KEGG   PATHWAY: btax04218
Entry
btax04218                   Pathway                                
Name
Cellular senescence - Budorcas taxicolor (takin)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
btax04218  Cellular senescence
btax04218

Other DBs
GO: 0090398
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128043310  RBBP4; histone-binding protein RBBP4 [KO:K10752]
128043403  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128043619  E2F2; transcription factor E2F2 [KO:K09389]
128043920  TSC2; tuberin isoform X1 [KO:K07207]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128044537  NRAS; GTPase NRas [KO:K07828]
128044871  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
128044902  MRAS; ras-related protein M-Ras [KO:K07831]
128045718  HIPK1; homeodomain-interacting protein kinase 1 isoform X1 [KO:K08826] [EC:2.7.11.1]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128046226  HIPK2; homeodomain-interacting protein kinase 2 isoform X1 [KO:K08826] [EC:2.7.11.1]
128046429  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
128046520  RHEB; GTP-binding protein Rheb [KO:K07208]
128046632  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
128046639  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
128046685  HUS1; checkpoint protein HUS1 [KO:K10903]
128046952  IL6; interleukin-6 [KO:K05405]
128047278  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
128047312  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
128047314  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
128047322  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
128047393  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
128047426  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
128047622  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
128047758  FOXM1; forkhead box protein M1 [KO:K09406]
128047937  KRAS; GTPase KRas [KO:K07827]
128048047  CDK1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
128048354  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
128048381  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
128048391  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
128048410  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
128048527  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
128049417  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
128049447  PPP3CA; protein phosphatase 3 catalytic subunit alpha isoform X1 [KO:K04348] [EC:3.1.3.16]
128049572  [KO:K10752]
128049822  [KO:K04451]
128049849  LIN54; protein lin-54 homolog [KO:K21776]
128049924  CCNA2; cyclin-A2 [KO:K06627]
128049958  CXCL8; interleukin-8 [KO:K10030]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128050636  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
128050664  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
128050874  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
128050979  [KO:K06751]
128051214  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
128051656  SQSTM1; sequestosome-1 isoform X1 [KO:K14381]
128051987  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
128052044  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
128052144  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
128052323  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
128052514  CDKN2B; cyclin-dependent kinase 4 inhibitor B [KO:K04685]
128052529  [KO:K06621]
128052606  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
128052750  GATA4; transcription factor GATA-4 [KO:K09183]
128053092  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
128053227  TRAF3IP2; E3 ubiquitin ligase TRAF3IP2 isoform X1 [KO:K21124]
128053483  FOXO3; forkhead box protein O3 [KO:K09408]
128053757  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
128053888  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
128053954  ZFP36L1; mRNA decay activator protein ZFP36L1 [KO:K18753]
128053970  LIN52; protein lin-52 homolog isoform X1 [KO:K21775]
128054045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128054080  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
128054267  CALM1; calmodulin-1 [KO:K02183]
128054390  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
128054493  SMAD3; mothers against decapentaplegic homolog 3 [KO:K23605]
128054812  TRPM7; transient receptor potential cation channel subfamily M member 7 [KO:K04982] [EC:2.7.11.1]
128054910  CDC25A; M-phase inducer phosphatase 1 [KO:K06645] [EC:3.1.3.48]
128055125  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
128055236  [KO:K06751]
128055280  [KO:K06751]
128055281  [KO:K06751]
128055294  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
128055305  [KO:K06751]
128055318  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
128055411  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
128055801  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
128055953  ZFP36L2; mRNA decay activator protein ZFP36L2 [KO:K18753]
128056281  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
128056580  E2F3; transcription factor E2F3 [KO:K06620]
128056632  TSC1; hamartin isoform X1 [KO:K07206]
128056679  IL1A; interleukin-1 alpha [KO:K04383]
128056684  CALM2; calmodulin-2 [KO:K02183]
128056953  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
128057478  FOXO1; forkhead box protein O1 [KO:K07201]
128057539  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
128057751  CCNA1; cyclin-A1 [KO:K06627]
128058150  RBL1; retinoblastoma-like protein 1 [KO:K04681]
128058230  [KO:K02183]
128058335  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
128058399  E2F1; transcription factor E2F1 [KO:K17454]
128058546  MYBL2; myb-related protein B [KO:K21769]
128058634  [KO:K05862]
128059118  [KO:K15040]
128059120  MYC; myc proto-oncogene protein [KO:K04377]
128059232  E2F5; transcription factor E2F5 [KO:K04682]
128059332  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
128059402  NBN; nibrin [KO:K10867]
128059988  [KO:K07205]
128060054  RRAS2; ras-related protein R-Ras2 [KO:K07830]
128060085  HIPK3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
128060244  MRE11; double-strand break repair protein MRE11 [KO:K10865]
128060504  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
128061180  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
128061269  CALML6; LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061503  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128061511  LIN9; protein lin-9 homolog [KO:K21773]
128061687  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
128061699  RASSF5; ras association domain-containing protein 5 [KO:K08015]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128061864  MAPKAPK2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
128062069  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128062181  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
128062293  TRPV4; transient receptor potential cation channel subfamily V member 4 [KO:K04973]
128062388  CHEK2; serine/threonine-protein kinase Chk2 [KO:K06641] [EC:2.7.11.1]
128062431  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
128062569  RAD9B; cell cycle checkpoint control protein RAD9B [KO:K10995]
128062909  HIPK4; homeodomain-interacting protein kinase 4 [KO:K08826] [EC:2.7.11.1]
128062924  RBL2; retinoblastoma-like protein 2 [KO:K16332]
128062946  LIN37; protein lin-37 homolog isoform X1 [KO:K21774]
128063078  RRAS; ras-related protein R-Ras [KO:K07829]
128063191  E2F4; transcription factor E2F4 isoform X1 [KO:K04682]
128063320  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
128063478  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
128063810  CALM3; calmodulin-3 [KO:K02183]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128064208  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
128064641  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
128064672  TP53; cellular tumor antigen p53 [KO:K04451]
128065178  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
128065993  FBXW11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
128066149  CCNB1; G2/mitotic-specific cyclin-B1 [KO:K05868]
128066193  RAD1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128066902  [KO:K05868]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067290  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
128067292  SMAD2; mothers against decapentaplegic homolog 2 [KO:K04500]
128067734  BTRC; F-box/WD repeat-containing protein 1A isoform X1 [KO:K03362]
128068055  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
128068182  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
128068203  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 isoform X1 [KO:K07205]
128068228  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
128068502  RAD9A; cell cycle checkpoint control protein RAD9A isoform X1 [KO:K10994] [EC:3.1.11.2]
128068503  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
128068539  ETS1; protein C-ets-1 isoform X1 [KO:K02678]
128068546  RELA; transcription factor p65 [KO:K04735]
128068689  HRAS; GTPase HRas isoform X1 [KO:K02833]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128068939  CHEK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
128069030  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
128069183  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
128069199  SERPINE1; plasminogen activator inhibitor 1 [KO:K03982]
128069760  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
128070382  CCNB3; G2/mitotic-specific cyclin-B3 [KO:K21771]
128070620  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
128071171  [KO:K06641] [EC:2.7.11.1]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
btax04020  Calcium signaling pathway
btax04068  FoxO signaling pathway
btax04110  Cell cycle
btax04115  p53 signaling pathway
btax04150  mTOR signaling pathway
KO pathway
ko04218   

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