X1 [KO:K05862]
141132525  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
141132533  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
141132538  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
141132602  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
141132636  FGF23; fibroblast growth factor 23 [KO:K22428]
141132715  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
141132766  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
141132835  ITPR2; inositol 1,4,5-trisphosphate-gated calcium channel ITPR2 isoform X1 [KO:K04959]
141132874  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
141132955  TACR1; substance-P receptor isoform X1 [KO:K04222]
141132972  TGFA; protransforming growth factor alpha [KO:K08774]
141133045  FGF10; fibroblast growth factor 10 [KO:K04358]
141133048  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
141133057  [KO:K09565] [EC:5.2.1.8]
141133105  [KO:K04143]
141133125  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
141133150  VDAC3; non-selective voltage-gated ion channel VDAC3 [KO:K15041]
141133155  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
141133193  MCOLN1; mucolipin-1 [KO:K04992]
141133212  [KO:K04345] [EC:2.7.11.11]
141133231  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
141133384  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
141133602  [KO:K03914]
141133603  [KO:K03914]
141133604  [KO:K03914]
141133613  [KO:K03914]
141133614  [KO:K03914]
141133615  [KO:K03914]
141133616  [KO:K03914]
141133617  [KO:K03914]
141133993  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
141134338  [KO:K03914]
141134342  [KO:K03914]
141134344  [KO:K03914]
141134450  [KO:K03914]
141134461  [KO:K03914]
141134622  FGF6; fibroblast growth factor 6 [KO:K04358]
141134874  [KO:K03914]
141134884  [KO:K03914]
141134885  [KO:K03914]
141134886  [KO:K03914]
141134887  [KO:K03914]
141134888  [KO:K03914]
141134890  [KO:K03914]
141134891  [KO:K03914]
141137724  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
141139060  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
141139079  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
141139084  [KO:K08043] [EC:4.6.1.1]
141139085  [KO:K08043] [EC:4.6.1.1]
141139086  [KO:K08043] [EC:4.6.1.1]
141139350  NTSR2; LOW QUALITY PROTEIN: neurotensin receptor type 2 [KO:K04211]
141139500  NOS1; nitric oxide synthase 1 isoform X1 [KO:K13240] [EC:1.14.13.39]
141139604  AGTR1; type-1 angiotensin II receptor [KO:K04166]
141139683  [KO:K04322]
141139896  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
141139915  P2RX7; P2X purinoceptor 7 [KO:K05220]
141139923  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
141139925  P2RX4; P2X purinoceptor 4 [KO:K05218]
141140003  [KO:K16056]
141140233  PLN; phospholamban [KO:K05852]
141140522  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
141140658  [KO:K05849]
141140754  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
141140798  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
141140949  [KO:K02183]
141140950  [KO:K02183]
141140960  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
141141001  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
141141002  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
141141045  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
141141513  [KO:K05865]
141142258  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
141144060  [KO:K01116] [EC:3.1.4.11]
141144354  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
141144388  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 [KO:K05857] [EC:3.1.4.11]
141144564  TPCN1; two pore channel protein 1 isoform X1 [KO:K16896]
141144607  [KO:K04361] [EC:2.7.10.1]
141144660  PDE1C; LOW QUALITY PROTEIN: dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
141144696  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
141144870  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
141144897  P2RX2; P2X purinoceptor 2 [KO:K05216]
141145003  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
141145049  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
141145204  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
141145243  [KO:K04297]
141145269  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
141145282  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
141145442  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
141145507  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
141145698  NOS3; LOW QUALITY PROTEIN: nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
141146844  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
141146855  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
141146932  PDE1A; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
141146993  [KO:K04634]
141147007  [KO:K04636]
141147126  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
141147210  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
141147279  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
141148116  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
141148602  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
141148724  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
141148777  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
141148812  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
141148944  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
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Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
acat04010  MAPK signaling pathway
acat04070  Phosphatidylinositol signaling system
acat04210  Apoptosis
KO pathway
ko04020   

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