KEGG   PATHWAY: gvr05202
Entry
gvr05202                    Pathway                                
Name
Transcriptional misregulation in cancer - Galeopterus variegatus (Sunda flying lemur)
Description
In tumor cells, genes encoding transcription factors (TFs) are often amplified, deleted, rearranged via chromosomal translocation and inversion, or subjected to point mutations that result in a gain- or loss-of- function. In hematopoietic cancers and solid tumors, the translocations and inversions increase or deregulate transcription of the oncogene. Recurrent chromosome translocations generate novel fusion oncoproteins, which are common in myeloid cancers and soft-tissue sarcomas. The fusion proteins have aberrant transcriptional function compared to their wild-type counterparts. These fusion transcription factors alter expression of target genes, and thereby result in a variety of altered cellular properties that contribute to the tumourigenic process.
Class
Human Diseases; Cancer: overview
Pathway map
gvr05202  Transcriptional misregulation in cancer
gvr05202

Organism
Galeopterus variegatus (Sunda flying lemur) [GN:gvr]
Gene
103581652  [KO:K11253]
103581771  [KO:K02583]
103581851  [KO:K10500]
103581869  RUNX2; runt-related transcription factor 2 [KO:K09278]
103582159  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
103582933  [KO:K10784]
103583500  [KO:K06856]
103583502  CD86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
103584188  [KO:K15592]
103584250  [KO:K11253]
103584785  [KO:K11253]
103585043  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
103585073  SIX4; homeobox protein SIX4 [KO:K15615]
103585074  SIX1; homeobox protein SIX1 [KO:K15614]
103585184  H3F3B; histone H3.3 [KO:K11253]
103585398  HPGD; 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [KO:K00069] [EC:1.1.1.141]
103585498  EYA1; eyes absent homolog 1 isoform X1 [KO:K15616] [EC:3.1.3.48]
103585514  FLI1; Friend leukemia integration 1 transcription factor [KO:K09436]
103585568  CEBPE; CCAAT/enhancer-binding protein epsilon [KO:K10051]
103585676  NFKBIZ; NF-kappa-B inhibitor zeta isoform X1 [KO:K14242]
103585766  PTCRA; pre T-cell antigen receptor alpha [KO:K06056]
103585928  IL6; interleukin-6 [KO:K05405]
103586074  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
103586448  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
103586528  HMGA2; high mobility group protein HMGI-C isoform X1 [KO:K09283]
103586548  [KO:K11253]
103586556  [KO:K11253]
103586659  WT1; Wilms tumor protein [KO:K09234]
103586735  ZEB1; zinc finger E-box-binding homeobox 1 [KO:K09299]
103586898  HOXA9; homeobox protein Hox-A9 [KO:K21950]
103586899  HOXA11; homeobox protein Hox-A11 [KO:K21951]
103586904  HOXA10; homeobox protein Hox-A10 [KO:K17443]
103586963  RUNX1; runt-related transcription factor 1 isoform X1 [KO:K08367]
103587023  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
103587301  TRAF1; TNF receptor-associated factor 1 [KO:K03172]
103587501  ATF1; cyclic AMP-dependent transcription factor ATF-1 isoform X1 [KO:K09053]
103587526  HHEX; hematopoietically-expressed homeobox protein HHEX [KO:K08024]
103587619  WHSC1; histone-lysine N-methyltransferase NSD2 isoform X1 [KO:K11424] [EC:2.1.1.357]
103587762  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103587820  MYC; myc proto-oncogene protein [KO:K04377]
103587934  MLF1; myeloid leukemia factor 1 [KO:K15622]
103587984  JMJD1C; probable JmjC domain-containing histone demethylation protein 2C [KO:K11449] [EC:1.14.11.-]
103588070  PML; protein PML isoform X1 [KO:K10054] [EC:2.3.2.-]
103588192  [KO:K11253]
103588200  EWSR1; LOW QUALITY PROTEIN: RNA-binding protein EWS [KO:K13209]
103588373  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
103588459  REL; proto-oncogene c-Rel [KO:K09254]
103588539  SPINT1; kunitz-type protease inhibitor 1 [KO:K15619]
103588563  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
103588587  PRCC; proline-rich protein PRCC isoform X1 [KO:K13105]
103588757  SS18L1; calcium-responsive transactivator [KO:K15623]
103588868  CCNT1; cyclin-T1 [KO:K15188]
103588935  MYCN; N-myc proto-oncogene protein [KO:K09109]
103588966  NCOR1; nuclear receptor corepressor 1 isoform X1 [KO:K04650]
103589001  CDK9; cyclin-dependent kinase 9 [KO:K02211] [EC:2.7.11.22 2.7.11.23]
103589137  MAF; transcription factor Maf [KO:K09035]
103589174  JUP; junction plakoglobin [KO:K10056]
103589268  PLAT; tissue-type plasminogen activator [KO:K01343] [EC:3.4.21.68]
103589282  TMPRSS2; transmembrane protease serine 2 [KO:K09633] [EC:3.4.21.122]
103589313  MPO; myeloperoxidase [KO:K10789] [EC:1.11.2.2]
103589438  TFE3; transcription factor E3 isoform X1 [KO:K09105]
103589570  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
103589573  MMP9; matrix metalloproteinase-9 [KO:K01403] [EC:3.4.24.35]
103589755  TSPAN7; tetraspanin-7 [KO:K06571]
103590058  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
103590430  KLF3; Krueppel-like factor 3 [KO:K15605]
103590603  MEN1; menin [KO:K14970]
103590613  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
103591002  MEIS1; homeobox protein Meis1 isoform X1 [KO:K15613]
103591210  [KO:K01353] [EC:3.4.21.79]
103591211  [KO:K01353] [EC:3.4.21.79]
103591212  [KO:K01353] [EC:3.4.21.79]
103591214  KDM6A; lysine-specific demethylase 6A isoform X1 [KO:K11447] [EC:1.14.11.68]
103591379  CXCL8; interleukin-8 [KO:K10030]
103591400  TP53; cellular tumor antigen p53 [KO:K04451]
103591675  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
103591905  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
103591966  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
103592005  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
103592089  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
103592096  DDB2; DNA damage-binding protein 2 [KO:K10140]
103592221  ITGB7; integrin beta-7 [KO:K06590]
103592282  KMT2A; histone-lysine N-methyltransferase 2A [KO:K09186] [EC:2.1.1.354]
103592695  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
103592813  SP1; transcription factor Sp1 [KO:K04684]
103592947  MLLT1; protein ENL [KO:K15187]
103593324  ASPSCR1; tether containing UBX domain for GLUT4 isoform X1 [KO:K15627]
103593819  DDX5; probable ATP-dependent RNA helicase DDX5 [KO:K12823] [EC:5.6.2.7]
103593947  [KO:K11447] [EC:1.14.11.68]
103594063  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103594134  ETV6; transcription factor ETV6 [KO:K03211]
103594198  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
103594326  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
103594348  TLX3; T-cell leukemia homeobox protein 3 [KO:K15607]
103594449  PROM1; prominin-1 isoform X1 [KO:K06532]
103594594  ZBTB16; zinc finger and BTB domain-containing protein 16 [KO:K10055]
103594598  RUNX1T1; protein CBFA2T1 [KO:K10053]
103594638  ETV5; ETS translocation variant 5 [KO:K15593]
103594789  ETV1; ETS translocation variant 1 isoform X1 [KO:K09431]
103594928  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
103595105  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
103595134  PLAU; urokinase-type plasminogen activator [KO:K01348] [EC:3.4.21.73]
103595208  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
103595264  SMAD1; mothers against decapentaplegic homolog 1 isoform X1 [KO:K04676]
103595334  RELA; transcription factor p65 [KO:K04735]
103595601  NUPR1; nuclear protein 1 [KO:K15626]
103595669  MLLT3; protein AF-9 isoform X1 [KO:K15187]
103595759  PAX8; paired box protein Pax-8 [KO:K09293]
103595815  LYL1; protein lyl-1 [KO:K15604]
103596078  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
103596079  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
103596428  BCL6; B-cell lymphoma 6 protein [KO:K15618]
103596430  SIN3A; paired amphipathic helix protein Sin3a [KO:K11644]
103596721  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
103596792  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
103596800  NR4A3; nuclear receptor subfamily 4 group A member 3 [KO:K08559]
103596809  ELK4; LOW QUALITY PROTEIN: ETS domain-containing protein Elk-4 [KO:K04376]
103596996  H3F3A; histone H3.3 [KO:K11253]
103597016  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
103597025  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
103597189  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
103597250  FOXO1; LOW QUALITY PROTEIN: forkhead box protein O1 [KO:K07201]
103597428  BAIAP3; BAI1-associated protein 3 isoform X1 [KO:K15621]
103597464  BCL2A1; bcl-2-related protein A1 [KO:K02162]
103597510  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
103597936  RXRB; retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
103598025  [KO:K11253]
103598026  [KO:K11253]
103598027  [KO:K11253]
103598088  BMP2K; BMP-2-inducible protein kinase [KO:K08854] [EC:2.7.11.1]
103598508  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
103598645  FUT8; alpha-(1,6)-fucosyltransferase [KO:K00717] [EC:2.4.1.68]
103598878  MAX; protein max isoform X1 [KO:K04453]
103598905  [KO:K15610]
103598950  CEBPA; CCAAT/enhancer-binding protein alpha [KO:K09055]
103599351  CCNT2; cyclin-T2 isoform X1 [KO:K15188]
103599614  IGFBP3; insulin-like growth factor-binding protein 3 [KO:K10138]
103599851  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
103600250  FEV; protein FEV [KO:K09437]
103600379  MMP3; stromelysin-1 [KO:K01394] [EC:3.4.24.17]
103600828  AFF1; AF4/FMR2 family member 1 [KO:K15184]
103600891  CDKN2C; cyclin-dependent kinase 4 inhibitor C [KO:K06622]
103601162  DOT1L; histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [KO:K11427] [EC:2.1.1.360]
103601188  [KO:K11253]
103601365  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
103601449  CD14; monocyte differentiation antigen CD14 [KO:K04391]
103601506  PER2; period circadian protein homolog 2 [KO:K02633]
103601524  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
103602238  SS18; protein SSXT [KO:K15623]
103602373  CCNA1; cyclin-A1 [KO:K06627]
103603083  [KO:K15589]
103603147  [KO:K11253]
103603150  [KO:K11253]
103603158  [KO:K11253]
103603305  TLX1; T-cell leukemia homeobox protein 1 [KO:K09340]
103603441  PAX5; paired box protein Pax-5 isoform X1 [KO:K09383]
103603454  LMO2; rhombotin-2 [KO:K15612]
103603769  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
103603964  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
103604227  [KO:K10784]
103604259  [KO:K10500]
103604403  ETV4; ETS translocation variant 4 [KO:K15592]
103604993  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
103605007  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
103605353  [KO:K10785]
103605523  TAF15; TATA-binding protein-associated factor 2N isoform X1 [KO:K14651]
103606025  TCF3; transcription factor E2-alpha isoform X1 [KO:K09063]
103606208  [KO:K09435]
103606342  [KO:K11253]
103606392  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
103606671  [KO:K06856]
103606901  [KO:K06498]
103606959  [KO:K09381]
103607313  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
103607349  RXRG; retinoic acid receptor RXR-gamma [KO:K08526]
103607357  [KO:K06856]
103607369  ETV7; transcription factor ETV7 isoform X1 [KO:K03211]
103607669  ELANE; neutrophil elastase [KO:K01327] [EC:3.4.21.37]
103607734  RARA; retinoic acid receptor alpha isoform X1 [KO:K08527]
103607913  [KO:K11459]
103608004  CCNA2; cyclin-A2 [KO:K06627]
103608271  [KO:K15624]
103608929  LDB1; LIM domain-binding protein 1 isoform X1 [KO:K15617]
103609194  ID2; DNA-binding protein inhibitor ID-2 [KO:K17693]
103609215  PAX3; paired box protein Pax-3 isoform X1 [KO:K09381]
103609769  [KO:K06856]
103610076  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
103610124  ITGAM; integrin alpha-M [KO:K06461]
103610195  [KO:K05230]
103610197  [KO:K05230]
103610237  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
103610385  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
103610970  [KO:K05092] [EC:2.7.10.1]
Reference
PMID:11607818
  Authors
Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciari C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicci PG
  Title
Common themes in the pathogenesis of acute myeloid leukemia.
  Journal
Oncogene 20:5680-94 (2001)
DOI:10.1038/sj.onc.1204642
Reference
PMID:12032780
  Authors
Scandura JM, Boccuni P, Cammenga J, Nimer SD
  Title
Transcription factor fusions in acute leukemia: variations on a theme.
  Journal
Oncogene 21:3422-44 (2002)
DOI:10.1038/sj.onc.1205315
Reference
PMID:12529654
  Authors
Roumier C, Fenaux P, Lafage M, Imbert M, Eclache V, Preudhomme C
  Title
New mechanisms of AML1 gene alteration in hematological malignancies.
  Journal
Leukemia 17:9-16 (2003)
DOI:10.1038/sj.leu.2402766
Reference
PMID:10717473
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7
Reference
PMID:19075268
  Authors
Koschmieder S, Halmos B, Levantini E, Tenen DG
  Title
Dysregulation of the C/EBPalpha differentiation pathway in human cancer.
  Journal
J Clin Oncol 27:619-28 (2009)
DOI:10.1200/JCO.2008.17.9812
Reference
PMID:11340171
  Authors
Johansen LM, Iwama A, Lodie TA, Sasaki K, Felsher DW, Golub TR, Tenen DG
  Title
c-Myc is a critical target for c/EBPalpha in granulopoiesis.
  Journal
Mol Cell Biol 21:3789-806 (2001)
DOI:10.1128/MCB.21.11.3789-3806.2001
Reference
PMID:15985538
  Authors
Gery S, Gombart AF, Yi WS, Koeffler C, Hofmann WK, Koeffler HP
  Title
Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia.
  Journal
Blood 106:2827-36 (2005)
DOI:10.1182/blood-2005-01-0358
Reference
PMID:12393465
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288
Reference
PMID:12130514
  Authors
Mueller BU, Pabst T, Osato M, Asou N, Johansen LM, Minden MD, Behre G, Hiddemann W, Ito Y, Tenen DG
  Title
Heterozygous PU.1 mutations are associated with acute myeloid leukemia.
  Journal
Blood 100:998-1007 (2002)
DOI:10.1182/blood.V100.3.998
Reference
PMID:15160934
  Authors
Jing Y
  Title
The PML-RARalpha fusion protein and targeted therapy for acute promyelocytic leukemia.
  Journal
Leuk Lymphoma 45:639-48 (2004)
DOI:10.1080/10428190310001609933
Reference
PMID:15024077
  Authors
Muller-Tidow C, Steffen B, Cauvet T, Tickenbrock L, Ji P, Diederichs S, Sargin B, Kohler G, Stelljes M, Puccetti E, Ruthardt M, deVos S, Hiebert SW, Koeffler HP, Berdel WE, Serve H
  Title
Translocation products in acute myeloid leukemia activate the Wnt signaling pathway in hematopoietic cells.
  Journal
Mol Cell Biol 24:2890-904 (2004)
DOI:10.1128/MCB.24.7.2890-2904.2004
Reference
PMID:19855079
  Authors
Rice KL, Hormaeche I, Doulatov S, Flatow JM, Grimwade D, Mills KI, Leiva M, Ablain J, Ambardekar C, McConnell MJ, Dick JE, Licht JD
  Title
Comprehensive genomic screens identify a role for PLZF-RARalpha as a positive regulator of cell proliferation via direct regulation of c-MYC.
  Journal
Blood 114:5499-511 (2009)
DOI:10.1182/blood-2009-03-206524
Reference
PMID:10500199
  Authors
McWhirter JR, Neuteboom ST, Wancewicz EV, Monia BP, Downing JR, Murre C
  Title
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemia.
  Journal
Proc Natl Acad Sci U S A 96:11464-9 (1999)
DOI:10.1073/pnas.96.20.11464
Reference
PMID:15156184
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
PMID:14630078
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
PMID:19141473
  Authors
Guenther MG, Lawton LN, Rozovskaia T, Frampton GM, Levine SS, Volkert TL, Croce CM, Nakamura T, Canaani E, Young RA
  Title
Aberrant chromatin at genes encoding stem cell regulators in human mixed-lineage leukemia.
  Journal
Genes Dev 22:3403-8 (2008)
DOI:10.1101/gad.1741408
Reference
PMID:16169901
  Authors
Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ
  Title
The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression.
  Journal
Proc Natl Acad Sci U S A 102:14028-33 (2005)
DOI:10.1073/pnas.0506464102
Reference
PMID:21518926
  Authors
Wang QF, Wu G, Mi S, He F, Wu J, Dong J, Luo RT, Mattison R, Kaberlein JJ, Prabhakar S, Ji H, Thirman MJ
  Title
MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome.
  Journal
Blood 117:6895-905 (2011)
DOI:10.1182/blood-2010-12-324699
Reference
PMID:14701735
  Authors
Zeisig BB, Milne T, Garcia-Cuellar MP, Schreiner S, Martin ME, Fuchs U, Borkhardt A, Chanda SK, Walker J, Soden R, Hess JL, Slany RK
  Title
Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization.
  Journal
Mol Cell Biol 24:617-28 (2004)
DOI:10.1128/MCB.24.2.617-628.2004
Reference
PMID:19133982
  Authors
Riz I, Hawley TS, Johnston H, Hawley RG
  Title
Role of TLX1 in T-cell acute lymphoblastic leukaemia pathogenesis.
  Journal
Br J Haematol 145:140-3 (2009)
DOI:10.1111/j.1365-2141.2008.07556.x
Reference
PMID:12511414
  Authors
Barth TF, Martin-Subero JI, Joos S, Menz CK, Hasel C, Mechtersheimer G, Parwaresch RM, Lichter P, Siebert R, Mooller P
  Title
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma.
  Journal
Blood 101:3681-6 (2003)
DOI:10.1182/blood-2002-08-2577
Reference
PMID:11313274
  Authors
Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C
  Title
Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells.
  Journal
Blood 97:2798-807 (2001)
DOI:10.1182/blood.V97.9.2798
Reference
PMID:12670461
  Authors
Zuzel M, Cawley JC.
  Title
The biology of hairy cells.
  Journal
Best Pract Res Clin Haematol 16:1-13 (2003)
DOI:10.1016/S1521-6926(02)00082-8
Reference
PMID:14998494
  Authors
Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM
  Title
Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma.
  Journal
Cancer Cell 5:191-9 (2004)
DOI:10.1016/S1535-6108(04)00019-4
Reference
PMID:20974671
  Authors
Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD
  Title
The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells.
  Journal
Blood 117:211-20 (2011)
DOI:10.1182/blood-2010-07-298349
Reference
PMID:19059936
  Authors
Brito JL, Walker B, Jenner M, Dickens NJ, Brown NJ, Ross FM, Avramidou A, Irving JA, Gonzalez D, Davies FE, Morgan GJ
  Title
MMSET deregulation affects cell cycle progression and adhesion regulons in t(4;14) myeloma plasma cells.
  Journal
Haematologica 94:78-86 (2009)
DOI:10.3324/haematol.13426
Reference
PMID:10350329
  Authors
Iida S, Rao PH, Ueda R, Chaganti RS, Dalla-Favera R
  Title
Chromosomal rearrangement of the PAX-5 locus in lymphoplasmacytic lymphoma with t(9;14)(p13;q32).
  Journal
Leuk Lymphoma 34:25-33 (1999)
DOI:10.3109/10428199909083377
Reference
PMID:10784387
  Authors
Ohno H, Ueda C, Akasaka T
  Title
The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
  Journal
Leuk Lymphoma 36:435-45 (2000)
DOI:10.3109/10428190009148390
Reference
PMID:19233641
  Authors
Prensner JR, Chinnaiyan AM
  Title
Oncogenic gene fusions in epithelial carcinomas.
  Journal
Curr Opin Genet Dev 19:82-91 (2009)
DOI:10.1016/j.gde.2008.11.008
Reference
PMID:19406209
  Authors
Brenner JC, Chinnaiyan AM
  Title
Translocations in epithelial cancers.
  Journal
Biochim Biophys Acta 1796:201-15 (2009)
DOI:10.1016/j.bbcan.2009.04.005
Reference
PMID:16946003
  Authors
Reddi HV, McIver B, Grebe SK, Eberhardt NL
  Title
The paired box-8/peroxisome proliferator-activated receptor-gamma oncogene in thyroid tumorigenesis.
  Journal
Endocrinology 148:932-5 (2007)
DOI:10.1210/en.2006-0926
Reference
PMID:19422821
  Authors
Medendorp K, van Groningen JJ, Vreede L, Hetterschijt L, Brugmans L, van den Hurk WH, van Kessel AG
  Title
The renal cell carcinoma-associated oncogenic fusion protein PRCCTFE3 provokes p21 WAF1/CIP1-mediated cell cycle delay.
  Journal
Exp Cell Res 315:2399-409 (2009)
DOI:10.1016/j.yexcr.2009.04.022
Reference
PMID:18563191
  Authors
Kumar-Sinha C, Tomlins SA, Chinnaiyan AM
  Title
Recurrent gene fusions in prostate cancer.
  Journal
Nat Rev Cancer 8:497-511 (2008)
DOI:10.1038/nrc2402
Reference
PMID:20478527
  Authors
Yu J, Yu J, Mani RS, Cao Q, Brenner CJ, Cao X, Wang X, Wu L, Li J, Hu M, Gong Y, Cheng H, Laxman B, Vellaichamy A, Shankar S, Li Y, Dhanasekaran SM, Morey R, Barrette T, Lonigro RJ, Tomlins SA, Varambally S, Qin ZS, Chinnaiyan AM
  Title
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
  Journal
Cancer Cell 17:443-54 (2010)
DOI:10.1016/j.ccr.2010.03.018
Reference
PMID:21747944
  Authors
Leshem O, Madar S, Kogan-Sakin I, Kamer I, Goldstein I, Brosh R, Cohen Y, Jacob-Hirsch J, Ehrlich M, Ben-Sasson S, Goldfinger N, Loewenthal R, Gazit E, Rotter V, Berger R
  Title
TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
  Journal
PLoS One 6:e21650 (2011)
DOI:10.1371/journal.pone.0021650
Reference
PMID:17505060
  Authors
Cai C, Hsieh CL, Omwancha J, Zheng Z, Chen SY, Baert JL, Shemshedini L
  Title
ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
  Journal
Mol Endocrinol 21:1835-46 (2007)
DOI:10.1210/me.2006-0480
Reference
PMID:18172298
  Authors
Helgeson BE, Tomlins SA, Shah N, Laxman B, Cao Q, Prensner JR, Cao X, Singla N, Montie JE, Varambally S, Mehra R, Chinnaiyan AM
  Title
Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer.
  Journal
Cancer Res 68:73-80 (2008)
DOI:10.1158/0008-5472.CAN-07-5352
Reference
PMID:21849159
  Authors
Westermark UK, Wilhelm M, Frenzel A, Henriksson MA
  Title
The MYCN oncogene and differentiation in neuroblastoma.
  Journal
Semin Cancer Biol 21:256-66 (2011)
DOI:10.1016/j.semcancer.2011.08.001
Reference
PMID:20153925
  Authors
Bell E, Chen L, Liu T, Marshall GM, Lunec J, Tweddle DA
  Title
MYCN oncoprotein targets and their therapeutic potential.
  Journal
Cancer Lett 293:144-57 (2010)
DOI:10.1016/j.canlet.2010.01.015
Reference
PMID:15644444
  Authors
Slack A, Chen Z, Tonelli R, Pule M, Hunt L, Pession A, Shohet JM
  Title
The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.
  Journal
Proc Natl Acad Sci U S A 102:731-6 (2005)
DOI:10.1073/pnas.0405495102
Reference
PMID:20190806
  Authors
Ochiai H, Takenobu H, Nakagawa A, Yamaguchi Y, Kimura M, Ohira M, Okimoto Y, Fujimura Y, Koseki H, Kohno Y, Nakagawara A, Kamijo T
  Title
Bmi1 is a MYCN target gene that regulates tumorigenesis through repression of KIF1Bbeta and TSLC1 in neuroblastoma.
  Journal
Oncogene 29:2681-90 (2010)
DOI:10.1038/onc.2010.22
Reference
PMID:20145147
  Authors
Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA
  Title
p53 is a direct transcriptional target of MYCN in neuroblastoma.
  Journal
Cancer Res 70:1377-88 (2010)
DOI:10.1158/0008-5472.CAN-09-2598
Reference
PMID:17327229
  Authors
Beierle EA, Trujillo A, Nagaram A, Kurenova EV, Finch R, Ma X, Vella J, Cance WG, Golubovskaya VM
  Title
N-MYC regulates focal adhesion kinase expression in human neuroblastoma.
  Journal
J Biol Chem 282:12503-16 (2007)
DOI:10.1074/jbc.M701450200
Reference
PMID:21123453
  Authors
Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G
  Title
A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF.
  Journal
Cancer Res 71:404-12 (2011)
DOI:10.1158/0008-5472.CAN-10-2627
Reference
PMID:17024155
  Authors
Dreijerink KM, Hoppener JW, Timmers HM, Lips CJ
  Title
Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.
  Journal
Nat Clin Pract Endocrinol Metab 2:562-70 (2006)
DOI:10.1038/ncpendmet0292
Reference
PMID:19075677
  Authors
Wu X, Hua X
  Title
Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.
  Journal
Curr Mol Med 8:805-15 (2008)
DOI:10.2174/156652408786733702
Reference
PMID:19564705
  Authors
Sakurai A, Murakami A, Sano K, Uchino S, Fukushima Y
  Title
Unusual clinical and pathological presentation of a neuroendocrine tumor in a patient with multiple endocrine neoplasia type 1.
  Journal
Endocr J 56:887-95 (2009)
DOI:10.1507/endocrj.K09E-126
Reference
PMID:17222504
  Authors
Yang Y, Hua X
  Title
In search of tumor suppressing functions of menin.
  Journal
Mol Cell Endocrinol 265-266:34-41 (2007)
DOI:10.1016/j.mce.2006.12.032
Reference
PMID:15826838
  Authors
Aman P
  Title
Fusion oncogenes in tumor development.
  Journal
Semin Cancer Biol 15:236-43 (2005)
DOI:10.1016/j.semcancer.2005.01.009
Reference
PMID:12527902
  Authors
Fukuma M, Okita H, Hata J, Umezawa A
  Title
Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma.
  Journal
Oncogene 22:1-9 (2003)
DOI:10.1038/sj.onc.1206055
Reference
PMID:18648544
  Authors
Cironi L, Riggi N, Provero P, Wolf N, Suva ML, Suva D, Kindler V, Stamenkovic I
  Title
IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.
  Journal
PLoS One 3:e2634 (2008)
DOI:10.1371/journal.pone.0002634
Reference
PMID:17250957
  Authors
Riggi N, Stamenkovic I.
  Title
The Biology of Ewing sarcoma.
  Journal
Cancer Lett 254:1-10 (2007)
DOI:10.1016/j.canlet.2006.12.009
Reference
PMID:20490326
  Authors
Jedlicka P
  Title
Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions.
  Journal
Int J Clin Exp Pathol 3:338-47 (2010)
Reference
PMID:19738075
  Authors
Ordonez JL, Osuna D, Herrero D, de Alava E, Madoz-Gurpide J
  Title
Advances in Ewing's sarcoma research: where are we now and what lies ahead?
  Journal
Cancer Res 69:7140-50 (2009)
DOI:10.1158/0008-5472.CAN-08-4041
Reference
PMID:12527906
  Authors
Jishage M, Fujino T, Yamazaki Y, Kuroda H, Nakamura T
  Title
Identification of target genes for EWS/ATF-1 chimeric transcription factor.
  Journal
Oncogene 22:41-9 (2003)
DOI:10.1038/sj.onc.1206074
Reference
PMID:15826834
  Authors
Gerald WL, Haber DA
  Title
The EWS-WT1 gene fusion in desmoplastic small round cell tumor.
  Journal
Semin Cancer Biol 15:197-205 (2005)
DOI:10.1016/j.semcancer.2005.01.005
Reference
PMID:18855877
  Authors
Filion C, Motoi T, Olshen AB, Lae M, Emnett RJ, Gutmann DH, Perry A, Ladanyi M, Labelle Y
  Title
The EWSR1/NR4A3 fusion protein of extraskeletal myxoid chondrosarcoma activates the PPARG nuclear receptor gene.
  Journal
J Pathol 217:83-93 (2009)
DOI:10.1002/path.2445
Reference
PMID:18330902
  Authors
Kim S, Lee HJ, Jun HJ, Kim J
  Title
The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator.
  Journal
Int J Cancer 122:2446-53 (2008)
DOI:10.1002/ijc.23379
Reference
PMID:10537274
  Authors
Sjogren H, Meis-Kindblom J, Kindblom LG, Aman P, Stenman G
  Title
Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma.
  Journal
Cancer Res 59:5064-7 (1999)
Reference
PMID:15688424
  Authors
Goransson M, Elias E, Stahlberg A, Olofsson A, Andersson C, Aman P
  Title
Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression.
  Journal
Int J Cancer 115:556-60 (2005)
DOI:10.1002/ijc.20893
Reference
PMID:18850010
  Authors
Goransson M, Andersson MK, Forni C, Stahlberg A, Andersson C, Olofsson A, Mantovani R, Aman P
  Title
The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ.
  Journal
Oncogene 28:270-8 (2009)
DOI:10.1038/onc.2008.378
Reference
PMID:20863376
  Authors
Willems SM, Schrage YM, Bruijn IH, Szuhai K, Hogendoorn PC, Bovee JV
  Title
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.
  Journal
Mol Cancer 9:257 (2010)
DOI:10.1186/1476-4598-9-257
Reference
PMID:18457914
  Authors
Linardic CM
  Title
PAX3-FOXO1 fusion gene in rhabdomyosarcoma.
  Journal
Cancer Lett 270:10-8 (2008)
DOI:10.1016/j.canlet.2008.03.035
Reference
PMID:11863357
  Authors
Barber TD, Barber MC, Tomescu O, Barr FG, Ruben S, Friedman TB
  Title
Identification of target genes regulated by PAX3 and PAX3-FKHR in embryogenesis and alveolar rhabdomyosarcoma.
  Journal
Genomics 79:278-84 (2002)
DOI:10.1006/geno.2002.6703
Reference
PMID:17101797
  Authors
Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T
  Title
The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.
  Journal
Mol Cell Biol 27:1348-55 (2007)
DOI:10.1128/MCB.00658-06
Reference
PMID:19472090
  Authors
Jun HJ, Lee J, Lim do H, Park JO, Ahn G, Seo SW, Sung KS, Lim do H, Yoo KH, Choi YL
  Title
Expression of MET in alveolar soft part sarcoma.
  Journal
Med Oncol 27:459-65 (2010)
DOI:10.1007/s12032-009-9234-8
Reference
PMID:21779514
  Authors
Rivlin N, Brosh R, Oren M, Rotter V
  Title
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis.
  Journal
Genes Cancer 2:466-74 (2011)
DOI:10.1177/1947601911408889
Reference
PMID:21765642
  Authors
Suzuki K, Matsubara H
  Title
Recent advances in p53 research and cancer treatment.
  Journal
J Biomed Biotechnol 2011:978312 (2011)
DOI:10.1155/2011/978312
Related
pathway
gvr04115  p53 signaling pathway
gvr05211  Renal cell carcinoma
gvr05215  Prostate cancer
gvr05216  Thyroid cancer
gvr05221  Acute myeloid leukemia
KO pathway
ko05202   

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