KEGG   PATHWAY: acat04010
Entry
acat04010                   Pathway                                
Name
MAPK signaling pathway - Aquarana catesbeiana (American bullfrog)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
acat04010  MAPK signaling pathway
acat04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Aquarana catesbeiana (American bullfrog) [GN:acat]
Gene
141101732  [KO:K04392]
141101733  [KO:K04392]
141101734  [KO:K04392]
141102474  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
141102684  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
141102702  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
141102953  [KO:K04441] [EC:2.7.11.24]
141103080  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
141103086  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
141103121  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
141103137  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
141103138  [KO:K04374]
141103166  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
141103177  CACNG2; voltage-dependent calcium channel gamma-2 subunit isoform X1 [KO:K04867]
141103206  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
141103210  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
141103260  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
141103359  PLA2G4A; LOW QUALITY PROTEIN: cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
141103447  INSR; insulin receptor [KO:K04527] [EC:2.7.10.1]
141103536  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
141103587  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
141103736  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
141103788  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
141103789  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
141103837  JUN; transcription factor Jun [KO:K04448]
141103883  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
141105330  [KO:K04372] [EC:2.7.11.1]
141105467  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
141105511  TNFRSF1A; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 1A [KO:K03158]
141105786  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
141105951  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
141105961  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
141106022  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
141106086  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
141106141  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
141106208  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
141106234  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
141106283  EFNA2; ephrin-A2 [KO:K05462]
141106367  [KO:K04440] [EC:2.7.11.24]
141106712  [KO:K08774]
141107233  FGF5; fibroblast growth factor 5 [KO:K04358]
141107369  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
141107390  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
141107471  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
141107613  [KO:K03156]
141107626  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
141107629  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
141107642  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
141107742  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
141107767  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K04350]
141107771  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
141107873  NRTN; neurturin [KO:K25414]
141107888  [KO:K03283]
141107889  [KO:K03283]
141107890  [KO:K03283]
141107891  [KO:K03283]
141107892  [KO:K03283]
141107893  [KO:K03283]
141107947  RELB; transcription factor RelB [KO:K09253]
141108075  NRK; nik-related protein kinase isoform X1 [KO:K04407] [EC:2.7.11.1]
141108141  JUND; transcription factor JunD [KO:K04449]
141108162  [KO:K05096] [EC:2.7.10.1]
141108269  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
141108346  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
141108355  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
141108390  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
141108462  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
141108546  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
141108551  FLNA; filamin-A isoform X1 [KO:K04437]
141108618  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
141108799  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
141108862  FGF16; fibroblast growth factor 16 [KO:K04358]
141109366  AREG; amphiregulin [KO:K09782]
141109382  EREG; proepiregulin [KO:K09784]
141110076  FGF21; fibroblast growth factor 21 [KO:K22429]
141110228  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
141110283  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
141110330  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
141110538  [KO:K03283]
141110680  RRAS; ras-related protein R-Ras isoform X1 [KO:K07830]
141110690  [KO:K13769]
141110721  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
141110755  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
141110762  [KO:K07827]
141110782  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
141110930  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
141110931  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
141110932  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
141110934  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
141110968  NTF4; neurotrophin-4 [KO:K12457]
141111241  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
141111327  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
141111362  FGF2; fibroblast growth factor 2 [KO:K18497]
141111821  RRAS2; ras-related protein R-Ras2 [KO:K07830]
141111912  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
141111950  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
141111989  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
141112085  BDNF; neurotrophic factor BDNF precursor form isoform X1 [KO:K04355]
141112172  IGF2; insulin-like growth factor 2 isoform X1 [KO:K13769]
141112268  HRAS; GTPase HRas [KO:K02833]
141112347  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
141112353  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
141112401  RELA; transcription factor p65 isoform X1 [KO:K04735]
141112452  [KO:K16510] [EC:2.7.11.1]
141112514  [KO:K20216] [EC:3.1.3.16 3.1.3.48]
141112555  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
141112676  PDGFC; platelet-derived growth factor C [KO:K05450]
141112821  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
141112948  FGF3; fibroblast growth factor 3 [KO:K04358]
141112950  FGF4; fibroblast growth factor 4 [KO:K04358]
141112951  FGF19; fibroblast growth factor 19 [KO:K22603]
141112978  INS; insulin [KO:K04526]
141113504  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
141113534  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
141113547  VEGFC; vascular endothelial growth factor C [KO:K05449]
141113669  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
141113826  CACNG5; voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
141113827  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
141113828  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
141113836  [KO:K02187] [EC:3.4.22.56]
141113848  [KO:K02187] [EC:3.4.22.56]
141113859  [KO:K02187] [EC:3.4.22.56]
141114116  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
141114125  [KO:K04380]
141114166  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
141114235  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
141114265  [KO:K02677] [EC:2.7.11.13]
141114391  STK4; serine/threonine-protein kinase 4 [KO:K04411]
141114430  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
141114437  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
141114465  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
141114502  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
141114970  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
141114986  KIT; mast/stem cell growth factor receptor Kit [KO:K05091] [EC:2.7.10.1]
141115002  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
141116437  EFNA4; ephrin-A4 [KO:K05462]
141116442  [KO:K05462]
141116929  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
141116950  MAP3K9; mitogen-activated protein kinase kinase kinase 9 [KO:K04417] [EC:2.7.11.25]
141116983  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
141117011  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
141117049  MAX; protein max isoform X1 [KO:K04453]
141117068  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
141117131  NTRK1; LOW QUALITY PROTEIN: high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
141117419  FOS; protein c-Fos [KO:K04379]
141117501  [KO:K16342] [EC:3.1.1.4]
141117610  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
141117672  [KO:K16342] [EC:3.1.1.4]
141117791  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
141118604  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
141121499  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
141123276  [KO:K16342] [EC:3.1.1.4]
141123342  [KO:K16342] [EC:3.1.1.4]
141123368  [KO:K16342] [EC:3.1.1.4]
141123432  [KO:K16342] [EC:3.1.1.4]
141123532  [KO:K16342] [EC:3.1.1.4]
141123548  [KO:K16342] [EC:3.1.1.4]
141124164  FGF20; fibroblast growth factor 20 [KO:K04358]
141126663  [KO:K04439]
141126788  [KO:K03283]
141126789  [KO:K03283]
141126790  [KO:K03283]
141126791  [KO:K03283]
141126792  [KO:K03283]
141126793  [KO:K03283]
141126794  [KO:K03283]
141126795  [KO:K03283]
141126796  [KO:K03283]
141126824  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
141126996  PDGFD; platelet-derived growth factor D [KO:K05450]
141127158  FLT3; receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
141127159  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
141127197  FGF9; fibroblast growth factor 9 [KO:K04358]
141127296  MAP3K12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
141127401  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
141127475  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
141127531  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
141127541  NR4A1; nuclear receptor subfamily 4immunitygroup A member 1 [KO:K04465]
141127897  [KO:K04386]
141127898  [KO:K04386]
141127902  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 [KO:K04407] [EC:2.7.11.1]
141127994  NF1; neurofibromin isoform X1 [KO:K08052]
141128362  [KO:K05466]
141128397  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
141128413  NRAS; GTPase NRas [KO:K07828]
141128449  RAP1A; ras-related protein Rap-1A [KO:K04353]
141128481  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
141128487  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
141128598  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
141128611  STMN1; stathmin isoform X1 [KO:K04381]
141128672  [KO:K04441] [EC:2.7.11.24]
141128714  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
141128874  [KO:K16342] [EC:3.1.1.4]
141128876  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
141128916  [KO:K16342] [EC:3.1.1.4]
141128922  [KO:K16342] [EC:3.1.1.4]
141128932  [KO:K16342] [EC:3.1.1.4]
141128976  CRK; adapter molecule crk isoform X1 [KO:K04438]
141128992  [KO:K16342] [EC:3.1.1.4]
141128993  NLK; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
141129068  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
141129127  VEGFD; vascular endothelial growth factor D [KO:K05449]
141129234  [KO:K16342] [EC:3.1.1.4]
141129726  [KO:K03283]
141129727  [KO:K03283]
141129932  HSPB1; heat shock protein beta-1 [KO:K04455]
141131197  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
141131221  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
141131231  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
141131277  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
141131412  FGF7; fibroblast growth factor 7 [KO:K04358]
141131678  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
141131832  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
141131833  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
141131925  [KO:K04441] [EC:2.7.11.24]
141131927  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
141131968  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
141132010  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
141132062  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
141132079  RAP1B; ras-related protein Rap-1b [KO:K07836]
141132134  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
141132136  KITLG; kit ligand [KO:K05461]
141132197  IGF1; insulin-like growth factor 1 [KO:K05459]
141132258  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
141132319  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
141132348  FGF1; fibroblast growth factor 1 [KO:K18496]
141132525  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
141132531  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
141132533  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
141132636  FGF23; fibroblast growth factor 23 [KO:K22428]
141132661  [KO:K04356]
141132662  [KO:K04356]
141132663  [KO:K04356]
141132714  KRAS; GTPase KRas isoform X1 [KO:K07827]
141132715  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
141132744  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
141132766  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
141132770  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
141132888  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
141132972  TGFA; protransforming growth factor alpha [KO:K08774]
141133035  [KO:K04519]
141133038  [KO:K04519]
141133039  [KO:K04519]
141133045  FGF10; fibroblast growth factor 10 [KO:K04358]
141133125  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
141133149  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
141133155  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
141133208  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
141133212  [KO:K04345] [EC:2.7.11.11]
141133350  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
141133384  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
141133449  [KO:K04439]
141133496  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
141133887  TP53; cellular tumor antigen p53 [KO:K04451]
141134622  FGF6; fibroblast growth factor 6 [KO:K04358]
141134662  [KO:K04519]
141135531  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
141135898  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
141136030  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
141137425  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
141139315  [KO:K16342] [EC:3.1.1.4]
141139461  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
141139470  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
141139486  RASA2; ras GTPase-activating protein 2 [KO:K08053]
141139691  MAPKAPK5; MAP kinase-activated protein kinase 5 [KO:K04442] [EC:2.7.11.1]
141139743  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
141139861  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
141139977  ANGPT2; angiopoietin-2 [KO:K05466]
141140116  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
141140309  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
141140357  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
141140370  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
141140457  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
141140486  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
141140754  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
141140839  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
141140852  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
141140923  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
141141008  SRF; serum response factor isoform X1 [KO:K04378]
141141045  VEGFA; vascular endothelial growth factor A, long form isoform X1 [KO:K05448]
141141272  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
141141353  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
141141954  CRKL; crk-like protein [KO:K04438]
141144249  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
141144303  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
141144384  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
141144387  [KO:K04421] [EC:2.7.11.25]
141144513  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
141144607  [KO:K04361] [EC:2.7.10.1]
141144741  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
141145003  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
141145398  STK3; serine/threonine-protein kinase 3 [KO:K04412]
141145438  ANGPT1; angiopoietin-1 [KO:K05465]
141145501  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
141145630  [KO:K02583]
141146176  [KO:K04381]
141146234  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
141146820  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
141146844  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
141146855  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
141146971  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
141146985  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
141147085  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
141147238  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
141147306  [KO:K04388] [EC:2.7.11.30]
141148277  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
141148414  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
141148434  [KO:K04468] [EC:2.7.11.24]
141148470  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
141148724  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
141148777  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
141148778  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
141148861  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
141148944  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
acat04070  Phosphatidylinositol signaling system
acat04110  Cell cycle
acat04115  p53 signaling pathway
acat04210  Apoptosis
acat04310  Wnt signaling pathway
KO pathway
ko04010   

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