KEGG   PATHWAY: ccar04120
Entry
ccar04120                   Pathway                                
Name
Ubiquitin mediated proteolysis - Cyprinus carpio (common carp)
Description
Protein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to proteins being degraded is performed by a reaction cascade consisting of three enzymes, named E1 (ubiquitin activating enzyme), E2 (ubiquitin conjugating enzyme), and E3 (ubiquitin ligase). Each E3 has specificity to its substrate, or proteins to be targeted by ubiquitination. Many E3s are discovered in eukaryotes and they are classified into four types: HECT type, U-box type, single RING-finger type, and multi-subunit RING-finger type. Multi-subunit RING-finger E3s are exemplified by cullin-Rbx E3s and APC/C. They consist of a RING-finger-containing subunit (RBX1 or RBX2) that functions to bind E2s, a scaffold-like cullin molecule, adaptor proteins, and a target recognizing subunit that binds substrates.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
ccar04120  Ubiquitin mediated proteolysis
ccar04120

Other DBs
GO: 0016567
Organism
Cyprinus carpio (common carp) [GN:ccar]
Gene
109045177  [KO:K10575] [EC:2.3.2.23]
109045178  ube2g1b; ubiquitin-conjugating enzyme E2G 1b [KO:K10575] [EC:2.3.2.23]
109045222  [KO:K02207] [EC:2.3.2.23]
109045558  [KO:K10594] [EC:2.3.2.26]
109045559  [KO:K10594] [EC:2.3.2.26]
109045647  [KO:K10577]
109045822  [KO:K16063] [EC:2.3.2.-]
109046086  socs3b; suppressor of cytokine signaling 3b [KO:K04696]
109046132  [KO:K04696]
109046182  pias2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063] [EC:2.3.2.-]
109046733  pias4a; E3 SUMO-protein ligase PIAS4-A [KO:K16065] [EC:2.3.2.27]
109046807  [KO:K06689] [EC:2.3.2.23]
109048011  ube2b; ubiquitin-conjugating enzyme E2 B [KO:K10574] [EC:2.3.2.23]
109048012  [KO:K10574] [EC:2.3.2.23]
109048021  [KO:K03094]
109048171  [KO:K07868]
109048435  [KO:K10592] [EC:2.3.2.26]
109048589  [KO:K10447]
109049122  [KO:K10577]
109049134  [KO:K04678] [EC:2.3.2.26]
109049636  [KO:K10583] [EC:2.3.2.23]
109049918  [KO:K07868]
109050014  uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
109050259  [KO:K06643] [EC:2.3.2.27]
109050295  nedd4l; E3 ubiquitin-protein ligase NEDD4-like isoform X1 [KO:K13305] [EC:2.3.2.26]
109050538  [KO:K10577]
109050732  [KO:K04678] [EC:2.3.2.26]
109050806  [KO:K05630] [EC:2.3.2.26]
109050906  [KO:K04678] [EC:2.3.2.26]
109050974  wwp2; NEDD4-like E3 ubiquitin-protein ligase WWP2 isoform X1 [KO:K05630] [EC:2.3.2.26]
109051255  [KO:K10582] [EC:2.3.2.23]
109051786  [KO:K10580] [EC:2.3.2.23]
109051787  ube2na; ubiquitin-conjugating enzyme E2Na [KO:K10580] [EC:2.3.2.23]
109052131  [KO:K06688] [EC:2.3.2.23]
109052133  [KO:K06688] [EC:2.3.2.23]
109052264  [KO:K03178] [EC:6.2.1.45]
109052845  itcha; LOW QUALITY PROTEIN: itchy E3 ubiquitin protein ligase a [KO:K05632] [EC:2.3.2.26]
109052862  ube2g2; ubiquitin-conjugating enzyme E2 G2 [KO:K04555] [EC:2.3.2.23]
109053857  keap1b; kelch-like ECH-associated protein 1B [KO:K10456]
109053945  [KO:K04725] [EC:2.3.2.27]
109054012  [KO:K10602] [EC:2.3.2.27]
109054162  [KO:K10456]
109054175  ube2r2; ubiquitin-conjugating enzyme E2 R2 [KO:K02207] [EC:2.3.2.23]
109054466  [KO:K03871]
109054624  cdc23; cell division cycle protein 23 homolog [KO:K03355]
109054829  [KO:K04554] [EC:2.3.2.23]
109054976  [KO:K10573] [EC:2.3.2.23]
109054978  ube2al; ubiquitin conjugating enzyme E2 A, like [KO:K10573] [EC:2.3.2.23]
109055371  rhobtb2b; LOW QUALITY PROTEIN: rho-related BTB domain-containing protein 2 [KO:K07868]
109055661  [KO:K03869]
109055898  [KO:K20217] [EC:2.3.2.23]
109056155  [KO:K10607] [EC:2.3.2.27]
109056241  [KO:K10604] [EC:2.3.2.27]
109056392  pias4b; E3 SUMO-protein ligase PIAS4b isoform X2 [KO:K16065] [EC:2.3.2.27]
109056470  [KO:K04694]
109056928  [KO:K10604] [EC:2.3.2.27]
109057647  [KO:K04678] [EC:2.3.2.26]
109057811  birc2; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2 [KO:K16060]
109057965  [KO:K10291]
109058859  [KO:K10582] [EC:2.3.2.23]
109059503  [KO:K03869]
109059504  [KO:K03869]
109059967  vhll; von Hippel-Lindau-like protein [KO:K03871]
109060079  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
109060230  [KO:K04554] [EC:2.3.2.23]
109060247  [KO:K03364]
109060387  [KO:K04694]
109060595  elob; elongin-B [KO:K03873]
109060888  [KO:K07868]
109060938  [KO:K10597] [EC:2.3.2.27]
109061212  uba3; NEDD8-activating enzyme E1 catalytic subunit isoform X1 [KO:K10686] [EC:6.2.1.64]
109061224  [KO:K10686] [EC:6.2.1.64]
109061338  [KO:K03348]
109061841  [KO:K10576] [EC:2.3.2.23]
109062022  [KO:K03350]
109062104  [KO:K10580] [EC:2.3.2.23]
109062117  [KO:K03354]
109062478  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
109062479  [KO:K03872]
109062545  [KO:K10607] [EC:2.3.2.27]
109062588  [KO:K03350]
109062625  ube3c; ubiquitin-protein ligase E3C [KO:K10589] [EC:2.3.2.26]
109062711  [KO:K10260]
109062782  cul1a; cullin-1a [KO:K03347]
109062788  [KO:K03347]
109063418  [KO:K07868]
109064717  [KO:K10571]
109064728  [KO:K10615] [EC:2.3.2.26]
109064744  herc4; probable E3 ubiquitin-protein ligase HERC4 isoform X1 [KO:K10615] [EC:2.3.2.26]
109064895  [KO:K10603]
109064900  [KO:K10603]
109065358  [KO:K10592] [EC:2.3.2.26]
109065463  [KO:K03175] [EC:2.3.2.27]
109065637  [KO:K04506] [EC:2.3.2.27]
109066169  [KO:K10610]
109066183  [KO:K05633] [EC:2.3.2.26]
109066554  [KO:K04649] [EC:2.3.2.23]
109066709  [KO:K03871]
109066993  herc2; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 [KO:K10595] [EC:2.3.2.26]
109067543  ubox5; RING finger protein 37 [KO:K10600] [EC:2.3.2.27]
109067897  skp1; S-phase kinase-associated protein 1 [KO:K03094]
109067991  cop1; E3 ubiquitin-protein ligase COP1 [KO:K10143] [EC:2.3.2.27]
109068704  [KO:K07868]
109068918  ube2o; (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O [KO:K10581] [EC:2.3.2.24]
109068949  anapc16; anaphase-promoting complex subunit 16 [KO:K25229]
109069140  cul5b; LOW QUALITY PROTEIN: cullin-5 [KO:K10612]
109069904  [KO:K22517] [EC:2.3.2.27]
109069925  [KO:K10601] [EC:2.3.2.27]
109069997  [KO:K06689] [EC:2.3.2.23]
109070422  [KO:K06689] [EC:2.3.2.23]
109070467  [KO:K10586] [EC:2.3.2.23]
109070478  birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
109070836  pias1b; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
109071396  ube2e2; ubiquitin-conjugating enzyme E2 E2 [KO:K20217] [EC:2.3.2.23]
109072253  [KO:K02207] [EC:2.3.2.23]
109072272  [KO:K10608] [EC:2.3.2.27]
109073055  [KO:K10687] [EC:2.3.2.34]
109073060  [KO:K04696]
109073421  anapc13; anaphase-promoting complex subunit 13 [KO:K12456]
109073485  [KO:K03362]
109073846  [KO:K10599] [EC:2.3.2.27]
109074339  [KO:K10578] [EC:2.3.2.23]
109074538  ube4b; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
109074586  socs1b; suppressor of cytokine signaling 1b [KO:K04694]
109076363  [KO:K06689] [EC:2.3.2.23]
109076410  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
109076699  rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
109076720  birc7; baculoviral IAP repeat-containing protein 7 isoform X1 [KO:K16061]
109076892  [KO:K03353]
109077206  [KO:K04706] [EC:2.3.2.-]
109077613  [KO:K10686] [EC:6.2.1.64]
109077631  [KO:K03872]
109078179  [KO:K25229]
109078425  si:rp71-68n21.9; kelch-like protein 9 isoform X1 [KO:K10447]
109078718  [KO:K10144] [EC:2.3.2.27]
109078815  [KO:K07868]
109079221  [KO:K10598] [EC:5.2.1.8]
109080086  trip12; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase TRIP12 [KO:K10590] [EC:2.3.2.26]
109080785  [KO:K10587] [EC:2.3.2.26]
109080800  ube3a; ubiquitin-protein ligase E3A [KO:K10587] [EC:2.3.2.26]
109081048  [KO:K03363]
109081168  siah1; E3 ubiquitin-protein ligase Siah1 isoform X1 [KO:K04506] [EC:2.3.2.27]
109081461  prkn; E3 ubiquitin-protein ligase parkin isoform X1 [KO:K04556] [EC:2.3.2.31]
109081798  [KO:K10575] [EC:2.3.2.23]
109082606  [KO:K04552] [EC:2.3.2.23]
109082719  [KO:K10582] [EC:2.3.2.23]
109082973  [KO:K10588] [EC:2.3.2.26]
109083412  [KO:K04649] [EC:2.3.2.23]
109083880  [KO:K10612]
109084368  [KO:K03357]
109084462  [KO:K10571]
109085092  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
109085106  [KO:K03872]
109085509  [KO:K22518] [EC:2.3.2.27]
109085814  [KO:K05632] [EC:2.3.2.26]
109086140  [KO:K04554] [EC:2.3.2.23]
109086991  [KO:K06689] [EC:2.3.2.23]
109087306  [KO:K03358]
109087847  [KO:K10684] [EC:6.2.1.45]
109087849  [KO:K10684] [EC:6.2.1.45]
109088280  cdc26; anaphase-promoting complex subunit CDC26 [KO:K03359]
109088281  trim37; E3 ubiquitin-protein ligase TRIM37 isoform X1 [KO:K10608] [EC:2.3.2.27]
109088459  [KO:K03349]
109088509  [KO:K03349]
109088654  [KO:K10579] [EC:2.3.2.34]
109088656  [KO:K10579] [EC:2.3.2.34]
109089132  [KO:K13305] [EC:2.3.2.26]
109089173  eloca; elongin C paralog a isoform X1 [KO:K03872]
109089182  [KO:K10609]
109089349  [KO:K10585] [EC:2.3.2.23]
109089419  [KO:K02207] [EC:2.3.2.23]
109089659  [KO:K04554] [EC:2.3.2.23]
109090410  [KO:K02927]
109090423  ube2l3b; ubiquitin-conjugating enzyme E2 L3b [KO:K04552] [EC:2.3.2.23]
109090503  ube2g1a; ubiquitin-conjugating enzyme E2 G1a isoform X1 [KO:K10575] [EC:2.3.2.23]
109090618  [KO:K10264]
109090632  [KO:K03359]
109090701  [KO:K10447]
109090703  [KO:K10447]
109091039  [KO:K10595] [EC:2.3.2.26]
109091426  vhl; von Hippel-Lindau disease tumor suppressor [KO:K03871]
109091837  cdc20; cell division cycle protein 20 homolog [KO:K03363]
109092401  anapc11; anaphase-promoting complex subunit 11 isoform X3 [KO:K03358]
109092443  [KO:K10577]
109092448  [KO:K10577]
109092670  [KO:K10594] [EC:2.3.2.26]
109092676  [KO:K10594] [EC:2.3.2.26]
109092712  cdc16; cell division cycle protein 16 homolog isoform X1 [KO:K03353]
109093197  [KO:K04649] [EC:2.3.2.23]
109093401  [KO:K03175] [EC:2.3.2.27]
109093483  [KO:K10588] [EC:2.3.2.26]
109093715  [KO:K10591] [EC:2.3.2.26]
109093716  [KO:K10591] [EC:2.3.2.26]
109094171  pias1a; E3 SUMO-protein ligase PIAS1 isoform X1 [KO:K04706] [EC:2.3.2.-]
109094369  ube2wb; probable ubiquitin-conjugating enzyme E2 W-B isoform X1 [KO:K10688] [EC:2.3.2.23 2.3.2.25]
109094495  [KO:K10573] [EC:2.3.2.23]
109094574  [KO:K06689] [EC:2.3.2.23]
109094581  ube2d4; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
109095174  fzr1a; fizzy/cell division cycle 20 related 1a [KO:K03364]
109095197  [KO:K10291]
109095216  [KO:K03354]
109095316  anapc5; anaphase-promoting complex subunit 5 [KO:K03352]
109096100  [KO:K10589] [EC:2.3.2.26]
109096103  [KO:K10573] [EC:2.3.2.23]
109096392  [KO:K20217] [EC:2.3.2.23]
109096447  mid1; E3 ubiquitin-protein ligase Midline-1 [KO:K08285] [EC:2.3.2.27]
109096751  [KO:K02927]
109097173  [KO:K10687] [EC:2.3.2.34]
109097257  map3k1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
109097258  [KO:K04416] [EC:2.7.11.25]
109097432  [KO:K10099]
109097434  [KO:K10099]
109098133  cul4a; cullin-4A [KO:K10609]
109098921  [KO:K20217] [EC:2.3.2.23]
109098998  [KO:K03362]
109099533  [KO:K10578] [EC:2.3.2.23]
109099553  [KO:K10604] [EC:2.3.2.27]
109099712  [KO:K06689] [EC:2.3.2.23]
109100105  [KO:K10260]
109100384  anapc1; anaphase-promoting complex subunit 1 [KO:K03348]
109101003  [KO:K10699] [EC:6.2.1.45]
109101218  [KO:K10606] [EC:2.3.2.27]
109101492  ube2a; ubiquitin-conjugating enzyme E2 A [KO:K10573] [EC:2.3.2.23]
109101593  stub1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
109101622  [KO:K06689] [EC:2.3.2.23]
109102102  [KO:K03869]
109102115  [KO:K10573] [EC:2.3.2.23]
109102506  fbxw11b; F-box and WD repeat domain-containing 11-B [KO:K03362]
109102535  [KO:K10599] [EC:2.3.2.27]
109102726  [KO:K10609]
109102805  [KO:K04706] [EC:2.3.2.-]
109103193  [KO:K04707] [EC:2.3.2.27]
109103207  [KO:K10596] [EC:2.3.2.27]
109103208  ube4a; ubiquitin conjugation factor E4 A [KO:K10596] [EC:2.3.2.27]
109103546  [KO:K04707] [EC:2.3.2.27]
109104254  [KO:K03870]
109104257  [KO:K03870]
109105190  [KO:K10570]
109105792  [KO:K10582] [EC:2.3.2.23]
109105817  [KO:K10583] [EC:2.3.2.23]
109105955  [KO:K10688] [EC:2.3.2.23 2.3.2.25]
109105962  [KO:K22518] [EC:2.3.2.27]
109106940  [KO:K05632] [EC:2.3.2.26]
109106943  [KO:K05632] [EC:2.3.2.26]
109107091  ppil2; RING-type E3 ubiquitin-protein ligase PPIL2 [KO:K10598] [EC:5.2.1.8]
109107294  mgrn1a; probable E3 ubiquitin-protein ligase MGRN1 isoform X1 [KO:K10604] [EC:2.3.2.27]
109107324  [KO:K10143] [EC:2.3.2.27]
109107382  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
109107429  ube2l3a; ubiquitin-conjugating enzyme E2 L3a [KO:K04552] [EC:2.3.2.23]
109108621  [KO:K10580] [EC:2.3.2.23]
109109129  rnf7; RING-box protein 2 [KO:K10611]
109109631  syvn1; LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase synoviolin [KO:K10601] [EC:2.3.2.27]
109109929  [KO:K03364]
109109984  [KO:K10140]
109110260  cdc34a; LOW QUALITY PROTEIN: cell division cycle 34 homolog (S. cerevisiae) a [KO:K02207] [EC:2.3.2.23]
109110269  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
109110364  [KO:K04552] [EC:2.3.2.23]
109110490  [KO:K10140]
109110905  [KO:K03178] [EC:6.2.1.45]
109111162  uba1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
109111365  [KO:K10456]
109111428  [KO:K20217] [EC:2.3.2.23]
109111603  ube2ql1; ubiquitin-conjugating enzyme E2Q-like protein 1 [KO:K10582] [EC:2.3.2.23]
109112058  [KO:K22517] [EC:2.3.2.27]
109112224  [KO:K10582] [EC:2.3.2.23]
109112268  [KO:K10685] [EC:6.2.1.45]
109112278  [KO:K10685] [EC:6.2.1.45]
109112904  [KO:K03351]
109113043  [KO:K10610]
109113451  [KO:K04694]
109113793  [KO:K03873]
122133983  ube2kb; ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) [KO:K04649] [EC:2.3.2.23]
122134200  [KO:K20217] [EC:2.3.2.23]
122135121  [KO:K03357]
122135347  [KO:K03347]
122135872  [KO:K10699] [EC:6.2.1.45]
122136582  [KO:K10585] [EC:2.3.2.23]
122137141  [KO:K10576] [EC:2.3.2.23]
122137465  [KO:K08770]
122138158  [KO:K03868] [EC:2.3.2.32]
122139616  ube2d2; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
122139847  anapc15; anaphase-promoting complex subunit 15 [KO:K25228]
122140147  [KO:K06689] [EC:2.3.2.23]
122142186  cul1b; cullin-1b [KO:K03347]
122145146  [KO:K08770]
122145261  [KO:K02977]
122146485  [KO:K08770]
122147460  cul4b; LOW QUALITY PROTEIN: cullin-4B [KO:K10609]
122147567  [KO:K03362]
Reference
PMID:16922370
  Authors
Kamura T.
  Title
[Cullin-based E3 family]
  Journal
Tanpakushitsu Kakusan Koso 51:1167-72 (2006)
Reference
PMID:16922408
  Authors
Matsuda N.
  Title
[Overview: hereditary disorders caused by dysfunction of ubiquitylation]
  Journal
Tanpakushitsu Kakusan Koso 51:1402-7 (2006)
Reference
PMID:16922367
  Authors
Tokunaga F.
  Title
[E2 ubiquitin-conjugating enzymes: structures and functions]
  Journal
Tanpakushitsu Kakusan Koso 51:1150-6 (2006)
Reference
PMID:16816840
  Authors
Nalepa G, Rolfe M, Harper JW.
  Title
Drug discovery in the ubiquitin-proteasome system.
  Journal
Nat Rev Drug Discov 5:596-613 (2006)
DOI:10.1038/nrd2056
Reference
PMID:16405856
  Authors
Hsu YJ, Goodman SR.
  Title
Spectrin and ubiquitination: a review.
  Journal
Cell Mol Biol (Noisy-le-grand) Suppl 51:OL801-7 (2005)
Reference
PMID:12944364
  Authors
Hatakeyama S, Nakayama KI.
  Title
Ubiquitylation as a quality control system for intracellular proteins.
  Journal
J Biochem 134:1-8 (2003)
DOI:10.1093/jb/mvg106
Reference
PMID:17588513
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
DOI:10.1016/j.molcel.2007.06.001
Related
pathway
ccar03050  Proteasome
KO pathway
ko04120   

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